9 research outputs found
The Passing of Sovereign Immunity in Montana: The King Is Dead!
- Author
- Publication venue
- ScholarWorks at University of Montana
- Publication date
- 01/07/1973
- Field of study
The Passing Of Sovereign Immunity In Montana: The King Is Dead
The Passing of Sovereign Immunity in Montana: The King Is Dead!
- Author
- Publication venue
- The Scholarly Forum @ Montana Law
- Publication date
- 01/07/1973
- Field of study
The Passing Of Sovereign Immunity In Montana: The King Is Dead
The Natural History of Time Series
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Evolutionary cell biology: functional insight from “endless forms most beautiful”
- Author
- Adl SM
- Anastasios Tsaousis
- Aridor M
- Aridor M
- Bachvaroff TR
- Barry JD
- Baurain D
- Brodsky FM
- Brown MW
- Burki F
- Burki F
- Burki F
- Cavalier-Smith T
- Dacks JB
- David G. Drubin
- Del Campo J
- Derelle R
- Dorrell RG
- Elisabeth Richardson
- Embley TM
- Eme L
- Gadeyne A
- Goldberg AV
- Gray MW
- Heazlewood JL
- Helmke KJ
- Hirst J
- Hirst J
- Hirst J
- Hjort K
- Jedelský PL
- Joel B. Dacks
- Kelly Zerr
- Kim K
- Koumandou VL
- Lane N
- Lill R
- Lynch M
- Maralikova B
- McMahon HT
- Muller M
- Nývltová E
- Place AR
- Richard G. Dorrell
- Schneider RE
- Sickmann A
- Smith DGS
- Stairs CW
- Stiller JW
- Tsaousis AD
- Tsaousis AD
- Tsaousis AD
- Varki A
- Walker G
- Yubuki N
- Publication venue
- 'American Society for Cell Biology (ASCB)'
- Publication date
- Field of study
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
- Author
- Aarnio K.
- Acosta Boris Raul
- Aegidius Karen
- Akutsu Tsugio
- Albiker Christian
- Alegiani Anna
- Alemseged F.
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Althaus-Knaurer Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Anderson C.
- Ang T.
- Aniculaesei Adriana
- Aoki Junya
- Appleton Jason
- Arakawa Shuji
- Archer M. L.
- Arenillas Juan
- Attia J.
- Back Christina
- Bailey P.
- Balabanski A.
- Barber A.
- Barber P. A.
- Bardutzky J. rgen
- Baronnet-Chauvet Flore
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan L.
- Beck Christoph
- Belchí Guillamon Olga
- Bendszus Martin
- Benoit Amandine
- Berhoune Nadia
- Bernhardt J.
- Berrouschot J. rg
- Betensky Rebecca A.
- Bindila Daniela
- Birchenall Julia
- Bivard A.
- Blacker D.
- Bladin C. F.
- Bladin Christopher F.
- Blanc-Lasserre Karine
- Blanco Gonzales Miguel
- Bluhmki Erich
- Bobinger Tobias
- Bodechtel Ulf
- Bodiguel Eric
- Bojaryn Urszula
- Bonnet Louise
- Bouamra Benjamin
- Boulouis Gregoire
- Bourgeois Paul
- Boutitie Florent
- Bovi Paolo
- Breuer Lorenz
- Breynaert Ludovic
- Brodtmann A.
- Broughton David
- Brouns Raf
- Brugirard S. bastian
- Bruneel Bart
- Buggle Florian
- Bähr Christian
- Cadilhac D.
- Cakmak Serkan
- Calleja Ana
- Calvet David
- Campbell B. C. V.
- Campbell Bruce C. V.
- Carandang Raphael A.
- Carey L.
- Carrera David
- Celestino S.
- Chan L.
- Chang W. H.
- ChangI A.
- Chatellier Gilles
- Chen C. H.
- Chen C. I.
- Chen H. F.
- Chen Hsin-Chieh
- Chen T. C.
- Chen W. H.
- Chen Y. Y.
- Cheng Bastian
- Cheng C. A.
- Cheong E.
- Cheripelli Bharath
- Chiou Y. W.
- Cho Tae-Hee
- Choe Chi-un
- Choi P. M.
- Choy Lillian
- Christensen Hanne
- Chu H. J.
- Chuang C. S.
- Chung T. C.
- Churilov L.
- Churilov Leonid
- Ciatipis Mareva
- Clissold B.
- Cloud Geoffrey
- Cogez Julien
- Connelly A.
- Coote S.
- Copen William A.
- Cortijo Elisa
- Cougo Pedro
- Coulton B.
- Cove Lynda
- Cowley E.
- Cranefield J.
- Crozier Sophie
- Curtze S.
- Cutting Shawna
- D'Este C.
- Damgaard Dorte
- Dani Krishna
- Davis S. M.
- Davis Stephen
- Davis Stephen M.
- Day S.
- de Coene Beatrijs
- de Hollander Isabel
- de Keyser Jacques
- de Klippel Nina
- de Maeseneire Charlotte
- de Smedt Ann
- del Mar Castellanos Rodrigo Maria
- Deltour Sandrine
- Demeestere Jelle
- Derex Laurent
- Desfontaines Philippe
- Desmond P. M.
- Dewey H. M.
- Ding C.
- Dittrich Ralf
- Dixit A.
- Dixit Anand
- Dobbels Laurens
- Doijiri Ryosuke
- Domigo Valérie
- Donnan G. A.
- Donnan Geoffrey
- Donnan Geoffrey A.
- Dorado Laura
- Drake Kendra
- Drew R.
- Druart Charlotte
- Dupont Kristina Hougaard
- Dusart Anne
- Dziewas Rainer
- Ebinger Martin
- Ebner Matthias
- Edjali-Goujon Myriam
- Egashira Yusuke
- Ehrenkrona Christina
- Eirola S.
- Eisele Philipp
- el Tawil Salwa
- Elhfnawy Ahmed
- Endres Matthias
- Enomoto Yukiko
- Eschenfelder Christoph
- Etexberria Ana
- Evans Nicholas
- Fandler Simon
- Fatar Marc
- Fazekas Franz
- Felix Sandra
- Fiebach Jochen B.
- Fiebach Jochen B.
- Fiehler Jens
- Field D.
- Filipov Alexandra
- Filipski Katharina
- Fleischmann Robert
- Foerch Christian
- Ford Andria L.
- Ford Ian
- Francisco Arenillas Juan
- Frost T.
- Fukuda-Doi Mayumi
- Furui Eisuke
- Furuta Konosuke
- Gaenslen Alexandra
- Galinovic Ivana
- Gancedo Elena Meseguer
- Ganeshan Ramanan
- Garcia-Esperon C.
- García Esperón Carlos
- Garrido Alicia
- Gattringer Thomas
- George K.
- Geraghty Olivia
- Geran Rohat
- Gerloff Christian
- Gerner Stefan
- Gerraty R.
- Godon-Hardy Sylvie
- Golsari Amir
- Gomis Meritxell
- Gorriz David
- Gotoh Seiji
- Gramse Verena
- Grau Laia
- Griebe Martin
- Grimley R.
- Gruber Franz
- Guerrero Cristina
- Guerzoglu Damla
- Guettier Sophie
- Guiraud Vincent
- Gumbinger Christoph
- Gunreben Ignaz
- Guo Y. C.
- Göhler Jos
- Hacke Werner
- Haertig Florian
- Hallenbeck John
- Hamasaki Toshimitsu
- Hametner Christian
- Hankey G.
- Hanseeuw Bernard
- Hansen Andreas
- Hansen Jakob
- Harbo Thomas
- Harloff Andreas
- Harmel Peter
- Harris Gordon J.
- Harvey J.
- Hasegawa Yasuhiro
- Heinen Florian
- Held Valentin
- Hellwig Simon
- Hemelsoet Dimitri
- Hennerici Michael
- Herm Juliane
- Hermans Sylvia
- Hernández María
- Hervas Vicente Jose
- Hirano Teryuki
- Hjort Niels
- Ho S. C.
- Hobeanu Cristina
- Hobohm Carsten
- Hoesch Robert
- Hogan K.
- Hohenbichler Katharina
- Homma Kazunari
- Hommel Marc
- Hoppe Julia
- Hornberger Eva
- Howells D.
- Hoyer Carolin
- Hsia Amie
- Hsiao P. M.
- Hsu C. H.
- Hsu C. S.
- Hsu C. T.
- Hsu Chung Y.
- Hsu J. P.
- Hsu Y. D.
- Hsu Y. T.
- Hu C. J.
- Huang C. C.
- Huang H. Y.
- Huang M. Y.
- Huang S. C.
- Huang W. S.
- Huang Xuya
- Häusler Karl Georg
- Höfner Elmar
- Ichijyo Masahiko
- Ide Toshihiro
- Igarashi Shuichi
- Iguchi Yasuyuki
- Ihara Masafumi
- Ikenouchi Hajime
- Inoue Manabu
- Inoue Tsuyoshi
- Ipsen Nils
- Isern Irina
- Ispierto Lourdes
- Itabashi Ryo
- Ito Yasuhiro
- Iversen Helle
- Iwama Toru
- Jackson D.
- Jeng J. S.
- Jeppesen Lise
- Jiang S. K.
- Jimenez Marta
- Jungehülsing Jan
- Jüttler Eric
- Kaauwai L.
- Kala Lalit
- Kalladka Dheeraj
- Kallmünzer Bernd
- Kamiyama Kenji
- Kamiyoshi Shoko
- Kanai Haruka
- Kanematsu Yasuhisa
- Kanzawa Takao
- Kapeller Peter
- Kar Arindam
- Kasari O.
- Kase Carlos
- Kaste Markku
- Kellert Lars
- Kemmling André
- Kessler Christof
- Kessler Tobias
- Khan Usman
- Kimura Kazumi
- King J.
- Kitayama Jiro
- Kitazono Takanari
- Klein Matthias
- Kleinig T. J.
- Kleinig Timothy J.
- Kleinschnitz Christoph
- Klockziem Matti
- Knops Michael
- Koehler Luzie
- Koehrmann Martin
- Koga Masatoshi
- Kohlfürst Heinz
- Koivu M.
- Kolbe J.
- Kollmar Rainer
- Kondo Rei
- Kraft Peter
- Krause M.
- Krause Thomas
- Kristensen Bo
- Kröber Jan M.
- Kuan C. W.
- Kudo Kohsuke
- Kung W. L.
- Kurka Natalia
- Kusumi Masayoshi
- Kuwahara Ken
- Kyndt C.
- Köhrmann Martin
- Laage Rico
- Ladoux Alexandre
- Laloux Patrice
- Lamy Catherine
- Landrault Emmanuelle
- Latour Lawrence
- Latour Lawrence L.
- Lau C. L.
- Lauer Arne
- Lebely Claire
- Lee A.
- Lee C. Y.
- Lee J. T.
- Lee Y.
- Lee Y. C.
- Leempoel Jonathan
- Lees Kennedy
- Lees Kennedy R.
- Leger Anne
- Legrand Laurence
- Lemmens Robin
- Lev Michael H.
- Levi C.
- Levi C. R.
- Levi Christopher R.
- Leys Didier
- Li Lin
- Lien L. M.
- Lim J. C.
- Lin C. C.
- Lin C. H.
- Lin C. M.
- Lin D.
- Liu C. H.
- Liu J.
- Lo Y. C.
- Loh P. S.
- London Frederic
- Lopez-cancio Elena
- Lorenz Matthias
- Louw Stephen
- Lovelock Caroline
- Low E.
- Lozano Sánchez Manuel
- Lu C. H.
- Lu C. J.
- Lu M. K.
- Lucente Giuseppe
- Luna Rodriguez Alain
- Luna Alain
- Ly J.
- Löbbe Anna-Mareike
- Lückl Janos
- Ma H.
- Ma Henry
- Macaulay L.
- Macdonnell R.
- Macha Kosmas
- Machet Alexandre
- Mackenrodt Daniel
- Mackey E.
- Macleod M.
- Madzar Dominik
- Mahadevan J.
- Majoie Charles
- Maqueda Vicky
- Marstrand Jacob
- Martinez Alicia
- Marzina Annika
- Mas Jean-Louis
- Matsumoto Shoji
- Matsuoka Hideki
- Maxwell V.
- McCoy R.
- McDonald A.
- McModie S.
- Mechthouff Laura
- Meden Per
- Meersman Guy
- Meier Julia
- Mellerio Charles
- Menn Oliver
- Meretoja A.
- Meyer Nadja
- Michalski Dominik
- Michels Peter
- Michelsen Lene
- Mihara Ban
- Mikulik Robert
- Millán Torne Monica
- Minematsu Kazuo
- Minnerup Jens
- Mishra S.
- Mitchell P. J.
- Miteff F.
- Miura Ken
- Miwa Kaori
- Modrau Boris
- Moeller Sebastian
- Molina Carlos
- Molina Carlos A.
- Moore A.
- Morel Nathalie
- Moreton Fiona
- Morin Ludovic
- Morita Naomi
- Moulin Thierry
- Mouri Wataru
- Moynihan Barry
- Muddegowda Girish
- Mueller Anne K.
- Muir Keith
- Muir Keith W.
- Muir Keith W.
- Mulero Patricia
- Muller C.
- Mundiyanapurath Sibu
- Murata Kayo
- Mutzenbach Johannes
- Muzikansky Alona
- Männer Anika
- Møller Anette
- Nagakane Yoshinari
- Nagaraja Nandakumar
- Nagel Simon
- Naggara Oliver
- Nakase Taizen
- Nallasivan Arumugam
- Navalpotro Irene
- Nave Alexander H.
- Nederkoorn Paul
- Neeb Lars
- Neugebauer Hermann
- Neumann-Haefelin Tobias
- Ng F.
- Ng F. C.
- Ng J. L.
- Niederkorn Kurt
- Nighoghossian Norbert
- Nuñez Xavier
- O'Brian W.
- O'Collins V.
- Oberndorfer Stefan
- Ohara Hiromi
- Ohara Nobuyuki
- Ohnishi Hideyuki
- Ohta Hajime
- Ohtaki Masafumi
- Ohtani Ryo
- Ohtsuki Toshiho
- Ohyama Hideo
- Okada Takashi
- Okada Yasushi
- Opherk Christian
- Oppel Lorenz
- Oppenheim Catherine
- Orthgieß Johannes
- Osaki Masato
- Ostergaard Leif
- Oxley T. J.
- Paindeville Perrine
- Palomeras Ernest
- Panitz Verena
- Parsons M. W.
- Parsons Mark W.
- Patel Bhavni
- Patel S.
- Pedraza Salvador
- Peeters Andre
- Peeters Dirk
- Pellisé Anna
- Pelz Johann
- Peng G. S.
- Pereira Anthony
- Perry Richard
- Pesavento L.
- Petraza Salvador
- Peysson Stéphane
- Pfeilschifter Waltraud
- Phan T.
- Pichler Alexander
- Pierskalla Alexandra
- Pledl Hans-Werner
- Poli Sven
- Pomrehn Katrin
- Poulsen Marika
- Prats Luis
- Presas Silvia
- Prohaska Elisabeth
- Puetz Volker
- Puig Alcántara Josep
- Puig Josep
- Purrucker Jan
- Pérez de la Ossa Natalia
- Quenardelle Veronique
- Ramachandran Sankaranarayanan
- Raphaelle Soulliard
- Raposo Nicolas
- Reiff Tilman
- Remmers Michel
- Renou Pauline
- Ribitsch Martin
- Richter Hardy
- Ringleb Peter
- Ritter Martin
- Ritzenthaler Thomas
- Rodier Gilles
- Rodrigues E.
- Rodriguez-Regent Christine
- Rodríguez-Yáñez Manuel
- Roennefarth Maria
- Roffe Christine
- Rosenbaum Sverre
- Ross Z.
- Rosso Charlotte
- Rozanski Michal
- Ruiz de Morales Noelia
- Russo Francesca
- Rutgers Matthieu
- Röther Joachim
- Sabet A.
- Sagnier Sharmilla
- Sakai Nobuyuki
- Sallaberger M.
- Salvaris P.
- Samson Yves
- Sanbongi Yoshiki
- Sasaki Makoto
- Sasaki Naoshi
- Sato Shoichiro
- Sauer Tamara
- Schellinger Peter
- Schellinger Peter D.
- Schieber Simon
- Schill Josef
- Schlak Dennis
- Schlemm Ludwig
- Schmidt Sein
- Schonewille Wouter
- Schröder Julian
- Schulz Andreas
- Schurig Johannes
- Schwab Stefan
- Schwamm Lee H.
- Schwamm Lee H.
- Schwarting S. nke
- Schwarz Alexander
- Schwarzbach Christopher
- Schäfer Jan H.
- Searls Eric
- Seidel Matthias
- Seiler Alexander
- Seki Kenta
- Sembill Jochen
- Serena Leal Joaquin
- Serena Joaquin
- Shah D.
- Sharma G.
- Shetty Ashit
- Shimizu Wataru
- Shiokawa Yoshiaki
- Sibolt G.
- Sibon Igor
- Simonsen Claus Z.
- Simonsen Claus Z.
- Simpson M.
- Singer Oliver
- Singhal S.
- Sivagnanaratham Aravinth
- Smets Ide
- Smith Craig
- Snow B.
- Sobesky Jan
- Song Shlee S.
- Song Shlee S.
- Soors Peter
- Sozu Takashi
- Spratt N.
- Sprigg Nikola
- Spruegel Maximilian
- Stark David
- Stark R.
- Starkman Sidney
- Steiner Thorsten
- Steinert Susanne
- Stuermlinger Markus
- Sturm J.
- Stösser Sebastian
- Sun M. C.
- Sun Y.
- Sung P. S.
- Sung Y. F.
- Suzuki Junichiro
- Suzuki M.
- Suzuki Rieko
- Svenson Ann-Sofie
- Swinnen Bart
- Sánchez Josep
- Takagi Yasushi
- Takizawa Shunya
- Tamazyan Ruben
- Tan M.
- Tanahashi Norio
- Tanaka Eijiro
- Tanaka Ryota
- Tang S. C.
- Tateishi Yohei
- Tatlisumak T.
- Tembl Jose
- Terada Tomoaki
- Terasaki Tadashi
- Terceno Izaga Mikel
- Thijs V.
- Thijs Vincent
- Thomalla G. tz
- Tiainen M.
- Todo Kenichi
- Tokunaga Azusa
- Toni Danilo
- Touze Emmanuel
- Toyoda Kazunori
- Truelsen Thomas
- Tsai C. H.
- Tsai C. K.
- Tsai C. L.
- Tsai H. T.
- Tsai L. K.
- Tseng C. H.
- Tseng L. T.
- Tsoleridis J.
- Tsujino Akira
- Tu H.
- Tu H. T. H.
- Turc Guillaume
- Turine Gaetane
- Tyrell Pippa
- Tütüncü Serdar
- Ueda Toshihiro
- Uesaka Yoshikazu
- Uotani Mihoko
- Urabe Takao
- Ustrell Xavier
- Vadot Wilfried
- Vallat W.
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- van Hooff Robbert-Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Viguier Alain
- Vilas Dolores
- Villringer Kersten
- Virta J.
- Voget Dieke
- von Kummer R. diger
- von Schrader J. rg
- von Weitzel Paul
- Wahlgren Nils
- Wang W. C.
- Wang Y. T.
- Warach Steven
- Warburton Elisabeth
- Wardlaw Joanna
- Watanabe Masao
- Waters M.
- Weber Claudia
- Weber J. rg
- Wegscheider Karl
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weir L.
- Weise Christopher
- Weise Gesa
- Wijeratne T.
- Willems Chris
- Williams C.
- Wilson W.
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wong A. A.
- Wong K.
- Wouters Anke
- Wu Ona
- Wu T. Y.
- Wu Y. H.
- Yagita Yoshiki
- Yakushiji Yusuke
- Yalo Bertrand
- Yamamoto Haruko
- Yan B.
- Yang F. C.
- Yang Y. W.
- Yassi N.
- Yassi Nawaf
- Yasui Keizo
- Yeh H. L.
- Yeh J. H.
- Yeh S. J.
- Yen C. H.
- Yger Marion
- Yonehara Toshiro
- Yoo Albert J.
- Yoshimura Shinichi
- Yoshimura Sohei
- Younan Nadia
- Young D.
- Yperzeele Laetita
- Ysai C. L.
- Zand Ramin
- Zegarac Vesna
- Zeiner Pia
- Zhang W. W.
- Zhao H.
- Zhao L.
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- 'Elsevier BV'
- Publication date
- 14/11/2020
- Field of study
Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I 2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
- Aceituno A
- Acosta I
- Adams A
- Adatia S
- Aerden Leo A.m.
- Aeron-thomas John
- Aggour Mohamed
- Aghaebrahim A
- Agid R
- Aguettaz Pierre
- Ahle Guido
- Aja L
- Akhtar N
- Al Najjar-carpentier Amen-adam
- Al'boutros S
- Al-ajlan F
- Albers Gregory W
- Albers Gregory W.
- Alexandrou M
- Alhazzaa M
- Ali L
- Allen E
- Almekhlafi M
- Alseraya A
- Aly J
- Amar Arun
- Amaro S
- Amato-marzialli B
- Amerson L
- Amiri H
- Andersen G
- Andersen L
- Anderson A
- Andersson Tommy
- Ang Timothy
- Anton C
- Anxionnat René
- Apoil-brissard Marion
- Aram H
- Arenillas Lara Jf
- Arenillas J
- Ariño H
- Arkin S
- Armbruster K
- Armitage K
- Arquizan C
- Arquizan Caroline
- Arteaga Charles
- Ashforth Ra
- Ashok Vasdev
- Attia John
- Ayrignac X
- Azizi A
- Añon J
- Bach E
- Badve Monica
- Baillot Pierre-alexandre
- Bain M
- Bakchine Serge
- Baker C
- Balasa M
- Balgude A
- Bamford John
- Banaras Azra
- Bang Oh Young
- Bang Oy
- Barber P. Alan
- Barber Pa
- Barbier Charlotte
- Barbieux Marianne
- Barnwell S
- Baronnet-chauvet Flore
- Barral Francis-guy
- Barreau Xavier
- Barros Renan Sales
- Bartolini Mario Bruno
- Barton K
- Barton K
- Bartt R
- Basir G
- Bataille Mathieu
- Bauer A
- Baxendell L
- Baxendell L
- Baxter B
- Baxter Bw
- Beadell N
- Beauchamp B
- Beaujeux Rémy
- Beck C
- Beck P
- Becker M
- Beenen Ludo F.m.
- Bejot Yannick
- Belagaje Sr
- Belden J
- Bellew M
- Bellon R
- Bendszus M
- Bennett Patricia
- Berge Jérôme
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- Touze Emmanuel
- Trenkler J
- Trivedi A
- Trystram Denis
- Tu Hans
- Tummala R
- Tunguturi A
- Turc Guillaume
- Turjman Francis
- Turjman Francis
- Turk As
- Turner R
- Uchino K
- Urra X
- Urra Xabier
- Utpadel Fischler D
- Van Boxtel Tiemen
- Van Den Berg Jan S.p.
- Van Den Berg Lucie A
- Van Den Berg Lucie A
- Van Den Berg René
- Van Den Berg-vos Renske M.
- Van Der Heijden Esther
- Van Der Lugt Aad
- Van Der Lugt Aad
- Van Dijk Ewoud J.
- Van Dijk Lukas C.
- Van Dijk R
- Van Hasselt Boudewijn A.a.m.
- Van Oostayen Jacques A.
- Van Oostenbrugge Robert J
- Van Oostenbrugge Robert J.
- Van Rooij Willem Jan J.
- Van Vemde Gina
- Van Walderveen Marianne Aa
- Van Zwam Wim H
- Van Zwam Wim H.
- Vandorpe R
- Velasco Stephane
- Venema Esmee
- Veraque Emelda
- Viader Fausto
- Villar C
- Villwock M
- Vincent F
- Vinken Stefan
- Visser Marieke C.
- Vitello Nicolas
- Voguet Charlotte
- Voguet Charlotte
- Von Kummer Ruüdiger
- Von Weitzel Mudersbach P
- Vora N
- Vos Jan Albert
- Vroomen Patrick C.
- Vuillemet Françis
- Vuillier Fabrice
- Wagner A
- Wagner J
- Wagner M
- Wahlgren Nils
- Wakhloo A
- Walsh T
- Wang Adrien
- Wanke I
- Wardlaw Joanna
- Watson Tw
- Watt M
- Watts M
- Weaver M
- Wechsler L
- Wechsler L
- Weill A
- Weill A
- Weimar C
- Weinstein C
- Weisman Dc
- Wermer Marieke Jh
- Weymayr F
- Whaley M
- Whelan R
- White Philip
- White Philip
- Wiegner R
- Wiertlewski Sandrine
- Wiese C
- Wiggam I
- Wijeratne Tissa
- Williams D
- Williams D
- Williams J
- Willinsky Ra
- Willinsky Ra
- Wisco D
- Witteler A
- Wodarg F
- Wolff Valérie
- Wong Andrew
- Wong Jh
- Wong Jh
- Wong Kitty
- Wortmann G
- Wright Mr
- Wright Mr
- Wu Teddy Y
- Wunderlich S
- Yan Bernard
- Yanase L
- Yang V
- Yassi Nawaf
- Yavagal D
- Yavagal Dileep R
- Yavagal Dileep R.
- Yeo Ta
- Yger Marion
- Yoo Albert J
- Yoo J
- You Sj
- Young Dennis
- Yu Y
- Zacharatos H
- Zaidat O
- Zaidi S
- Zavanone Chiara
- Zech M
- Zegarac V
- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons
Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
- Author
- Acosta Boris Raul
- Aegidius Karen
- Albiker Christian
- Alcantara Josep Puig
- Alegiani Anna
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Aniculaesei Adriana
- Appleton Jason
- Arenillas Juan
- Back Christina
- Bahr Christian
- Bardutzky Jurgen
- Baronnet-Chauvet Flore
- Barow Ewgenia
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan L
- Beck Christoph
- Benoit Amandine
- Berhoune Nadia
- Bindila Daniela
- Birchenall Julia
- Blanc-Lasserre Karine
- Bobinger Tobias
- Bodechtel Ulf
- Bodiguel Eric
- Bojaryn Urszula
- Bonnet Anne-Laure
- Bonnet Louise
- Bouamra Benjamin
- Bourgeois Paul
- Boutitie Florent
- Breuer Lorenz
- Breynaert Ludovic
- Broughton David
- Brouns Raf
- Brugirard Sebastian
- Bruneel Bart
- Buggle Florian
- Cakmak Serkan
- Calleja Ana
- Calvet David
- Carrera David
- Chen Hsin-Chieh
- Cheng Bastian
- Cheripelli Bharath
- Cho Tae-Hee
- Choe Chi-un
- Choy Lillian
- Christensen Hanne
- Ciatipis Mareva
- Cloud Geoffrey
- Cogez Julien
- Cortijo Elisa
- Crozier Sophie
- Damgaard Dorte
- Dani Krishna
- De Coene Beatrijs
- de Hollander Isabel
- De Klippel Nina
- de la Ossa Natalia Perez
- De Maeseneire Charlotte
- de Morales Noelia Ruiz
- De Smedt Ann
- DeKeyser Jacques
- Deltour Sandrine
- Demeestere Jelle
- Derex Laurent
- Desfontaines Philippe
- Dittrich Ralf
- Dixit Anand
- Dobbels Laurens
- Domigo Valerie
- Dorado Laura
- Druart Charlotte
- Dupont Kristina Hougaard
- Dusart Anne
- Dziewas Rainer
- Ebinger Martin
- Ebner Matthias
- Edjali-Goujon Myriam
- Eisele Philipp
- El Tawil Salwa
- Elhfnawy Ahmed
- Endres Matthias
- Esperon Carlos Garcia
- Etexberria Ana
- Evans Nicholas
- Fandler Simon
- Fazekas Franz
- Felix Sandra
- Fiebach Jochen B
- Fiehler Jens
- Filipov Alexandra
- Filipski Katharina
- Fleischmann Robert
- Foerch Christian
- Ford Ian
- Gaenslen Alexandra
- Galinovic Ivana
- Galinovic Ivana
- Gancedo Elena Meseguer
- Ganeshan Ramanan
- Garrido Alicia
- Gattringer Thomas
- Geraghty Olivia
- Geran Rohat
- Gerloff Christian
- Gerloff Christian
- Gerner Stefan
- Godon-Hardy Sylvie
- Gohler Jos
- Golsari Amir
- Gomis Meritxell
- Gonzales Miguel Blanco
- Gorriz David
- Gramse Verena
- Grau Laia
- Griebe Martin
- Guerrero Cristina
- Guerzoglu Damla
- Guettier Sophie
- Guillamon Olga Belchi
- Guiraud Vincent
- Gumbinger Christoph
- Gunreben Ignaz
- Gutierrez Salvador Pedraza
- Haertig Florian
- Hametner Christian
- Hanseeuw Bernard
- Hansen Andreas
- Hansen Jakob
- Harbo Thomas
- Harloff Andreas
- Harmel Peter
- Heinen Florian
- Held Valentin
- Hellwig Simon
- Hemelsoet Dimitri
- Hennerici Michael
- Herm Juliane
- Hermans Sylvia
- Hernandez Maria
- Hjort Niels
- Hobeanu Cristina
- Hobohm Carsten
- Hofner Elmar
- Hohenbichler Katharina
- Hoppe Julia
- Hornberger Eva
- Hoyer Carolin
- Huang Xuya
- Ipsen Nils
- Isern Irina
- Ispierto Lourdes
- Iversen Helle
- Izaga Mikel Terceno
- Jeppesen Lise
- Jimenez Marta
- Jungehulsing Jan
- Juttler Eric
- Kalladka Dheeraj
- Kallmunzer Bernd
- Kar Arindam
- Kellert Lars
- Kessler Tobias
- Khan Usman
- Klein Matthias
- Kleinschnitz Christoph
- Klockziem Matti
- Knops Michael
- Koehler Luzie
- Koehrmann Martin
- Kohlfurst Heinz
- Kollmar Rainer
- Kraft Peter
- Krause Thomas
- Kristensen Bo
- Krober Jan M
- Kurka Natalia
- Ladoux Alexandre
- Laloux Patrice
- Lamy Catherine
- Landrault Emmanuelle
- Lauer Arne
- Leal Joaquin Serena
- Lebely Claire
- Leempoel Jonathan
- Leger Anne
- Legrand Laurence
- Lemmens Robin
- Lemmens Robin
- Li Lin
- Lobbe Anna-Mareike
- London Frederic
- Lopez-Cancio Elena
- Lorenz Matthias
- Louw Stephen
- Lovelock Caroline
- Lucente Giuseppe
- Luckl Janos
- Luna Alain
- Macha Kosmas
- Machet Alexandre
- Mackenrodt Daniel
- Madzar Dominik
- Magnus Tim
- Majoie Charles
- Manner Anika
- Maqueda Vicky
- Marstrand Jacob
- Martinez Alicia
- Marzina Annika
- Mechthouff Laura
- Meden Per
- Meersman Guy
- Meier Julia
- Mellerio Charles
- Menn Oliver
- Meyer Nadja
- Michalski Dominik
- Michels Peter
- Michelsen Lene
- Minnerup Jens
- Modrau Boris
- Moeller Sebastian
- Moller Anette
- Morel Nathalie
- Moreton Fiona
- Morin Ludovic
- Moulin Thierry
- Moynihan Barry
- Mueller Anne K
- Muir Keith W
- Muir Keith W
- Mulero Patricia
- Mundiyanapurath Sibu
- Mutzenbach Johannes
- Nagel Simon
- Naggara Oliver
- Nallasivan Arumugam
- Navalpotro Irene
- Nave Alexander H
- Nederkoorn Paul
- Neugebauer Hermann
- Neumann-Haefelin Tobias
- Nickel Alina
- Nighoghossian Norbert
- Nighoghossian Norbert
- Oberndorfer Stefan
- Opherk Christian
- Oppel Lorenz
- Oppenheim Catherine
- Orthgiess Johannes
- Ostergaard Leif
- Paindeville Perrine
- Palomeras Ernest
- Panitz Verena
- Patel Bhavni
- Pedraza Salvador
- Peeters Andre
- Peeters Dirk
- Pellise Anna
- Pelz Johann
- Pereira Anthony
- Perry Richard
- Peysson Stephane
- Pfeilschifter Waltraud
- Pichler Alexander
- Pierskalla Alexandra
- Pledl Hans-Werner
- Poli Sven
- Pomrehn Katrin
- Poulsen Marika
- Prats Luis
- Presas Silvia
- Prohaska Elisabeth
- Puetz Volker
- Puig Josep
- Purrucker Jan
- Quenardelle Veronique
- Ramachandran Sankaranarayanan
- Raphaelle Soulliard
- Raposo Nicolas
- Reiff Tilman
- Remmers Michel
- Renou Pauline
- Ribitsch Martin
- Richter Hardy
- Ringleb Peter
- Ritter Martin
- Ritzenthaler Thomas
- Rodier Gilles
- Rodrigo Maria del Mar Castellanos
- Rodriguez-Regent Christine
- Rodriguez-Yanez Manuel
- Roennefarth Maria
- Roffe Christine
- Rosenbaum Sverre
- Rosso Charlotte
- Rother Joachim
- Roy Pascal
- Rozanski Michal
- Russo Francesca
- Rutgers Matthieu
- Sagnier Sharmilla
- Samson Yues
- Sanchez Josep
- Sanchez Manuel Lozano
- Sauer Tamara
- Schafer Jan H
- Schieber Simon
- Schill Josef
- Schlak Dennis
- Schlemm Ludwig
- Schmidt Sein
- Schonewille Wouter
- Schroder Julian
- Schulz Andreas
- Schurig Johannes
- Schwarting Sonke
- Schwarz Alexander
- Schwarzbach Christopher
- Seidel Matthias
- Seiler Alexander
- Sembill Jochen
- Shetty Ashit
- Sibon Igor
- Simonsen Claus Z
- Simonsen Claus Z
- Singer Oliver
- Sivagnanaratham Aravinth
- Smets Ide
- Smith Craig
- Soors Peter
- Sprigg Nikola
- Spruegel Maximilian
- Stark David
- Steinert Susanne
- Stosser Sebastian
- Stuermlinger Markus
- Swinnen Bart
- Tamazyan Ruben
- Tembl Jose
- Thijs Vincent
- Thijs Vincent
- Thomalla Goetz
- Thomalla Gotz
- Torne Monica Millan
- Touze Emmanuel
- Touze Emmanuel
- Truelsen Thomas
- Turc Guillaume
- Turine Gaetane
- Tutuncu Serdar
- Tyrell Pippa
- Ustrell Xavier
- Vadot Wilfried
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- Van Hooff Robbert-Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Vicente Jose Hervas
- Viguier Alain
- Vilas Dolores
- Voget Dieke
- von Schrader Jorg
- von Weitzel Paul
- Warburton Elisabeth
- Weber Claudia
- Weber Jorg
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weise Christopher
- Weise Gesa
- Willems Chris
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wouters Anke
- Wouters Anke
- Yalo Bertrand
- Yger Marion
- Younan Nadia
- Yperzeele Laetita
- Zegarac Vesna
- Zeiner Pia
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
Importance: The rationale for intravenous thrombolysis in patients with lacunar infarcts is debated, since it is hypothesized that the microvascular occlusion underlying lacunar infarcts might not be susceptible to pharmacological reperfusion treatment. Objective: To study the efficacy and safety of intravenous thrombolysis among patients with lacunar infarcts. Design, Setting, and Participants: This exploratory secondary post hoc analysis of the WAKE-UP trial included patients who were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). The WAKE-UP trial was a multicenter, double-blind, placebo-controlled randomized clinical trial to study the efficacy and safety of intravenous thrombolysis with alteplase in patients with an acute stroke of unknown onset time, guided by magnetic resonance imaging. All 503 patients randomized in the WAKE-UP trial were reviewed for lacunar infarcts. Diagnosis of lacunar infarcts was based on magnetic resonance imaging and made by consensus of 2 independent investigators blinded to clinical information. Main Outcomes and Measures: The primary efficacy variable was favorable outcome defined by a score of 0 to 1 on the modified Rankin Scale at 90 days after stroke, adjusted for age and severity of symptoms. Results: Of the 503 patients randomized in the WAKE-UP trial, 108 patients (including 74 men [68.5%]) had imaging-defined lacunar infarcts, whereas 395 patients (including 251 men [63.5%]) had nonlacunar infarcts. Patients with lacunar infarcts were younger than patients with nonlacunar infarcts (mean age [SD], 63 [12] years vs 66 [12] years; P = .003). Of patients with lacunar infarcts, 55 (50.9%) were assigned to treatment with alteplase and 53 (49.1%) to receive placebo. Treatment with alteplase was associated with higher odds of favorable outcome, with no heterogeneity of treatment outcome between lacunar and nonlacunar stroke subtypes. In patients with lacunar strokes, a favorable outcome was observed in 31 of 53 patients (59%) in the alteplase group compared with 24 of 52 patients (46%) in the placebo group (adjusted odds ratio [aOR], 1.67 [95% CI, 0.77-3.64]). There was 1 death and 1 symptomatic intracranial hemorrhage according to Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria in the alteplase group, while no death and no symptomatic intracranial hemorrhage occurred in the placebo group. The distribution of the modified Rankin Scale scores 90 days after stroke also showed a nonsignificant shift toward better outcomes in patients with lacunar infarcts treated with alteplase, with an adjusted common odds ratio of 1.94 (95% CI, 0.95-3.93). Conclusions and Relevance: While the WAKE-UP trial was not powered to demonstrate the efficacy of treatment in subgroups of patients, the results indicate that the association of intravenous alteplase with functional outcome does not differ in patients with imaging-defined lacunar infarcts compared with those experiencing other stroke subtypes.status: publishe
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- Davidson
- Davies
- Davies
- Davies
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- Davies
- Davies
- Davis
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- Davis
- Davis
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- Dawson
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- Dawson
- De Groot
- de L. Brooke
- de L. Brooke
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- Dick
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- Doyle
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- Eastwood
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- Ellis
- Elmberg
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- Emlen
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- Eriksson
- Eriksson
- Eriksson
- Erni
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- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Evans
- Eyster
- Faaborg
- Faaborg
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- Farner
- Farner
- Farner
- Farnsworth
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- Feare
- Feare
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- Fiedler
- Fiedler
- Fiedler
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- Figuerola
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- Fisher
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- Formosov
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- Formosov
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- Fox
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- Franz
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- Frazer
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- Fry
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- Fuller
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- Gauthier
- Gauthier
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gauthreaux
- Gavin
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- Gessaman
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- Gill
- Gill
- Gill
- Gilroy
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- Ginn
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- Goldstein
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- Green
- Green
- Green
- Green
- Green
- Greenberg
- Greenberg
- Greenberg
- Greenberg
- Greenberg
- Greenberg
- Greenberg
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- Gudmundsson
- Gudmundsson
- Gudmundsson
- Gullestad
- Gunnarsson
- Gunnarsson
- Gustafsson
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gwinner
- Gylfe
- Gätke
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- Haapanen
- Haas
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- Hagan
- Hagan
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- Hahn
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- Hall
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- Harris
- Harris
- Harris
- Harris
- Harrison
- Harrison
- Harrison
- Hart
- Hartley
- Harvey
- Harvey
- Hau
- Hayden
- Hayden
- Hays
- Hebrard
- Hedenström
- Hedenström
- Hedenström
- Hedenström
- Hedenström
- Hedenström
- Heibl
- Heise
- Heitmeyer
- Helander
- Helbig
- Helbig
- Helbig
- Helbig
- Helbig
- Helbig
- Helbig
- Helbig
- Helbig
- Helm
- Helm
- Helm
- Helm
- Helms
- Helms
- Hengeveld
- Henningsson
- Henny
- Henny
- Hepp
- Hepp
- Hepp
- Hepp
- Herremans
- Herremans
- Herremans
- Herremans
- Herremans
- Herrera
- Herrera
- Herrera
- Herzog
- Hestbeck
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- Hewitt
- Hickling
- Hicks
- Higgins
- Higuchi
- Higuchi
- Higuchi
- Higuchi
- Higuchi
- Higuchi
- Higuchi
- Hildén
- Hildén
- Hildén
- Hildén
- Hildén
- Hildén
- Hildén
- Hildén
- Hill
- Hill
- Hiraldo
- Hixon
- Hjertaas
- Hjort
- Hjort
- Hke
- Hke
- Hobbs
- Hobson
- Hobson
- Hobson
- Hobson
- Hobson
- Hobson
- Hobson
- Hochachka
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- Hoffman
- Hoffman
- Hoffman
- Hoffman
- Hogstad
- Hogstad
- Holberton
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- Holland
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- Holmes
- Holmes
- Holmes
- Holmes
- Holmgren
- Holmgren
- Holmgren
- Hoover
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- Houston
- Houston
- Houston
- Houston
- Houston
- Howe
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- Howlett
- Howlett
- Huin
- Huin
- Hume
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- Hummel
- Hunt
- Hunt
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- Hupp
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- Hussell
- Hutto
- Hutto
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- Hüppop
- Igual
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- Imboden
- Immelmann
- Inouye
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- Irwin
- Irwin
- Iverson
- Izhaki
- Izhaki
- Izhaki
- Jackson
- Jaeger
- Jaeger
- Jahn
- Jakober
- James
- James
- Jansson
- Jardine
- Javed
- Jehl
- Jehl
- Jehl
- Jehl
- Jehl
- Jehl
- Jenkins
- Jenkins
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni
- Jenni-Eiermann
- Jenni-Eiermann
- Jenni-Eiermann
- Jenni-Eiermann
- Jensen
- Jensen
- Jensen
- John
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnston
- Johnston
- Johnston
- Johnston
- Jones
- Jones
- Jones
- Jones
- Jones
- Jordano
- Joseph
- Joseph
- Joseph
- Jouventin
- Jukema
- Järvinen
- Jönsson
- K.P.
- Kaiser
- Kaitala
- Kalela
- Kalela
- Kalmbach
- Kaminski
- Kanai
- Kanai
- Kanai
- Kanyamibwa
- Karasov
- Karasov
- Karr
- Karr
- Kaufman
- Kaufman
- Keast
- Keast
- Keast
- Keast
- Keast
- Keeton
- Keith
- Keith
- Keller
- Keller
- Kelly
- Kelly
- Kelly
- Kelly
- Kelsey
- Kemp
- Kemper
- Kendeigh
- Kendeigh
- Kennard
- Kennedy
- Kent
- Kenward
- Kenward
- Kenyon
- Kerlinger
- Kerlinger
- Kerlinger
- Kerlinger
- Kerlinger
- Keskpaik
- Kessel
- kesson
- kesson
- kesson
- kesson
- kesson
- kesson
- kesson
- kesson
- Ketterson
- Ketterson
- Ketterson
- Ketterson
- Ketterson
- Ketterson
- Ketterson
- Kikkawa
- Kilpi
- Kilpi
- King
- King
- King
- King
- King
- King
- King
- King
- King
- King
- King
- Kirkwood
- Kirschvink
- Kjellén
- Kjellén
- Kjellén
- Kjellén
- Kjellén
- Kjellén
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klaassen
- Klein
- Klein
- Klomp
- Klomp
- Kluijver
- Kluijver
- Knox
- Kodric-Brown
- Koerner
- Kok
- Kokko
- Kokko
- Kolunen
- Komar
- Komdeur
- Korpimäki
- Korpimäki
- Korpimäki
- Korpimäki
- Korpimäki
- Korpimäki
- Kosarev
- Koskimies
- Kramer
- Kramer
- Kramer
- Krapu
- Krapu
- Krapu
- Krapu
- Krause
- Kress
- Kuenzi
- Kuhnen
- Kullberg
- Kullberg
- Kullberg
- Kuroda
- Kuyt
- Kvist
- Kvist
- Kvist
- Köenig
- Köenig
- Köenig
- Köenig
- Köenig
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Lack
- Laing
- Landmann
- Landys
- Landys-Ciannelli
- Lane
- Lank
- Lank
- Lanner
- Lanyon
- Larson
- Larson
- Larsson
- Larsson
- Lasiewski
- Latta
- Latta
- Latta
- Lavée
- Lawn
- Le Houerou
- Lee
- Lehikoinen
- Leisler
- Leisler
- Leitner
- Lemon
- Lensink
- Lepczyk
- Leshem
- Leshem
- Leshem
- Leshem
- Levey
- Lewis
- Lewis
- Lid
- Liechti
- Liechti
- Liechti
- Liechti
- Liechti
- Ligon
- Ligon
- Limpert
- Lin
- Lincoln
- Lincoln
- Lind
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Lindström
- Littlefield
- Litwin
- Liu
- Liversidge
- Lloyd
- Locke
- Lockie
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- Loftin
- Lofts
- Lofts
- Lofts
- Lofts
- Lofts
- Lofts
- Lofts
- Long
- Long
- Lopez
- Lorenzana
- Loria
- Lowery
- Loxton
- Loxton
- Lozano
- Ludwigs
- Lundberg
- Lundberg
- Lundberg
- Lundberg
- Lundberg
- Lundberg
- Lundberg
- Lundgren
- Lynch
- Lynch
- Lynch
- Lyngs
- Lyons
- Lyuleeva
- Lõhmus
- Lõhmus
- Lõhmus
- Löfgren
- Löhrl
- Mabie
- MacArthur
- Macdonald
- Macdonald
- MacInnes
- MacMillan
- Maddock
- Maddock
- Madsen
- Madsen
- Madsen
- Madsen
- Madsen
- Magnin
- Maher
- Main
- Main
- Mainguy
- Mainwood
- Maisonneuve
- Maitav
- Malherbe
- Manolis
- Manville
- Marchant
- Marchant
- Marchant
- Marchette
- Marcström
- Marion
- Marjakangas
- Markgren
- Markovets
- Marks
- Marks
- Marks
- Marks
- Marks
- Marquiss
- Marquiss
- Marra
- Marra
- Marra
- Marra
- Marra
- Marsh
- Marsh
- Marshall
- Marshall
- Marshall
- Martell
- Martell
- Marti
- Martin
- Martin
- Martin
- Martinez
- Martínez-Meyer
- Massa
- Mattes
- Matthews
- Matthysen
- Matthysen
- Mattocks
- May
- Mayaud
- Mayfield
- Mayfield
- Mayr
- Mazerolle
- McCaskie
- McClelland
- McClintock
- McClure
- McCulloch
- McGrady
- McGrady
- McGrady
- McIlhenny
- McIlhenny
- McLachlan
- McLandress
- McLandress
- McLaren
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- McNeil
- McNeil
- McWilliams
- McWilliams
- Mead
- Mead
- Mead
- Mead
- Mead
- Mead
- Mead
- Mearns
- Medway
- Mehl
- Mehlum
- Meltofte
- Meltofte
- Mendelsohn
- Mendelssohn
- Menu
- Merilä
- Merkel
- Merkel
- Merkel
- Merom
- Metcalfe
- Metcalfe
- Metcalfe
- Meury
- Mewaldt
- Mewaldt
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Meyburg
- Michener
- Michener
- Mihelsons
- Mihelsons
- Mikkonen
- Mikkonen
- Miller
- Miller
- Mills
- Mills
- Milne
- Milot
- Milwright
- Milwright
- Milá
- Minami
- Mindell
- Minton
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- Montalvo
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Moore
- Morales
- Morbey
- Moreau
- Moreau
- Moreau
- Moreau
- Moreau
- Moreau
- Moreau
- Moreau
- Morel
- Morel
- Morgan
- Moritz
- Morris
- Morris
- Morris
- Morrison
- Morrison
- Morrison
- Morse
- Morse
- Morton
- Morton
- Morton
- Morton
- Morton
- Morton
- Morton
- Morton
- Morton
- Morton
- Mosbech
- Moser
- Moss
- Mouritsen
- Mouritsen
- Mouritsen
- Mueller
- Mueller
- Mueller
- Mueller
- Muheim
- Muheim
- Mukhin
- Mukhin
- Mukhin
- Mullié
- Munro
- Munro
- Murphy
- Murphy
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- Murray
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- Myers
- Myers
- Myers
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- Mönkkönen
- Mönkkönen
- Mönkkönen
- Møller
- Møller
- Møller
- Møller
- Møller
- Møller
- Møller
- Møller
- Nachtigall
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- Nager
- Nakazawa
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- Nebel
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- Nelson
- Nero
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- Newton
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- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Newton
- Nice
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- Nichols
- Nichols
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- Nichols
- Nichols
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- Nilsson
- Nilsson
- Nilsson
- Nilsson
- Nilsson
- Nilsson
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- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nisbet
- Nix
- Nolan
- Nolan
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- Norberg
- Norman
- Norman
- Norman
- Norris
- Norris
- Norris
- Norris
- Noskov
- Noskov
- Nott
- Novoa
- Nowakowski
- Nowakowski
- Nuorteva
- Nyström
- O'Briain
- O'Connor
- O'Connor
- O'Connor
- O'Hara
- O'Hara
- Oatley
- Oatley
- Obmascik
- Obst
- Odum
- Odum
- Oeming
- Ohmart
- Ojanen
- Ojanen
- Olea
- Olsen
- Olssen
- Orell
- Oring
- Oring
- Oring
- Ormerod
- Ormerod
- Osborne
- Osorio-Beristain
- Otahal
- Ottich
- Ottosson
- Ottosson
- Outlaw
- Overskaug
- Owen
- Owen
- Owen
- Owen
- Owen
- Owen
- Owen
- Owre
- Ozarowska
- Pace
- Page
- Palmer
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- Paradis
- Parks
- Parmelee
- Parr
- Parrish
- Parrish
- Paton
- Paton
- Patten
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- Patterson
- Payevski
- Payevski
- Payne
- Payne
- Payne
- Payne
- Paynter
- Peach
- peach
- Peach
- Peach
- Pearson
- Pearson
- Pearson
- Pearson
- Pearson
- Pearson
- Pearson
- Peiponen
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Pennycuick
- Percival
- Perdeck
- Perdeck
- Perdeck
- Perdeck
- Perrins
- Perrins
- Perrins
- Perrins
- Perrins
- Peterjohn
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- Petrie
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- Petty
- Petty
- Pfister
- Phillips
- Phillips
- Phillips
- Phillips
- Phillips
- Phillips
- Phillips
- Phillips
- Pickering
- Pienaar
- Pienkowski
- Pienkowski
- Pienkowski
- Pierce
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piersma
- Piertney
- Pilastro
- Pineau
- Pinowski
- Pitches
- Pitelka
- Pitra
- Ploeger
- Poole
- Poole
- Popa-Lisseanu
- Porter
- Porter
- Pospahala
- Post
- Postma
- Potapov
- Potti
- Pratt
- Prescott
- Prescott
- Preston
- Prevett
- Price
- Price
- Prill
- Prince
- Prop
- Prop
- Prop
- Prop
- Prop
- Pulido
- Pulido
- Pulido
- Pulido
- Pulido
- Pulido
- Pulliam
- Putnam
- Putz
- Putz
- Pynnönen
- Pärt
- Pärt
- Pérez-Tris
- Pérez-Tris
- Pützig
- Quay
- Questiau
- R.W.
- Rabenold
- Rabøl
- Rabøl
- Rabøl
- Rabøl
- Rabøl
- Rabøl
- Rabøl
- Rabøl
- Ralph
- Ralph
- Ralph
- Ramenofsky
- Ramenofsky
- Rappole
- Rappole
- Rappole
- Rappole
- Rappole
- Rappole
- Rappole
- Rappole
- Raveling
- Raveling
- Raveling
- Rayner
- Rayner
- Rayner
- Rayner
- Recher
- Reed
- Reed
- Reed
- Reed
- Rees
- Rees
- Rees
- Rehfisch
- Rehfisch
- Reid
- Reid
- Reinikainen
- Remisiewicz
- Rensch
- Restani
- Rey
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- Reynolds
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- Richardson
- Richdale
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- Robb
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- Robbins
- Robbins
- Robbins
- Robbins
- Robert
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- Roberts
- Robertson
- Robertson
- Robertson
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- Robinson
- Robinson
- Robinson
- Robinson
- Rockenbauch
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- Rogers
- Rogers
- Rohner
- Rohner
- Rohwer
- Rohwer
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- Roos
- Root
- Root
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- Rothstein
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- Rowan
- Rowan
- Rowan
- Rowan
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- Safriel
- Sagar
- Saino
- Salewski
- Salewski
- Salewski
- Salomonsen
- Salomonsen
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- World Resources Institute United Nations Environment Program, United Nations Development Program
- Wunderle
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2007
- Field of study
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
- Author
- A Aceituno
- A Adams
- A Aghaebrahim
- A Alseraya
- A Anderson
- A Azizi
- A Balgude
- A Bauer
- A Bharatha
- A Bhatt
- A Binder
- A Bitner
- A Blue-Schaller
- A Cayley
- A Cervera
- A Chamorro
- A Cullen
- A Dogan
- A Drofa
- A Ducruet
- A Ducruet
- A Durocher
- A Dávalos
- A Farrag
- A Farrow-Schmidt
- A Flores
- A Fulton
- A Grande
- A Hassan
- A Hendrickson
- A Horev
- A Huberle
- A Hunter
- A Itreat
- A Jadhav
- A Jadhav
- A Jedlitschka
- A Kansara
- A Kastrup
- A Knox
- A Krützelmann
- A Lima
- A López
- A Malek
- A Malik
- A Manosalva
- A Martin
- A Martínez-Piñeiro
- A Minaeian
- A Mohammad
- A Moore
- A Noorian
- A Novak
- A O'Driscoll
- A O'Hare
- A Patel
- A Porter
- A Puri
- A Rai
- A Ranft
- A Renu
- A Richmond
- A Ringlestein
- A Rohr
- A Rontal
- A Rontal
- A Rovira
- A Russman
- A Saad
- A Shuaib
- A Shuaib
- A Siddiqui
- A Sirelkhatim
- A Sirelkhatim
- A Swarnkar
- A Taqui
- A Tarabishy
- A Tomasello
- A Trivedi
- A Tunguturi
- A Wagner
- A Wakhloo
- A Weill
- A Weill
- A Witteler
- Aad van der Lugt
- Aad van der Lugt
- Aboubaker Cherifi
- Aditya Bharatha
- Adnan H. Siddiqui
- Adriaan Ros
- Adrien Chavent
- Adrien Wang
- AI Calleja Sanz
- Alain Bonafé
- Alain Bonafé
- Alain Bonafé
- Alain Tournade
- Alan Coulthard
- Albers
- Albers
- Albert J Yoo
- Alderic Lecluse
- Alejandro Tomasello
- Alessandra Biondi
- Alexander V. Tielbeek
- Alexandre Leautaud
- Alicia Murray
- Alina Lintia-Gaultier
- Alis Heshmatollah
- AM Demchuk
- Amanda Gilligan
- Amen-Adam Al Najjar-Carpentier
- Amit Herwadkar
- Amy McDonald
- Anand Dixit
- Andrew Clifton
- Andrew Lee
- Andrew M Demchuk
- Andrew Wong
- André Gaston
- Andy Clifton
- Andy Molyneux
- Anna Ferrier
- Anna-Raquel Marques
- Annabelle Kazadi
- Anne Leger
- Anne Pasco-Papon
- Anne-Laure Bonnet
- Anne-Laure Derelle
- Annemieke Lindl-Velema
- Annet Geerling
- Ans de Ridder
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- Antoine Gueguen
- Antoni Dávalos
- AP Mitha
- AP Mitha
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- Apolline Kazemi
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- Arnaud Gentil
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- Aurélia Schunck
- AY Poppe
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- Azra Banaras
- B Amato-Marzialli
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- B Jankowitz
- B Jankowitz
- B Klein
- B Knier
- B Lara
- B Peterson
- B Sapkota
- B Sapkota
- B Schwaiger
- B Schwindt
- B Spencer
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- Bivard
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- M Alexandrou
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- M Ezzeddine
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- M Guglielmetti
- M Hamberger
- M Hammer
- M Hammer
- M Hernández-Pérez
- M Hjørringgaard
- M Hogan
- M Holtmannspötter
- M Horton
- M Howk
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- M Kowarik
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- M Salluzzi
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- M Salvat-Plana
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- MA de Miquel
- Manon Kappelhof
- Marc Bintner
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- Mariana Sarov
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- S Subramaniam
- S Tateshima
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- S Wunderlich
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- Sabrina Debruxelles
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- Sanjeev Nayak
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- Stephen M Davis
- Stephen M Davis
- Susan Day
- Sylvain Lachaud
- Sylvie Godon-Hardy
- Sébastien Richard
- Sébastien Richard
- Séverine Debiais
- T Boeckh-Behrens
- T Coughlan
- T Daly
- T Daly
- T Davis
- T Devlin
- T Devlin
- T Galvin
- T Harbo
- T Hendrickson
- T Hyldal
- T Jeerakathil
- T Kahles
- T Krings
- T Larson
- T Lowenkopf
- T Lynch
- T Marotta
- T Meindl
- T Musuka
- T Nguyen
- T Reiff
- T Roberts
- T Sajobi
- T Sajobi
- T Scheibe-Mirek
- T Stavngaard
- T Stewart
- T Stewart
- T Stewart
- T Walsh
- TA Yeo
- Tae-Hee Cho
- Tanya Frost
- TB Kotylak
- Teddy Y Wu
- TG Jovin
- Thanh Phan
- Theo Stijnen
- Thibaud Lebouvier
- Thierry Moulin
- Thomas J Oxley
- Thomas Liebig
- Thomas Ritzenthaler
- Thomas Ronziere
- Thompson Robinson
- Tiemen van Boxtel
- Timo Krings
- Timothy Ang
- Timothy J Harrington
- Timothy J Kleinig
- Tiphaine Rouaud
- Tissa Wijeratne
- Tobien H.C.M.L. Schreuder
- Tommy Andersson
- Tony Goddard
- TS Field
- Tudor G Jovin
- Tudor G. Jovin
- TW Watson
- U Grzyska
- V Biberacher
- V Chang
- V Costalat
- V Deshmukh
- V Dubuc
- V Kalugdan
- V Nambiar
- V Obach
- V Pandey
- V Patel
- V Reddy
- V Snyder
- V Szeder
- V Totoraitis
- V Totoraitis
- V Yang
- V Zegarac
- VA Coté
- Valérie Domigo
- Valérie Wolff
- Vasdev Ashok
- Vincent Cahagne
- Vincent Costalat
- Vincent Guiraud
- Violaine Rouaud Jaffrenou
- Vitor Mendes Pereira
- VK Reddy
- W Clark
- W Holloway
- W Maloney
- W Montanera
- W Morgan
- W Pfeilschifer
- W Poon
- W Tekle
- Wade Smith
- Werner Hacke
- WF Morrish
- WF Morrish
- Willem Jan J. van Rooij
- Willy Struijk
- Wilma Pellikaan
- Wim H van Zwam
- Wim H. van Zwam
- Winston Chong
- Wintermark
- WJ Hicks
- WJ Montanera
- WJ Montanera
- Wouter J Schonewille
- X Ayrignac
- X Urra
- Xavier Barreau
- Xavier Ducrocq
- Xavier Leclerc
- Y Deschaintre
- Y Li
- Y Yu
- Yannick Bejot
- YD Kim
- Yince Loh
- Yves Chau
- Yves Samson
- Yvo B W E M Roos
- Yvo B.W.E.M. Roos
- Z El-Zammar
- Z Khawaja
- Zofia Ross
- Zoltan Szatmary
- Zwenneke Flach
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