A genomic approach to the study of Tribolium castaneum genetics, development & evolution

During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development with a focus on segmentation and homeotic genes. In order to acquire independent knowledge on the genetic basis of insect development, a genomic approach consisting of EST and BAC-ends sequencing projects has been initiated in Tribolium. The EST project resulted in the production of 2,246 random sequences representing 488 non-redundant EST contigs. Of those, 280 sequences were selected, along with 86 independently cloned putative transcription factors, and further characterized by in situ hybridization. Expression analysis led to the identification of at least 25 novel genes putatively involved in diverse aspects of Tribolium embryonic development such as segmentation, appendage development, neurogenesis, myogenesis and terminal patterning. Comparative evolutionary analysis of the EST sequences verified that Tribolium is a slow evolving species when compared to dipterans. As predicted by the neutral theory, the data also revealed that evolutionary rates are a composite measure of both gene and species specific rates. To date, the BAC-ends sequencing project resulted in the production of 8,640 sequences covering 2.9% of the Tribolium genome. A functional analysis of a subset of these BAC-end sequences (BES) allowed the identification of 486 putative ORFs. It is estimated that of the 53,000 BES to be produced, 6,900 ORFs will be found, comprising 18% of the genome. Random sequencing of ESTs and production of BES are shown to be powerful ways to identify new genes, to help mapping the Tribolium genome and to identify coding regions in genomic sequences

Scaling up infrastructure spending in the Philippines: A CGE top-down bottom-up microsimulation approach

In this paper we use a top-down bottom-up CGE microsimulation model with endogenous labour supply and unemployment to explore the impact of scaling up infrastructure spending in the Philippines. In the current debate on the importance of scaling up infrastructure to stimulate growth, some analysts raise concerns about potential negative macroeconomic impacts (Dutch disease). This study aims to provide some insight into this debate by extending the analysis to include distributional analysis. We draw from the infrastructure productivity literature to postulate positive productive externalities of new infrastructure and from Fay and Yepes (2003) to include operating and maintenance costs associated with new infrastructure. We investigate two fiscal tools and foreign aid as mechanisms to fund the new infrastructure and associated costs. The distributional analysis is performed with FGT indices and growth incidence curves. Our results reveal that infrastructure spending reduces poverty. Foreign aid is shown to be the most equitable funding mechanism, whereas a value added tax provides the strongest poverty reduction.Investment externalities, infrastructure, foreign aid, fiscal reforms, poverty, CGE, microsimulation.

Poverty and Income Distribution in a CGE-Household Micro-Simulation Model: Top-Down/Bottom Up Approach

This paper highlights the idea of combining CGE modeling with a micro-household model (micro-simulation) to generate a convergent solution, thus providing the basis to perform counterfactual analysis of trade and fiscal policies, and their impact on poverty. In recent years, a number of papers have presented differen approaches using CGE models to analyze poverty. Among them, the standard CGE models, which generates changes in the income of representative households in order to allow poverty analysis, albeit with no intra-group changes in the distribution; CGE models with high levels of household disaggregation (3200) and the micro-simulation approach to modeling (with no feedback effect to the CGE model). In this paper, we provide an alternative to these methods that allows a richer micro-household modeling than the first two approaches, while keeping the properties of standard CGE (feedback effect of household behavior) which is usually simplified in micro-simulation context. We also introduce segmented labor markets, with waiting unemployment, inspired by Magnac (1991), which provides a basis for important changes in household income (i.e. when a worker leaves unemployment or becomes unemployed). Global and decomposable poverty analysis and income distribution indicators are computed at base year and after a 50% reduction in trade.Computable general equilibrium models, estimation, personal income and wealth distribution, measurement and analysis of poverty

A Study of the Cyclotron Gas-Stopping Concept for the Production of Rare Isotope Beams

The proposed cyclotron gas-stopping scheme for the efficient thermalization of intense rare isotope beams is examined. Simulations expand on previous studies and expose many complications of such an apparatus arising from physical effects not accounted for properly in previous work. The previously proposed cyclotron gas-stopper geometry is found to have a near null efficiency, but extended simulations suggest that a device with a much larger pole gap could achieve a stopping efficiency approaching roughly 90% and at least a 10 times larger acceptance. However, some of the advantages that were incorrectly predicted in previous simulations for high intensity operation of this device are compromised.Comment: Accepted for publication in Nuclear Inst. and Methods in Physics Research,

The labour market in CGE models

This chapter reviews options of labour market modelling in a CGE framework. On the labour supply side, two principal modelling options are distinguished and discussed: aggregated, representative households and microsimulation based on individual household data. On the labour demand side, we focus on the substitution possibilities between different types of labour in production. With respect to labour market coordination, we discuss several wage-forming mechanisms and involuntary unemployment. --computable general equilibrium model,labour market,labour supply,labour demand,microsimulation,involuntary unemployment

The Labour Market in CGE Models

This paper reviews options of labour market-modelling in a CGE framework. On the labour-supply side, two principal modelling options are distinguished and discussed: aggregated, representative households and microsimulation based on individual household data.On the labour-demand side, we focus on the substitution possibilities between different types of labour in production.With respect to labour-market coordination, we discuss several wage-forming mechanisms and involuntary unemployment. � �

Achieving an optimal trade-off between revenue and energy peak within a smart grid environment

We consider an energy provider whose goal is to simultaneously set revenue-maximizing prices and meet a peak load constraint. In our bilevel setting, the provider acts as a leader (upper level) that takes into account a smart grid (lower level) that minimizes the sum of users' disutilities. The latter bases its decisions on the hourly prices set by the leader, as well as the schedule preferences set by the users for each task. Considering both the monopolistic and competitive situations, we illustrate numerically the validity of the approach, which achieves an 'optimal' trade-off between three objectives: revenue, user cost, and peak demand