PhD

thesis1. Eleven species of wild rodents and one species of cottontail were found to be extremely susceptible to subcutaneous infection with the virulent Schu A strain of P. tularensis. In addition, grasshopper mice, wood rate, and/or deer mice were very susceptible to subcutaneous infection with any of the 12 strains, of P. tularensis isolated from rabbits, rodents or ticks, and one strain isolated from a horse. All three species were completely resistant to inoculation with the avirulent 38 strain. Deer mice and wood rats were completely resistant to the Russian NIIEG (gray variant) and partially resistant to NIIEG (blue variant). 2. Jack rabbits of the subspecies L. c. deserticola were highly susceptible to subcutaneous infection with the Schu A strain, whereas the subspecies L. c. texianus showed some resistance. Complement fixing, but not agglutinating, antibodies were demonstrated in the sera of L. c. texianus surviving experimental infection. 3. Of five species of rodents exposed to subcutaneous infection with the moderately virulent Jap4 strain of P tularensis, only the grasshopper mouse was very susceptible. Wood rats were completely resistant, while deer mice and kangaroo rats were lethally susceptible only to high does. 4. Tularemia infection in young coyote pups caused death when massive doses were inoculated. However, subcutaneous and oral infection usually resulted only to production of antibody. The disease followed a mild, subacute course and was completely resolved within 2-3 weeks. No carrier state or chronic infection resulted. 5. The presence of citrulline ureidase enzyme system in P. tularensis strains of high virulence and its absence of avirulent strains and strains of low virulence has been confirmed. 6. The only wild strains of P. tularensis tested which lacked a citrulline ureidase system were the two isolated from rodents or rodent ticks. All strains isolated from rabbits, rabbit ticks, a human, and a horse, that were tested, possessed this system. 5. The citrulline ureidase system has been shown to be no directly related to virulence. 8. The existence of two North American strains of P. tularensis has been postulated on the bases of the presence or absence of a citrulline ureidase enzyme system. It has been further postulated that the strains lacking this enzyme system may have evolved in rodents and the strains possessing the ability to metabolize citrulline may have evolved in rabbits

Network intrusion detection

Attacks against computers and the internet are in the news every week. These primarily take the form of malicious code such as viruses and worms, or denial of service attacks. Less commonly reported are attacs with gain access to computers, either for the purpose of producing damage (such as defacing web sites or deleting data) or for the opportunities such as access provides to the attacker, such as accessto bank accounts or controlsystems of power stations. This chapter will discuss some of the areas in which computational statistics can be applied to these and related problems. --

Fusion and Inference from Multiple Data Sources in a Commensurate Space

Abstract: Given objects measured under multiple conditions—for example, indoor lighting versus outdoor lighting for face recognition, multiple language translation for document matching, etc.—the challenging task is to perform data fusion and utilize all the available information for inferential purposes. We consider two exploitation tasks: (i) how to determine whether a set of feature vectors represent a single object measured under different conditions; and (ii) how to create a classifier based on training data from one condition in order to classify objects measured under other conditions. The key to both problems is to transform data from multiple conditions into one commensurate space, where the (transformed) feature vectors are comparable and would be treated as if they were collected under the same condition. Toward this end, we studied Procrustes analysis and developed a new approach, which uses the interpoint dissimilarities for each condition. We impute the dissimilarities between measurements of different conditions to create one omnibus dissimilarity matrix, which is then embedded into Euclidean space. We illustrate our methodology on English and French documents collected from Wikipedia, demonstrating superior performanc

Aviões paulistas nos céus de agosto: o prefeito Brasil Pinheiro Machado e a cidade de Ponta Grossa - PR em meados de 1932

Neste artigo, o momento selecionado da trajetória intelectual do historia-dor paranaense Brasil Pinheiro Machado (1907-1997) não é um dos mais significativos do ponto de vista da sua fortuna crítica. A atuação dele como prefeito municipal da cidade de Ponta Grossa (PR) – entre agosto de 1932 e janeiro de 1933 – é aqui explorada no sentido de fornecer subsídios para o entendimento sobre a formação do perfil do intelectual dedicado ao pensamento social brasileiro, na década de 1930. O episódio de curta duração na carreira pública de Machado mostrou ter a capacidade de argumentar sobre e ação política no período em questão, então marcado por grandes desafios enfrentados pelo governo provisório e por todas as unidades da federação no complexo jogo entre regionalismo e centralização política

Assimilation of Cholesterol by Strains of Lactobacillus Acidophilus of Human Intestinal Origin

Food Scienc