495 research outputs found
Advanced code-division multiplexers for superconducting detector arrays
Multiplexers based on the modulation of superconducting quantum interference
devices are now regularly used in multi-kilopixel arrays of superconducting
detectors for astrophysics, cosmology, and materials analysis. Over the next
decade, much larger arrays will be needed. These larger arrays require new
modulation techniques and compact multiplexer elements that fit within each
pixel. We present a new in-focal-plane code-division multiplexer that provides
multiplexing elements with the required scalability. This code-division
multiplexer uses compact lithographic modulation elements that simultaneously
multiplex both signal outputs and superconducting transition-edge sensor (TES)
detector bias voltages. It eliminates the shunt resistor used to voltage bias
TES detectors, greatly reduces power dissipation, allows different dc bias
voltages for each TES, and makes all elements sufficiently compact to fit
inside the detector pixel area. These in-focal-plane code-division multiplexers
can be combined with multi-gigahertz readout based on superconducting
microresonators to scale to even larger arrays.Comment: 8 pages, 3 figures, presented at the 14th International Workshop on
Low Temperature Detectors, Heidelberg University, August 1-5, 2011,
proceedings to be published in the Journal of Low Temperature Physic
Naïve CD8 + T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment
Despite of the potential implications for cancer immunotherapy, conventional approaches using in vitro expanded CD8 + T cells have suboptimal outcomes, mostly due to loss of functionality from cellular exhaustion. We therefore investigated the phenotypic and functional differences among in vitro activated CD8 + T cells of three different sources, namely naïve (NT eff), memory (MT eff) and tumor-infiltrating lymphocytes (TIL eff) from human and mice, to better understand mechanisms behind potent effector functions and potential for overcoming current limitations. In line with the greater proliferation activity and longer telomere lengths of NT eff populations, cells of naïve origin exhibited significantly less amounts of T cell exhaustion markers than those of MT eff and TIL eff, and moreover, acquired distinct expression patterns of memory-promoting transcription factors, T-bet and Eomes, induced in a rapid and sustainable manner. NT eff cells appeared to have lower expression of Foxp1 and were refractory to apoptosis upon TGF-β conditioning, implying better survival potential and resistance to tumor-induced immune suppression. Of CD8 + T cell pools activated to tumor-specific CTLs, naïve cell generated effectors possessed the most potent cytotoxic activity, validating implications for use in rational design of adoptive immunotherapy11091sciescopu
Calculation of two-loop virtual corrections to b --> s l+ l- in the standard model
We present in detail the calculation of the virtual O(alpha_s) corrections to
the inclusive semi-leptonic rare decay b --> s l+ l-. We also include those
O(alpha_s) bremsstrahlung contributions which cancel the infrared and mass
singularities showing up in the virtual corrections. In order to avoid large
resonant contributions, we restrict the invariant mass squared s of the lepton
pair to the range 0.05 < s/mb^2 < 0.25. The analytic results are represented as
expansions in the small parameters s/mb^2, z = mc^2/mb^2 and s/(4 mc^2). The
new contributions drastically reduce the renormalization scale dependence of
the decay spectrum. For the corresponding branching ratio (restricted to the
above s-range) the renormalization scale uncertainty gets reduced from +/-13%
to +/-6.5%.Comment: 41 pages including 9 postscript figures; in version 2 some typos and
inconsistent notation correcte
Spinning Strings, Black Holes and Stable Closed Timelike Geodesics
The existence and stability under linear perturbation of closed timelike
curves in the spacetime associated to Schwarzschild black hole pierced by a
spinning string are studied. Due to the superposition of the black hole, we
find that the spinning string spacetime is deformed in such a way to allow the
existence of closed timelike geodesics.Comment: 5 pages, RevTex4, some corrections and new material adde
Singularities in scalar-tensor gravity
The analysis of certain singularities in scalar-tensor gravity contained in a
recent paper is completed, and situations are pointed out in which these
singularities cannot occur.Comment: 6 pages, LaTe
On Traversable Lorentzian Wormholes in the Vacuum Low Energy Effective String Theory in Einstein and Jordan Frames
Three new classes (II-IV) of solutions of the vacuum low energy effective
string theory in four dimensions are derived. Wormhole solutions are
investigated in those solutions including the class I case both in the Einstein
and in the Jordan (string) frame. It turns out that, of the eight classes of
solutions investigated (four in the Einstein frame and four in the
corresponding string frame), massive Lorentzian traversable wormholes exist in
five classes. Nontrivial massless limit exists only in class I Einstein frame
solution while none at all exists in the string frame. An investigation of test
scalar charge motion in the class I solution in the two frames is carried out
by using the Plebanski-Sawicki theorem. A curious consequence is that the
motion around the extremal zero (Keplerian) mass configuration leads, as a
result of scalar-scalar interaction, to a new hypothetical "mass" that confines
test scalar charges in bound orbits, but does not interact with neutral test
particles.Comment: 18 page
CD4(+) T-cell responses mediate progressive neurodegeneration in experimental ischemic retinopathy
Retinal ischemic events, which result from occlusion of the ocular vasculature share similar causes as those for central nervous system stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T-cell- mediated responses, is thought to be intricately involved, but the exact roles remain elusive. We found that acute ischemia-reperfusion injury to the retina induced a prolonged phase of retinal ganglion cell loss that continued to progress during 8 weeks after the procedure. This phase was accompanied by microglial activation and CD4+ T-cell infiltration into the retina. Adoptive transfer of CD4+ T cells isolated from diseased mice exacerbated retinal ganglion cell loss in mice with retinal reperfusion damage. On the other hand, T-cell deficiency or administration of T-cell or interferon-gamma-neutralizing antibody attenuated retinal ganglion cell degeneration and retinal function loss after injury. These findings demonstrate a crucial role for T-cell-mediated responses in the pathogenesis of neural ischemia. These findings point to novel therapeutic targets of limiting or preventing neuron and function loss for currently untreatable conditions of optic neuropathy and/or central nervous system ischemic stroke.Ophthalmic researc
Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya
Large datasets are often not amenable to analysis using traditional single-step approaches. Here, our general objective was to apply imputation techniques, principal component analysis (PCA), elastic net and generalized linear models to a large dataset in a systematic approach to extract the most meaningful predictors for a health outcome. We extracted predictors for Plasmodium falciparum infection, from a large covariate dataset while facing limited numbers of observations, using data from the People, Animals, and their Zoonoses (PAZ) project to demonstrate these techniques: data collected from 415 homesteads in western Kenya, contained over 1500 variables that describe the health, environment, and social factors of the humans, livestock, and the homesteads in which they reside. The wide, sparse dataset was simplified to 42 predictors of P. falciparum malaria infection and wealth rankings were produced for all homesteads. The 42 predictors make biological sense and are supported by previous studies. This systematic data-mining approach we used would make many large datasets more manageable and informative for decision-making processes and health policy prioritization
Global Search for New Physics with 2.0/fb at CDF
Data collected in Run II of the Fermilab Tevatron are searched for
indications of new electroweak-scale physics. Rather than focusing on
particular new physics scenarios, CDF data are analyzed for discrepancies with
the standard model prediction. A model-independent approach (Vista) considers
gross features of the data, and is sensitive to new large cross-section
physics. Further sensitivity to new physics is provided by two additional
algorithms: a Bump Hunter searches invariant mass distributions for "bumps"
that could indicate resonant production of new particles; and the Sleuth
procedure scans for data excesses at large summed transverse momentum. This
combined global search for new physics in 2.0/fb of ppbar collisions at
sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D
Rapid Communication
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
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