6 research outputs found
The effects of oxygen and reactive oxygen species on antibiotic resistance and microbial communities in chronic wounds
- Author
- Publication venue
- 'University of Plymouth'
- Publication date
- 01/01/2013
- Field of study
Infection is one of the factors that may contribute to non-healing of chronic
wounds; the presence of antibiotic resistant bacteria serves to exacerbate the
problem due to limited treatment options. Bacteria utilise several mechanisms to
survive exposure to antibiotics, including synthesis of deactivating enzymes,
target modification or substitution, changes to membrane permeability,
upregulation of efflux pumps and the formation of a biofilm. Quorum sensing is
a density-dependent mechanism of bacterial cell to cell communication that can
be instrumental in co-ordinating biofilm initiation. Hyperbaric oxygen therapy
(HBOT) is an option offered to some patients with chronic wounds, including
diabetic foot ulcers. Evidence suggests that HBOT can reduce the incidence of
major amputation in these patients. As well as the direct toxicity of increased
tissue oxygenation on anaerobic bacteria HBOT may also increase levels of
reactive oxygen and nitrogen species in the wound environment. This study
aimed to investigate the effects of hyperoxia and oxidative damage on three
specific mechanisms of antibiotic resistance: the activity of penicillinase, an
antibiotic deactivating enzyme synthesised by bacteria; the activity of quorum
sensing signalling molecules (AHLs); and biofilms and their associated bacteria.
It also analysed the population dynamics of, primarily, bacteria in diabetic foot
ulcers during HBOT, by the use of molecular analysis tools such as PCRDGGE.
The presence of fungal species was investigated in wounds prior to
HBOT and in two wounds at two points during HBOT. This study found that
hydrogen peroxide, hypochlorous acid and peroxynitrite reduced the activity of
penicillinase in vitro. Hypochlorous acid reduced the activity of a range of AHLs
in vitro but not in vivo. Oxygen concentration did not have any impact on biofilm
mass, nor did it significantly affect the ability of an oxidant-generating enzyme to
reduce live bacterial cells within a biofilm. The population dynamics of bacterial
species identified in all the wounds were complex and did not undergo
identifiable changes during HBOT. Fungal species were identified in all wounds
prior to HBOT, though different profiles were observed in the two wounds
investigated during HBOT. These results suggest that oxidants could play a role
in the attenuation of antibiotic resistance in chronic wound bacteria. It is unclear
whether HBOT alters the population dynamics of non-healing wound microfloraThe Diving Diseases Research Centr
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Author
- Aanensen David M.
- Abell Chris
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Ahmadi-Assalemi Gabriela
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angelis Daniela De
- Angelis Daniela De
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela H.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Lisa
- Berry Louise
- Berry Sarah
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T.
- Bradshaw Daniel
- Braithwaite Vickie
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brierley Craig
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Christopher
- Brown Christopher A.
- Brown Julianne R.
- Brown Nicholas M.
- Brown Paul E.
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Carabelli Alessandro M.
- Carden Holli
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Caspersz Michelle
- Ceaser Matt
- Cerda Alberto C.
- Chalker Vicki
- Chand Meera
- Chapman Michael H. S.
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Afzal
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K. J.
- Churcher Carol M.
- Clark Gemma
- Clark Roger
- Clarke Rebecca
- Cogger Benjamin J.
- Coll Francesc
- Collins Jennifer
- Connor David
- Connor Thomas R.
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Crowcroft Jon
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dadrah Ashok
- Dahal Aastha
- Danaei Darius
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Richard
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dhada Maharshi
- Dias Joana
- Dorman Matthew J.
- Dougan Gordon
- Douthwaite Julie
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Dyer Rory
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Emanuela P.
- Enright Jessica
- Ensell Leah
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben W.
- Fatseas Tania
- Faulkner Kathryn
- Fearn Christopher
- Feather Tom
- Feltwell Theresa
- Fenton Melisa L.
- Ferris Mark
- Fieldman Thomas
- Fina Laia
- Fisher Chloe L.
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeling Anthony
- Freeman Timothy M.
- Frost Lucy R.
- Fuller Stewart
- Fuller William
- Galai Katerina
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Georgiou Christine
- Gibbs Karen
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Girgis Sophia T.
- Glaysher Sharon
- Glew Rob
- Glover Michael
- Golubchik Tanya
- Goncalves Sonia
- Goodall Robin
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Gransden Lucie
- Greatorex Jane
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Hamilton William L.
- Hamilton William L.
- Hancock Dawn
- Hannan Sophie
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hart Jennifer
- Hartley John A.
- Hartman Hassan
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson Robert
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hilborne Sarah
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Hoensch Steve
- Hogsden Wendy
- Holden Matthew T. G.
- Holgate Jon
- Hollamby Victoria
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hopes Richard
- Hosaja Aleksandra
- Hosmillo Myra
- Hosmillo Myra
- Howe Robin
- Howes Rob
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Gareth J.
- Hughes Joseph
- Hughes Margaret
- Hughes Robert
- Hunt Martin
- Hutchings Stephanie
- Illingworth Chris
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu
- Jahun Aminu S.
- James Keith
- James Laura
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron R.
- Jeremiah Sarah
- Jesudason Natasha G.
- John Michaela
- Johnson Dean
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher R.
- Jones Daniel R.
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jordan Sinead
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kahkeshi Mahin Bagheri
- Kane Leanne
- Karamani Angeliki
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Keen Martin
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen
- Kitchen Christine
- Knapton James
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz U. G.
- Kristiansen Mark
- Kuenzi Fred
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Lacy Elen De
- Lambson Oliver
- Langford Cordelia F.
- Lawniczak Mara
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack C. D.
- Leek Danielle
- Lehner Paul
- Lensing Stefanie V.
- Leonard Steven
- Leong Clare
- Leslie Ian
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Lewis Kevin
- Li Kathy K.
- Liddell Kathleen
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Maclean Alasdair
- Mactavous Lenette
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra S.
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Marchetti Filippo
- Margolis Ben
- Martincorena Inigo
- Masoli Jane A. H.
- Mason Jenifer
- Mather Alison E.
- Matheson Nicholas
- Matheson Nicholas J.
- Mathieson Nick
- Matthews Steve
- Maxwell Patrick
- Maxwell Patrick H.
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick C.
- McFarlane Duncan
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McNally Alan
- McNulty Claire
- Meader Emma J.
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy V.
- Metaxaki Marina
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Mills John
- Mirza Jeremy
- Moles-Garcia Emma
- Moll Robin J.
- Mollett Guy
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sally
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Mozdzen Barbara
- Muir Peter
- Mungovan Diane
- Munn Robert
- Murphy Edna
- Myers Richard
- Nascimento Fabricia F.
- Nebbia Gaia
- Neely Andy
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc O.
- Nikitina Katya
- Nomikou Kyriaki
- Nsonwu Olisaeloka
- Nunez Rocio T. Martinez
- Oliver Karen
- Orton Alexandra
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Brien Sarah
- O’Grady Justin
- O’Toole Elaine
- O’Toole Áine
- Pacchiarini Nicole
- Packer Simon
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi R.
- Parker Matthew D.
- Parlikad Ajith
- Parmar Surendra
- Parsons Paul J.
- Partridge David G.
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan AI.
- Peacock Sharon J.
- Peacock Sharon J.
- Pearson Clare
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Poppitt Steve
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui A.
- Puethe Christoph
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Quinnell Natalie
- Radecki Asako
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Rankin Jennifer
- Ratcliffe Liz
- Raub Gabor
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rees Steve
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Ridgman Tom
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Russell Matthew
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine M.
- Samtani Vijay
- Samworth Richard
- Sang Fei
- Sato Aris
- Scarlett Garry P.
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Searle Paul
- Shaaban Sharif
- Shah Divya
- Shah Rajiv N.
- Shankar Giri
- Shaw Ashley
- Sheldrake Zara
- Shepherd James G.
- Sheridan Linda
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Silveira Siona
- Simpson David A.
- Sing Robert
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Southgate Joel
- Spellman Karla
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben E. W.
- Taylor Graham P.
- Taylor Peter
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate E.
- The Cambridge Covid-19 testing Centre
- The COVID-19 Genomics UK (COG-UK) Consortium
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tolhurst Jonathan
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Twohig Katherine A.
- Tynan Jo
- Underwood Anthony P.
- University of Cambridge Asymptomatic COVID-19 Screening Programm
- Unnikrishnan Meera
- Valletta Sally
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vignoles Anna
- Vinnell Martin
- Vipond Ian B.
- Volz Erik M.
- Waddell Ian
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Emmeline
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Weale Gillian
- Webster Hermione J.
- Weekes Michael P.
- Weldon Danni
- Westhorpe Adam P.
- White Phil
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Williman Jack
- Willingham Iona
- Wills Mark
- Wilson Harry D.
- Wilson Karl
- Wilson Rebekah E.
- Wilson-Davies Eleri
- Winster Jennifer
- Wise Emma
- Witele Eric
- Workman Chris
- Workman Trudy
- Wright Elizabeth
- Wright Elizabeth
- Wright Giles
- Wright Jo
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Communications
- Publication date
- 08/02/2022
- Field of study
AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p
Gene Rearrangements in the vsa
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Effect of Clot Aging and Cholesterol Content on Ultrasound-Assisted Thrombolysis
- Author
- A Eden
- A Undas
- AD Wijnhoud
- AL Wadey
- AV Alexandrov
- AV Savushkinl
- BB Stewart
- BD Lindsey
- CK Holland
- DV Sakharov
- G Tsivgoulis
- GJ Shaw
- H Iso
- HR Glew
- J Eggers
- J Minnerup
- JD Ferry
- JV Braaten
- JW Weisel
- K Minematsu
- K Saku
- KR Lees
- M Daffertshofer
- M Nedelmann
- M Zabczyk
- N Poungvarin
- P Riha
- R Corti
- RJ Siegel
- RS Eliot
- S Meairs
- S Pfaffenberger
- S Ueshima
- SB Pai
- Suresh Kanna Murugappan
- T Brott
- V Suchkova
- Vijay Kumar Sharma
- Yufeng Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Author
- Aanensen DM
- Abell C
- Abudahab K
- Acheson E
- Adams A
- Adams H
- Afifi S
- Aggarwal D
- Aggarwal D
- Ahmad SSY
- Ahmadi-Assalemi G
- Aigrain L
- Alam MT
- Alcolea-Medina A
- Alderton A
- Alikhan N-F
- Allara E
- Amato R
- Andersson M
- Angelis DD
- Angelis DD
- Angyal A
- Aranday-Cortes E
- Ariani CV
- Asad H
- Asamaphan P
- Ash A
- Ashcroft F
- Atkinson L
- Attwood SW
- Auckland C
- Awan AR
- Aydin A
- Baker DJ
- Baker P
- Balcazar CE
- Ball J
- Barrett J
- Barton E
- Bashton M
- Bassett AR
- Batra R
- Baxter L
- Bayzid N
- Beale MA
- Beaver C
- Beckett AH
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Berry L
- Berry L
- Berry S
- Best A
- Betancor G
- Betteridge E
- Bewshea CM
- Bibby D
- Bicknell K
- Birchley A
- Bird P
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Boswell T
- Bosworth A
- Bourgeois Y
- Boyd O
- BoYes J
- Bradley A
- Bradley DT
- Bradshaw D
- Braithwaite V
- Breen C
- Bresner C
- Breuer J
- Bridgewater HE
- Brierley C
- Bronner IF
- Brooks E
- Broos A
- Brown C
- Brown CA
- Brown JR
- Brown NM
- Brown PE
- Brown R
- Bucca G
- Buck D
- Bull M
- Burton-Fanning S
- Campbell S
- Carabelli AM
- Carden H
- Carlile M
- Carmichael SN
- Casey A
- Caspersz M
- Ceaser M
- Cerda AC
- Chalker V
- Chand M
- Chapman MHS
- Chapman MR
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry A
- Chaudhry Y
- Chauhan AJ
- Cheng JKJ
- Churcher CM
- Clark G
- Clark R
- Clarke R
- Cogger BJ
- Coll F
- Collins J
- Connor D
- Connor TR
- Constantinidou C
- Cook K
- Coombes J
- Corden S
- Cormie C
- Cortes N
- Cotic M
- Cottrell S
- Coupland L
- Cowell A
- Cox A
- Craine N
- Crawford L
- Cronin M
- Crook D
- Crowcroft J
- Cumley N
- Curran MD
- Curran T
- da Silva Filipe A
- Dabrera G
- Dadrah A
- Dahal A
- Danaei D
- Danesh J
- Darby AC
- Davidson RK
- Davies A
- Davies R
- Davies R
- Davis T
- de Cesare M
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Dent H
- Dervisevic S
- Dewar R
- Dhada M
- Dias J
- Dorman MJ
- Dougan G
- Douthwaite J
- Downing F
- Drury E
- du Plessis L
- du Plessis L
- Duckworth N
- Durham J
- Dyer R
- Eccles R
- Edgeworth J
- Edwards S
- Eldirdiri S
- Ellaby N
- Ellard S
- Elliott S
- Eltringham G
- Emanuela P
- Enright J
- Ensell L
- Essex S
- Evans C
- Evans JM
- Eyre D
- Fairley DJ
- Fallon K
- Farbos A
- Farr BW
- Fatseas T
- Faulkner K
- Fearn C
- Feather T
- Feltwell T
- Fenton ML
- Ferris M
- Fieldman T
- Fina L
- Fisher CL
- Flaviani F
- Fleming VM
- Forrest S
- Foulser L
- Francois S
- Fraser C
- Freeling A
- Freeman TM
- Frost LR
- Fuller S
- Fuller W
- Galai K
- Gallagher E
- Gallagher MD
- Gallis M
- Gaskin A
- Gatica-Wilcox B
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Georgiou C
- Gibbs K
- Gifford L
- Gilbert L
- Gill HK
- Girgis ST
- Glaysher S
- Glew R
- Glover M
- Golubchik T
- Goncalves S
- Goodall R
- Goodfellow I
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gourtovaia M
- Graham C
- Graham L
- Grammatopoulos D
- Gransden L
- Greatorex J
- Green A
- Green LR
- Greenaway J
- Gregory R
- Groves DC
- Groves N
- Guest M
- Gulliver H
- Gunson RN
- Gupta RK
- Gutierrez B
- Hadjirin NF
- Haldenby ST
- Hale AD
- Hall G
- Halstead F
- Hamilton WL
- Hamilton WL
- Hamilton WL
- Hancock D
- Hannan S
- Haque T
- Harper KL
- Harris KA
- Harrison EM
- Harrison I
- Harrison JW
- Hart J
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- Zhang P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/02/2022
- Field of study
Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics
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- Isabelle
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- Kamal
- Kamath
- Kamdee
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- Karabulut
- Karabulut
- Karaca
- Karmarkar
- Kasim
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- Kienzle
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- Kodithuwakku
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- Lakshminarayana
- Lakshminarayana
- Lakshminarayana
- Lalel
- Lalel
- Lallu
- Lallu
- Lallu
- Lam
- Lam
- Lammertyn
- Lange
- Lanza
- Larson
- Lassois
- Lassois
- Lassois
- Laszlo
- Lau
- Lau
- Lau
- Lavrik
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- Lazan
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- Le
- Le
- Le
- Le
- Le Bellec
- Lebrun
- Lee
- Lee
- Lee
- Lee
- Lee
- Lee
- Lee
- LeFlufy
- Leggott
- Lenker
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- Leong
- Lers
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- Levin
- Levine
- Levitt
- Li
- Li
- Li
- Li
- Li
- Liang
- Liao
- Lichanporn
- Lichanporn
- Lichtenthäler
- Lichter
- Lichter
- Lidster
- Lieten
- Lill
- Lill
- Lim
- Lima
- Lima
- Lima
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- Lin
- Lindsey
- Liner
- Link
- Lipton
- Lipton
- Littmann
- Liu
- Liu
- Liu
- Lizada
- Lizada
- Lizana
- Lizana
- Lizana
- Lizana
- Lockhart
- Lonsdale
- Lonsdale
- Lonsdale
- Lopez
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- Louw
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- Lu
- Lu
- Lu
- Lu
- Luchsinger
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- Lulai
- Luna
- Luo
- Luo
- Ma
- Maalekuu
- MacLeod
- Madamba
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- Maekawa
- MAFF
- Magomedov
- Mahajan
- Maharaj
- Mahendra
- Maia
- Mainland
- Majumder
- Maksymowych
- Malaman
- Malik
- Maneenuam
- Manenoi
- Manganaris
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- Manso
- Mansour
- Mansour
- Manzano-Mendez
- Mao
- Maojun
- Maqbool
- Maqbool
- Marandi
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- Maranz
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- Marcellin
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- Marchal
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- Maskan
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- Matsuo
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- Mattheis
- Mattoo
- Maxin
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- McGuire
- McGuire
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- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Medlicott
- Meheriuk
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- Meir
- Meir
- Melo
- Melo
- Mencareili
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- Mencarelli
- Mencarelli
- Mendlinger
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- Meredith
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- Mezadri
- Miller
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- Miller
- Miller
- Miller
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- Miyazaki
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- Moelich
- Mohamed
- Mohamed
- Mohammed
- Mohammed
- Mohammed
- Montesinos-Herrero
- Moon
- Moore
- Mootoo
- Moradinezhad
- Morais
- Morales
- Moran
- Moreno
- Moreno
- Moretti
- Moreuil
- Morris
- Morris
- Morton
- Moy
- Moya-Leon
- Moyer
- Muchui
- Muchui
- Muirhead
- Muirhead
- Mukherjee
- Muller
- Mura
- Murillo
- Murphy
- Muthoo
- Mutlak
- Muñoz
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- Mworia
- Mélo
- Mélo
- Nabavi
- Nabialek
- Nagai
- Nakasone
- Nakatsuka
- Nally
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- Narain
- Narain
- Narain
- Narayan
- Nardin
- Nath
- Nazeeb
- Neale
- Nelson
- Nelson
- Nelson
- Nelson
- Nerd
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- New
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- Ngoh
- Nicolas
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- Noma
- Noomhorm
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- Nunes
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- Nuñes
- Nwankno
- Nyanjage
- O'Beirne
- O'Hare
- O'Hare
- O'Hare
- O'Hare
- Obande
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- Obenland
- OECD
- Ogali
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- Olivas
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- Oliveira
- Oliveira
- Olsson
- Ong
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- Osajima
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- Osunde
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- Ovalle Huertas
- Ozelkok
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- Padda
- Padmini
- Paiva
- Pal
- Pal
- Pal
- Palapol
- Palma
- Palou
- Pan
- Pan
- Paniandy
- Panique
- Pankasemsuk
- Panpatil
- Pantastico
- Pantastico
- Pantoja
- Papadopoulou Mourkidou
- Pareek
- Park
- Park
- Park
- Parmar
- Parodi
- Parsons
- Pastor
- Patel
- Pathak
- Paton
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Paull
- Peacock
- Peacock
- Peirs
- Pekmezci
- Pelayo
- Peleg
- Pelser
- Peng
- Pennock
- Pentzer
- Perdones
- Pereira
- Pereira
- Perera
- Perez
- Perez Tello
- Perkins-Veazie
- Perkins-Veazie
- Perkins-Veazie
- Perkins-Veazie
- Perry
- Pertot
- Pesis
- Pesis
- Pesis
- Pesis
- Pesis
- Pesis
- Pessoa
- Phakawatmongkol
- Phillips
- Pierre-éric
- Pinheiro
- Pino
- Pino
- Pino
- Pino
- Pinto
- Pinto
- Piriyavinit
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- Plotto
- Plumbley
- Pombo
- Pongprasert
- Pongprasert
- Ponnuswami
- Popenoe
- Popenoe
- Popenoe
- Porat
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- Prakash
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- Pranamornkith
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- Pratt
- Pratt
- Predieri
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- Prohens
- Promyou
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- Prusky
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- Pryke
- Puri
- Purseglove
- Purseglove
- Purseglove
- Pérez
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- Pérez-Marín
- Qadir
- Qi
- Qiu
- Qu
- Quazi
- Quimio
- Raban
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- Radler
- Raffo
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- Rahman
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- Raman
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- Sangchote
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- Selvarajah
- Semple
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- Sfakiotakis
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- Shamsudin
- Sharma
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- Sharma
- Sharma
- Sharma
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- Sharples
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- Sharples
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- Shashirekha
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- Shear
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- Shellie
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- Shibairo
- Shiesh
- Shillingford
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- Shillingford
- Shin
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- Silva
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- Simmonds
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- Simon
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- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Singh
- Siriphanich
- Sirisomboon
- Sistrunk
- Sites
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- Sites
- Sivakumar
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- Sivakumar
- Sivakumar
- Sivakumar
- Sivakumar
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- Sive
- Skog
- Skrzynski
- Skultab
- Smillie
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smock
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- Snowdon
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- Soares
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- Spalding
- Spalding
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- Spalding
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- Sugar
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- Sugiyama
- Suhaila
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- Sun
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- Suslow
- Suwanagul
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- Sánchez-González
- Taesakul
- Tamer
- Tamim
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- Tee
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- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thompson
- Thorp
- Tian
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- Tian
- Tiangco
- Tietel
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- Tongdee
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- Trejo-Marquez
- Tressl
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- Trindade
- Tripathi
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- Tu
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- Turbin
- Turk
- Turner
- Uip
- Ullah
- Ulrich
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- Urushizaki
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- Verma
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- Vigneault
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- Vijaysegaran
- Vilas-Boas
- Vilcosqui
- Villalobos-Acuña
- Villanueva Suarez
- Villatoro
- Vinci
- Visintin
- Von Loesecke
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- Wade
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- Wang
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- Wardlaw
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- Xuetong
- Xuewu
- Yabuta
- Yahia
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- Yang
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- Yantarasri
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- Yueming
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- Publication venue
- 'Wiley'
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