6 research outputs found
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian Preußer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
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- Émilie Velot
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- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
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- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
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- Goberdhan Deborah C. I.
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- Gregory Lavieu
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- Hang Yin
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- Hanser Edveena
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- Hao Zhang
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- Harmeet Malhi
- Harris Adrian L.
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- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
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- Honami Naora
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- Tania Limongi
- Tania Martins-Marques
- Tanina Arab
- Tara Thompson-Felix
- Taral R Lunavat
- Tatiane De Rossi
- Tatu Rojalin
- Tecla Marangon
- Teena Kjb Gamage
- Ter‐Ovanesyan Dmitry
- Thabiso E Motaung
- Thanh Kha Phan
- Theresa L Whiteside
- Théry Clotilde
- Thibaud Dauphin
- Thomas Kislinger
- Thomas Michael Shiju
- Thupten Tsering
- Tiana F Koukoulis
- Tijana Jovanovic-Talisman
- Timothea Konstantinou
- Timothy V Domashevich
- Tine Hiorth Schøyen
- Tobias Tertel
- Tom Ap Driedonks
- Tom G Keulers
- Tommaso Neri
- Tomofumi Yamamoto
- Tong Wang
- Torrecilhas Ana C.
- Tosar Juan P.
- Trude Aspelin
- Tsuneya Ikezu
- Ursula S Sandau
- Useckaite Zivile
- Uta Erdbrügger
- Valentina R Minciacchi
- Valentina Zappulli
- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
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- Zhang Y
- Zhao C
- Zhao JIAYI STELLA
- Zhao L
- Zhao P
- Zhao R
- Zhao Y
- Zheng Y
- Zheng Z
- Zhi Y
- Zhong H
- Zhong R
- Zhou C
- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Charles Schwager papers 1909-1948
- Author
- Aiken George D
- Barkley Alben W 1877-
- Bergson Peter H b. 1910
- Curtis Charles Vice-President, U.S 1860-1936
- Edison Thomas A 1847-1931
- Fish Hamilton Jr 1888-
- LaFollette Charles M
- LaGuardia Fiorello 1882-1947
- Lodge Henry Cabot Jr 1902-
- Luce Clare Boothe 1903-
- Marshall Louis 1856-1929
- McCormack John W 1891-
- Powell Adam Clayton Jr
- Schwager Charles 1879-
- Truman Harry S President, U.S 1884-1972
- Wagner Robert F 1910-
- Publication venue
- Publication date
- Field of study
The collection consists of letters written to Schwager by Americans and non-Americans on a variety of topics pertaining to Jews. The majority of the letters are from members of the U.S. House of Representatives, the Senate, and American governors, expressing their views on Jews, anti-Semitism, and Palestine as a Jewish homeland. Also included are letters on this topic from Thomas Edison, Charles Curtis, and Adam Clayton Powell, Jr. Other letters concern the First Solotwiner Sick and Benevolent Society, the proposed formation by Schwager of a cloak-maker's union, and other topics of general Jewish interestAmong the correspondents are Charles M. LaFollette, Hamilton Fish, Jr., Henry Cabot Lodge, Jr., John W. McCormack, Alben W. Barkley, Robert F. Wagner, Clare Boothe Luce, Louis Marshall, Fiore La Guardia, and George D. AikenGift, in part, of the Elsie O. and Philip D. Sang Foundatio
Thigh-length compression stockings and DVT after stroke
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- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Defining the role of common variation in the genomic and biological architecture of adult human height
- Author
- Abecasis Goncalo R
- Absher Devin
- Afzal Uzma
- Albrecht Eva
- Alizadeh B
- Altshuler D
- Altshuler D
- Ambite JL
- Amin Najaf
- Amouyel Philippe
- Anand S
- Anand S
- Anderson G
- Anderson Denise
- Ardissino D
- Ardissino D
- Ardissino D
- Arnold A
- Arscott Gillian M
- Arveiler Dominique
- Asselbergs Folkert W
- Asselta R
- Assimes Themistocles L
- Avery C
- Avila PC
- Bakker Stephan J. L
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Baron Jeffrey
- Barrett Amy
- Barroso Inês
- Basford M
- Beckmann Jacques S
- Beekman Marian
- Beilby John
- Bellis Claire
- Bennett Amanda J
- Berg R
- Berger K
- Berglund G
- Bergman Richard N
- Bergmann Sven
- Bernardi F
- BERNARDINELLI LUISA
- Berndt Sonja I
- Berne Christian
- Berzuini C
- Bielinski S
- Biffar Reiner
- Blangero John
- Blüher Matthias
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle E
- Boerwinkle Eric
- Boezen HM
- Bolton Jennifer L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Boston J
- Bottinger Erwin P
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Brambilla Paolo
- Braund PS
- Brown Gentry K
- Brown Morris J
- Bruinenberg M
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Burke W
- Burnett MS
- Burtt N
- Bush WS
- Buyske S
- Buyske Steven
- Buzkova P
- Böttcher Yvonne
- Cambien F
- Campbell Harry
- Carlson C
- Carlson C
- Carrell D
- Carty C
- Casari G
- Caspersen Ida H
- Cauchi Stéphane
- Caulfield Mark J
- Celli P
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- Chasman Daniel I
- Chen L
- Chen Z
- Cheng I
- Chines Peter S
- Chisholm RL
- Choudary V
- Chu Audrey Y
- Churchill LR
- Chute C
- Clarke Robert
- Claudi Boehm Simone
- Clayton E
- Cochran B
- Cole S
- Collins Francis S
- Collins Rory
- Cooper Matthew
- Cooper Richard S
- Cornfield D
- Corrocher R
- Crane P
- Crawford D
- Crawford D
- Crawford Dana C
- Croteau Chonka Damien C
- Cupples L. Adrienne
- Daly MJ
- Danesh John
- Darbar D
- Daw E. Warwick
- Day Felix R
- de Andrade M
- De Bakker Paul I. W
- de Boer RA
- De Faire Ulf
- De Groot Lisette C. P. G. M.
- De Jong Pim A
- Dedoussis George
- Deelen Joris
- Deelman E
- Delgado Graciela
- Deloukas P
- Deloukas Panos
- Demirkan Ayse
- Den Ruijter Hester M
- Denny JC
- Denny Josh C
- Devaney J
- Dhonukshe Rutten Rosalie
- Dimitriou Maria
- Ding K
- Do R
- Doney Alex S. F
- Duan Yanan
- Duga S
- Duggan D
- Dumitrescu L
- Durda P
- Dörr Marcus
- Ehret Georg B
- Eklund Niina
- Elosua R
- Elosua R
- Elosua R
- Elosua R
- Engert JC
- Engert JC
- Epstein SE
- Erbel Raimund
- Erdmann J
- Erdmann J
- Erdmann J
- Erdmann J
- Erdmann Jeanette
- Eriksson Johan G
- Esko Tonu
- Estrada Karol
- Eury Elodie
- Fall Tove
- Farrall Martin
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary F
- Ferrannini Ele
- Ferrario M
- Ferreira Teresa
- Ferrières Jean
- Ferrucci Luigi
- Fetiveau R
- Fischer M
- Fischer M
- Fischer Krista
- Folkersen Lasse
- Ford Ian
- Fornage M
- Forouhi Nita G
- Forrester Terrence
- Fost N
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- Fox Caroline S
- Franceschini N
- Franke L
- Franke Lude
- Franks Paul W
- Fraser Ross M
- Frayling Timothy M
- Friedlander Y
- Froguel Philippe
- Fullerton SM
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- Galli M
- Gansevoort Ron T
- Garcia Melissa E
- Gejman Pablo V
- Geller Frank
- Gianniny L
- Giedraitis Vilmantas
- Gieger Christian
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- Groves Christopher J
- Gräßler Jürgen
- Grönberg Henrik
- Gudnason Vilmundur
- Guiducci C
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- Gyllensten Ulf
- Haas David W
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- Haessler Jeffrey
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- Hall AS
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- Hallmans Goran
- Hamsten Anders
- Hannemann Anke
- Harris Tamara B
- Hart G
- Hart L
- Hartman Catharina A
- Hassinen Maija
- Hattersley Andrew T
- Havulinna AS
- Hayes M
- Hayes M. Geoffrey
- Hayward Caroline
- Heard Costa Nancy L
- Heath Andrew C
- Heid Iris M
- Heiss G
- Helmer Quinta
- Hemani Gibran
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- Henriksen J
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- Hillege HL
- Hillege Hans L
- Hindorff L
- Hindorff Lucia A
- Hingorani Aroon D
- Hirschhorn JN
- Hirschhorn Joel N
- Hlatky Mark A
- Hoffmann Per
- Hoffmann Wolfgang
- Hofman Albert
- Holmen Oddgeir
- Houwing Duistermaat Jeanine J
- Hovingh G. Kees
- Huge A
- Hui Jennie
- Humowiecki J
- Humphries Steve E
- Hunt Steven C
- Hunter David J
- Hutchinson F
- Hveem Kristian
- Hypponen Elina
- Hólm H
- Illig Thomas
- Ingelsson Erik
- Isaacs Aaron
- Jackson R
- Jackson Anne U
- Jacobs Kevin B
- James Alan L
- Jarvelin Marjo Riitta
- Jarvik G
- Jeff J
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- Jenny N
- Johansen Berit
- Johansson Åsa
- Jolley Jennifer
- Jousilahti Pekka
- Jukema J. Wouter
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- Juliusdottir Thorhildur
- Junttila Juhani
- Justice Anne E
- Kanoni Stavroula
- Kao L
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- Kaprio Jaakko
- Karjalainen Juha
- Kastelein John J. P
- Kathiresan S
- Kathiresan S
- Kathiresan S
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- Kayser Manfred
- Kee Frank
- Keinanen Kiukaanniemi Sirkka M
- Kent KM
- Kho A
- Kho Abel N
- Kibbe WA
- Kiemeney Lambertus A
- Kinnunen Leena
- Kitchner T
- Kivimaki Mika
- Kleber Marcus E
- Klopp Norman
- Knouff CW
- Kocarnik J
- Kocher Thomas
- Koenig B
- Kolonel L
- Kooner Jaspal S
- Kooperberg C
- Kooperberg Charles
- Korn JM
- Koskinen Seppo
- Kovacs Peter
- Kraja Aldi T
- Kratzer Wolfgang
- Kristiansson Kati
- Kuh Diana
- Kuller L.
- Kullo I
- Kumari Meena
- Kutalik Zoltán
- Kuusisto Johanna
- König I
- König IR
- Laakso Markku
- LaCroix A
- Lakka Timo A
- Langenberg Claudia
- Larson EB
- Law M
- Le Marchand L
- Le Marchand Loic
- Leach Irene Mateo
- Lehtimäki Terho
- Lemke AA
- Lettre Guillaume
- Li M
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- Lieb W
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- Lim U
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- Lin D
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- Lind Lars
- Lindgren Cecilia M
- Lindsay JM
- Lindström Jaana
- Linneman J
- Linsel Nitschke P
- Linsel Nitschke P
- Liu Yongmei
- Lo Ken Sin
- Lobbens Stéphane
- Locke Adam E
- Loos Ruth J. F
- Lorentzon Mattias
- Lotay Vaneet
- Lowe WL
- Lu Yingchang
- Luan Jian'An
- Lucas G
- Lucas G
- Ludman E
- Lui Julian C
- Lupoli Sara
- Lyssenko Valeriya
- MacCluer J
- MacRae CA
- Madden Pamela A. F
- Magnusson Patrik K. E
- Mahajan Anubha
- Maillard Marc
- Malin BA
- Malinowski J
- Mangino Massimo
- Mannucci PM
- Mannucci PM
- Mannucci PM
- Manolio T
- Manunta Paolo
- Marette André
- Marrugat J
- Martin Nicholas G
- Martinelli N
- Marziliano N
- Masys DR
- Matise T
- Matise Tara C
- Matthai W
- Mcardle Wendy L
- McCarroll SA
- Mccarthy Mark I
- McCarty CA
- McDavid A
- Mckenzie Colin A
- McKeown PP
- McKeown PP
- Mcknight Barbara
- Mclachlan Stela
- Mclaren Paul J
- Medina Gomez Carolina
- Meigs JB
- Meitinger Thomas
- Melander O
- Melander O
- Melander O
- Melbye Mads
- Menni Cristina
- Merger Sigrun
- Merlini PA
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Miller A
- Mirel D
- Mitchell SL
- Moayyeri Alireza
- Moebus Susanne
- Mohlke Karen L
- Moll Frans L
- Monda Keri L
- Monroe K
- Montgomery Grant W
- Mooser V
- Morgan T
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- Morken Mario A
- Morris Andrew D
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- Munroe Patricia B
- Murdock D
- Murray Jeffrey C
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- Musunuru K
- Musunuru K
- Mägi Reedik
- Männistö Satu
- März Winfried
- Müller Nurasyid Martina
- Müller Gabriele
- Nalls Michael A
- Narisu Narisu
- Nathan DM
- Nato A
- Nauck Matthias
- Navis G
- Nelis Mari
- Nemesh J
- Newton K
- Njølstad Inger
- Nolte Ilja M
- North KE
- North Kari E
- Nyholt Dale R
- Nöthen Markus M
- O'Connell Jeffrey R
- O'Donnell CJ
- O'Donnell CJ
- O'Donnell CJ
- Oetjens M
- Ohlsson Claes
- Oldehinkel Albertine J
- Olivieri O
- Ong Ken K
- Oostra Ben A
- Oozageer Laticia
- Ormel J
- Ouwehand W
- Ouwehand Willem H
- Pacheco JA
- Palbicki J
- Palmer Cameron D
- Palmer Colin N. A
- Pankow J
- Park L
- Parkin M
- Pasko Dorota
- Pasterkamp Gerard
- Pathak J
- Patsy B
- Patterson CC
- Patterson CC
- Pechlivanis Sonali
- Pedersen Nancy L
- Peissig P
- Peltonen L
- Peltonen L
- Peltonen L
- Pendergrass S
- Perola Markus
- Pers Tune H
- Person S
- Peters U
- Peters Annette
- Peters Ulrike
- Peyvandi F
- Piazza A
- Pichard AD
- Pilz Stefan
- Porcu Eleonora
- Postma DS
- Powell Joseph E
- Power Chris
- Pramstaller Peter P
- Prentice R
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- Preuss M
- Price Alkes L
- Price Jackie F
- Prokopenko Inga
- Pulley J
- Purcell S
- Purcell S
- Purcell S
- Pérusse Louis
- Qasim A
- Qi Lu
- Quertermous Thomas
- Quibrera M
- Rader DJ
- Rader DJ
- Raitakari Olli T
- Ramirez AH
- Ramos R
- Randall Joshua C
- Rankinen Tuomo
- Rao D. C.
- Rasmussen L
- Rauramaa Rainer
- Rayner Nigel W
- Reeser J
- Reilly MP
- Reilly MP
- Reinmaa Eva
- Renstrom Frida
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- Ribichini F
- Rice Treva K
- Ridker Paul M
- Ried Janina S
- Ripke Stephan
- Ritchie M
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- Ritchie MD
- Ritchie Marylyn
- Rivadeneira Fernando
- Robertson Neil R
- Roden DM
- Rose Lynda M
- Rosmalen JG
- Rosse S
- Rossi M
- Rotter Jerome I
- Roussel Ronan
- Rudan Igor
- Saaristo Timo E
- Sala J
- Saleheen Danish
- Salomaa V
- Salomaa V
- Salomaa V
- Salomaa Veikko
- Samani NJ
- Samani NJ
- Samani NJ
- Samani NJ
- Samani Nilesh J
- Sanna Serena
- Saramies Jouko
- Sarzynski Mark A
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- Scheffold T
- Scherag André
- Schildcrout JS
- Schlessinger David
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- Schreiber S
- Schumacher F
- Schumacher Fredrick R
- Schunkert H
- Schunkert H
- Schunkert H
- Schunkert I
- Schunkert Heribert
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwarz Peter E. H
- Scott Robert A
- Sebert Sylvain
- Sehmi Joban
- Seufferlein Thomas
- Sever Peter
- Shi Jianxin
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- Wichmann H. Erich
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- Wilkens Lynne R
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- Wilson James F
- Winkler Thomas W
- Wojczynski Mary K
- Wolf WA
- Wolffenbuttel BH
- Wong Andrew
- Wood Andrew R
- Workalemahu Tsegaselassie
- Wright BJ
- Wright Alan F
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- Xu H
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- Yee J
- Yee J
- Yengo Loïc
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- Zanen Pieter
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zheng W
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- Ziegler A
- Zonzin P
- Ärnlöv Johan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research