Local Martingale and Pathwise Solutions for an Abstract Fluids Model

We establish the existence and uniqueness of both local martingale and local pathwise solutions of an abstract nonlinear stochastic evolution system. The primary application of this abstract framework is to infer the local existence of strong, pathwise solutions to the 3D primitive equations of the oceans and atmosphere forced by a nonlinear multiplicative white noise. Instead of developing our results specifically for the 3D primitive equations we choose to develop them in a slightly abstract framework which covers many related forms of these equations (atmosphere, oceans, coupled atmosphere-ocean, on the sphere, on the {\beta}-plane approximation etc and the incompressible Navier-Stokes equations). In applications, all of the details are given for the {\beta}-plane approximation of the oceans equations

Epidemic space

The aim of this article is to highlight the importance of 'spatiality' in understanding the materialization of risk society and cultivation of risk sensibilities. More specifically it provides a cultural analysis of pathogen virulence (as a social phenomenon) by means of tracing and mapping the spatial flows that operate in the uncharted zones between the microphysics of infection and the macrophysics of epidemics. It will be argued that epidemic space consists of three types of forces: the vector, the index and the vortex. It will draw on Latour's Actor Network Theory to argue that epidemic space is geared towards instability when the vortex (of expanding associations and concerns) displaces the index (of finding a single cause)

Writing in Britain and Ireland, c. 400 to c. 800

No abstract available

REVISTAS NA ESCOLA: UMA PRÁTICA SITUADA DE LINGUAGEM NAS AULAS DE LÍNGUA PORTUGUESA

Objetiva-se discutir o estudo situado da língua portuguesa no contexto escolar, a partir de práticas desenvolvidas na educação básica por uma bolsista de iniciação à docência (bolsista de ID) do Subprojeto Letras-Português do PIBID UNIVERSIDADE[1]. Para atingir esse objetivo, busca-se realizar, por meio de um estudo qualitativo com um olhar etnográfico, uma reflexão a partir de um recorte do relato de experiências vivenciadas pela bolsista de ID. Diante das discussões propostas neste estudo, concebe-se o trabalho por meio de projetos de letramento e sequências didática como importantes metodologias pedagógicas para envolver estudantes nos usos socialmente situados da língua na escola.   [1] A fim de mantermos a autoria sigilosa neste artigo, para sua avaliação entre os pareceristas, não iremos nomear a universidade em que o projeto foi desenvolvido

Inside and out: the activities of senescence in cancer.

The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/nrc377

The evolution of sex-specific virulence in infectious diseases

Fatality rates of infectious diseases are often higher in men than women. Although this difference is often attributed to a stronger immune response in women, we show that differences in the transmission routes that the sexes provide can result in evolution favouring pathogens with sex-specific virulence. Because women can transmit pathogens during pregnancy, birth or breast-feeding, pathogens adapt, evolving lower virulence in women. This can resolve the long-standing puzzle on progression from Human T-cell Lymphotropic Virus Type 1 (HTLV-1) infection to lethal Adult T-cell Leukaemia (ATL); a progression that is more likely in Japanese men than women, while it is equally likely in Caribbean women and men. We argue that breastfeeding, being more prolonged in Japan than in the Caribbean, may have driven the difference in virulence between the two populations. Our finding signifies the importance of investigating the differences in genetic expression profile of pathogens in males and females

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

Cellular senescence is a widespread stress response and is widely considered to be an alternative cancer therapeutic goal. Unlike apoptosis, senescence is composed of a diverse set of subphenotypes, depending on which of its associated effector programs are engaged. Here we establish a simple and sensitive cell-based prosenescence screen with detailed validation assays. We characterize the screen using a focused tool compound kinase inhibitor library. We identify a series of compounds that induce different types of senescence, including a unique phenotype associated with irregularly shaped nuclei and the progressive accumulation of G1 tetraploidy in human diploid fibroblasts. Downstream analyses show that all of the compounds that induce tetraploid senescence inhibit Aurora kinase B (AURKB). AURKB is the catalytic component of the chromosome passenger complex, which is involved in correct chromosome alignment and segregation, the spindle assembly checkpoint, and cytokinesis. Although aberrant mitosis and senescence have been linked, a specific characterization of AURKB in the context of senescence is still required. This proof-of-principle study suggests that our protocol is capable of amplifying tetraploid senescence, which can be observed in only a small population of oncogenic RAS-induced senescence, and provides additional justification for AURKB as a cancer therapeutic target.This work was supported by the University of Cambridge, Cancer Research UK, Hutchison Whampoa; Cancer Research UK grants A6691 and A9892 (M.N., N.K., C.J.T., D.C.B., C.J.C., L.S.G, and M.S.); a fellowship from the Uehara Memorial Foundation (M.S.).This is the author accepted manuscript. The final version is available from the American Society for Cell Biology via http://dx.doi.org/10.1091/mbc.E15-01-000

Contemporaneidade e sofrimento psíquico: Relações entre modos de vida e demandas psicoterapêuticas

Este artigo é desdobramento de trabalho realizado no Serviço de Psicologia da Universidade do Estado do Rio de Janeiro, durante o qual foram pesquisados 327 relatórios de triagens realizadas no serviço, com o objetivo de compreender o contexto social das demandas por psicoterapia e como estas sofrem influencia de tal contexto. Através de uma análise quantitativa, foi observada que a principal queixa era referente à dificuldade de se relacionar com os outros, seguida por depressão, pânico e medos, e ansiedade. Em análise qualitativa, os resultados evidenciaram estreita relação entre as demandas por psicoterapia e o cenário atual, marcado pela “fluidez”, pelo excesso, “urgência”, desempenho e técnica, que geram insegurança e medos diversos, notadamente expressos nas queixas clínicas. Esses dados apontam para a importância de entender a queixa clínica dentro de um contexto histórico-social, fazendo-nos refletir sobre os modos de vida na atualidade

Editorial

Deise Mancebo, Anna Uziel, Ariane P. Ewald, Eleonôra T. Prestrelo, Luciano da Fonseca Eli