454 research outputs found

    Evaluation of practice change following SAFE obstetric courses in Tanzania: : a prospective cohort study

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    Funding Information: The study was funded by the Laerdal Foundation. ML and AZ are joint first authors. We would like to thank the World Federation of Societies of Anaesthesiologists and the Association of Anaesthetists, UK for operational and administrative support. We would also like to express our deepest gratitude to the faculty and research assistants: B. Asnake, A. Chamwanzi, A. Cheng, T. Kasole, K. Khalid, L. Frostan Komba, C. L. S. Kwan, A. F. Lwiza, P. Massawe, B. McKenna, S. S. Mohamed, C. Msadabwe, P. Murambi, A. Musgrave, M. C. Mutagwaba, G. Mwakisambwe, A. S. Ndebeya, S. G. Ndezi, H. Phiri, P. Ponsian, R. Samwel, E. Shang'a and R. Swai. This paper is dedicated to the memory of our dear friend and colleague, Soloman Gerald Ndezi (1984–2022), who was a dedicated teacher and compassionate doctor. No competing interests declared. Publisher Copyright: © 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.Peer reviewedPublisher PD

    Balloon dilatation and stenting for aortic coarctation: a systematic review and meta-analysis

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    Background—There is no systematic assessment of available evidence on effectiveness and comparative effectiveness of balloon dilatation and stenting for aortic coarctation. Methods and Results—We systematically searched 4 online databases to identify and select relevant studies of balloon dilatation and stenting for aortic coarctation based on a priori criteria (PROSPERO 2014:CRD42014014418). We quantitatively synthesized results for each intervention from single-arm studies and obtained pooled estimates for relative effectiveness from pairwise and network meta-analysis of comparative studies. Our primary analysis included 15 stenting (423 participants) and 12 balloon dilatation studies (361 participants), including patients ≥10 years of age. Post-treatment blood pressure gradient reduction to ≤20 and ≤10 mm Hg was achieved in 89.5% (95% confidence interval, 83.7–95.3) and 66.5% (44.1–88.9%) of patients undergoing balloon dilatation, and in 99.5% (97.5–100.0%) and 93.8% (88.5–99.1%) of patients undergoing stenting, respectively. Odds of achieving ≤20 mm Hg were lower with balloon dilatation as compared with stenting (odds ratio, 0.105 [0.010–0.886]). Thirty-day survival rates were comparable. Numerically more patients undergoing balloon dilatation experienced severe complications during admission (6.4% [2.6–10.2%]) compared with stenting (2.6% [0.5–4.7%]). This was supported by meta-analysis of head-to-head studies (odds ratio, 9.617 [2.654–34.845]) and network meta-analysis (odds ratio, 16.23, 95% credible interval: 4.27–62.77) in a secondary analysis in patients ≥1 month of age, including 57 stenting (3397 participants) and 62 balloon dilatation studies (4331 participants). Conclusions—Despite the limitations of the evidence base consisting predominantly of single-arm studies, our review indicates that stenting achieves superior immediate relief of a relevant pressure gradient compared with balloon dilatation

    A candidate relativistic tidal disruption event at 340 Mpc

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    We present observations of an extreme radio flare, VT J024345.70-284040.08, hereafter VT J0243, from the nucleus of a galaxy with evidence for historic Seyfert activity at redshift z=0.074z=0.074. Between NRAO VLA Sky Survey observations in 1993 to VLA Sky Survey observations in 2018, VT J0243 rose from a {\sim}GHz radio luminosity of νLν1038\nu L_\nu \lesssim 10^{38} erg s1^{-1} to νLν1040\nu L_\nu{\sim}10^{40} erg s1^{-1}, and still continues to brighten. The radio spectral energy distribution (SED) evolution is consistent with a nascent jet that has slowed over 3000{\sim}3000 days with an average 0.1<β<0.60.1 < \langle \beta \rangle < 0.6. The jet is energetic (105152{\sim}10^{51-52} erg), and had a radius 0.7{\sim}0.7 pc in Dec. 2021. X-ray observations suggest a persistent or evolving corona, possibly associated with an accretion disk, and IR and optical observations constrain any high-energy counterpart to be sub-Eddington. VT J0243 may be an example of a young, off-axis radio jet from a slowly evolving tidal disruption event. Other more mysterious triggers for the accretion enhancement and jet launching are possible. In either case, VT J0243 is a unique example of a nascent jet, highlighting the unknown connection between supermassive black holes, the properties of their accretion flows, and jet launching.Comment: 20 pages, 5 figures, 3 tables. Submitted to Ap

    Criminal redress in cases of environmental victimisation: a defence

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    In recent years growing concern has been voiced in the environmental justice literature regarding the ability of criminal justice mechanisms to adequately address environmental harms, especially when such harms are perpetrated by large corporations. Commentators argue that criminal justice processes are often ill-suited to the particular features of environmental cases, where the chain of causation between wrongful actions/omissions and environmentally harmful consequence can be very complex and extend over the course of many years. As an alternative, many such commentators now favour the adoption of more administrative resolutions when corporate bodies breach their environmental obligations (which may or may not amount to ‘crimes’). Others favour the use of civil sanction regimes, which is now the preferred approach of the UK Environment Agency. In this paper I will argue that the debate on how best to respond to environmental harm has so far neglected to factor in the perspective of the victims of those harms and, in particular, their need for redress. I will argue that by incorporating such a perspective, as opposed to focusing largely on questions of efficiency and cost-effectiveness, the criminal justice route still has much to recommended it, especially in relation to the provision of meaningful redress and/or compensation to the victims of environmental harm. Consequently, this paper will provide a victimological defence of the criminal justice process, and of criminal penalties, in their application to cases of environmental harms

    Care planning: a neoliberal three card trick

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    Introduction The three card game, sometimes called find the queen, is a classic confidence trick, typically taking place on an impromptu table top, set up on pavement or street corner. The tricksters usually operate in teams, pulling in punters and ‘losing’ games with their fellows to persuade prospective speculators the game is winnable. For our titular purposes the three card trick serves as a metaphor for broader deceits. We are concerned with how well-meaning mental health nurses can enter into a set of apparently rational practices, insisted upon by policy and protocol, seemingly motivated by ideals of care and protection from harm, yet functioning to destroy the very essence of what it might mean to be a caring, progressive practitioner by contributing to a mutuality of alienation that, at the relational level, is the opposite of what services intend to achieve. This may prove to be the case because an external confidence trickster (neoliberalism) is actually in charge, and the real function of the game serves other ends. The whole point of the game is that genuine players can never win, and for the trickster to triumph it is necessary that these punters are willing, gullible and in most circumstances accept losses without too much fuss. When the losers do not go quietly this is referred to in the argot of the con as ‘squawking’, and personnel are deployed on the periphery to ensure any squawk is minimised. Various strategies can be used to ‘cool out the mark’, and are analogous to the means by which people are assisted to adjust to life’s disappointments in other contexts, including encounters with priests or sundry psy-professionals (Goffman 1952; McKeown et al. 2013). This commentary paper seeks to provoke nursing out of its state of gullibility and self-deception even if this involves painful reflection on the losses inherent in our collective game of mental health care. If we are to defend the importance of mental health nursing we must think more critically about our complicity within oppressive systems of control and do something about it. There is a lengthy critical tradition to draw on. We urge mental health nurses to squawk, asserting a more recalcitrant and rebellious standpoint, preferably in alliance with service users, refusers and survivors. Acknowledging the constraints upon nursing’s agency, deficits of power, and structural disadvantage need not default to impotence and inaction: collective resistance is always possible, however difficult the circumstances

    Writing in Britain and Ireland, c. 400 to c. 800

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    Hypothyroidism among military infants born in countries of varied iodine nutrition status

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    <p>Abstract</p> <p>Background</p> <p>Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been questioned. This study was designed to compare hypothyroidism among infants born to US military families in countries of varied iodine nutrition status.</p> <p>Methods</p> <p>A cohort design was used to analyze data from the Department of Defense Birth and Infant Health Registry for infants born in 2000-04 (<it>n </it>= 447,691). Hypothyroidism was defined using ICD-9-CM codes from the first year of life (<it>n </it>= 698). The impact of birth location on hypothyroidism was assessed by comparing rates in Germany, Japan, and US territories with the United States, while controlling for infant gender, plurality, gestational age, maternal age, maternal military status, and military parent's race/ethnicity.</p> <p>Results</p> <p>Hypothyroidism did not vary by birth location with adjusted odds ratios (OR) as follows: Germany (OR 0.82, [95% CI 0.50, 1.35]), Japan (OR 0.67, [95% CI 0.37, 1.22]), and US territories (OR 1.29, [95% CI 0.57, 2.89]). Hypothyroidism was strongly associated with preterm birth (OR 5.44, [95% CI 4.60, 6.42]). Hypothyroidism was also increased among infants with civilian mothers (OR 1.24, [95% CI 1.00, 1.54]), and older mothers, especially ages 40 years and older (OR 2.09, [95% CI 1.33, 3.30]).</p> <p>Conclusions</p> <p>In this study, hypothyroidism in military-dependent infants did not vary by birth location, but was associated with other risk factors, including preterm birth, civilian maternal status, and advanced maternal age.</p
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