13 research outputs found
Marine and river environments: A pattern of Integrated Coastal Zone Management (ICZM) in Calabria (Southern Italy)
- Author
- Barcena
- Borja
- Callegari
- Callegari
- Cantasano
- Cendrero
- Cicin-Sain
- Coccossis
- Cori
- Courtney
- de Groot
- European Commission
- European Commission
- European Commission
- European Parliament and Council
- Gaetano Pellicone
- Hayward
- IUCN
- Kelleher
- Koutrakis
- McKenna
- McLeod
- Micallef
- Micallef
- Nicola Cantasano
- Olsen
- Pavasovic
- Phillips
- Reiners
- Rivas
- Rochette
- Rochette
- Suman
- U.N.
- U.N.C.H.S. (United Nations Centre for Human Settlements Habitat)
- U.S. Commission on Marine Science
- UNEP/MAP/PAP
- van der Maarel
- van der Weide
- van der Weide
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Full text linkDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Abu-Arafeh A.
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- Adewunmi E.
- Adeyemo T.
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- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
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- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
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- Allanson A.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
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- Addo A.
- Adedeji O.
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- Adewunmi E.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Albert P.
- Alegria A.
- Alexander A.
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- Byrne J.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
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- Chilvers A.
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- Chineka R.
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- Chisnall B.
- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
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- Clayton-Smith J.
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- Clemente de la Torre C.
- Clifford S.
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- Coe A.
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- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
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- Colton H.
- Condliffe R.
- Connell E.
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- Connor E.
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- Conteh V.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- De Soyza A.
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- Desai A.
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- Dhani S.
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- Dimitri P.
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- Dobbie L.
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- Dolan D.
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- Duggan A.
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- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
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- Early J.
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- Elgohary A.
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- Emberson Jonathan R.
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- Essa F.
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- Everden C.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Fenton C.
- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Multi-omic atlas of the parahippocampal gyrus in Alzheimer’s disease
- Author
- Publication venue
- Nature Portfolio
- Publication date
- 01/09/2023
- Field of study
No full textAbstract Alzheimer’s disease (AD) is the most common form of dementia worldwide, with a projection of 151 million cases by 2050. Previous genetic studies have identified three main genes associated with early-onset familial Alzheimer’s disease, however this subtype accounts for less than 5% of total cases. Next-generation sequencing has been well established and holds great promise to assist in the development of novel therapeutics as well as biomarkers to prevent or slow the progression of this devastating disease. Here we present a public resource of functional genomic data from the parahippocampal gyrus of 201 postmortem control, mild cognitively impaired (MCI) and AD individuals from the Mount Sinai brain bank, of which whole-genome sequencing (WGS), and bulk RNA sequencing (RNA-seq) were previously published. The genomic data include bulk proteomics and DNA methylation, as well as cell-type-specific RNA-seq and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) data. We have performed extensive preprocessing and quality control, allowing the research community to access and utilize this public resource available on the Synapse platform at https://doi.org/10.7303/syn51180043.2
Physical and biotic factors limiting the distribution and abundance of littoral molluscs on Macquarje Island (sub-Antarctic)
- Author
- Arnold
- Arnold
- Bennett
- Broekhuysen
- Brown
- Courtney
- Davies
- Davies
- Dayton
- Dearborn
- Dearborn
- Dearborn
- Evans
- Fraenkel
- Fraenkel
- Fuller
- Grua
- Grua
- Grua
- Gruzov
- Hedgpeth
- Holme
- Kanwisher
- Kanwisher
- Kenny
- Kenny
- Kensler
- Law
- Lewis
- Lewis
- Mayes
- Micallef
- Micallef
- Neushul
- Newell
- Paine
- Paine
- Peckham
- Price
- Ramsay
- Sandison
- Shabica
- Simpson
- Simpson
- Southward
- Tomlin
- Vermeij
- Walker
- Wohlschlag
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textThigh-length compression stockings and DVT after stroke
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- Abbas M
- Abbasi S
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- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Seasonal changes in the effect of temperature on the oxygen consumption of the winkle Littorina littorea (L.) and the mussel Mytilus edulis L.
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textTurning the wheel away from biophysical indicators in coastal zone management: Towards a stakeholder-based systemic framework
- Author
- Abdullaev
- Adger
- Adger
- Alkire
- Appelquist
- Appelquist
- Appelquist
- Appelquist
- Azhoni
- Bagstad
- Baines
- Bandoc
- Barragán
- Becken
- Berrios
- Biedenweg
- Borges
- Boyd
- Brugger
- Buot
- Calhoun
- Camill
- Choobchian
- Clements
- Courtney
- Cretchley
- Dacks
- Dannevig
- Dogliotti
- Dondeynaz
- Engler
- Eriksen
- Flora
- Ghisellini
- Giampietro
- Griggs
- Hoppe
- Hove
- Howe
- Inácio
- King
- Knott
- Koricheva
- Kronen
- Lawson
- Lele
- Li
- Lins-de-Barros
- Loomis
- Magpayo
- Maliao
- Marín-Monroy
- McCallen
- McCarter
- Meng
- Micallef
- Minar
- Miswar
- Mollah
- Murphy
- Narra
- Navarro
- Nemes
- Nguyen
- Nunez-Mir
- Odemerho
- Oppenheimer
- Penn-Edwards
- Pomeroy
- Powell
- Rakhmanissazly
- Rasul
- Roy
- Saillard
- Sherman
- Sorensen
- Stojanovic
- Stronkhorst
- Suinyuy
- Sullivan
- Thaler
- Tian
- Van Dongeren
- Van Eijck
- Vugteveen
- Wavrek
- Werner
- Yun
- Zaldívar-Jiménez
- Zhu
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textMechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis
- Author
- Algamas-Dimantov
- Aljada
- Antico Arciuch
- Anubhuti
- Balogh
- Bellacosa
- Bernardi
- Bhargava
- Bjorkbacka
- Bondia-Pons
- Braun
- Bremer
- Buckley
- Byeon
- Chawla
- Chen
- Codoner-Franch
- Courtney
- Crompton
- Daiber
- Dalmas
- de Heredia
- Donohoe
- Drevon
- Eddi
- Fantuzzi
- Fini
- Fiume
- Frasca
- Frystyk
- Fujisaka
- Gallagher
- Garaulet
- Garaulet
- Gauthier
- Gravaghi
- Gunter
- Harper
- Harvey
- Huang
- Iannone
- Ibrahim
- Jacobson
- Jaffe
- Jemal
- Jemal
- Kaaman
- Kaler
- Kalupahana
- Kant
- Kashyap
- Kershaw
- Klein
- Kopecky
- Kopp
- Kursawe
- Kus
- Laharrague
- Lawson
- Le Marchand
- Lee
- Lee
- Liu
- Liu
- Lund
- Lysaght
- Merrill
- Micallef
- Mutoh
- Mutoh
- Mutoh
- Nkondjock
- Ohman
- Osborn
- Otake
- Pais
- Park
- Patsouris
- Popivanova
- Pories
- Poullis
- Ronti
- Rutter
- Ruzickova
- Sala
- Samovski
- Sartipy
- Schaeffler
- Schwartz
- Shi
- Singla
- Stienstra
- Subauste
- Suganami
- Suganami
- Sung
- Tiaka
- Vykoukal
- West
- Westbrook
- Westerink
- Wieckowski
- Xu
- Yehuda-Shnaidman
- Yehuda-Shnaidman
- Zeyda
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textBeyond chemotherapy: new agents for targeted treatment of lymphoma
- Author
- A Aboukameel
- A Advani
- A Dutton
- A Goy
- A Hagenbeek
- A Hagenbeek
- A Jemal
- A Spencer
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- A Younes
- AD Barker
- AD Zelenetz
- Anas Younes
- AW Thomson
- AW Tolcher
- B Coiffier
- B Coiffier
- B Coiffier
- BB Ding
- BD Cheson
- BD Cheson
- BD Cheson
- BJ Lannutti
- BS Jaiswal
- C Renné
- C Tse
- CB Reeder
- D Del Bufalo
- D Kube
- D Nagorsen
- D O'Mahony
- D Wu
- DA Pollyea
- DG Maloney
- E Oflazoglu
- EA Eisenhauer
- EL Korn
- FA Scheeren
- G Hess
- GV Georgakis
- H Linardou
- HM Amin
- I Melzner
- I Melzner
- IM Berenjeno
- IN Micallef
- IW Flinn
- J Dancey
- J Kuruvilla
- J Wiezorek
- JA Engelman
- JA Morrison
- JC Byrd
- JP Leonard
- JP Leonard
- JW Friedberg
- K Dunleavy
- K Flaherty
- KA Blum
- KA Blum
- KD Courtney
- L Chen
- L Wang
- L Zhao
- M Crump
- M Duvic
- M Fanale
- M Jücker
- MA Weniger
- MA Yared
- MH Kirschbaum
- MJ Robertson
- MS Topp
- N Dhomen
- N Fowler
- NH Dang
- NL Bartlett
- NR Gough
- NT Ihle
- P McLaughlin
- PA Baeuerle
- PB Johnston
- PM LoRusso
- R Advani
- R Advani
- R Bargou
- R Lieberman
- R Piekarz
- R Sridhara
- RI Fisher
- RJ Kreitman
- RL Piekarz
- S Alas
- S Hunsberger
- S Nagel
- S Viviani
- S Wang
- SJ Strauss
- SM Ansell
- SM Ansell
- SM Smith
- T Satoh
- TA Fehniger
- TA Fehniger
- TE Witzig
- TE Witzig
- TE Witzig
- TF Franke
- U Holtick
- V Joliot
- W Wilson
- WS Xu
- XM Ma
- Y Zheng
- ZS Nagy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
