29 research outputs found

    Paleomagnetism and Tectonic Significance of the Goble Volcanics of Southern Washington

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    The upper Eocene to lower Oligocene Goble Volcanic series of southwest Washington is a thick sequence of areal to submarine basaltic to andesitic flows, pyroclastics, and minor sediments. Major element geochemical analyses suggest that these rocks may represent early magmatism of the Cascade arc. Paleomagnetic results from 37 sites indicate that the direction of remanent magnetization in the Goble Volcanics has a declination of 18.5°, an inclination of 57.5°, and a circle of 95% confidence (∝ 95)of 4.33°. The expected upper Eocene direction in the sampling area is D = 353.5°; Ī = 61.5°. Thus the Goble Volcanics block appears to have rotated approximately 25° in a clockwise direction relative to the North American interior since the late Eocene. Comparison of this result with those of Cox, Simpson, and Plumley for the Oregon Coast Range, which show an apparently greater degree of rotation, suggests that the Goble Volcanics are not part of the Coast Range block. This also is supported by geochemical and geophysical differences between the provinces. Simpson (1977) has proposed two models to explain the Coast Range rotation. Model I assumes that the block extends to the Olympic Mountains and rotated seaward around its northern end in response to extension from behind. Model II assumes the block did not extend as far as the Olympic Mountains, and that it rotated around a pivot point at its southern end. Both models have major problems, which are compounded by results from the Goble Volcanics. Two possible models for rotation of the Goble Volcanics as part of an independent block have been examined. These are: (1) the ball-bearing model , in which an equant block rotates between right-lateral faults in a large continental shear zone; and (2) the Fitch model , wherein an equant block rotates between a subduction zone and a transcurrent fault pair formed in response to oblique subduction. A preferred but very tentative model proposed in this thesis to explain rotation in both the Goble and Coast Range blocks is a revised model I. It assumes a break in the Coast Range block near the Columbia River. The Coast Range would then rotate around a pivot point in the Tillamook highland area. The Goble Volcanics, which would lie northeast of the rotating block, might then rotate independently in a ball-bearing fashion between right-lateral strike-slip faults trending northwest-southeast. These faults, including the Brothers, Eugene - Denio, Vale and Portland fault may have formed in response to basin and range extension. In particular, the Portland fault which may extend through the Coast Range block, and possible faults to the north parallel to the Olympic - Wallowa lineament may have been responsible for the rotation of the Goble Volcanics

    Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials

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    ACC/AHA 2006 Practice Guidelines for the Management of Patients With Valvular Heart Disease: Executive Summary. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise t

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    "The ACC and the AHA have long been involved in the joint development of practice guidelines designed to assist healthcare providers in the management of selected cardiovascular disorders or the selection of certain cardiovascular procedures. The determination of the disorders or procedures to develop guidelines for is based on several factors, including importance to healthcare providers and whether there are sufficient data from which to derive accepted guidelines. One important category of cardiac disorders that affect a large number of patients who require diagnostic procedures and decisions regarding long-term management is valvular heart disease. During the past 2 decades, major advances have occurred in diagnostic techniques, the understanding of natural history, and interventional cardiology and surgical procedures for patients with valvular heart disease. These advances have resulted in enhanced diagnosis, more scientific selection of patients for surgery or catheter-based intervention versus medical management, and increased survival of patients with these disorders. The information base from which to make clinical management decisions has greatly expanded in recent years, yet in many situations, management issues remain controversial or uncertain. Unlike many other forms of cardiovascular disease, there is a scarcity of large-scale multicenter trials addressing the diagnosis and treatment of patients with valvular disease from which to derive definitive conclusions, and the information available in the literature represents primarily the experiences reported by single institutions in relatively small numbers of patients.

    American College of Cardiology; American Heart Association Task Force; European Society of Cardiology Committee for Practice Guidelines. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death).

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    The purpose this document is to update and combine the previously published recommendations into one source approved by the major cardiology organizations in the United States and Europe. We have consciously attempted to create a streamlined document, not a textbook, that would be useful specifically to locate recommendations on the evaluation and treatment of patients who have or may be at risk for ventricular arrhythmias. Thus, sections on epidemiology, mechanisms and substrates, and clinical presentations are brief, because there are no recommendations for those sections. For the other sections, the wording has been kept to a minimum, and clinical presentations have been confined to those aspects relevant to forming recommendations

    Search for the rare hadronic decay Bs0ppˉB_s^0\to p \bar{p}

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    A search for the rare hadronic decay Bs0→pp¯ is performed using proton-proton collision data recorded by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6  fb-1. No evidence of the decay is found and an upper limit on its branching fraction is set at B(Bs0→pp¯)&lt;4.4(5.1)×10-9 at 90% (95%) confidence level; this is currently the world’s best upper limit. The decay mode B0→pp¯ is measured with very large significance, confirming the first observation by the LHCb experiment in 2017. The branching fraction is determined to be B(B0→pp¯)=(1.27±0.15±0.05±0.04)×10-8, where the first uncertainty is statistical, the second is systematic and the third is due to the external branching fraction of the normalization channel B0→K+π-. The combination of the two LHCb measurements of the B0→pp¯ branching fraction yields B(B0→pp¯)=(1.27±0.13±0.05±0.03)×10-8.A search for the rare hadronic decay Bs0ppˉB_s^0\to p \bar{p} is performed using proton-proton collision data recorded by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb1^{-1}. No evidence of the decay is found and an upper limit on its branching fraction is set at B(Bs0ppˉ)<4.4 (5.1)×109{\cal B}(B_s^0\to p \bar{p}) < 4.4~(5.1) \times 10^{-9} at 90% (95%) confidence level; this is currently the world's best upper limit. The decay mode B0ppˉB^0\to p \bar{p} is measured with very large significance, confirming the first observation by the LHCb experiment in 2017. The branching fraction is determined to be B(B0ppˉ)=(1.27±0.15±0.05±0.04)×108{\cal B}(B^0\to p \bar{p}) = \rm (1.27 \pm 0.15 \pm 0.05 \pm 0.04) \times 10^{-8}, where the first uncertainty is statistical, the second is systematic and the third is due to the external branching fraction of the normalization channel B0K+πB^0\to K^+\pi^-. The combination of the two LHCb measurements of the B0ppˉB^0\to p \bar{p} branching fraction yields B(B0ppˉ)=(1.27±0.13±0.05±0.03)×108{\cal B}(B^0\to p \bar{p}) = \rm (1.27 \pm 0.13 \pm 0.05 \pm 0.03) \times 10^{-8}

    Nuclear modification factor of neutral pions in the forward and backward regions in ppPb collisions

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    The nuclear modification factor of neutral pions is measured in proton-lead collisions collected at a center-of-mass energy per nucleon of 8.168.16 TeV with the LHCb detector. The π0\pi^0 production cross section is measured differentially in transverse momentum (pTp_{T}) for 1.5π0 production cross section is measured differentially in transverse momentum (pT) for 1.5<pT<10.0  GeV and in center-of-mass pseudorapidity (ηc.m.) regions 2.5<ηc.m.<3.5 (forward) and -4.0<ηc.m.<-3.0 (backward) defined relative to the proton beam direction. The forward measurement shows a sizable suppression of π0 production, while the backward measurement shows the first evidence of π0 enhancement in proton-lead collisions at the LHC. Together, these measurements provide precise constraints on models of nuclear structure and particle production in high-energy nuclear collisions.The nuclear modification factor of neutral pions is measured in proton-lead collisions collected at a center-of-mass energy per nucleon of 8.16~{\rm TeV}withtheLHCbdetector.The with the LHCb detector. The \pi^0productioncrosssectionismeasureddifferentiallyintransversemomentum( production cross section is measured differentially in transverse momentum (p_{\rm T})for) for 1.5<p_{\rm T}<10.0~{\rm GeV}andincenterofmasspseudorapidity( and in center-of-mass pseudorapidity (\eta_{\rm c.m.})regions) regions 2.5<\eta_{\rm c.m.}<3.5(forward)and (forward) and -4.0<\eta_{\rm c.m.}<-3.0(backward)definedrelativetotheprotonbeamdirection.Theforwardmeasurementshowsasizablesuppressionof (backward) defined relative to the proton beam direction. The forward measurement shows a sizable suppression of \pi^0production,whilethebackwardmeasurementshowsthefirstevidenceof production, while the backward measurement shows the first evidence of \pi^0$ enhancement in proton-lead collisions at the LHC. Together, these measurements provide precise constraints on models of nuclear structure and particle production in high-energy nuclear collisions

    Observation of sizeable ω\omega contribution to χc1(3872)π+πJ/ψ\chi_{c1}(3872) \to \pi^+\pi^- J/\psi decays

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    Resonant structures in the dipion mass spectrum from χc1(3872)π+πJ/ψ\chi_{c1}(3872)\to\pi^+\pi^- J/\psi decays, produced via B+K+χc1(3872)B^+\to K^+\chi_{c1}(3872) decays, are analyzed using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb1^{-1}. A sizeable contribution from the isospin conserving χc1(3872)ωJ/ψ\chi_{c1}(3872)\to\omega J/\psi decay is established for the first time, (21.4±2.3±2.0)%(21.4\pm2.3\pm2.0)\%, with a significance of more than 7.1σ7.1\sigma. The amplitude of isospin violating decay, χc1(3872)ρ0J/ψ\chi_{c1}(3872)\to\rho^0 J/\psi, relative to isospin conserving decay, χc1(3872)ωJ/ψ\chi_{c1}(3872)\to\omega J/\psi, is properly determined, and it is a factor of six larger than expected for a pure charmonium state.Resonant structures in the dipion mass spectrum from χc1(3872)→π+π-J/ψ decays, produced via B+→K+χc1(3872) decays, are analyzed using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9  fb-1. A sizeable contribution from the isospin conserving χc1(3872)→ωJ/ψ decay is established for the first time, (21.4±2.3±2.0)%, with a significance of more than 7.1σ. The amplitude of isospin violating decay, χc1(3872)→ρ0J/ψ, relative to isospin conserving decay, χc1(3872)→ωJ/ψ, is properly determined, and it is a factor of 6 larger than expected for a pure charmonium state.Resonant structures in the dipion mass spectrum from χc1(3872)π+πJ/ψ\chi_{c1}(3872)\to\pi^+\pi^- J/\psi decays, produced via B+K+χc1(3872)B^+\to K^+\chi_{c1}(3872) decays, are analyzed using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb1fb^{-1}. A sizeable contribution from the isospin conserving χc1(3872)ωJ/ψ\chi_{c1}(3872)\to\omega J/\psi decay is established for the first time, (21.4±2.3±2.0)%(21.4\pm2.3\pm2.0)\%, with a significance of more than 7.1σ7.1\sigma. The amplitude of isospin violating decay, χc1(3872)ρ0J/ψ\chi_{c1}(3872)\to\rho^0 J/\psi, relative to isospin conserving decay, χc1(3872)ωJ/ψ\chi_{c1}(3872)\to\omega J/\psi, is properly determined, and it is a factor of six larger than expected for a pure charmonium state
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