On the formation of hot Neptunes and super-Earths

The discovery of short-period Neptune-mass objects, now including the remarkable system HD69830 (Lovis et al. 2006) with three Neptune analogues, raises difficult questions about current formation models which may require a global treatment of the protoplanetary disc. Several formation scenarios have been proposed, where most combine the canonical oligarchic picture of core accretion with type I migration (e.g. Terquem & Papaloizou 2007) and planetary atmosphere physics (e.g. Alibert et al. 2006). To date, published studies have considered only a small number of progenitors at late times. This leaves unaddressed important questions about the global viability of the models. We seek to determine whether the most natural model -- namely, taking the canonical oligarchic picture of core accretion and introducing type I migration -- can succeed in forming objects of 10 Earth masses and more in the innermost parts of the disc. This problem is investigated using both traditional semianalytic methods for modelling oligarchic growth as well as a new parallel multi-zone N-body code designed specifically for treating planetary formation problems with large dynamic range (McNeil & Nelson 2009). We find that it is extremely difficult for oligarchic tidal migration models to reproduce the observed distribution. Even under many variations of the typical parameters, we form no objects of mass greater than 8 Earth masses. By comparison, it is relatively straightforward to form icy super-Earths. We conclude that either the initial conditions of the protoplanetary discs in short-period Neptune systems were substantially different from the standard disc models we used, or there is important physics yet to be understood.Comment: 19 pages, 18 figures. Final version accepted to MNRAS 30 September 200

Oligarchic and giant impact growth of terrestrial planets in the presence of gas giant planet migration

We present the results of N--body simulations which examine the effect that gas giant planet migration has on the formation of terrestrial planets. The models incorporate a 0.5 Jupiter mass planet undergoing type II migration through an inner protoplanet--planetesimal disk, with gas drag included. Each model is initiated with the inner disk being at successively increased levels of maturity, so that it is undergoing either oligarchic or giant impact style growth as the gas giant migrates. In all cases, a large fraction of the disk mass survives the passage of the giant, either by accreting into massive terrestrial planets shepherded inward of the giant, or by being scattered into external orbits. Shepherding is favored in younger disks where there is strong dynamical friction from planetesimals and gas drag is more influential, whereas scattering dominates in more mature disks where dissipation is weaker. In each scenario, sufficient mass is scattered outward to provide for the eventual accretion of a set of terrestrial planets in external orbits, including within the system's habitable zone. An interesting result is the generation of massive, short period, terrestrial planets from compacted material pushed ahead of the giant. These planets are reminiscent of the short period Neptune mass planets discovered recently, suggesting that such `hot Neptunes' could form locally as a by-product of giant planet migration.Comment: 17 pages, 11 figures, to be published in A&A. Higher resolution pdf available at: http://www.users.globalnet.co.uk/~mfogg/3453fogg.pd

Collisions between equal sized ice grain agglomerates

Following the recent insight in the material structure of comets, protoplanetesimals are assumed to have low densities and to be highly porous agglomerates. It is still unclear if planetesimals can be formed from these objects by collisional growth. Therefore, it is important to study numerically the collisional outcome from low velocity impacts of equal sized porous agglomerates which are too large to be examined in a laboratory experiment. We use the Lagrangian particle method Smooth Particle Hydrodynamics to solve the equations that describe the dynamics of elastic and plastic bodies. Additionally, to account for the influence of porosity, we follow a previous developed equation of state and certain relations between the material strength and the relative density. Collisional growth seems possible for rather low collision velocities and particular material strengths. The remnants of collisions with impact parameters that are larger than 50% of the radius of the colliding objects tend to rotate. For small impact parameters, the colliding objects are effectively slowed down without a prominent compaction of the porous structure, which probably increases the possibility for growth. The protoplanetesimals, however, do not stick together for the most part of the employed material strengths. An important issue in subsequent studies has to be the influence of rotation to collisional growth. Moreover, for realistic simulations of protoplanetesimals it is crucial to know the correct material parameters in more detail.Comment: 7 pages, 11 figures, accepted by A&

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Identification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombe

Bortezomib/PS-341/Velcade, a proteasome inhibitor, is widely used to treat multiple myeloma. While several mechanisms of the cytotoxicity of the drug were proposed, the actual mechanism remains elusive. We aimed to identify genes affecting the cytotoxicity of Bortezomib in the fission yeast S.pombe as the drug inhibits this organism's cell division cycle like proteasome mutants. Among the 2815 genes screened (covering 56% of total ORFs), 19 genes, whose deletions induce strong synthetic lethality with Bortezomib, were identified. The products of the 19 genes included four ubiquitin enzymes and one nuclear proteasome factor, and 13 of them are conserved in humans. Our results will provide useful information for understanding the actions of Bortezomib within cells

Angular momentum exchange during secular migration of two-planet systems

We investigate the secular dynamics of two-planet coplanar systems evolving under mutual gravitational interactions and dissipative forces. We consider two mechanisms responsible for the planetary migration: star-planet (or planet-satellite) tidal interactions and interactions of a planet with a gaseous disc. We show that each migration mechanism is characterized by a specific law of orbital angular momentum exchange. Calculating stationary solutions of the conservative secular problem and taking into account the orbital angular momentum leakage, we trace the evolutionary routes followed by the planet pairs during the migration process. This procedure allows us to recover the dynamical history of two-planet systems and constrain parameters of the involved physical processes.Comment: 20 pages, 9 figures, accepted for publication in Celestial Mechanics and Dynamical Astronomy (special issue on Exoplanets

Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells

Variant late-infantile neuronal ceroid lipofuscinosis (vLINCL), caused by CLN6 mutation, and juvenile neuronal ceroid lipofuscinosis (JNCL), caused by CLN3 mutation, share clinical and pathological features, including lysosomal accumulation of mitochondrial ATP synthase subunit c, but the unrelated CLN6 and CLN3 genes may initiate disease via similar or distinct cellular processes. To gain insight into the NCL pathways, we established murine wild-type and CbCln6nclf/nclf cerebellar cells and compared them to wild-type and CbCln3Δex7/8/Δex7/8 cerebellar cells. CbCln6nclf/nclf cells and CbCln3Δex7/8/Δex7/8 cells both displayed abnormally elongated mitochondria and reduced cellular ATP levels and, as cells aged to confluence, exhibited accumulation of subunit c protein in Lamp 1-positive organelles. However, at sub-confluence, endoplasmic reticulum PDI immunostain was decreased only in CbCln6nclf/nclf cells, while fluid-phase endocytosis and LysoTracker® labeled vesicles were decreased in both CbCln6nclf/nclf and CbCln3Δex7/8/Δex7/8 cells, though only the latter cells exhibited abnormal vesicle subcellular distribution. Furthermore, unbiased gene expression analyses revealed only partial overlap in the cerebellar cell genes and pathways that were altered by the Cln3Δex7/8 and Cln6nclf mutations. Thus, these data support the hypothesis that CLN6 and CLN3 mutations trigger distinct processes that converge on a shared pathway, which is responsible for proper subunit c protein turnover and neuronal cell survival

Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells

In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant huntingtin. We determined how to enhance UPS function and influence catalytic protein degradation and cell survival in HD. Proteasome activators involved in either the ubiquitinated or the non-ubiquitinated proteolysis were overexpressed in HD patients' skin fibroblasts or mutant huntingtin-expressing striatal neurons. Following compromise of the UPS, overexpression of the proteasome activator subunit PA28γ, but not subunit S5a, recovered proteasome function in the HD cells. PA28γ also improved cell viability in mutant huntingtin-expressing striatal neurons exposed to pathological stressors, such as the excitotoxin quinolinic acid and the reversible proteasome inhibitor MG132. These results demonstrate the specific functional enhancements of the UPS that can provide neuroprotection in HD cells

Proteasome Nuclear Import Mediated by Arc3 Can Influence Efficient DNA Damage Repair and Mitosis in Schizosaccharomyces Pombe

Proteasomes must efficiently remove their substrates throughout the cells in a timely manner as many of these proteins can be toxic. This study shows that proteasomes can do so efficiently because they are highly mobile. Furthermore this study uncovers that proteasome mobility requires functional Arc3, a subunit of the Arp2/3 complex

Seasonal pattern of regional carbon balance in the central Rocky Mountains from surface and airborne measurements

[1] High-elevation forests represent a large fraction of potential carbon uptake in North America, but this uptake is not well constrained by observations. Additionally, forests in the Rocky Mountains have recently been severely damaged by drought, fire, and insect outbreaks, which have been quantified at local scales but not assessed in terms of carbon uptake at regional scales. The Airborne Carbon in the Mountains Experiment was carried out in 2007 partly to assess carbon uptake in western U.S. mountain ecosystems. The magnitude and seasonal change of carbon uptake were quantified by (1) paired upwind-downwind airborne CO2 observations applied in a boundary layer budget, (2) a spatially explicit ecosystem model constrained using remote sensing and flux tower observations, and (3) a downscaled global tracer transport inversion. Top-down approaches had mean carbon uptake equivalent to flux tower observations at a subalpine forest, while the ecosystem model showed less. The techniques disagreed on temporal evolution. Regional carbon uptake was greatest in the early summer immediately following snowmelt and tended to lessen as the region experienced dry summer conditions. This reduction was more pronounced in the airborne budget and inversion than in flux tower or upscaling, possibly related to lower snow water availability in forests sampled by the aircraft, which were lower in elevation than the tower site. Changes in vegetative greenness associated with insect outbreaks were detected using satellite reflectance observations, but impacts on regional carbon cycling were unclear, highlighting the need to better quantify this emerging disturbance effect on montane forest carbon cycling