36 research outputs found
Spatial and temporal reconstructions of surface and deepwater flow in the subtropical NW Atlantic at sharp climatic transitions
- Author
- Publication venue
- Publication date
- Field of study
A suite of deep-marine sediment cores recovered from the Blake Outer Ridge (BOR) in the subtropical North West Atlantic (28-34 N, 75-71 W) provide material for centennial to millennial scale investigations of abyssal circulation and surface ocean conditions during selected intervals in the last 130 kyr. Particular focus is placed on reconstructing the position and strength of the Deep Western Boundary Current (DWBC) at a high temporal resolution. Palaeocurrent dynamics are reconstructed using the 'sortable silt' (10-63 urn terrigeneous fraction) mean grain size sedimentological proxy. Paired Mg/Ca and 8 () records from the planktonic foraminifera G. ruber (white) are used to reconstruct deglacial sea surface temperature (SSI) and salinity variations, while benthic 513C data from Cibicidoides spp. document the interchange of northern- and southern source deepwater (NSW/SSW) in the subtropical Atlantic. Comparison of Holocene sediments with modern physical hydrographic measurements reveals a DWBC high velocity core between 3,000-4,000 m water depth. A deep position for the DWBC core below 3,500 m was also observed during the peak of the last interglaciation, marine isotope stage (MIS) 5e. The benthic 5I3C during these interglacial intervals reveals little chemical stratification and a water column dominated by NSW. A shallow Labrador Sea Water (LSW)-sourced secondary fast flowing DWBC core is also apparent during the Holocene, however during MIS 5e palaeocurrent data at intermediate depths suggest a weaker and possibly shallower position for the LSW-sourced secondary DWBC limb. The last glacial maximum and Younger Dryas reconstructions show similar hydrographic regimes with nutrient-depleted, vigorously flowing NSW above 2,500 m consistent with intermediate water formation. Northern sourced intermediate water was first apparent in the records presented at 111 kyr BP and is suggested to have persisted throughout the last glacial. Benthic 5I3C data suggest the presence of a highly stratified water column with an increasing influence of SSW with depth. Coupled suborbital oscillations in DWBC flow variability and palaeo-hydrography persist throughout the records. There is evidence for a broad-scale divergence in flow speed changes in the deep subtropical North Atlantic, with the presence of a vigorous, but poorly ventilated SSW mass below 4,200 m water depth during cold episodes of the last deglaciation and LGM, when shallower palaeocurrent and geochemical data suggest that NSW was suppressed. This is consistent with the operation of a bipolar see-saw effect. This study suggests a hitherto unrecognised degree of linkage between oscillations in subtropical North Atlantic SST and DWBC flow. During the last deglaciation the SST record is dominated by the position/strength of the Gulf Stream, while the effects of tropical heat retention are restricted prior to Heinrich event 1. A combination of meridional overturning strength, meltwater inputs and hydrological changes control salinity variability
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
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- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
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- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
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- Armitage Lewis
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- Beddall Ayda
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- Caminal Armadans Roger
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- Caron Sascha
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- Chelkov Gueorgui
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- Chen Cheng
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- Chen Jing
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- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
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- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
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- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
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- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
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- Daneri Maria
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- de Asmundis Riccardo
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- De Lorenzi Francesco
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- Dewhurst Alastair
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- Dobos Daniel
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- Dodsworth David
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- Dubreuil Arnaud
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- Ducourthial Audrey
- Ducu Otilia
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- Dudarev Alexey
- Dudder Andreas
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- Dumancic Mirta
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- Dyndal Mateusz
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- Glasman Claudia
- Glatzer Julian
- Glaysher Paul
- Glazov Alexandre
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- Godlewski Jan
- Goldfarb Steven
- Golling Tobias
- Golubkov Dmitry
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- Gonella Giulia
- Gonella Laura
- Gongadze Alexi
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- Gonzalez-Sevilla Sergio
- González de la Hoz Santiago
- Gonçalo Ricardo
- Goossens Luc
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- Gorini Edoardo
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- Goshaw Alfred
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- Goudet Christophe
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- Govender Nicolin
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- Grabowska-Bold Iwona
- Gradin Per
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- Gray Heather
- Greenwood Zeno
- Grefe Christian
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- Grenier Philippe
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- Griffiths Justin
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- Grossi Giulio
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- Guan Wen
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- Guest Daniel
- Gueta Orel
- Gui Bin
- Guido Elisa
- Guillemin Thibault
- Guindon Stefan
- Gul Umar
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- Guo Jun
- Guo Wen
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- Gupta Ruchi
- Gurbuz Saime
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- Gutelman Benjamin
- Gutierrez Ortiz Nicolas
- Gutierrez Phillip
- Gutschow Christian
- Guyot Claude
- Guzik Marcin
- Gwenlan Claire
- Gwilliam Carl
- Gössling Claus
- Haas Andy
- Haber Carl
- Hadavand Haleh
- Haddad Nacim
- Hadef Asma
- Hageböck Stephan
- Hagihara Mutsuto
- Hakobyan Hrachya
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- Haley Joseph
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- Haney Bijan
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- Hansen Jorn
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- Hansen Maike
- Hansen Peter
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- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
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- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
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- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
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- Young Christopher
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- Yuen Stephanie
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- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
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- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
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- Ayele Mulu
- Babayan Primo
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- Baldwin Jennifer
- Banda Michael
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- Baptiste Pertrice
- Barbaria Joseph A.
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- Bercovitz John
- Berghoff Amy
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- Beugelsdijk Tony J.
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- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
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- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
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- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
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- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
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- Buck David
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- Hitchens Matthew Edward
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- Ishikawa Sabine K.
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- Kruchowski Scott S.
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- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmed Soheir H
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M
- Al-Othman Amani Rashed
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N
- Amiri Parisa
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A
- Angquist Lars
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E
- Arlappa Nimmathota
- Aryal Krishna K
- Aspelund Thor
- Assah Felix K
- Assuncao Maria Cecilia F
- Aung May Soe
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azimi-Nezhad Mohsen
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V
- Baharudin Azli
- Bahijri Suhad
- Baker Jennifer L
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas Jose R
- Baran Joanna
- Barbagallo Carlo M
- Barcelo Alberto
- Barkat Amina
- Barros Aluisio JD
- Barros Mauro Virgilio Gomes
- Basit Abdul
- Bastos Joao Luiz D
- Bata Iqbal
- Batieha Anwar M
- Batista Rosangela L
- Battakova Zhamilya
- Batyrbek Assembekov
- Baur Louise A
- Beaglehole Robert
- Bebakar Wan Mohamad Wan
- Bel-Serrat Silvia
- Belavendra Antonisamy
- Ben Romdhane Habiba
- Benedics Judith
- Benet Mikhail
- Bennett James E
- Bennett James E
- Bentham James
- Bergh Ingunn Holden
- Berkinbayev Salim
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloisa
- Bezerra Jorge
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K
- Bhutta Zulfiqar A
- Bhutta Zulfiqar A
- Bi Hongsheng
- Bi Yufang
- Bia Daniel
- Bikbov Mukharram M
- Bista Bihungum
- Bixby Honor
- Bjelica Dusko J
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B
- Bjorkelund Cecilia
- Black Robert
- Bloch Katia V
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boddy Lynne M
- Boehm Bernhard O
- Boeing Heiner
- Boggia Jose G
- Bogova Elena
- Boissonnet Carlos P
- Bojesen Stig E
- Boker Lital Keinan
- Bonaccio Marialaura
- Bongard Vanina
- Bonilla-Vargas Alice
- Bopp Matthias
- Borghs Herman
- Bovet Pascal
- Braeckevelt Lien
- Braeckman Lutgart
- Bragt Marjolijn CE
- Brajkovich Imperia
- Branca Francesco
- Braunerova Radka Taxova
- Breckenkamp Juergen
- Breda Joao
- Brenner Hermann
- Brewster Lizzy M
- Brian Garry R
- Brinduse Lacramioara
- Brophy Sinead
- Bruno Graziella
- Bueno-de-Mesquita H Bas
- Bugge Anna
- Buoncristiano Marta
- Burazeri Genc
- Burns Con
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cai Hui
- Cama Tilema
- Cameron Christine
- Camolas Jose
- Can Gunay
- Candido Ana Paula C
- Canete Felicia
- Capanzana Mario V
- Capkova Nadezda
- Capuano Eduardo
- Capuano Vincenzo
- Cardol Marloes
- Cardoso Viviane C
- Carlsson Axel C
- Carmuega Esteban
- Carrillo-Larco Rodrigo M
- Carvalho Joana
- Casajus Jose A
- Casanueva Felipe F
- Celikcan Ertugrul
- Censi Laura
- Cervantes-Loaiza Marvin
- Cesar Juraci A
- Chamukuttan Snehalatha
- Chan Angelique W
- Chan Queenie
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- Chaturvedi Nish
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Cheraghian Bahman
- Chetrit Angela
- Chikova-Iscener Ekaterina
- Chinh Nguyen Huu
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Christensen Kaare
- Christofaro Diego G
- Chudek Jerzy
- Cifkova Renata
- Cilia Michelle
- Cinteza Eliza
- Cisneros Julio Zuniga
- Claessens Frank
- Clarke Janine
- Clays Els
- Cohen Emmanuel
- Concin Hans
- Confortin Susana C
- Cooper Cyrus
- Coppinger Tara C
- Corpeleijn Eva
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie J
- Cowell Chris
- Craig Cora L
- Crampin Amelia C
- Crujeiras Ana B
- Csilla Semanova
- Cucu Alexandra M
- Cui Liufu
- Cureau Felipe V
- D'Arrigo Graziella
- d'Orsi Eleonora
- da Silva Bruna Goncalves Cordeiro
- Dacica Liliana
- Dallongeville Jean
- Damasceno Albertino
- Damsgaard Camilla T
- Danaei Goodarz
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M
- Dasgupta Parasmani
- Dastgiri Saeed
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- de Gaetano Giovanni
- De Henauw Stefaan
- de Leon Antonio Cabrera
- de Oliveira Paula Duarte
- de Paiva Karina Mary
- De Ridder David
- De Ridder Karin
- de Rooij Susanne R
- De Smedt Delphine
- de Souza Rildo
- de Wit Tobias F Rinke
- Deepa Mohan
- Deev Alexander D
- DeGennaro Vincent
- Dehghan Abbas
- Delisle Helene
- Delpeuch Francis
- Demarest Stefaan
- Dennison Elaine
- Deren Katarzyna
- Deschamps Valerie
- Dhana Klodian
- Dhimal Meghnath
- Di Castelnuovo Augusto F
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Diaz-Sanchez Maria Elena
- Dika Zivka
- Djalalinia Shirin
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- Do Ha TP
- Dobson Annette J
- Donati Maria Benedetta
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- Donoso Silvana P
- Doring Angela
- Dorobantu Maria
- Dorosty Ahmad Reza
- Doua Kouamelan
- Drygas Wojciech
- Duan Jia Li
- Duante Charmaine A
- Duboz Priscilla
- Duda Rosemary B
- Duleva Vesselka
- Dulskiene Virginija
- Dumith Samuel C
- Dushpanova Anar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eddie Ricky
- Eftekhar Ebrahim
- Egbagbe Eruke E
- Eggertsen Robert
- Eghtesad Sareh
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- El-Khateeb Mohammad
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
- Engle-Stone Reina
- Enguerran Macia
- Erasmus Rajiv T
- Erbel Raimund
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G
- Escobedo-de la Pena Jorge
- Eslami Saeid
- Esmaeili Ali
- Evans Alun
- Ezzati Majid
- Faeh David
- Fakhretdinova Albina A
- Fall Caroline H
- Faramarzi Elnaz
- Farjam Mojtaba
- Farzadfar Farshad
- Fattahi Mohammad Reza
- Fawwad Asher
- Felix-Redondo Francisco J
- Ferguson Trevor S
- Fernandes Romulo A
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrao Thomas
- Ferrari Marika
- Ferrario Marco M
- Ferreccio Catterina
- Ferrer Eldridge
- Ferrieres Jean
- Figueiro Thamara Hubler
- Fijalkowska Anna
- Fink Gunther
- Fischer Krista
- Foger Bernhard
- Foo Leng Huat
- Forsner Maria
- Fouad Heba M
- Francis Damian K
- Franco Maria do Carmo
- Franco Oscar H
- Frikke-Schmidt Ruth
- Frontera Guillermo
- Fuchs Flavio D
- Fuchs Sandra C
- Fujiati Isti I
- Fujita Yuki
- Fumihiko Matsuda
- Furusawa Takuro
- Gaciong Zbigniew
- Gafencu Mihai
- Galbarczyk Andrzej
- Galenkamp Henrike
- Galeone Daniela
- Galfo Myriam
- Galvano Fabio
- Gao Jingli
- Garba Jamila Abubakar
- Garcia-de-la-Hera Manoli
- Garcia-Solano Marta
- Gareta Dickman
- Garnett Sarah P
- Gaspoz Jean-Michel
- Gasull Magda
- Gaya Adroaldo Cesar Araujo
- Gaya Anelise Reis
- Gazzinelli Andrea
- Gehring Ulrike
- Geiger Harald
- Geleijnse Johanna M
- Ghaffar Suhaila Abdul
- Ghanbari Ali
- Ghasemi Erfan
- Gheorghe-Fronea Oana-Florentina
- Giampaoli Simona
- Gianfagna Francesco
- Gill Tiffany K
- Giovannelli Jonathan
- Gironella Glen
- Giwercman Aleksander
- Gkiouras Konstantinos
- Godos Justyna
- Gogen Sibel
- Goldsmith Rebecca A
- Goltzman David
- Gomez Santiago F
- Gomula Aleksandra
- Goncalves Helen
- Gonzalez Angel R
- Gonzalez-Chica David A
- Gonzalez-Gross Marcela
- Gonzalez-Leon Margot
- Gonzalez-Rivas Juan P
- Gonzalez-Villalpando Clicerio
- Gonzalez-Villalpando Maria-Elena
- Gottrand Frederic
- Graca Antonio Pedro
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G
- Gregg Edward W
- Gregor Ronald D
- Grodzicki Tomasz
- Groholt Else Karin
- Grontved Anders
- Grosso Giuseppe
- Gruden Gabriella
- Gu Dongfeng
- Gualdi-Russo Emanuela
- Guallar-Castillon Pilar
- Gualtieri Andrea
- Gudmundsson Elias F
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L
- Gulliford Martin C
- Gunnlaugsdottir Johanna
- Gunter Marc J
- Guo Xiu-Hua
- Guo Yin
- Gupta Prakash C
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutierrez-Gonzalez Enrique
- Gutzwiller Felix
- Ha Seongjun
- Hadaegh Farzad
- Hadjigeorgiou Charalambos A
- Haghshenas Rosa
- Hakimi Hamid
- Halkjaer Jytte
- Hambleton Ian R
- Hamzeh Behrooz
- Hange Dominique
- Hanif Abu AM
- Hantunen Sari
- Hashemi-Shahri Seyed Mohammad
- Hassapidou Maria
- Hata Jun
- Haugsgjerd Teresa
- Hayes Alison J
- He Jiang
- He Yuan
- He Yuna
- Heidinger-Felso Regina
- Heinen Mirjam
- Hejgaard Tatjana
- Hendriks Marleen Elisabeth
- Henrique Rafael dos Santos
- Henriques Ana
- Herrala Sauli
- Herrera Victor M
- Herter-Aeberli Isabelle
- Heshmat Ramin
- Hill Allan G
- Ho Sai Yin
- Ho Suzanne C
- Hoang Van Minh
- Hobbs Michael
- Hofman Albert
- Holdsworth Michelle
- Homayounfar Reza
- Homs Clara
- Hopman Wilma M
- Horimoto Andrea RVR
- Hormiga Claudia M
- Horta Bernardo L
- Houti Leila
- Howitt Christina
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Husseini Abdullatif
- Huybrechts Inge
- Hwalla Nahla
- Hyska Jolanda
- Iacoviello Licia
- Ibarluzea Jesus M
- Ibrahim Mohsen M
- Ikeda Nayu
- Ikram M Arfan
- Ioannidou Eliza Markidou
- Iotova Violeta
- Irazola Vilma E
- Ishida Takafumi
- Islam Muhammad
- Islam Sheikh Mohammed Shariful
- Iurilli Maria LC
- Iwasaki Masanori
- Jackson Rod T
- Jacobs Jeremy M
- Jaddou Hashem Y
- Jafar Tazeen
- James Kenneth
- Jamil Kazi M
- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarani Juel
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
- Jerome Charles Sossa
- Jha Anjani Kumar
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- Jimenez Ramon O
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- Joffres Michel
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- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
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- Kalmatayeva Zhanna
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- Kameli Yves
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- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khang Young-Ho
- Khanh Le Nguyen Bao
- Khaw Kay-Tee
- Kheiri Bahareh
- Kheradmand Motahareh
- Khosravi Alireza
- Khouw Ilse MSL
- Khuong Quynh Long
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
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- Klumbiene Jurate
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- Korrovits Paul
- Korzycka Magdalena
- Kos Jelena
- Koskinen Seppo
- Kouda Katsuyasu
- Kovacs Viktoria A
- Kowlessur Sudhir
- Koziel Slawomir
- Kratzer Wolfgang
- Kriemler Susi
- Kristensen Peter Lund
- Krokstad Steiner
- Kromhout Daan
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- Kruger Herculina S
- Kubinova Ruzena
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- Kuulasmaa Kari
- Kyobutungi Catherine
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
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- Laxmaiah Avula
- Laxmaiah Avula
- Lazo-Porras Maria
- Le Port Agnes
- Le Tuyen D
- Lee Jeannette
- Lee Jeonghee
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- Lin Hsien-Ho
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- Lotufo Paulo A
- Lozano Jose Eugenio
- Lukrafka Janice L
- Luksiene Dalia
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- Malyutina Sofia K
- Maniego Lynell V
- Manios Yannis
- Mann Jim I
- Mansour-Ghanaei Fariborz
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- Marques Larissa Pruner
- Marques-Vidal Pedro
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- Martin Rosemarie
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- Martinez Eduardo Salazar
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- Martos Eva
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- Nikitin Yury P
- Ning Guang
- Ninomiya Toshiharu
- Nishtar Sania
- Noale Marianna
- Noboa Oscar A
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- Noto Davide
- Nowak-Szczepanska Natalia
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- Nurk Eha
- O'Neill Terence W
- O'Reilly Dermot
- Obreja Galina
- Ochimana Caleb
- Ochoa-Aviles Angelica M
- Oda Eiji
- Oh Kyungwon
- Ohara Kumiko
- Ohlsson Claes
- Ohtsuka Ryutaro
- Olafsson Orn
- Olinto Maria Teresa A
- Oliveira Isabel O
- Omar Mohd Azahadi
- Onat Altan
- Ong Sok King
- Ono Lariane M
- Ordunez Pedro
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- Ortiz Ana P
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- Osler Merete
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- Otero Johanna A
- Overvad Kim
- Owusu-Dabo Ellis
- Paccaud Fred Michel
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- Padez Cristina
- Pagkalos Ioannis
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palloni Alberto
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Pandey Arvind
- Panza Francesco
- Papandreou Dimitrios
- Park Soon-Woo
- Park Suyeon
- Parnell Winsome R
- Parsaeian Mahboubeh
- Pascanu Ionela M
- Pasquet Patrick
- Patel Nikhil D
- Pednekar Mangesh S
- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C
- Peres Marco A
- Perez Cynthia M
- Perez-Farinos Napoleon
- Peterkova Valentina
- Peters Annette
- Petersmann Astrid
- Petkeviciene Janina
- Petrauskiene Ausra
- Petrescu Constanta Huidumac
- Pettenuzzo Emanuela
- Peykari Niloofar
- Pichardo Rafael N
- Pierannunzio Daniela
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pistelli Francesco
- Pitakaka Freda
- Piwonska Aleksandra
- Pizarro Andreia N
- Plans-Rubio Pedro
- Poh Bee Koon
- Pohlabeln Hermann
- Pop Raluca M
- Popovic Stevo R
- Popovic Stevo R
- Porta Miquel
- Posch Georg
- Poudyal Anil
- Poulimeneas Dimitrios
- Pouraram Hamed
- Pourfarzi Farhad
- Pourshams Akram
- Poustchi Hossein
- Pradeepa Rajendra
- Price Alison J
- Price Jacqueline F
- Providencia Rui
- Puder Jardena J
- Pudule Iveta
- Puhakka Soile E
- Puiu Maria
- Punab Margus
- Qasrawi Radwan F
- Qorbani Mostafa
- Quang Ngoc La
- Quang Ngoc Nguyen
- Radic Ivana
- Radisauskas Ricardas
- Rahim Hanan F Abdul
- Rahim Norsyamlina Che Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
- Rahman Mahmudur
- Raitakari Olli
- Raj Manu
- Rakhimova Ellina
- Rakhmatulloev Sherali
- Rakovac Ivo
- Ramachandran Ambady
- Ramke Jacqueline
- Ramos Elisabete
- Ramos Rafel
- Rampal Lekhraj
- Rampal Sanjay
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rarra Vayia
- Rascon-Pacheco Ramon A
- Rasmussen Mette
- Rech Cassiano Ricardo
- Redon Josep
- Reganit Paul Ferdinand M
- Regecova Valeria
- Revilla Luis
- Rezaianzadeh Abbas
- Ribas-Barba Lourdes
- Ribeiro Robespierre
- Riboli Elio
- Richter Adrian
- Rigo Fernando
- Riley Leanne M
- Rinaldo Natascia
- Rito Ana
- Ritti-Dias Raphael M
- Rivera Juan A
- Robitaille Cynthia
- Roccaldo Romana
- Rodrigues Daniela
- Rodriguez-Artalejo Fernando
- Rodriguez-Martinez Andrea
- Rodriguez-Perez Maria del Cristo
- Rodriguez-Villamizar Laura A
- Roggenbuck Ulla
- Rojas-Martinez Rosalba
- Rojroongwasinkul Nipa
- Romaguera Dora
- Romeo Elisabetta L
- Rosario Angelika Schaffrath
- Rosario Rafaela V
- Rosengren Annika
- Rouse Ian
- Roy Joel GR
- Rubinstein Adolfo
- Ruhli Frank J
- Ruidavets Jean-Bernard
- Ruiz-Betancourt Blanca Sandra
- Rusakova Iuliia A
- Russo Paola
- Rust Petra
- Rutkowski Marcin
- Saavedra Maria Angeles Dal Re
- Sabanayagam Charumathi
- Sacchini Elena
- Sachdev Harshpal S
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saidi Olfa
- Saki Nader
- Salanave Benoit
- Salmeron Diego
- Salomaa Veikko
- Salonen Jukka T
- Salvetti Massimo
- Samoutian Margarita
- Sanchez-Abanto Jose
- Sandjaja
- Sans Susana
- Sant'Angelo Victoria Farrugia
- Santos Diana A
- Santos Ina S
- Santos Lelita C
- Santos Maria Paula
- Santos Osvaldo
- Santos Rute
- Sanz Sara Santos
- Saramies Jouko L
- Sardinha Luis B
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O
- Schmidt Ida Maria
- Schnohr Peter
- Schottker Ben
- Schramm Sara
- Schramm Stine
- Schroder Helmut
- Schultsz Constance
- Schutte Aletta E
- Sebert Sylvain
- Sein Aye Aye
- Selamat Rusidah
- Sember Vedrana
- Sen Abhijit
- Senbanjo Idowu O
- Sepanlou Sadaf G
- Sequera Victor
- Serra-Majem Luis
- Servais Jennifer
- Sevcikova Ludmila
- Shalnova Svetlana A
- Shamah-Levy Teresa
- Shamshirgaran Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K
- Shaw Jonathan E
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Shengelia Lela
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shin Youchan
- Shirani Majid
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M
- Silva Antonio M
- Silva Diego Augusto Santos
- Simina Iulia Jurca
- Simon Mary
- Simons Judith
- Simons Leon A
- Sjoberg Agneta
- Sjostrom Michael
- Skodje Gry
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobek Grzegorz
- Sobngwi Eugene
- Sodemann Morten
- Soderberg Stefan
- Soekatri Moesijanti YE
- Soemantri Agustinus
- Sofat Reecha
- Solfrizzi Vincenzo
- Somi Mohammad Hossein
- Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K
- Sorensen Thorkild IA
- Sorensen Thorkild IA
- Sorgjerd Elin P
- Soric Maroje
- Soric Maroje
- Soto-Rojas Victoria E
- Soumare Aicha
- Sovic Slavica
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A
- Stamm Hanspeter
- Starc Gregor
- Starc Gregor
- Stathopoulou Maria G
- Staub Kaspar
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D
- Stergiou George S
- Stessman Jochanan
- Stevanovic Ranko
- Stevens Gretchen A
- Stieber Jutta
- Stockl Doris
- Stocks Tanja
- Stokwiszewski Jakub
- Stoyanova Ekaterina
- Stratton Gareth
- Stronks Karien
- Strufaldi Maria Wany
- Sturua Lela
- Suarez-Medina Ramon
- Suka Machi
- Sun Chien-An
- Sundstrom Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Swinburn Boyd A
- Sy Rody G
- Syddall Holly E
- Sylva Rene Charles
- Szklo Moyses
- Szponar Lucjan
- Taddei Cristina
- Tai E Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B
- Taylor Anne
- Taylor Julie
- Tchibindat Felicite
- Tebar William R
- Tell Grethe S
- Tello Tania
- Thankappan KR
- Thein Thein Htay
- Theobald Holger
- Theodoridis Xenophon
- Thet Thet Mu
- Thi Tuyet-Hanh Tran
- Thijs Lutgarde
- Thomas Nihal
- Thuesen Betina H
- Ticha Lubica
- Timmermans Erik J
- Tjonneland Anne
- Tolonen Hanna K
- Tolstrup Janne S
- Topbas Murat
- Topor-Madry Roman
- Torheim Liv Elin
- Tormo Maria Jose
- Tornaritis Michael J
- Torrent Maties
- Torres-Collado Laura
- Toselli Stefania
- Traissac Pierre
- Tran Quoc Bao
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh TH
- Trivedi Atul
- Tshepo Lechaba
- Tsigga Maria
- Tsugane Shoichiro
- Tuliakova Azaliia M
- Tulloch-Reid Marshall K
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L
- Tynelius Per
- Tzotzas Themistoklis
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ukoli Flora AM
- Ulmer Hanno
- Unal Belgin
- Usupova Zhamyila
- Uusitalo Hannu MT
- Uysal Nalan
- Vaitkeviciute Justina
- Valdivia Gonzalo
- Vale Susana
- Valvi Damaskini
- van Dam Rob M
- Van der Heyden Johan
- van der Schouw Yvonne T
- Van Herck Koen
- van Valkengoed Irene GM
- Vanderschueren Dirk
- Vanuzzo Diego
- Varbo Anette
- Varela-Moreiras Gregorio
- Varona-Perez Patricia
- Vasan Senthil K
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Velika Biruta
- Veronesi Giovanni
- Verschuren WM Monique
- Victora Cesar G
- Viegi Giovanni
- Viet Lucie
- Villalpando Salvador
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K
- Visser Marjolein
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vladulescu Mihaela
- Vlasoff Tiina
- Vocanec Dorja
- Volzke Henry
- Voutilainen Ari
- Voutilainen Sari
- Vrijheid Martine
- Vrijkotte Tanja GM
- Vrkic Tajana Zeljkovic
- Wade Alisha N
- Wagner Aline
- Waldhor Thomas
- Walton Janette
- Wambiya Elvis OA
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Weber Adelheid
- Wedderkopp Niels
- Weerasekera Deepa
- Weghuber Daniel
- Wei Wenbin
- Weres Aneta
- Werner Bo
- Whincup Peter H
- Widhalm Kurt
- Widyahening Indah S
- Wiecek Andrzej
- Wilks Rainford J
- Willeit Johann
- Willeit Peter
- Williams Julianne
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Andrew
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A
- Woo Jean
- Woodward Mark
- Wu Frederick C
- Wu Jianfeng
- Wu Li Juan
- Wu Shouling
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A
- Zainuddin Ahmad A
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilova Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zocalo Yanina
- Zuziak Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
- Author
- Abdelrahim Mohamed
- Abo-Leyah Hani
- Abo-Leyah Hani
- Adamson Simon
- Adamson Simon
- Almaden-Boyle Christine
- Anderson Samantha
- Baker-Moffat Michelle
- Balan Andrea
- Bamgboye Adefunke
- Band Margaret
- Band Margaret
- Barker Joann
- Barnes Debi
- Baryschpolec Sonia
- Birchall Katie
- Bird Sarah
- Bourne Michelle
- Bowler Helen
- Brightling Christopher
- Brightling Christopher
- Broad Lauren
- Brogan Fiona
- Brown Tom
- Bungue-Tuble Roneleeh
- Burns Tricia
- Burrows Kate
- Cassidy Diane
- Cawthron Kay
- Chalmers James
- Chalmers James D.
- Collini Paul
- Collins Andrea
- Colton Hayley
- Condliffe Alison
- Condliffe Alison M.
- Connell David
- Connell David
- Cook Chris
- Cook Gemma
- Cooper Jamie
- Cooper Jamie
- Coote Elizabeth
- Couser Mandy
- Cowen Elena
- Darbyshire Alexander
- Davey Fleur
- Davies Rhys
- Delgado Lilia
- Dhasmana Devesh
- Dhasmana Devesh
- Diver Sarah
- Diwakar Lavanya
- Diwakar Lavanya
- Dosanjh Davinder
- Dosanjh Davinder P.S.
- Dowey Rebecca
- Dowey Rebecca
- Ducker Shelley
- Dyer Nichole
- Edmond Ian
- Elneima Omer
- Emery Anna
- Evans Terriann
- Finn Joanne
- Ford Amber
- Forde Donal
- Fox Lauren
- Frayling Sharon
- Gabriel Zoé
- George Jacob
- George Jacob
- Giam Yan Hui
- Giles Benjamin
- Gilmour Amy
- Goodall Vicky
- Haboubi Dr
- Hardman Simon
- Hargadon Beverley
- Harrington Kate
- Harrington-Davies Yasmin
- Harris Sophie
- Hartley Tom
- Hawes Elizabeth
- Haynes Matthew
- Henderson Eilidh
- Hicks Alexander
- Hicks Alexander
- Hilton Zoe
- Hogarth Fiona
- Housley Kay
- Howe Serena
- Howell Alice
- Hughes Chloe
- Hull Rebecca
- Hull Rebecca C.
- Hurditch Elizabeth
- Jackson Tracy
- Jackson Yvonne
- Jaques Carol
- Jones Laura
- Keiller Marney
- Keir Holly R.
- Kibutu Faith
- Kirby Alison
- Lahnsteiner Eva
- Lahnsteiner Eva
- Lenagh Rebecca
- Liu Patrick
- Loftus Heather
- Long Merete B.
- Longhurst Bev
- Macharia Irene
- MacKenzie Rob
- MacLennan Graeme
- Marchand Clare
- Masan Vidan
- Mason Rebecca
- Mbuyisa Angeline
- McAuley Hamish
- McCourt Paula
- McGenily Laura
- McLaren-Neil Fiona
- McLaren-Neil Fiona
- McQueen Alison
- Meda Manjula
- Middle Janet
- Miller David
- Minnis Chrissie
- Moon Maria
- Morrow Ana
- Muir Carol
- Murray Lisa
- New Benjamin J.M.
- New Benjamin J.M.
- Newell Helen
- Nye Clemency
- Oliver Catherine
- Parker Sarah
- Patel Manish
- Patel Manish
- Pembridge Thomas
- Pilvinyte Kristina
- Rahilly Karen
- Rauchhaus Petra
- Richardson Hollian
- Rowley Megan
- Rupani Hitasha
- Russell Peter
- Russell Peter
- Russell Richard
- Sage Beth
- Sage Elizabeth
- Salutous Dario
- Scott Rhona
- Shoemark Amelia
- Simpson Phillip
- Smart Lynne
- Smith Andrew
- Smith Andrew
- Spears Mark
- Spears Mark
- Staines Nikki
- Strachan Angela
- Strachan Jodie
- Sturney Sharon
- Suntharalingam Jay
- Suntharalingam Jay
- Sutton Benjamin
- Taylor Jennifer
- Thompson A.A. Roger
- Thompson A.A. Roger
- Turner Charlotte
- Turner Kim
- Turton Helena
- Turton Helena
- Udale Emily
- Underwood Jonathan
- Underwood Jonathan
- Vadiveloo Thenmalar
- Walker Sara
- Wands Mary
- Watkins Lynn
- Watson Lisa
- Wesonga Joan
- White Katie
- Whitham Rachel
- Wiffen Laura
- Williams Jennie
- Wilson Anna
- Wilson Jayne
- Wong Charlotte
- Yang Yingjia
- Young Lesley
- Yousuf Ahmed
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/09/2022
- Field of study
Background
Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in severe and fatal infection. We investigated whether brensocatib, an inhibitor of dipeptidyl peptidase-1 (DPP-1; an enzyme responsible for the activation of neutrophil serine proteases), would improve outcomes in patients hospitalised with COVID-19.
Methods
In a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial, across 14 hospitals in the UK, patients aged 16 years and older who were hospitalised with COVID-19 and had at least one risk factor for severe disease were randomly assigned 1:1, within 96 h of hospital admission, to once-daily brensocatib 25 mg or placebo orally for 28 days. Patients were randomly assigned via a central web-based randomisation system (TruST). Randomisation was stratified by site and age (65 years or ≥65 years), and within each stratum, blocks were of random sizes of two, four, or six patients. Participants in both groups continued to receive other therapies required to manage their condition. Participants, study staff, and investigators were masked to the study assignment. The primary outcome was the 7-point WHO ordinal scale for clinical status at day 29 after random assignment. The intention-to-treat population included all patients who were randomly assigned and met the enrolment criteria. The safety population included all participants who received at least one dose of study medication. This study was registered with the ISRCTN registry, ISRCTN30564012.
Findings
Between June 5, 2020, and Jan 25, 2021, 406 patients were randomly assigned to brensocatib or placebo; 192 (47·3%) to the brensocatib group and 214 (52·7%) to the placebo group. Two participants were excluded after being randomly assigned in the brensocatib group (214 patients included in the placebo group and 190 included in the brensocatib group in the intention-to-treat population). Primary outcome data was unavailable for six patients (three in the brensocatib group and three in the placebo group). Patients in the brensocatib group had worse clinical status at day 29 after being randomly assigned than those in the placebo group (adjusted odds ratio 0·72 [95% CI 0·57–0·92]). Prespecified subgroup analyses of the primary outcome supported the primary results. 185 participants reported at least one adverse event; 99 (46%) in the placebo group and 86 (45%) in the brensocatib group. The most common adverse events were gastrointestinal disorders and infections. One death in the placebo group was judged as possibly related to study drug.
Interpretation
Brensocatib treatment did not improve clinical status at day 29 in patients hospitalised with COVID-19
Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study
- Author
- Aamir Ayesha
- Abdelbadiee Sherif
- Abdullah Saad
- Abiola Oluwatosin O.
- Abras Ahmed
- Abu Emmy
- Abu-Arafeh Hashem
- Achara Amaka
- Adam Muhammad
- Adams Lawrence A. T.
- Adams Phillipa
- Aggarwal Nisha
- Ahmad Asim
- Ahmad Sarah
- Ahmed Bilquis
- Ahmed Hamza
- Ahmed Jabed
- Ahmed Rohan
- Ain Qurrat Ul
- Akintade Olugbenro
- Alareed Ahmad
- Alhadadi Baraa
- Ali Jawad
- Allain Theresa J.
- Allen James
- Alsahab Mustafa
- Amarnani Raj
- Amin Zarah
- Anderson Clementine
- Andrusca Ana
- Annamalai Arunkumar
- Ansell Matthew
- Appiah-Odame Paapa
- Arkle Thomas
- Ashton Caroline
- Astaire Emma
- Austin Keziah
- Babar Laxmi
- Babb Laura
- Bahsoon Farrah
- Baillie Jonathan
- Baldwin Jack B. G.
- Ball Katie
- Bargaoanu Imola
- Barlow Ciaran
- Baron Alexander
- Basker Karthik
- Batho Rachel
- Bazaraa Amr
- Bedi Simran
- Beeley Laura J.
- Beharry Karen
- Behbahani Abolfazl
- Behbahani Ayoub
- Bei Zhao Xiao
- Bell Charlotte
- Bertagne Marc
- Berwick L.
- Beveridge Louise
- Bhakta Shiv
- Bhat Ganapathy
- Bhattacharya Saurav
- Bhatti Jamal
- Bilton Edward
- Blair Mairi
- Bowden Helen
- Bowen Emily
- Bowman Mark A.
- Box Emma
- Bremakumar Sanojan
- Briggs Laura
- Broadhurst Karen
- Brown Harriet
- Browne Marylin
- Bryant Catherine
- Bullock Stuart
- Bultynck Celine
- Burton Jenni K.
- Bygate Rachael
- Byravan Swetha
- Caines Laurence
- Cairns Christopher
- Cameron Ewen
- Campbell Angela
- Capek Eileen
- Carter Sammy
- Cavaliere Chiara
- Chai Chung Sien
- Chamberlain Helen
- Chamboult Aimee-Louise
- Champion Jennifer
- Chapman George
- Cheah Khai L.
- Cheema Anum
- Chevolleau Jasmine
- Chilton Angharad
- Chourot Christian
- Christie Lorna
- Christodoulides Natasha
- Chuter Charlotte
- Clayton Victoria
- Cleaver Sarah L.
- Clements Hollie A.
- Coffey Farah
- Cohen Samuel
- Connell Laura
- Connor Louise
- Cook Alan
- Cooper Freya
- Cooper Olivia
- Copeland Claire
- Cox Natalie
- Cricklow Tamsin
- Croft Paul
- Crofts Jodie
- Cummings Laura
- Cunningham Emma L.
- Currie Hannah
- Cushen Claire
- Dama Sindhoora
- Darko Sandra
- Davies Rhianna
- Davies-Morris Jayne
- Davis Daniel
- De Mucha Pedro Vila
- Deacon Elizabeth
- Debrah Kwasi
- Deosaran Jordanna
- Dhillon Amber
- Doherty Cal
- Dove James
- Dovey Julie
- Drozdowska Bogna
- Durcan Rory
- Durrant Sabrina K.
- Edwards Sarah
- Einarsson Alice
- Elliott Emma
- Elliott Marianne
- Ellis Elizabeth J.
- Enfield-Bance Amy
- Evans Elizabeth
- Evans Jenny
- Evans Olivia
- Evans Sarah
- Faheem Waleed
- Fancourt Sarah
- Farah Rinata
- Faruq Sana
- Fenneley Grace
- Ferguson Eilidh E. C.
- Fergusson Niall
- Ferreira Ana Silva
- Fisken Emma
- Foster Kate
- Fraser Debbie
- Frewen John
- Furmedge Daniel
- Gallagher Michael
- Gaskell Natalie
- Gaunt Victoria
- Gaywood James
- Giblin Eleanor
- Giddings Jane
- Giet Leeying
- Giles Alexis
- Giridharan Kumudhini
- Glasser Martin
- Glasser Martin
- Gluck Ilan
- Goujon Marie
- Govindji Suriti
- Grange Robert
- Greaves Isabel
- Green Jessica
- Gregory Jemma
- Griffiths Eliza
- Grundmann Natalie
- Gui Jonathan
- Gupta Abhishek
- Gurung Sneha
- Hackett Beth
- Haddad Nedaa
- Haley Michael
- Hall Giles
- Hall Susan A.
- Handley Olivia
- Harbinson Alexander
- Harkin Teresa
- Hart Jasmine
- Hayat Yasmeen
- Headlam John
- Healy Roisin
- Henderson Neil
- Henderson Sarah
- Herbert Fiona
- Hindley Esther
- Hodhody Ghazal
- Hoffman Katrin
- Holmes Elizabeth A. M.
- Horner Sarah
- Hornsby Alex
- Horton Robbie
- Houldershaw Katie
- House Shannelle
- Hughes Clare
- Hunt Clare
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- Hussain Ambreen
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- Ibanichuka Jacqueline
- Ikhwan Wan Idoracaera C.
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- Kalyaani Vickneswaran
- Kantczak Ada
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- Kelly Dominic
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- Khambay Ethan
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- Khan Asma
- Khizar Bushra
- Khor Ming
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- King Rachel
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- Konda Nagarjun
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- Lee Tammy
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- Lim Vee Han
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- Mackenzie Eilidh R.
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- Mahmood Al Wakkass
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- Matheswaran Yathu
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- Mithrakumar Pryankaran
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- Mohammedseid-Nurhussien Awolkhier
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- Moore Kirsty
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- Ng Liji
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- Nightingale Peter
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- Ostrowski Caroline
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- Page Valerie
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- Pang Norman
- Parkinson Megan
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- Parry Sarah
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- Patel Riana
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- Peck George
- Pendleton Hannah
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- Pinkney Thomas
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- Shah Hussun-Ara
- Shahid Muhammad
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- Sloan Gerrard W.
- Smith Abigail
- Smith Gemma M.
- Smith Nina
- Speed James
- Sprosen Charles
- Stambollouian Katharine
- Stapley Simon M.
- Stirling Adam
- Stratton Emma
- Straughan Jacqui
- Studley Mark
- Subhan Zahid
- Sundara Srividya
- Swietoslawski Adam
- Syed Nihaad
- Tan Felicia
- Tantam Kate
- Taranu Roxana
- Taylor Abigail
- Taylor Emily
- Taylor Jemima
- Taylor Joanne
- Taylor-Rowan Martin
- Tencheva Ani
- Tetlow Simon
- Thake Miriam
- Thayabaran Darmiga
- Thomas Philip
- Thyn Thyn
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- Tinson Guy
- Todd Oliver
- Torsney Kelli
- Traill Philippa K.
- Treml Jonathan
- Tse Connie
- Tumi Ebrahiem
- Turton Sophie
- Tyagi Bhavyas
- Usmani Kasim
- Valentine Janine
- Vardon Henry
- Varghese Jessel
- Vasudev Ashish
- Vedutla Tarunya
- Velusamy Karthika
- Venkat Shabnam
- Virk Jasmine
- Visvaratnam Parrthiepan
- Wahballa Afnan
- Walker Amy
- Walter Amy
- Waraich Hana
- Warwicker Sarah
- Watson Hannah
- Watt Nicola
- Webb Hannah
- Welch Carly
- Wheeler Alice
- Whyte Lindsay
- Wilcockson James
- Wilkes Claire
- Williamson Emily
- Williamson Katherine
- Willott Ruth
- Wilson Daisy
- Wilson Daisy
- Wilson Darcy S.
- Wilson Faye
- Wilson Joseph B.
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- Winearls Stuart
- Wong Li
- Wong Ting W.
- Woodman Hannah
- Woodward Beth L.
- Wrathall Abigail
- Wright Emily
- Wright Sophie
- Wu Chenxian
- Wu Edward
- Wynne Luke
- Yap Zhi Jiun
- Young Lesley J.
- Yule Ollie
- Yunus Aayenah
- Publication venue
- Springer
- Publication date
- 01/04/2023
- Field of study
Purpose:
Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom.
Methods:
Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded.
Results:
The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia.
Conclusion:
We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
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- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
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- Bucca Giselda
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- Buddenborg Sarah K.
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- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
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- Carlile Matthew
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- Coombes Jason
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- Cox Alison
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- Nebbia Gaia
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- Southgate Joel
- Southgate Joel
- Spellman Karla
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- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
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- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
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- Temperton Ben
- Templeton Kate E.
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- Tsoleridis Theocharis
- Tucker Rachel M.
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- Webber Mark A.
- Weeks Sam
- Weldon Danni
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- Williams Charlotte A.
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- Willingham Iona
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- Yew Wen C.
- Young Gregory R.
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- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant