Examination of Nursing Staffs’ Perceptions of the COVID-19 Vaccine Using the Health Belief Model

Background: The coronavirus (COVID-19) pandemic profoundly impacted patient care across the United States. Objective: To examine nursing staffs’ perceptions of the COVID-19 vaccine using the Health Belief Model (HBM) as a theoretical framework. Methods: A cross-sectional, anonymous, web-based survey was completed by practicing nursing staffs throughout the United States. Analyses involved descriptive and comparative statistics. Results: Of the 294 nursing staff who completed surveys, 50% were between 18 and 37 years of age, and 73.1% were registered nurses, with 49.3% employed in a hospital setting. Nursing staff reported their primary reason for vaccination was concern for others (mean: 84.44; SD: 28.26), vaccine prevents spread (mean: 81.85; SD: 28.94), and own health (mean: 79.63; SD: 30.0). Influencing factors that predicted vaccination included age, Wilks’ Λ = 0.76, F(32, 919.86) = 2.20, p \u3c .001, η2partial = 0.066, and the vaccine mandate, Wilks’ Λ = 0.63, F(8, 249) = 18.61, p \u3c .001, η2partial = 0.374. Conclusion: Nursing staffs’ perceptions using the HBM as a theoretical framework provided insight into their decisions to receive the COVID-19 vaccine. Further research is warranted to examine nurses’ attitudes and factors that influence their decision-making regarding vaccination

High-yield atmospheric water capture via bioinspired material segregation

Atmospheric water harvesting is urgently needed given increasing global water scarcity. Current sorbent-based devices that cycle between water capture and release have low harvesting rates. We envision a radically different multi-material architecture with segregated and simultaneous capture and release. This way, proven fast-release mechanisms that approach theoretical limits can be incorporated; however, no capture mechanism exists to supply liquid adequately for release. Inspired by tree frogs and airplants, our capture approach transports water through a hydrogel membrane ``skin'' into a liquid desiccant. We report an extraordinarily high capture rate of 5.50 $\text{kg}\,\text{m}^{-2}\,\text{d}^{-1}$ at a low humidity of 35%, limited by the convection of air to the device. At higher humidities, we demonstrate up to 16.9 $\text{kg}\,\text{m}^{-2}\,\text{d}^{-1}$, exceeding theoretical limits for release. Simulated performance of a hypothetical one-square-meter device shows that water could be supplied to two to three people in dry environments. This work is a significant step toward providing new resources to water-scarce regions.Comment: 22 pages, 23 figure

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Gothic Revival Architecture Before Horace Walpole's Strawberry Hill

The Gothic Revival is generally considered to have begun in eighteenth-century Britain with the construction of Horace Walpole’s villa, Strawberry Hill, Twickenham, in the late 1740s. As this chapter demonstrates, however, Strawberry Hill is in no way the first building, domestic or otherwise, to have recreated, even superficially, some aspect of the form and ornamental style of medieval architecture. Earlier architects who, albeit often combining it with Classicism, worked in the Gothic style include Sir Christopher Wren, Nicholas Hawksmoor, William Kent and Batty Langley, aspects of whose works are explored here. While not an exhaustive survey of pre-1750 Gothic Revival design, the examples considered in this chapter reveal how seventeenth- and eighteenth-century Gothic emerged and evolved over the course of different architects’ careers, and how, by the time that Walpole came to create his own Gothic ‘castle’, there was already in existence in Britain a sustained Gothic Revivalist tradition