EL RETABLO GADITANO DEL NEOCLASICISMO

In Cádiz, the neoclassic retable is one of the elements defining better the present city in its nineteenth-century features. Though after the evil year of 1596 Cádiz arises as a baroque city artistically depending both on Sevilla and on the traditional import of Genoese marbles, the last decades of the XVIIIth century bring in the adoption of new classicistic conceptions which are going to steady themselves down into the city life because of various reasons: the foundation of the Academy of Fine Arts in 1789, with a double action of training and control, the new City Regulations of 1792, or the characteristics of the early illustrated Gaditan society, both bourgeoisie and noblesse, from which very important patrons did arise. The typology of the retables is inspired upon the works,of the italian manierist preceptors; among the main reredos we muy differenciate two types: the parietal one, with a monumental character, and the tabernable, influenced by Herrera and Bernini. These works were made in marble and, when it was not possible to use it, in wood and stucco imitating marble. So solemn and classicistic architectures build the frame for the iconography, comparativel y reduced in relation to the baroque period: the former repertoires are simplified, but it remains the same subjects. The titular image, usually a carving, is generally placed in the niche of the body, the attic being usually reserved for a painting, the subject of which related to the tutelar Saint.In Cádiz, the neoclassic retable is one of the elements defining better the present city in its nineteenth-century features. Though after the evil year of 1596 Cádiz arises as a baroque city artistically depending both on Sevilla and on the traditional import of Genoese marbles, the last decades of the XVIIIth century bring in the adoption of new classicistic conceptions which are going to steady themselves down into the city life because of various reasons: the foundation of the Academy of Fine Arts in 1789, with a double action of training and control, the new City Regulations of 1792, or the characteristics of the early illustrated Gaditan society, both bourgeoisie and noblesse, from which very important patrons did arise. The typology of the retables is inspired upon the works,of the italian manierist preceptors; among the main reredos we muy differenciate two types: the parietal one, with a monumental character, and the tabernable, influenced by Herrera and Bernini. These works were made in marble and, when it was not possible to use it, in wood and stucco imitating marble. So solemn and classicistic architectures build the frame for the iconography, comparativel y reduced in relation to the baroque period: the former repertoires are simplified, but it remains the same subjects. The titular image, usually a carving, is generally placed in the niche of the body, the attic being usually reserved for a painting, the subject of which related to the tutelar Saint

Aportaciones de Alonso de Vandelvira a la configuración de Cádiz tras el asalto anglo-holandés de 1596

El Renacimiento en Jaén tuvo una especial resonancia, sin lugar a dudas en ello ocupó un papel clave la figura del genial Andrés de Yandelvira. A su muerte y con la acentuación en el Alto Guadalquivir de la crisis de finales del quinientos, se frustró la posibilidad de que hubiera surgido aquí una amplia y fecunda escuela, pues muchos de sus colaboradores y discípulos tuvieron que emigrar. Algunos lo hicieron al Bajo Guadalquivir, destacando entre ellos su hijo Alonso de Vandelvira, quien desarrolló una amplia actividad en Sevilla y sobre todo en Cádiz. Así pues, a poner de manifiesto su amplia y variada labor en esta última ciudad va dirigido el presente trabajo, si bien nos centraremos en su intervención en la ciudad tras el asalto anglo-holandés de 1596.In Jaén the Renaissance was especially significan!, and among the most important figures was that of Andrés de Vandelvira. His death coincided with the economic crisis in the Upper Guadalquivir at the end of the 1 6thcentury, and these two factors prevented the establishing of a rich school of art: many young members of this school were forced to emigrate. Sorne -among them his son Alonso de Yandelvira- did so to the LowerGuadalquivir: Alonso was very active in Seville and above ali in Cadiz. The objective of the present paper is to emphasize this wide-ranging work, although we will concentrate specially on his activity in the town after the Anglo-Dutch attack of 1596

"Del estudio en la theórica y del trabajo en la práctica" observaciones sobre la formación, ideas y obra del arquitecto Vicente Acero

Vicente Acero continúa siendo un arquitecto infravalorado, a pesar de que intervino en la construcción de algunas de las más representativas creaciones del Barroco español, como pueden ser los sagrarios de las cartujas de Granada y El Paular, la Catedral de Cádiz, la fachada de la Catedral de Guadix, etc. En estas líneas analizamos las circunstancias y motivaciones que orientan su siempre difícil labor; atendiendo a su formación como cantero, la influencia y participación en las obras de su maestro Francisco Hurtado, los contactos con los ingenieros militares, los préstamos visibles de la arquitectura barroco italiana al igual que, a la luz de nuevos datos, profundizamos en sus conocimientos teóricos

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Post-Franco Theatre

In the multiple realms and layers that comprise the contemporary Spanish theatrical landscape, “crisis” would seem to be the word that most often lingers in the air, as though it were a common mantra, ready to roll off the tongue of so many theatre professionals with such enormous ease, and even enthusiasm, that one is prompted to wonder whether it might indeed be a miracle that the contemporary technological revolution – coupled with perpetual quandaries concerning public and private funding for the arts – had not by now brought an end to the evolution of the oldest of live arts, or, at the very least, an end to drama as we know it

Electroweak production of two jets in association with a Z boson in proton-proton collisions root s =13 TeV

A measurement of the electroweak (EW) production of two jets in association with a Z boson in proton-proton collisions at root s = 13 TeV is presented, based on data recorded in 2016 by the CMS experiment at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lljj final state with l including electrons and muons, and the jets j corresponding to the quarks produced in the hard interaction. The measured cross section in a kinematic region defined by invariant masses m(ll) > 50 GeV, m(jj) > 120 GeV, and transverse momenta P-Tj > 25 GeV is sigma(EW) (lljj) = 534 +/- 20 (stat) fb (syst) fb, in agreement with leading-order standard model predictions. The final state is also used to perform a search for anomalous trilinear gauge couplings. No evidence is found and limits on anomalous trilinear gauge couplings associated with dimension-six operators are given in the framework of an effective field theory. The corresponding 95% confidence level intervals are -2.6 <cwww/Lambda(2) <2.6 TeV-2 and -8.4 <cw/Lambda(2) <10.1 TeV-2. The additional jet activity of events in a signal-enriched region is also studied, and the measurements are in agreement with predictions.Peer reviewe

Measurement of nuclear modification factors of gamma(1S)), gamma(2S), and gamma(3S) mesons in PbPb collisions at root s(NN)=5.02 TeV

The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead-lead (PbPb) and proton-proton (pp) collisions at √sNN = 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied as functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of all three states are found to be significantly suppressed, and compatible with a sequential ordering of the suppression, RAA(ϒ(1S)) > RAA(ϒ(2S)) > RAA(ϒ(3S)). The suppression of ϒ(1S) is larger than that seen at √sNN = 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the RAA of ϒ(3S) integrated over pT, rapidity and centrality is 0.096 at 95% confidence level, which is the strongest suppression observed for a quarkonium state in heavy ion collisions to date. © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP3.Peer reviewe