Domain independent goal recognition

Goal recognition is generally considered to follow plan recognition. The plan recognition problem is typically defined to be that of identifying which plan in a given library of plans is being executed, given a sequence of observed actions. Once a plan has been identified, the goal of the plan can be assumed to follow. In this work, we address the problem of goal recognition directly, without assuming a plan library. Instead, we start with a domain description, just as is used for plan construction, and a sequence of action observations. The task, then, is to identify which possible goal state is the ultimate destination of the trajectory being observed. We present a formalisation of the problem and motivate its interest, before describing some simplifying assumptions we have made to arrive at a first implementation of a goal recognition system, AUTOGRAPH. We discuss the techniques employed in AUTOGRAPH to arrive at a tractable approximation of the goal recognition problem and show results for the system we have implemented

Who is Running the IMF: Critical Shareholders or the Staff?

The paper deals with the principal-agent relationship at the International Monetary Fund (IMF). We argue that residual control rights at the IMF are vested with the critical shareholders, the countries included in the G-7. This group controls vast financial resources and enjoys the highest regulatory and governance standards among IMF members. Imperfect incentives for monitoring and the complexity of the issues give staff and management a degree of autonomy. The evidence marshalled in the paper suggests that critical shareholders are in charge on those issues they care most about, leaving discretion to staff and management on peripheral issues.IMF, G-7, principal-agent relationship, critical shareholder, staff autonomy

Sea otter, Enhydra lutris, containment management: field studies and feasibility assessment

Limiting sea otter geographic distribution in California (containment management) has long been recognized as being necessary to preserve human recreational and commercial uses of shellfish resources. However, passage of federal legislation that focused preferentially on marine mammal protection and the 1977 listing of the California sea otter population as "threatened" effectively precluded any range-limiting management program. Research, however, that evaluated various non-lethal means of influencing sea otter movements and distribution was encouraged. Our research suggests that herding and acoustical devices may not have any real potential use in this context. Based on research-related capture success rates, capture and relocation techniques may be useful in influencing sea otter geographical distribution. The translocation of sea otters to San Nicolas Island provided the first opportunity to test the technical feasibility of maintaining a large area free of sea otters. Capture success rates were appreciably poorer than those achieved during research-related efforts. We identify several logistical and behavioral influences that contributed to the relatively poor success rate. Based on this evaluation, we discuss the factors likely to limit application of these techniques in the future. We feel that capture techniques can be useful in a long-term management program, if used in conjunction with efforts to limit the sea otter population growth rate. Consequently, we feel future research should focus on assessing individual health effects from using chemical contraceptives and assessing the feasibility of their use to safely control population growth. (12pp.

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies. Active regulator of SIRT1 (AROS) was the first reported post-transcriptional regulator of SIRT1 activity, enhancing SIRT1-mediated deacetylation and downregulation of the SIRT1 target p53. However, little is known regarding the role of AROS in regulation of SIRT1 during disease. Here, we report the cellular and molecular effects of RNAi-mediated AROS suppression, comparing this with the role of SIRT1 in a panel of human cell lines of both cancerous and non-cancerous origins. Unexpectedly, AROS is found to vary in its modulation of p53 acetylation according to cell context. AROS suppresses p53 acetylation only following the application of cell damaging stress, whereas SIRT1 suppresses p53 under all conditions analysed. This supplements the original characterization of AROS but indicates that SIRT1 activity can persist following suppression of AROS. We also demonstrate that knockdown of AROS induces apoptosis in three cancer cell lines, independent of p53 activation. Importantly, AROS is not required for the viability of three non-cancer cell lines indicating a putative role for AROS in specifically promoting cancer cell survival

Sea Otter, Enhydra lutris, mortalities in California, 1968 through 1993

Sea otter, Enhydra lutris, mortality in California and the relative contribution from specific causes was assessed for the 26 years from 1968 through 1993. There were 2,082 dead sea otters recorded from Tomales Bay (Marin County) south to Bluff Cove (Los Angeles County) during that period. The average number of carcasses recorded was 80 per year and seven per month. Sex was identified in 87% (n=1,819) of the cases and was composed of 47% female and 53% male. A relative age was assigned to 97% (n=2,017) of the cases and was composed of 28% pup, 18% subadult and 54% adult. Specific causes of death were determined for 26% (n=55 1) of the cases. The majority of these (n=381) were considered to be due to natural causes and included the following specific causes: shark bitten (n=78), probably shark bitten (n=106), other natural causes (n=140), and mating wounds (n=57). The remaining (n=170) were considered to be due to human-related causes and included the following specific causes: shot (n=72), probably shot (n=8), net drowned (n=76), and other human causes (n=14). The large proportion of carcasses without an identified specific cause of death prompted a more detailed necropsy effort in 1992 and 1993. During that period, 78 of the 232 recovered carcasses were examined by veterinary pathologists and a specific cause of death was determined in 76% (n=59) of the cases. This effort identified a wide range of specific causes of death that otherwise may have been categorized as "unknown without trauma". Considering the variety of diseases diagnosed in this expanded necropsy program, it would be prudent to continue this level of examination to refine our knowledge of sea otter pathology. (48pp.