Structural features of the Sierra Pampeana de Velasco and surrounding areas from gravimetric and magnetometric fields

La región que comprende la sierra de Velasco y el Sistema de Famatina, en el centro-oeste de la Provincia de La Rioja - Argentina, es un área clave para el estudio de la amalgamación de terrenos y tectónica vinculada con el levantamiento andino. En éste trabajo, se definen algunos rasgos de la estructura cortical de ésta región. Para ello, mediante la aplicación de métodos potenciales(gravedad y magnetismo), adecuadamente procesados e interpretados a través de técnicas semiautomáticas y de resalto de anomalías, se logró determinar: a) una región que respondería a la zona de sutura entre los terrenos Famatina y Pampia y b) fallas relacionadas al levantamiento de las sierras de Famatina y de Velasco. Los resultados anteriores se representan en una sección este - oeste en un modelo estructural de bloques de basamento entre Famatina y Velasco, hasta 12 km de profundidad. En él señalamos además la distribución de las fallas y sus buzamientos.The region comprising the Sierra de Velasco and Famatina System, in the center-west of the province of La Rioja in Argentina, is a key area for the study of the tectonic amalgamation of land and linked to the Andean uplift. In this paper, we define some features of the crustal structure of this region. To do this, by applying potential methods (gravity and magnetics), properly processed and interpreted through semiautomatic techniques and rib anomalies, it was determined: a) a region that respond to the suture zone between Famatina and Pampia Terrain b) faults related to the uplift of the Sierras de Famatina and Velasco. The above results are represented in a section east - west in a structural model of basement blocks between Famatina and Velasco, up to 12 km deep. It also noted the distribution of faults and dips.Fil: Sanchez, Marcos Ariel. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Spagnotto, Silvana Liz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; ArgentinaFil: Martinez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Processing and qualitative data analysis with views aeromagnetic exploration type hydrothermal deposits lode gold - La Rioja province, Argentina

La interpretación de los datos aeromagnéticos regionales de las Sierras de Chepes y Ulapes- Las Minas requirió el uso de técnicas relevantes de realce para definir con precisión rasgos geológicos que se relacionan con la presencia de yacimientos auríferos en la región. Los nuevos mapas magnéticos: del campo anómalo reducido al polo, filtro pasa alto, derivadas verticales, derivadas fraccionales, amplitud de señal analítica y fase de la señal analítica fueron usados para delinear zonas de cizalla, que en esta región representan el principal control metalogenético.Fil: Gimenez, Mario Ernesto. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; ArgentinaFil: Fanton, Gerardo Oscar. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico San Juan; ArgentinaFil: Martinez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentin

Geophysical model with gravimetric and aeromagnetometric data in northeast patagonian massif, Río Negro, Argentina

Se presenta un estudio gravi-magnetométrico en el borde noreste del macizo Norpatagónico provincia de Río Negro, con el objeto de conocer la distribución en profundidad de las distintas unidades aflorantes en el área de estudio, como así también, la geometría del Complejo Plutónico Navarrete. Se obtuvieron mapas de reducción al Polo y señal analítica a partir de una grilla de anomalías aeromagnetométricas. Los mismos permitieron delimitar distintos dominios magnéticos vinculados al basamento de edad proterozoica tardía a cámbrica y a cuerpos intrusivos de edad mesozoica. Datos magnetometricos aéreos y gravimétricos terrestres se utilizaron para realizar un modelo de doble inversión a lo largo de una sección transversal a los afloramientos del Complejo Plutónico Navarrete. Dicho modelo evidencia la geometría de los plutones intruídos en corteza superior y un escaso desarrollo en profundidad del complejo Yaminué de edad cámbrica. Esto es una nueva evidencia de que éste último es una serie de intrusiones y escamas tectónicas delgadas sub-horizontales y que su espesor es probablemente de poca magnitud.To infer crustal distribution for different outcrop lithological units in the northeastern North Patagonian Massif border, Rio Negro province, Argentine, a double inversion model was built using terrestrial gravimetric and aeromagnetometric data. This model, supported by pole reduction and analytic signal maps obtained from aeromagnetic anomaly grids, allows us divide the upper crust in three magnetic domains. The density and magnetic susceptibility lateral variations could be linked to crustal blocks which differ in their genetic origin. These interpretations are in agreement with hypothesis in the North of Patagonia presented by other authors. As a result from the obtained model, we propose a thicker layer related to Yaminué Complex and, probably, its lithological contact with the Nahuel Niyeu formation.Fil: Lince Klinger, Federico Gustavo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: León, Martin. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Fisicas y Naturales; ArgentinaFil: Martinez, Myriam Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; ArgentinaFil: Weidmann, María Cecilia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anci Araniti, Sheila Anabel. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez Pontoriero, Orlando. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofi­sico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Crustal structure and tectonic setting of the south central Andes from gravimetric analysis

En el presente trabajo, a partir de datos gravimétricos terrestres, se preparó una carta de anomalías de Bouguer, la cual fue adecuadamente filtrada a fin de separar efectos gravimétricos someros y profundos. Con base en un modelo de densidad, mediante de técnicas de inversión gravimétrica, se modeló la discontinuidad corteza-manto y el basamento cristalino, respectivamente. De forma posterior, se evaluó el espesor elástico equivalente considerando la información de la discontinuidad de la corteza-manto y la carga topográfica. Se encontraron valores altos de espesor elástico Te, al este de la precordillera Andina y al oeste de la sierra Pampeana de Velasco. Estos resultados son consistentes con los valores positivos de anomalía residual de Bouguer e isotáticos, lo que estaría indicando la presencia de rocas de alta densidad en corteza media a superior. Además, los análisis petrográficos y geoquímicos realizados en afloramientos en superficie indican un origen mantélico.Fil: Weidmann, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Spagnotto, Silvana Liz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Geología; ArgentinaFil: Gimenez, Mario Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; ArgentinaFil: Martinez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Fisicas y Naturales. Instituto Geofisico Sismologico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez Pontoriero, Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Sanchez, Marcos Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Lince Klinger, Federico Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentin

Type 2 Diabetes Modifies the association of Cad Genomic Risk Variants With Subclinical atherosclerosis

BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima-media thickness, or carotid plaque) may improve our understanding of the mechanisms leading to the increased CAD in T2D. METHODS: We compared the common and rare variant associations of known CAD loci from the literature on CAC, carotid intima-media thickness, and carotid plaque in up to 29 670 participants, including up to 24 157 normoglycemic controls and 5513 T2D cases leveraging whole-genome sequencing data from the Trans-Omics for Precision Medicine program. We included first-order T2D interaction terms in each model to determine whether CAD loci were modified by T2D. The genetic main and interaction effects were assessed using a joint test to determine whether a CAD variant, or gene-based rare variant set, was associated with the respective subclinical atherosclerosis measures and then further determined whether these loci had a significant interaction test. RESULTS: Using a Bonferroni-corrected significance threshold of CONCLUSIONS: These results highlight T2D as an important modifier of rare variant associations in CAD loci with CAC

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019 : a systematic analysis from the Global Burden of Disease Study 2019

Background Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings Globally in 2019, 1.14 billion (95% uncertainty interval 1.13-1.16) individuals were current smokers, who consumed 7.41 trillion (7.11-7.74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27.5% [26. 5-28.5] reduction) and females (37.7% [35.4-39.9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0.99 billion (0.98-1.00) in 1990. Globally in 2019, smoking tobacco use accounted for 7.69 million (7.16-8.20) deaths and 200 million (185-214) disability-adjusted life-years, and was the leading risk factor for death among males (20.2% [19.3-21.1] of male deaths). 6.68 million [86.9%] of 7.69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a dear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Predicting haplogroups using a versatile machine learning program (PredYMaLe) on a new mutationally balanced 32 Y-STR multiplex (CombYplex): Unlocking the full potential of the human STR mutation rate spectrum to estimate forensic parameters

We developed a new mutationally well-balanced 32 Y-STR multiplex (CombYplex) together with a machine learning (ML) program PredYMaLe to assess the impact of STR mutability on haplogourp prediction, while respecting forensic community criteria (high DC/HD). We designed CombYplex around two sub-panels M1 and M2 characterized by average and high-mutation STR panels. Using these two sub-panels, we tested how our program PredYmale reacts to mutability when considering basal branches and, moving down, terminal branches. We tested first the discrimination capacity of CombYplex on 996 human samples using various forensic and statistical parameters and showed that its resolution is sufficient to separate haplogroup classes. In parallel, PredYMaLe was designed and used to test whether a ML approach can predict haplogroup classes from Y-STR profiles. Applied to our kit, SVM and Random Forest classifiers perform very well (average 97 %), better than Neural Network (average 91 %) and Bayesian methods (< 90 %)

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks