37 research outputs found
Experiments Meet Hydrophobic Mismatch: A Re-evaluation Of The Orientation Of Model Transmembrane Peptides From Solid-State NMR
- Publication venue
- Biophysical Society. Published by Elsevier Inc.
- Publication date
- 28/02/2009
- Field of study
Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles
- Author
- A Aleksandrov
- A Allerhand
- A Mittermaier
- A Perez
- A Perez
- A Simone De
- AA Deniz
- AA Deniz
- AC Stelzer
- AC Stelzer
- AE Torda
- AG Palmer
- AK Jha
- AL Hodgkin
- AM Bonvin
- AM Bonvin
- AN Lane
- AT Frank
- AY Istomin
- B Hess
- B Ma
- B Ma
- B Richter
- B Vogeli
- BG Vertessy
- BL Groot de
- BP Hudson
- CD Schwieters
- CJ Tsai
- CJ Tsai
- CJ Tsai
- CJ Tsai
- D Long
- DD Boehr
- DE Koshland
- DE Shaw
- DEJ Koshland
- DL Theobald
- DM Korzhnev
- DW Li
- DW Li
- DW Li
- E Fischer
- EA Dethoff
- EF Pai
- F Qin
- FB Straub
- G Bouvignies
- G Nodet
- GB Fields
- GG Hammes
- GM Clore
- GM Clore
- GM Clore
- GR Kneller
- H Frauenfelder
- H Frauenfelder
- H Muirhead
- HX Zhou
- I Bahar
- I Faustino
- J Gsponer
- J Monod
- JA McCammon
- JC Kendrew
- JD Watson
- JE Fitzgerald
- JH Missimer
- JP Loria
- JR Allison
- JR Huang
- JR Williamson
- JS Hub
- JW Chu
- K Arora
- K Gunasekaran
- K Henzler-Wildman
- K Lindorff-Larsen
- K Lindorff-Larsen
- K Okazaki
- KA Henzler-Wildman
- KB Blagoev
- KL Mayer
- L Salmon
- L Salmon
- LE Kay
- M Eigen
- M Karplus
- M Tonelli
- M Viswanathan
- MA Durney
- MD Daily
- MD Daily
- MJ Whitley
- MO Jensen
- MS Searle
- NA Lakomek
- NK Goto
- O Beckstein
- OF Lange
- OF Lange
- OF Lange
- OF Lange
- P Bernado
- P Bernado
- P Bernado
- P Faure
- P Schuetz
- PK Agarwal
- PR Markwick
- PT Rajagopalan
- Q Zhang
- Q Zhang
- R Grunberg
- R Nechushtai
- R Salsas-Escat
- R. Bryn Fenwick
- RB Best
- RB Fenwick
- S Chaudhury
- S Esteban-Martin
- S Kumar
- SA Harris
- SA Showalter
- SA Showalter
- Santi Esteban-MartĂn
- SC Kamerlin
- T Ju
- T Liu
- T Meyer
- T Wlodarski
- TH Rod
- TJ Kamerzell
- U Olsson
- UD Ramirez
- VA Jarymowycz
- W Zheng
- WF Gunsteren van
- WR Scott
- Xavier Salvatella
- Y Chen
- Y Pan
- Y Pan
- Y Ryabov
- YE Shapiro
- Z Gaspari
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
We review the role conformational ensembles can play in the analysis of biomolecular dynamics, molecular recognition, and allostery. We introduce currently available methods for generating ensembles of biomolecules and illustrate their application with relevant examples from the literature. We show how, for binding, conformational ensembles provide a way of distinguishing the competing models of induced fit and conformational selection. For allostery we review the classic models and show how conformational ensembles can play a role in unravelling the intricate pathways of communication that enable allostery to occur. Finally, we discuss the limitations of conformational ensembles and highlight some potential applications for the future
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes GarcĂa F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (HellĂn Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
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- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
- Al- Najjar H.
- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
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- Alemanno G.
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- Alghamdi M.
- Alhamed A.
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- Ali M.
- Ali S.
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- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
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- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
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- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
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- Argentina: Alurralde C.
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- Ayyaz M. (Services Hospital Lahore)
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- Bergeat D. Merdrignac A. (CHU Rennes â General Surgery)
- Bernante P.
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- Bhalla A.
- Bhangu A.
- Bhangu Aneel
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- Bhatti M. I.
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- Bianco F.
- Bianco F. (ASST Papa Giovanni XXIII â Bergamo)
- Bigelow B. (Johns Hopkins Hospital)
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- Bisset C. Moug S. J. (Royal Alexandra Hospital)
- Blackwell L.
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- Bouche P. A. Tzedakis S. (HĂŽpital Cochin â APHP)
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- Campus Benjamin Franklin)
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- Capolupo G. T. Mazzotta E. (Policlinico Universitario Campus Bio Medico of Rome)
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- Cassinotti E. (Fondazione IRCCS Caâ Granda â Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
- Castro Ruiz C.
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- Cayetano Paniagua L. GĂłmez FernĂĄndez L. (Consorci Sanitari de Terrassa)
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- Cicerchia P. M.
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- Ciofic E.
- Cirillo B.
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- Claro M.
- Clifford R.
- Clinical Centre of Serbia)
- Coccolini F.
- Cocozza E.
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- Coughlin P.
- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
- Cozza V.
- Creavin B.
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- Dainius E.
- Daliya P.
- Daly A.
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- Day A. (East Surrey Hospital)
- De Andres Olabarria U.
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- De Manzoni Garberini A. (Ospedale Civile Spirito Santo)
- De Miguel Ardevines M. D. C.
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- De Sousa X. (Centro Hospitalar de SetĂșbal)
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- Dellaportas D.
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- Demir H.
- Demirli Atıcı S.
- Demyttenaere S.
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- Depalma N.
- Department of Biomedical Sciences
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- Dincer H. A. Erol T. (Hacettepe University Hospital)
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- Duchalais E. (Nantes University Hospital). Germany: Bork U.
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- EPE)
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- Health Affairs
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- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
- Tasis N. (Athens Naval and Veterans Hospital)
- Tatar O. C.
- Tavares F.
- Tayeh S. (Homerton University Hospital)
- Tebala G. D.
- Teixeira J. (Centro Hospitalar UniversitĂĄrio do Algarve â Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
- Tejero- Pintor F. J. (Hospital Universitario RĂo Hortega)
- Testa V. (Santa Croce E. Carle Hospital
- Tewari N. (University Hospitals Coventry and Warwickshire NHS Trusts)
- Tezas S. (Furness General Hospital)
- Thaha M.
- Thanapal M. R. (Hospital Kuala Lumpur)
- Theodosopoulos T.
- Theophilidou E. (Royal Derby Hospital)
- Thian A.
- Thomas A. (Royal Liverpool University Hospital)
- Thompson D. (Morriston Hospital Swansea)
- Thornhill M. (Dell Seton Medical Center at the University of Texas)
- Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
- Thulasiraman S. V.
- Timbrell S.
- Tirloni L.
- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
- Tonini V. (S. Orsola-Malpighi Hospital)
- Torres A. (Hospital ClĂnico de Madrid)
- Torres Arcos C.
- Townson A.
- Trabulsi N. (King Abdulaziz University Hospital)
- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
- Troncoso Pereira P. (Hospital Mateu Orfila)
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- Trujillo DĂaz J.
- Tsai L.
- Tsarkov P.
- Tsiamalou I.
- Tsiaoussis I.
- TU Dresden)
- Tucci R. (Azienda Ospedaliera Universitaria Careggi)
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- Tweedle E. (Addenbrookeâs Hospital)
- Ugarte-Sierra B. (Hospital Universitario de Galdakao)
- UludaÄ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
- UniversitĂ di Ferrara)
- Université Mohammed V Rabat). Netherlands: Hompes R.
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- Urbani A. (Azienda Ospedaliero Universitaria Sanâanna)
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- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center HamburgâEppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
- Valero Soriano M. (Hospital General Reina SofĂa)
- Valle Rubio A. (Getafe University Hospital)
- Valverde S. (Hospital Clinic Barcelona)
- Van den Eynde J.
- Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
- Varma M. (University of California
- VasljeviÄ J.
- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e UniversitĂĄrio de SĂŁo JoĂŁo)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
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- Vervoort D.
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- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
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- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
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- Xavier R. G.
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- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990â2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Kalkidan Hassen
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbasifard Mitra
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdi Parsa
- Abdollahi Mohammad
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- AbeldanÌo ZunÌiga Roberto Ariel
- Abiodun Olumide
- Abiso Temesgen Lera
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas GuimaraÌes
- Abu-Gharbieh Eman
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Abukhadijah Hana Jihad Jihad
- Aburuz Salahdein
- Adane Mesafint Molla
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Aden Bashir
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adha Rishan
- Adibi Amin
- Adnani Qorinah Estiningtyas Sakilah
- Adzigbli Leticia Akua
- Afolabi Aanuoluwapo Adeyimika
- Afolabi Rotimi Felix
- Afshin Ashkan
- Afyouni Shadi
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agbozo Faith
- Aghamiri Shahin
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Noah
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmed Ali
- Ahmed Anisuddin
- Ahmed Ayman
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Safoora
- Ahmed Syed Anees
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemiju Tomi
- Akkaif Mohammed Ahmed
- Akkala Sreelatha
- Akombi-Inyang Blessing
- Al Awaidy Salah
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-Fatly Bassam
- Al-Gheethi Adel Ali Saeed
- Al-Habbal Khairat
- Al-Marwani Sabah
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Al-Rifai Rami Hani
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Al-Zyoud Walid
- Alahdab Fares
- Alalalmeh Samer O
- Alalwan Tariq A
- Alam Khurshid
- Alam Nazmul
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albakri Almaza
- AlBataineh Mohammad T
- Aldhaleei Wafa A
- Aldridge Robert W
- Alemayohu Mulubirhan Assefa
- Alemu Yihun Mulugeta
- Alhabib Khalid F
- Alhassan Robert Kaba
- Ali Abid
- Ali Amjad
- Ali Beriwan Abdulqadir
- Ali Iman
- Ali Liaqat
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Waad
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Alla François
- Almustanyir Sami
- Alomari Mahmoud A
- Alonso Jordi
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Alrawashdeh Ahmad
- Alrousan Sahel Majed
- Alshahrani Najim Z
- Altaany Zaid
- Altaf Awais
- Altirkawi Khalid A
- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J
- Alwafi Hassan
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amaechi Uchenna Anderson
- Aman Mohammadi Masous
- Amani Reza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Ammirati Enrico
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Anenberg Susan C
- Angappan Dhanalakshmi
- Angus Colin
- Anil Abhishek
- Anil Sneha
- Anjum Afifa
- Anoushiravani Amir
- Antonazzo Ippazio Cosimo
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Boluwatife Stephen
- Anvari Davood
- Anvari Saeid
- Anwar Saleha
- Anwar Sumadi Lukman
- Anwer Razique
- Anyabolo Ekenedilichukwu Emmanuel
- Anyasodor Anayochukwu Edward
- Apostol Geminn Louis Carace
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Aregawi Brhane Berhe
- Aremu Abdulfatai
- Armocida Benedetta
- Arndt Michael Benjamin
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Aruleba Idowu Thomas
- Arumugam Ashokan
- Asbeutah Akram M
- Asgary Saeed
- Asgedom Akeza Awealom
- Ashbaugh Charlie
- Ashemo Mubarek Yesse
- Ashraf Tahira
- Askarinejad Amir
- Assmus Michael
- Astell-Burt Thomas
- Athar Mohammad
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atreya Alok
- Aujayeb Avinash
- Ausloos Marcel
- Avila-Burgos Leticia
- Awoke Andargie Abate
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayestas Portugal Carlos
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azevedo Rui M S
- Azhar Gulrez Shah
- Azizi Hosein
- Azzam Ahmed Y
- AÌrnloÌv Johan
- Backhaus Insa Linnea
- Badar Muhammad
- Badiye Ashish D
- Bagga Arvind
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bahrami Taghanaki Pegah
- Bai Ruhai
- Baig Atif Amin
- Baker Jennifer L
- Bakkannavar Shankar M
- Balasubramanian Madhan
- Baltatu Ovidiu Constantin
- Bam Kiran
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Banke-Thomas Aduragbemi
- Bansal Hansi
- Barchitta Martina
- Bardhan Mainak
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barrero Lope H
- Barrow Amadou
- Barteit Sandra
- Basharat Zarrin
- Basiru Afisu
- Basso JoaÌo Diogo
- Bastan Mohammad-Mahdi
- Basu Sanjay
- Batchu Sai
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- BaÌrnighausen Till Winfried
- Beaney Thomas
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bekele Alehegn
- Belgaumi Uzma Iqbal
- Bell Arielle Wilder
- Bell Michelle L
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bennitt Fiona B
- Bensenor Isabela M
- Benzian Habib
- Beran Azizullah
- Berezvai Zombor
- Bernabe Eduardo
- Bernstein Robert S
- Bettencourt Paulo J G
- BeÌjot Yannick
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhaskar Sonu
- Bhat Ajay Nagesh
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhuiyan Mohiuddin Ahmed
- Bhutta Zulfiqar A
- Bikbov Boris
- Bishai Jessica Devin
- Bisignano Catherine
- Biswas Atanu
- Biswas Bijit
- Biswas Raaj Kishore
- BjĂžrge Tone
- Boachie Micheal Kofi
- Boakye Hosea
- Bockarie Moses John
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bogale Eyob Ketema
- Bolla Srinivasa Rao
- Boloor Archith
- Bonakdar Hashemi Milad
- Boppana Sri Harsha
- Bora Basara Berrak
- Borhany Hamed
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boufous Soufiane
- Bourne Rupert
- Boxe Christopher
- Braithwaite Dejana
- Brant Luisa C
- Brar Amanpreet
- Brauer Michael
- Breitborde Nicholas J K
- Breitner Susanne
- Brenner Hermann
- Briko Andrey Nikolaevich
- Britton Gabrielle
- Brown Colin Stewart
- Browne Annie J
- Brunoni Andre R
- Bryazka Dana
- Bulamu Norma B
- Bulto Lemma N
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Nadeem Shafique
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Cagney Jack
- Cahuana-Hurtado Lucero
- Calina Daniela
- Campos Luciana Aparecida
- Campos-Nonato Ismael R
- Cao Chao
- Cao Fan
- Cao Yubin
- Capodici Angelo
- Carr Sinclair
- Carreras Giulia
- Carrero Juan J
- Carugno Andrea
- Carvalho Felix
- Carvalho MaÌrcia
- Castaldelli-Maia Joao Mauricio
- CastanÌeda-Orjuela Carlos A
- Castelpietra Giulio
- CatalaÌ-LoÌpez FerraÌn
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- CaÌmera Luis Alberto
- CaÌrdenas Rosario
- Cederroth Christopher R
- Cegolon Luca
- Cenderadewi Muthia
- Cercy Kelly M
- Cerin Ester
- Chadwick Joshua
- Chakraborty Chiranjib
- Chakraborty Promit Ananyo
- Chakraborty Sandip
- Chan Jeffrey Shi Kai
- Chan Raymond N C
- Chandan Joht Singh
- Chandika Rama Mohan
- Chaturvedi Pankaj
- Chen An-Tian
- Chen Catherine S
- Chen Haowei
- Chen Meng Xuan
- Chen Mingling
- Chen Simiao
- Cheng Ching-Yu
- Cheng Esther T W
- Cherbuin Nicolas
- Chi Gerald
- Chichagi Fatemeh
- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho William C S
- Chong Bryan
- Chopra Hitesh
- Chowdhury Rajiv
- Christopher Devasahayam J
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Chung Sheng-Chia
- Chutiyami Muhammad
- Cioffi Iolanda
- Cogen Rebecca M
- Cohen Aaron J
- Columbus Alyssa
- Conde Joao
- Corlateanu Alexandru
- Cortese Samuele
- Cortesi Paolo Angelo
- Costa Vera Marisa
- Costanzo Simona
- Criqui Michael H
- Cruz Jessica A
- Cruz-Martins NataÌlia
- Culbreth Garland T
- D'Amico Emanuele
- D'Anna Lucio
- D'Oria Mario
- da Silva Alanna Gomes
- Dadras Omid
- Dai Xiaochen
- Dai Zhaoli
- Daikwo Patience Unekwuojo
- Dalli Lachlan L
- Damiani Giovanni
- Darwesh Aso Mohammad
- Das Jai K
- Das Subasish
- Dash Nihar Ranjan
- Dashti Mohsen
- Davis Weaver Nicole
- Davitoiu Dragos Virgil
- DaÌvila-Cervantes Claudio Alberto
- De la Hoz Fernando Pio
- de la Torre-Luque Alejandro
- De Leo Diego
- Debopadhaya Shayom
- Degenhardt Louisa
- Del Bo' Cristian
- Delgado-Enciso Ivan
- Delgado-Saborit Juana Maria
- Demoze Chalachew Kassaw
- Denova-GutieÌrrez Edgar
- Dervenis Nikolaos
- DervisÌevicÌ Emina
- Desai Hardik Dineshbhai
- Desai Rupak
- Devanbu Vinoth Gnana Chellaiyan
- Dewan Syed Masudur Rahman
- Dhali Arkadeep
- Dhama Kuldeep
- Dhane Amol S
- Dhimal Mandira Lamichhane
- Dhimal Meghnath
- Dhingra Sameer
- Dhulipala Vishal R
- Dhungana Raja Ram
- Dias da Silva Diana
- Diaz Daniel
- Diaz Luis Antonio
- Diaz Michael J
- Dima Adriana
- Ding Delaney D
- Dinu Monica
- Djalalinia Shirin
- do Prado Camila Bruneli
- Do Thanh Chi
- Do Thao Huynh Phuong
- Dodangeh Masoud
- Dohare Sushil
- Dokova Klara Georgieva
- Dong Wanyue
- Dongarwar Deepa
- Dorostkar Fariba
- Dorsey E Ray
- Doshi Rajkumar
- Doshmangir Leila
- Dowou Robert Kokou
- Driscoll Tim Robert
- Dsouza Ashel Chelsea
- Dsouza Haneil Larson
- Dumith Samuel C
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Dushpanova Anar
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Ebrahimi Alireza
- Echieh Chidiebere Peter
- Ed-Dra Abdelaziz
- Edinur Hisham Atan
- Edvardsson David
- Edvardsson Kristina
- Efendi Ferry
- Eftekharimehrabad Aziz
- Eini Ebrahim
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
- El Sayed Zaki Maysaa
- El-Dahiyat Faris
- Elemam Noha Mousaad
- Elgar Frank J
- ElGohary Ghada Metwally Tawfik
- Elhabashy Hala Rashad
- Elhadi Muhammed
- Elmehrath Ahmed O
- Elmeligy Omar Abdelsadek Abdou
- Elshaer Mohammed
- Elsohaby Ibrahim
- Emeto Theophilus I
- Esfandiari Negin
- Eshrati Babak
- Eslami Majid
- Esmaeili Sayed Vahid
- Estep Kara
- Etaee Farshid
- Fabin Natalia
- Fagbamigbe Adeniyi Francis
- Fagbule Omotayo Francis
- Fahimi Saman
- Falzone Luca
- Fareed Mohammad
- Farinha Carla Sofia e SaÌ
- Faris MoezAlIslam Ezzat Mahmoud
- Faris Pawan Sirwan
- Faro Andre
- Fasina Folorunso Oludayo
- Fatehizadeh Ali
- Fauk Nelsensius Klau
- Fazylov Timur
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- Feng Xiaoqi
- Fereshtehnejad Seyed-Mohammad
- Feroze Abdullah Hamid
- Ferrara Pietro
- Ferrari Alize J
- Ferreira Nuno
- Fetensa Getahun
- Feyisa Bikila Regassa
- Filip Irina
- Fischer Florian
- Fitriana Ida
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- Flohr Carsten
- Flood David
- Flor Luisa S
- Foigt Nataliya A
- Folayan Morenike Oluwatoyin
- Force Lisa M
- Fortuna Daniela
- Foschi Matteo
- Franklin Richard Charles
- Freitas Alberto
- Friedman Sara D
- Fux Blima
- G Sridevi
- Gaal Peter Andras
- Gaihre Santosh
- GajdaÌcs MaÌrioÌ
- Gakidou Emmanuela
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- Zhang Meixin
- Zhang Yunquan
- Zhang Zhenyu
- Zhang Zhi-Jiang
- Zhao Hanqing
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- Zhao Xiu-Ju George
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
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- Zhou Juexiao
- Zhou Shangcheng
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- Zhu Lei
- Zhu Zhaohua
- Ziaeian Boback
- Ziafati Makan
- ZielinÌska Magdalena
- Zimsen Stephanie R M
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- Zoller Thomas
- Zumla Alimuddin
- Zyoud Sa'ed H
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 riskâoutcome pairs. Pairs were included on the basis of data-driven determination of a riskâoutcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each riskâoutcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of riskâoutcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7â9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4â9·2]), smoking (5·7% [4·7â6·8]), low birthweight and short gestation (5·6% [4·8â6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8â6·0]). For younger demographics (ie, those aged 0â4 years and 5â14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9â27·7]) and environmental and occupational risks (decrease of 22·0% [15·5â28·8]), coupled with a 49·4% (42·3â56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9â21·7] for high BMI and 7·9% [3·3â12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6â1·9) for high BMI and 1·3% (1·1â1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4â78·8) for child growth failure and 66·3% (60·2â72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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- Publication venue
- Publication date
- 22/09/2015
- Field of study
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- AdriĂŁo Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre KĂ©vin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
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- Alves Rita
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- Ammerlaan Heidi
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- Angheben Andrea
- ANGOULVANT François
- Ansart SĂ©verine
- Antonelli Massimo
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- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-BenoĂźt
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar LaurĂšne
- Azoulay CĂ©cile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
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- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento LuĂs
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
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- Bouhmani Dounia
- Bouhour Damien
- Bouiller KĂ©vin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- CamÔes João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- CascĂŁo Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- CastrillĂłn Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier SĂĄnchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras SofĂa
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- CĂĄrcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De AraĂșjo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dellâamore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier KĂ©vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet JĂ©rĂŽme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou FĂ©lix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival CĂ©line
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- Dâaragon FrĂ©dĂ©rick
- DâOrleans Charles Crepy
- Dâorleans Charles,
- DâOrtenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou HĂ©lĂšne
- Esposito-Farese Marina
- EstevĂŁo JoĂŁo
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes MarĂlia
- Fernandes Susana
- Ferraz MĂĄrio
- Ferreira Benigno
- Ferrer-Roca Ricard
- FerrĂŁo Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet BenoĂźt
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- GaiĂŁo SĂ©rgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcĂa Ruth NoemĂ Jorge
- GarcĂa Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard CĂ©cile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe SegolĂšne
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- GĂłmez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- HipĂłlito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-SĂ©bastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- InĂĄcio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
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- Javidfar Jeffrey
- Jean-BenoĂźt Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph CĂ©dric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee VĂ©ronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- LeĂłn Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- LâHer Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado MoĂŻse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet MylĂšne
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino FlĂĄvio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins JoĂŁo
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard CĂ©cile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita AntĂłnio
- Meybeck AgnĂšs
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei CĂ©line
- MihnovitĆĄ Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris MarlĂšne
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- MĂŒller Fredrik
- MĂŒller Karl Erik
- MĂŒller Karl,
- Neant NadĂšge
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- NâGuyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira JoĂŁo
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- Oâdonnell Max
- Oâhearn Katie
- Oâneil Conar
- Pagadoy MaĂŻder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- PatrĂŁo LuĂs
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- PetrouĆĄovĂĄ Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença LĂșcia
- Purcell Gregory
- Puéchal Oriane
- PĂłvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana LĂșcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia SimĂŁo
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz MĂ©lanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze BenoĂźt
- Russell Clark,
- Ryckaert Steffi
- RĂ€tsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator HĂ©lĂšne
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira TĂąnia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Solis Monserrat
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet AgnĂšs
- Song Myung Jin
- Song Myung,
- Song Rima
- Song Tae
- Sonntagbauer Michael
- Sotomayor Ruth Jimbo
- Sotomayor Ruth,
- Soum Edouard
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Sriskandan Shiranee
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Strudwick Samantha
- Stuart Ami
- Stuart David
- Suen Jacky,
- Sultana Asfia
- Summers Charlotte
- Svistunov Magdalena SurovcovĂĄ Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Tagherset Lysa
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tamlihat Younes,
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari,
- Tedder Richard,
- Teixeira JoĂŁo
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Thibault V.
- Thiberville Simon-Djamel
- Thill BenoĂźt
- Thompson A.,
- Thompson Shaun
- Thomson David
- Thomson Emma,
- Thuy Duong Bich
- Thuy Duong,
- Thwaites Ryan,
- Timashev Peter,
- Timsit Jean-François
- Toki Maria
- Tonby Kristian
- Torres Antoni
- Torres Margarida
- Trieu Huynh Trung
- Trieu Huynh,
- Trioux Théo
- Tromeur CĂ©cile
- Trontzas Ioannis
- Troost Jonathan
- Trouillon Tiffany
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turtle Lance,
- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores LuĂs
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira CĂ©sar
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik CĂ©cile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Experiments Meet Hydrophobic Mismatch: A Re-evaluation Of The Orientation Of Model Transmembrane Peptides From Solid-State NMR
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Orientation and Dynamics of Peptides in Membranes Calculated from 2H-NMR Data
- Author
- Afonin
- Afonin
- Anne S. Ulrich
- Axelsen
- Bond
- Daily
- Davis
- Davis
- Davis
- Erik Strandberg
- Esteban-Martin
- Esteban-MartĂn
- Glaser
- Glaser
- Goodyear
- Huang
- Huang
- Im
- JesĂșs Salgado
- Kandasamy
- Killian
- Killian
- Kim
- Marrink
- Matsuzaki
- Nymeyer
- Oren
- Page
- Page
- Petrache
- Prosser
- Ramamoorthy
- Salgado
- Santi Esteban-MartĂn
- Strandberg
- Strandberg
- Strandberg
- Strandberg
- Straus
- Tremouilhac
- Tremouilhac
- Ulrich
- Van der Wel
- Vostrikov
- Wadhwani
- Ăzdirekcan
- Ăzdirekcan
- Publication venue
- The Biophysical Society
- Publication date
- 22/04/2009
- Field of study
Solid-state 2H-NMR is routinely used to determine the alignment of membrane-bound peptides. Here we demonstrate that it can also provide a quantitative measure of the fluctuations around the distinct molecular axes. Using several dynamic models with increasing complexity, we reanalyzed published 2H-NMR data on two representative α-helical peptides: 1), the amphiphilic antimicrobial peptide PGLa, which permeabilizes membranes by going from a monomeric surface-bound to a dimeric tilted state and finally inserting as an oligomeric pore; and 2), the hydrophobic WALP23, which is a typical transmembrane segment, although previous analysis had yielded helix tilt angles much smaller than expected from hydrophobic mismatch and molecular dynamics simulations. Their 2H-NMR data were deconvoluted in terms of the two main helix orientation angles (representing the time-averaged peptide tilt and azimuthal rotation), as well as the amplitudes of fluctuation about the corresponding molecular axes (providing the dynamic picture). The mobility of PGLa is found to be moderate and to correlate well with the respective oligomeric states. WALP23 fluctuates more vigorously, now in better agreement with the molecular dynamics simulations and mismatch predictions. The analysis demonstrates that when 2H-NMR data are fitted to extract peptide orientation angles, an explicit representation of the peptide rigid-body angular fluctuations should be included
The Dynamic Orientation of Membrane-Bound Peptides: Bridging Simulations and Experiments
- Author
- Arkin
- Arkin
- Bechinger
- Berendsen
- Berger
- Bond
- Bond
- Davis
- Davis
- de Planque
- de Planque
- de Planque
- de Planque
- de Vries
- Duong-Ly
- Egberts
- Essmann
- Esteban-Martin
- Fares
- Feenstra
- Gaede
- Goodyear
- Hansson
- Im
- JesĂșs Salgado
- Kabsch
- Kandasamy
- Killian
- Koehorst
- Leontiadou
- Lindahl
- Marassi
- Marassi
- Marrink
- Marrink
- Mouritsen
- Nagle
- Norman
- Nymeyer
- Owicki
- Park
- Persson
- Petrache
- Ramamoorthy
- Saiz
- Salgado
- Santi Esteban-MartĂn
- Schwede
- Singer
- Sparr
- Strandberg
- Strandberg
- Straus
- van der Wel
- Venturoli
- Wang
- Weiss
- White
- Wu
- Ăzdirekcan
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Diagnostic and prognostic tumor markers in the gastrointestinal tract
- Author
- Aaltonen
- Abe
- Abelev
- Adachi
- Adrover
- Ahn
- Ahnen
- Akama
- Allen Mersh
- Amadori
- American Society of Clinical Oncology
- Andreyev
- Apple
- Arzimanoglou
- Ayhan
- Begent
- Benchimol
- Berling
- Bhatavdekar
- Birindelli
- Bodenmuller
- Bodmer
- Boland
- Bombardieri
- Bombardieri
- Brito
- Brown
- Brown
- Bruinvels
- Buamah
- Byrne
- Carethers
- Carneiro
- Cerottini
- Chow
- Ciaparrone
- Colcher
- Colcher
- Compton
- Compton
- Correa
- Costa
- Costanze
- Craanen
- Curran
- Curtis
- Czerniak
- D?Errico
- Danenberg
- de la Coste
- Del Favero
- Dhillon
- di Bisceglie
- Diez
- Dittmer
- Donehower
- Donnellan
- Donnellan
- Duffy
- Durr
- Eagon
- El-Deiry
- Elsaleh
- Eshleman
- Esteban
- Esteve
- Fearon
- Feinberg
- Ferrell
- Filella
- Finkelstein
- Flamini
- Fletcher
- Friedkin
- Friess
- Gansauge
- Ghimenti
- Ghimenti
- Giardiello
- Gitlin
- Gold
- Goldenberg
- Goldstein
- Goslin
- Greenblatt
- Guadagni
- Guo
- Haglund
- Hahn
- Hahn
- Hajdu
- Hallak
- Hamilton
- Hara
- Hartwell
- Hattori
- Hedrick
- Heinze
- Herlyn
- Hodgson
- Hollstein
- Houbiers
- Houze
- Hung
- Hussain
- Hynes
- Iacopetta
- Ichikawa
- Islam
- Ito
- Ito
- Itoh
- Jen
- Jiang
- Jiang
- Jimenez
- Johnson
- Johnston
- Johnston
- Johnston
- Jones
- Jones
- Jonson
- Joypaul
- Kamb
- Kasper
- Kastan
- Kato
- Kato
- Kato
- Kern
- Kim
- Kim
- Kim
- Kitadai
- Kitagawa
- Kuipers
- Lamerz
- Lamerz
- Lane
- Laurent-Puig
- Law
- Levine
- Levine
- Liggett Jr
- Lin
- Lin
- Lin
- Liu
- Lloyd
- Loda
- Longnecker
- Lowe
- Luce
- Lundin
- Macdonald
- Machover
- Maehara
- Maehara
- Maesawa
- Maketa
- Malesci
- Marinone
- Martin
- Marxsen
- Massa
- Matsubayashi
- Mayer
- McIntire
- McMahon
- Mealy
- Meltzer
- Midgley
- Miura
- Miyamoto
- Miyashita
- Miyoshi
- Moerkerk
- Moertel
- Moll
- Mori
- Mori
- Morinaga
- Motojima
- Mulcahy
- Muraro
- Murray
- Nagase
- Nagasue
- Nagasue
- Naitoh
- Nakanuma
- Naval
- Nemunaitis
- Nesbit
- Nobori
- Nomura
- O?Connell
- Ogasawara
- Okamoto
- Ozturk
- Park
- Park
- Parsons
- Perucho
- Peters
- Peters
- Piantino
- Poller
- Porter
- Powell
- Purdie
- Ranzani
- Ried
- Ritts
- Rosen
- Safi
- Sakaguchi
- Sakai
- Sakorafas
- Sanguedolce
- Sano
- Santi
- Sato
- Schneider
- Schwartz
- Sell
- Seregni
- Seregni
- Seregni
- Sessa
- Shani
- Sherr
- Shibata
- Shibuya
- Shinozaki
- Singh
- Sirivatanauksorn
- Smith
- Spirio
- Spruck
- Staab
- Stallmach
- Steinberg
- Stevens
- Suehara
- Suminami
- Sundrstrom
- Tahara
- Tahara
- Tahara
- Tahara
- Takanishi
- Tamura
- Tang
- Teh
- Teh
- Theret
- Tomita
- Torres
- Troungos
- Tsuda
- Uriel
- Van der Luijt
- van Triest
- von Kleist
- Wanebo
- Wang
- Winford-Thomas
- Wolmark
- Wright
- Wulbrand
- Yamachika
- Yamamoto
- Yang
- Yasui
- Yin
- Yu
- Zeng
- Zeng
- Zhou
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2001
- Field of study