Caracterización fenotípica, genotípica y susceptibilidad antifúngica de Candida spp aisladas de hemocultivos en el Hospital del Niño del 2009 al 2010.

El incremento en los últimos 10 años de los episodios de candidemia y la identificación de especies inusuales de Candida, nos obliga a realizar identificaciones con mayor exactitud y conocer los perfiles de susceptibilidad a los distintos anti fúngicos. Se realizó una caracterización de los aislados clínicos de levaduras procedentes de muestras de hemocultivos de pacientes hospitalizados en el Hospital del Niño del período 2009 al 2010. Se evaluaron 55 de estas cepas, las cuales fueron identificadas usando el sistema Vitek2, la prueba agar Harina de Maíz y el método de PCR fingerprinter. Los patrones de bandas de los aislados clínicos fueron comparados con cepas de referencia para confirmar las identificaciones fenotípicas. Se realizaron pruebas de susceptibilidad para 6 anti fúngicos de uso sistémico. La distribución final de los aislados fue la siguiente: complejo C.parapsiosis (40%), C.tropicalis (29.1%), C. albicans (20%), C. gullliermondii (3.64%), S. salmonicolor (1.81%), S. cerevisiae (1.81%), y complejo C.haemulonii (3.64%). Las especies del complejo C.parapsilosis presentaron 77.3% de resistencia a caspofungina y 4.3% a itraconazol; C.tropicalis presentó 6.3% de resistencia a caspofungina y a itraconazol, mientras que C.albicans resultó con 18.2% de resistencia a caspofungina y anfotericina B, y 9.1% de resistencia a fluconazol, itraconazol y voriconazol. Algunas cepas de C. albicans fueron resistentes a varios anti fúngicos. No se encontraron cepas con resistencia a posaconazol. Las especies del complejo C.parapsiosis fueron las más aisladas en el hospital y en la sala de neonatología con una alta prevalencia de resistencia a caspofungina

Application of the data envelopment analysis technique to measure the environmental efficiency of the 27 countries of the European Union during the period 2012-2020

In the last decade, we have experienced a changing geopolitical context that has caused changes in the energy context. In addition, human activity contributes to global warming or sea level rising, i.e., climate change. A set of action policies have been implemented to continue fighting against this environmental situation (such as the Paris Agreement, the COP27, or the European Green Deal for 2030); therefore, it is necessary to determine whether we are on the right track. It is compulsory to develop predictive models that accurately analyze the current status and the already path undertaken. To this end, this article analyzes the environmental efficiency of the 27 countries of the European Union (excluding the UK) using the so-called data envelopment analysis (DEA). In particular, economic (GDP and GDP per capita), environmental (CO2 and CH4 emissions), electricity production data, the volume of vehicles, and the industrial production rate of the different countries were collected to calculate environmental efficiency. Once these data were collected, the environmental efficiency was calculated using two methods based on the DEA. The results show that out of the 27 countries, only 12 have a relatively high environmental efficiency, although it could be improved, implementing a set of corrections. However, other countries have a low eco-efficiency performance and they must improve in the coming years. We can highlight that rich countries are closer to achieving high environmental efficiency than less developed countries.Funding for open access publishing: Universidad de Jaén / CBUA. This work is framed within the Research Project [Code UHU-202031] with the Title "Development of predictive models and analysis of evolution scenarios of CO2 emissions derived from the energy transition in Andalusia. Towards the fulfilment of the European Union goals for 2030", supported by Junta de Andalucía

Verdad, objetividad y neutralidad: ¿ilusiones del conocimiento científico?

El ensayo aborda la postura de las epistemologías críticas surgidas a mediados del siglo pasado respecto a las características del conocimiento científico consideradas cruciales por el positivismo y el neopositivismo: la verdad, la objetividad y la neutralidad de la ciencia.El ensayo aborda la postura de las epistemologías críticas surgidas a mediados del siglo pasado respecto a las características del conocimiento científico consideradas cruciales por el positivismo y el neopositivismo: la verdad, la objetividad y la neutralidad de la ciencia

Control strategy of a pseudo-stationary gait rehabilitation robot

[Resumen] La recuperación de la marcha es una prioridad para las personas con enfermedades neurológicas o lesión medular espinal. Los exoesqueletos actuales de reentrenamiento de la marcha implementan estrategias de control por seguimiento de la trayectoria o por asistencia según la necesidad, sin embargo, éstas no han mostrado aún ser superiores a la rehabilitación convencional de manera concluyente. En este artículo se presenta de forma conceptual la estrategia de control de un nuevo sistema robótico ambulatorio para la rehabilitación de la marcha basado en un exoesqueleto comercial, integrando módulos robóticos adicionales para proporcionar mayor libertad de movimiento al usuario y fomentar el control voluntario y la participación activa. De esta forma se espera que el sistema permita desarrollar de forma satisfactoria la terapia y, a futuro, favorezca la plasticidad neuronal y el aprendizaje motor.[Abstract] The restoration of gait is a priority for people with neurological disease or spinal cord injury. Current gait training exoskeletons implement path-following or assist-as-needed control strategies. However, they have not shown to be conclusively superior to conventional rehabilitation yet. This paper conceptually presents the control strategy of a new ambulatory robotic gait rehabilitation system based on a commercial exoskeleton. The system integrates additional robotic modules to provide more freedom to the user during motion and encourage voluntary control and active participation in the therapy. In this way, the system is expected to provide a successful therapy development and, in the future, to promote neural plasticity and motor learning.Ministerio de Ciencia e Innovación; PID2021-123657OB-C3

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks