Shahrekord University of Medical Sciences

shahrekord university of medical scinces
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    7411 research outputs found

    The Effect of Various Lasers on the Bond Strength Between Orthodontic Brackets and Dental Ceramics: A Systematic Review and Meta-Analysis

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    Background/objective: This systematic review and meta-Analysis aimed to assess how laser conditioning affected brackets bonded to dental ceramics' shear bond strength (SBS). Materials and methods: The study was conducted by searching Pubmed/Medline, Scopus, Embase, Web of Science, the Cochrane Library, and Google Scholar up to September 14, 2022. In addition, the reference lists of the relevant articles were checked manually. Articles that compared SBS of laser-Treated feldspathic, lithium disilicate, or zirconia surfaces with other standard techniques for bonding metal or ceramic orthodontic brackets were considered. Using a random-effects model, data pooling was carried out as the weighted mean difference (WMD). Results: This study initially contained 1717 reports, and following review, 32 articles were deemed suitable for our meta-Analysis. The pooling results showed that the treatments with lasers such as ''Er:YAG'' [WMD=-1.12 MPa; 95% confidence interval (CI):-1.93 to-0.31], ''Er:YAG + Silane'' (WMD=-3.08 MPa; 95% CI:-4.77 to-1.40), and ''Nd: YAG + Silane'' (WMD=-2.58 MPa; 95% CI:-3.76 to-1.40) had statistically significant lower adhesion values compared with controls. Contrarily, ''Ti:Sapphire femtosecond'' demonstrated significantly higher bonding values (WMD= 0.94 MPa; 95% CI: 0.29 to 1.60). In contrast, other interventions obtained no statistically significant difference in SBS. Conclusions: Most of the laser groups showed results comparable with those of conventional approaches. Although more research is necessary for definitive conclusions, laser treatment may be an effective option for treating the surfaces of ceramic materials

    Differentiation of human primary testicular cells in the presence of SCF using the organoid culture system

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    Purpose: Development of organoids using human primary testicular cells has remained a challenge due to the complexity of the mammalian testicular cytoarchitecture and culture methods. In this study, we generated testicular organoids derived from human primary testicular cells. Then, we evaluated the effect of stem cell factor (SCF) on cell differentiation and apoptosis in the testicular organoid model. Methods: The testicular cells were harvested from the three brain-dead donors. Human spermatogonial stem cells (SSCs) were characterized using immunocytochemistry (ICC), RT-PCR and flow cytometry. Testicular organoids were generated from primary testicular cells by hanging drop culture method and were cultured in three groups: control group, experimental group 1 (treated FSH and retinoic acid (RA)), and experimental group 2 (treated FSH, RA and SCF), for five weeks. We assessed the expression of SCP3 (Synaptonemal Complex Protein 3) as a meiotic gene, PRM2 (Protamine 2) as a post-meiotic marker and apoptotic genes of Bax (BCL2-Associated X Protein) and Bcl-2 (B-cell lymphoma 2), respectively by using RT-qPCR. In addition, we identified the expression of PRM2 by immunohistochemistry (IHC). Results: Relative expression of SCP3, PRM2 and Bcl-2 were highest in group 2 after five weeks of culture. In contrast, BAX expression level was lower in experimental group 2 in comparison with other groups. IHC analyses indicated the highest expression of PRM2 as a postmeiotic marker in group 2 in comparison to 2D culture and control groups but not find significant differences between experimental group 1 and experimental group 2 groups. Morphological evaluations revealed that organoids are compact spherical structures and in the peripheral region composed of uncharacterized elongated fibroblast-like cells. Conclusion: Our findings revealed that the testicular organoid culture system promote the spermatogonial stem cell (SSC) differentiation, especially in presence of SCF. Developed organoids are capable of recapitulating many important properties of a stem cell niche

    Investigating the Relationship between Exposure to Cadmium and the Risk of Pancreatic Cancer: A Systematic Review and Meta-Analysis

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    Background: Exposure to cadmium is associated with the occurrence of pancreatic cancer. In a situation where the results of previous studies are not consistent, this study, using a systematic review and meta-analysis method investigated the relationship between exposure to cadmium and the risk of pancreatic cancer in order to provide an appropriate conclusion in this regard. Methods: By searching the ISI web of science, Cochrane, Science Direct, Scopus, PubMed and Google Scholar databases and using the keywords (Cadmium, Pancreatic Cancer) and their synonyms, 391 articles were retrieved and considering the inclusion and exclusion criteria, finally 8 articles were included in the present study. Data analysis was done using Stata 15 software. The significance level was considered 0.05. Findings: In this systematic review and meta-analysis study, it was observed that compared to the group without exposure/exposure to the lowest dose of cadmium, the risk of pancreatic cancer in people exposed/exposure to the highest dose of cadmium is equal to 1.62 (95 CI: 1.18-2.21; P ≤ 0.001), this relationship was statistically significant. According to the results of Egger's test (P = 0.100) and Begg's test (P = 0.076); in this study, publication bias was not observed. Conclusion: According to the results of this Review research, exposure to cadmium leads to a 62 increase in the risk of developing pancreatic cancer. Therefore, it can be said that exposure to cadmium is a risk factor for developing pancreatic cancer and health policies should be aimed at reducing exposure to Cadmium goes forward

    The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases

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    MicroRNA-770 (miR-770) is an RNA gene, located on chromosome 14q32.2. It has important effects on the pathobiology of cancers and other human diseases. It is known to be a tumor suppressor in breast cancer, ovarian cancer, gastric cancer, non-small cell lung cancer, prostate cancer, and glioblastoma. In colorectal adenocarcinoma and oral squamous cell carcinoma, miR-770 is regarded as an oncogenic miRNA. In several disorders, miR-770 dysregulation has been recognized as a potential biomarker for disease diagnosis and prognosis. Dysregulation of miR-770 has also been demonstrated in non-malignant human disorders, including Alzheimer's disease, dilated cardiomyopathy, diabetic nephropathy, Hirschsprung's disease, osteoarthritis, silicosis, and type 2 diabetes mellitus. In the current review, we have obtained the miR-770 target genes, ontology, and related pathways. We have also provided a comprehensive review of miR-770 in both malignant and non-malignant disorders and explained its possible therapeutic implications

    Exosomal lncRNAs in gastrointestinal cancer

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    Gastrointestinal cancer (GIC) remains a leading cause of morbidity and mortality worldwide. Unfortunately, these cancers are diagnosed in advanced metastatic stages due to lack of reliable biomarkers that are sufficiently specific and sensitive in early disease. There has been growing evidence that circulating exosomes can be used to diagnose cancer non-invasively with limited risks and side effects. Furthermore, exosomal long non-coding RNAs (lncRNAs) are emerging as a new class of promising biomarkers in cancer. This review provides an overview of the extraction and detection of exosomal lncRNAs with a focus on their potential role in GI

    Prevalence of Pathological Lesion Due to Mild Head Trauma in Computed Tomography Scan of Patients’ Brains

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    Background and aims: This study investigated the prevalence of pathological lesions on the computed tomography (CT) scans of the brains of patients with mild head trauma based on the New Orleans-Canadian criteria at Shahrekord Ayatollah Kashani Hospital, Iran. Methods: All patients referred to the Emergency Department of Shahrekord Ayatollah Kashani Hospital in 2019 with a history of head trauma were included in this cross-sectional, descriptive-analytical study according to the criteria of mild head trauma. Then, the relevant checklist was used to record the patients’ level of consciousness, demographic information, and cause of trauma. Finally, the data were analyzed using SPSS 18, and the patient’s lesions were reported accordingly. Results: Out of 143 patients, 89 were males, and 54 were females in this study. Falling from a height was the cause of head trauma in most patients (43.3%). Among all patients, the CT scans of six patients were abnormal and had lesions. The vomiting had a significant relationship with the results of the CT scan, and for patients with mild head trauma, the Canadian and New Orleans indices had the same clinical importance. Conclusion: According to the results of the present study, the New Orleans index could identify more patients as CT scan candidates than the Canadian index; however, there was no difference in the final result (the presence of a pathological lesion in the CT scan) between these two indices. The New Orleans index has more features than the Canadian index, but its results are not different from the Canadian index. Thus, we believe that using the Canadian index can reduce imaging rates, costs, and protection from the side effects of radiation

    Effect of resistance and endurance training with ursolic acid on oxidative stress and cognitive impairment in hippocampal tissue in HFD/STZ-induced aged diabetic rats

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    Objective(s): The increase in age-related cognitive impairment (CIs) and diabetes mellitus is a global health concern. Exercise training has been reported to activate the Nrf2/Keap1/ARE signaling and enhance the antioxidant defense pathways in some animal models. This study aimed to investigate the effects of ursolic acid (UA) associated with resistance or endurance training on antioxidant markers, and the Nrf2/Keap1/ARE pathway in the brain of older diabetic rats. Materials and Methods: 23-month-aged diabetes induced male Wistar rats were randomly assigned to seven groups (n=8). UA supplementation (250 mg/kg, daily) was administered along with resistance (60 maximum capacity of voluntary carrying MVCC, 14-20 climbs) or endurance training (60-75% velocity at maximal oxygen uptake vVO2max), five days/week for eight weeks. Cognitive-motor functioning was assessed through open-field and passive avoidance response tests. Nrf2, Keap1, and antioxidant markers including SOD, CAT, GPx, and GSH were measured in the hippocampus tissue. Results: The results showed positive effect of resistance training (P≤0.001) on Nrf2. There was endurance training with supplementation main effect (P=0.018) on Keap1 concentration. SOD revealed a significant endurance/resistance training by supplementation interaction effect (P≤0.05); however, there was no main training or UA supplementation effects on CAT, GPx, and GSH, despite improving spatial memory changes in exercise or UA groups. Conclusion: It appears that UA treatment with resistance or endurance exercise has some beneficial effects on Nrf2 and some antioxidant markers. However, more research is needed to elucidate UA’s interaction effects and exercise interventions in diabetic situations

    Estilo de vida en mujeres con cáncer de mama: un estudio de revisión narrativa

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    Objective: The present review study aimed to assess the lifestyle of women with breast cancer. Methods: In this study, information on Life style in women with breast cancer was obtained from Persian and English databases using Persian keywords and their English equivalent for “Life style, Breast Cancer” based on MeSH (medical subject headings) from 2000 to 2020. Among all the articles searched, 48 studies were included in the review research. To collect information from the studies, the articles were carefully reviewed and the results were extracted. Results: According to the available scientific evidence, lifestyle has an effect on health and some related factors such as inadequate physical activity, stress, eating patterns, bad behaviors such as smoking and drinking alcohol are associated with breast cancer. Conclusion: Therefore, interventions and trainings should be planned to provide a suitable and sufficient ground for guiding women towards healthy lifestyles and behavioral habits

    The Effect of Folic Acid-Targeted Nanocarriers in Ultrasound Imaging-guided Sonodynamic Therapy of Human Cervical Carcinoma (HeLa): in vitro Study

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    Introduction: Theranostic nanocarriers can be used simultaneously for the diagnosis and treatment of cancer. In this study, the effect of dotarem-and doxorubicin-loaded nanodroplet as a theranostic agent for ultrasound-guided and-controlled release drug delivery on HeLa cervical cancer cells was investigated. Materials and Methods: Folic acid-targeted nanodroplets consisting of dotarm (Gd-DOTA) and doxorubicin (DOX) with alginate shells were synthesized and characterized. In this study, HeLa and L929 cell lines were used as cancer and normal cells, respectively. Intracellular uptake of nanocarriers was evaluated using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Doxorubicin release in response to ultrasound exposure and its effect on cancer treatment were investigated. Ultrasound imaging was performed to assess the ultrasound signal enhancement by nanodroplets. Results: The characterization results confirmed the successful synthesis of nanodroplets with desirable physicochemical properties. Cytotoxicity test showed that the synthesized nanodroplets had high biocompatibility for normal cells and induced more death in cancer cells (75.3 vs 62.1). This effect was enhanced under ultrasound exposure (51). The ICP-OES test showed that the uptake of Gd/DOX-loaded nanodroplets for sonicated cancer cells was approximately 1.5 times higher than that for non-sonicated cells after 12 h. The results showed that the ultrasound exposure significantly increased the doxorubicin release from nanodroplets (77.5 vs 2.1). Also, ultrasound imaging showed that perfluorohexane nanodroplets could enhance ultrasound signal intensity. Conclusion: According to the results, doxorubicin-and dotarem-loaded nanodroplets with proper diagnostic and therapeutic properties can be promising theranostic agents in ultrasound-guided and controlled drug delivery for sonodynamic therapy of cancer


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    shahrekord university of medical scinces is based in Iran
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