20 research outputs found
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- Author
- Aalfs Cora M.
- Adank Muriel A.
- Adenis Claude
- Adlard Julian
- Agata Simona
- Aghmesheh Morteza
- Agnarsson Bjarni A.
- Ahearn Thomas
- Aittomäki Kristiina
- Ambrosone Christine B.
- Amor David
- Andrews Lesley
- Andrulis Irene L.
- Antill Yoland
- Anton-Culver Hoda
- Antonenkova Natalia N.
- Antoniou Antonis C.
- Armitage Shane
- Arndt Volker
- Arnold Leanne
- Arnold Norbert
- Aronson Kristan J.
- Arun Banu K.
- Asseryanis Ella
- Auber Bernd
- Auvinen Päivi
- Azzollini Jacopo
- Balleine Rosemary
- Balmaña Judith
- Barkardottir Rosa B.
- Barnes Daniel R.
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barwell Julian
- Bastick Patti
- Baurand Amandine
- Baxter Robert
- Beane Freeman Laura E.
- Beauparlant Charles Joly
- Beckmann Matthias W.
- Beesley Jonathan
- Behrens Sabine
- Beilby John
- Belotti Muriel
- Benitez Javier
- Bennett Ian
- Berger Raanan
- Bermisheva Marina
- Berthet Pascaline
- Bertolone Geoffrey
- Bertrand Ophélie
- Bignon Yves-Jean
- Birot Anne-Marie
- Blackburn Anneke
- Blanco Amie M.
- Blomqvist Carl
- Bogdanova Natalia V.
- Bogliolo Massimo
- Bogwitz Michael
- Bojesen Anders
- Bojesen Stig E.
- Bolla Manjeet K.
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Botes Leon
- Bourdon Violaine
- Boutry-Kryza Nadia
- Brady Angela F.
- Brauch Hiltrud
- Braye Stephen
- Brennan Meagan
- Brenner Hermann
- Bressac-de-Paillerets Brigitte
- Bronner Myriam
- Brown Melissa
- Brüning Thomas
- Bubien Virginie
- Buckley Michael
- Buecher Bruno
- Burgess Matthew
- Burke Jo
- Burwinkel Barbara
- Butow Phyllis
- Buys Saundra S.
- Bézieau Stéphane
- Cadoo Karen
- Caldon Liz
- Caldés Trinidad
- Caleca Laura
- Calender Alain
- Caliebe Almuth
- Caligo Maria A.
- Callen David
- Campa Daniele
- Campbell Ian G.
- Canzian Federico
- Caputo Sandrine
- Caron Olivier
- Carpenter Jane
- Castelao Jose E.
- Castera Laurent
- Catucci Irene
- Chang-Claude Jenny
- Chanock Stephen J.
- Chauhan Deepa
- Chauhan Manisha
- Chenevix-Trench Georgia
- Chiesa Jean
- Christian Alice
- Chung Wendy K.
- Claes Kathleen B. M.
- Clarke Christine L.
- Cohen Paul
- Colas Chrystelle
- Collavoli Anita
- Colley Alison
- Collonge-Rame Marie-Agnès
- Conner Thomas A.
- Coron Fanny
- Couch Fergus J.
- Coulet Florence
- Coupier Isabelle
- Cox David G.
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret
- Cybulski Cezary
- Czene Kamila
- Dahlstrom Jane
- Daly Mary B.
- Damette Alexandre
- Dawson Sarah-Jane
- de la Hoya Miguel
- de Pauw Antoine
- DeFazio Anna
- Delatycki Martin
- Delnatte Capucine
- Dennis Joe
- Devilee Peter
- Dickson Rebecca
- Diez Orland
- Ding Yuan Chun
- Dite Gillian S.
- Ditsch Nina
- Dixon Joanne
- Dobrovic Alexander
- Domchek Susan M.
- Dorfling Cecilia M.
- dos-Santos-Silva Isabel
- Dreyfus Hélène
- Dudding Tracy
- Dumont Aurélie
- Dunning Alison M.
- Dupré Anaïs
- Durda Katarzyna
- Dwek Miriam
- Dörk Thilo
- Easton Douglas F.
- Eccles Diana M.
- Edkins Ted
- Edwards Stacey
- Eisenbruch Maurice
- Ekici Arif B.
- Eliassen A. Heather
- Ellberg Carolina
- Eriksson Mikael
- Evans D. Gareth
- Faivre Laurence
- Farshid Gelareh
- Fasching Peter A.
- Feillel Viviane
- Fellows Andrew
- Fenton Georgina
- Fert-Ferrer Sandra
- Field Michael
- Figlioli Gisella
- Figueroa Jonine
- Flanagan James
- Flyger Henrik
- Fong Peter
- Forbes John
- Forrest Laura
- Fostira Florentia
- Foulkes William D.
- Fourme Emmanuelle
- Fox Stephen
- French Juliet
- Friebel Tara M.
- Friedlander Michael
- Friedman Eitan
- Gabrielson Marike
- Gaddam Pragna
- Gaff Clara
- Gago-Dominguez Manuela
- Gallego-Ortega David
- Gao Chi
- Gapstur Susan M.
- Garber Judy
- García-Closas Montserrat
- García-Sáenz José A.
- Gattas Mike
- Gaudet Mia M.
- Gauthier-Villars Marion
- Gayther Simon A.
- George Peter
- Gesta Paul
- Giles Graham G.
- Gill Grantley
- Giraud Sophie
- Gladieff Laurence
- Glendon Gord
- Godwin Andrew K.
- Goldberg Mark S.
- Goldgar David E.
- Golmard Lisa
- Greene Mark H.
- Greening Sian
- Guillaud-Bataille Marine
- Guimbaud Rosine
- Gutierrez-Barrera Angelica M.
- Guénel Pascal
- Haan Eric
- Haeberle Lothar
- Hahnen Eric
- Haiman Christopher A.
- Hall Per
- Hamann Ute
- Harrington Patricia A.
- Harris Marion
- Hart Stewart
- Hayward Nick
- Hein Alexander
- Heiniger Louise
- Heyworth Jane
- Hillemanns Peter
- Hollestelle Antoinette
- Hopper John L.
- Hosgood H. Dean
- Howell Anthony
- Hu Chunling
- Hulick Peter J.
- Hunt Clare
- Hunter David J.
- Håkansson Niclas
- Imyanitov Evgeny N.
- Ingster Olivier
- Isaacs Claudine
- Jacquot Caroline
- Jakimovska Milena
- Jakubowska Anna
- James Paul
- Janavicius Ramunas
- Janni Wolfgang
- Jenkins Mark
- John Esther M.
- Jones Michael E.
- Jung Audrey
- Kaaks Rudolf
- Karlan Beth Y.
- Kefford Rick
- Khusnutdinova Elza
- Kidd Alexa
- Kientz Caroline
- Kiiski Johanna I.
- Kirk Judy
- Kitahara Cari M.
- Koehler Jessica
- Kollias James
- Konstantopoulou Irene
- Koutros Stella
- Kraft Peter
- Lakhani Sunil
- Lallaoui Hakima
- Lambrechts Diether
- Lasheras Sandra Viz
- Lasset Christine
- Lazaro Conxi
- Le Marchand Loic
- Le Mentec Marine
- Lebrun Marine
- Lee C. Soon
- Legrand Clémentine
- Lejbkowicz Flavio
- Lejeune Sophie
- Leroux Christine Dominique
- Leslie Goska
- Lester Jenny
- Lesueur Fabienne
- Lilyquist Jenna
- Lindeman Geoff
- Lipton Lara
- Lizard Sarab
- Lobb Liz
- Longy Michel
- Loud Jennifer T.
- Lu Karen H.
- Luben Robert N.
- Lubinski Jan
- Lush Michael
- Léone Mélanie
- Mann Graham
- Mannermaa Arto
- Manoochehri Mehdi
- Manoukian Siranoush
- Manouvrier-Hanu Sylvie
- Margolin Sara
- Mari Véronique
- Marsh Deborah
- Martens John W. M.
- Maurer Tabea
- Mavroudis Dimitrios
- McGuffog Lesley
- McLachlan Sue Anne
- Mebirouk Noura
- Meindl Alfons
- Meiser Bettina
- Menon Usha
- Michailidou Kyriaki
- Miller Austin
- Milne Roger L.
- Molina-Gomes Denise
- Moncoutier Virginie
- Montagna Marco
- Morey Adrienne
- Mortemousque Isabelle
- Muller Danièle
- Muranen Taru A.
- Nathanson Katherine L.
- Neuhausen Susan L.
- Nevanlinna Heli
- Newman William G.
- Nguyen-Dumont Tu
- Nielsen Finn Cilius
- Nielsen Sarah
- Nightingale Sophie
- Nikitina-Zake Liene
- Noguchi Tetsuro
- Noguès Catherine
- Offit Kenneth
- Olah Edith
- Olopade Olufunmilayo I.
- Olshan Andrew F.
- Olson Janet E.
- Olsson Håkan
- Osorio Ana
- Ottini Laura
- O’Connell Shona
- O’Sullivan Sarah
- Pachter Nick
- Parsons Michael T.
- Pathmanathan Nirmala
- Patterson Briony
- Peissel Bernard
- Peixoto Ana
- Peterlongo Paolo
- Peto Julian
- Peysselon Magalie
- Pharoah Paul D. P.
- Phillips Kelly
- Pieper Ellen
- Plaseska-Karanfilska Dijana
- Pocza Timea
- Popovici Cornel
- Presneau Nadege
- Prieur Fabienne
- Pujana Miquel Angel
- Pujol Pascal
- Pujol Roser
- Punie Kevin
- Rack Brigitte
- Radice Paolo
- Ramus Susan J.
- Rantala Johanna
- Rashid Muhammad U.
- Rau-Murthy Rohini
- Rebischung Christine
- Remenieras Audrey
- Rennert Gad
- Rhenius Valerie
- Rickard Edwina
- Robinson Bridget
- Romero Atocha
- Rookus Matti A.
- Ross Eric A.
- Rossing Maria
- Rudaitis Vilius
- Ruebner Matthias
- Révillion Françoise
- Saleh Mona
- Salisbury Elizabeth
- Saloustros Emmanouil
- Sambrook Joe
- Sanden Kristin
- Santamariña Marta
- Saule Claire
- Saunders Christobel
- Saunus Jodi
- Scheuner Maren T.
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Schneider Michael
- Scott Christopher
- Scott Clare
- Scott Elizabeth
- Scott Rodney
- Senter Leigha
- Sevenet Nicolas
- Sexton Adrienne
- Shah Mitul
- Sharma Priyanka
- Shelling Andrew
- Shu Xiao-Ou
- Simard Jacques
- Simpson Peter
- Singer Christian F.
- Sobol Hagay
- Sohn Christof
- Sokolowska Johanna
- Soubrier Florent
- Soucy Penny
- Southey Melissa C.
- Spigelman Allan
- Spinelli John J.
- Spurdle Amanda
- Steele Linda
- Stoppa-Lyonnet Dominique
- Surrallés Jordi
- Swerdlow Anthony J.
- Tapper William J.
- Taylor Jessica
- Teixeira Manuel R.
- Terry Mary Beth
- Thomassen Mads
- Thompson Jennifer
- Thorne Heather
- Thull Darcy L.
- Tischkowitz Marc
- Toland Amanda E.
- Tollenaar Rob A.E.M.
- Torres Diana
- Toulas Christine
- Trainer Alison
- Troester Melissa A.
- Truong Thérèse
- Tucker Kathy
- Tung Nadine
- Uhrhammer Nancy
- Untch Michael
- Vachon Celine M.
- van Rensburg Elizabeth J.
- van Veen Elke M.
- Vaur Dominique
- Vega Ana
- Viel Alessandra
- Visvader Jane
- Vénat-Bouvet Laurence
- Walker Logan
- Wang Qin
- Wappenschmidt Barbara
- Warcoin Mathilde
- Weitzel Jeffrey N.
- Wendt Camilla
- Wieme Greet
- Wilcken Nicholas
- Williams Rachael
- Winship Ingrid
- Wolk Alicja
- Yang Xiaohong R.
- Yip Desmond
- Young Mary Ann
- Zeps Nikolajs
- Zheng Wei
- Ziogas Argyrios
- Zorn Kristin K.
- Publication venue
- npj Breast Cancer
- Publication date
- 01/01/2019
- Field of study
Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton Turčan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- Avşar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça Gümüş
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu Taşdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- Başar Erdivanli
- Başar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- Benoît Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Özcan
- Beysim Özcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- Boğaç Özserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
- Carita Löfqvist
- Carlo Alberto Volta
- Carlos Alejandro Bascary
- Carlos Castro Delgado
- Carmel Chapman
- Carmel Georgiev
- Carmen Partera Luque
- Carmen Velasco Guillén
- Carole Boulanger
- Carole Boulanger
- Carole Brett
- Carolina Garzón-Tovar
- Carolina Palaez
- Caroline Lagerhäll
- Caroline O'Donnell
- Caroline Paillet
- Carrie Sona
- Casiano Barrera Groba
- Catalin Traian Guran
- Catarina Nunes
- Catarina Tingsvik
- Catherine Motherway
- Catherine O'Brien
- Catherine Smith
- Cathy Becker
- Catia Quagliotto
- Cecilia Inés Loudet
- Cecilia Loudet
- Celia Tirado
- Ceri Lynch
- Cesar Aponte
- Cesar Rodriguez Nuñez
- Chaiwut Sawawiboon
- Chaoqun Ma
- Charalampos Martinos
- Charalice Ramiro
- Charikleia Nikolaou
- Charlotte Carter
- Charlotte Young
- Charlotte Young
- Chen Yumei
- Cheng
- Chenghau Mu
- Chengxia Sun
- Cheryl Bealer
- Cheryl Davidson
- Chiara Gatti
- Chiara Megna
- Chiara Megna
- Cho Young-Jae
- Chris Gerome Ellazar
- Chris Smith
- Chrisi Diakaki
- Christian Ferretti
- Christian Frey
- Christian Theisen
- Christiana Chime
- Christine Fiedler
- Christine Sheehan
- Christophe Borin
- Christophe Giacardi
- Christopher Barnes
- Christopher Barnes
- Christopher Palfreeman
- Christopher Potestio
- Christos Christofis
- Christos Dragoumanis
- Chrysanthos Markoulias
- Chrysostomos Katsenos
- Chun Jie Xia
- Chunxia Li
- Cindy Barefield
- Cindy Pillard
- Cintia Valencia Hurtado
- Cinzia Borgognoni
- Claire Derbyshire
- Claire Randell
- Claire Reynolds
- Clara Hurtado
- Clara Santa Rita
- Clare Fielding
- Clare Howcroft
- Claude Sertznig
- Claudia Lizbeth Lopez Nava
- Claudia Martins
- Congcong Liu
- Constantina Constantinou
- Cristal April Jane Aperocho
- Cristian Quiroga
- Cristiana Mota Pinheiro
- Cristina Paños Espinosa
- Cristina Petrisor
- Cui Yuan
- Cynthia Xing
- Cyril Thix
- Cyril Thix
- Cédric Bruel
- Cédric Daubin
- Dagmar Holmquist
- Daira Gonzalez
- Daisy Mehay
- Dale Ventour
- Damei Wang
- Damien O'Connell Rosemary Finn
- Dana Tomescu
- Dana Tomescu
- Danca Lančaričová
- Daniel Blanco
- Daniel Horner
- Daniel Owens
- Daniel Sancho Muriel
- Daniela Alampi
- Daniela Carmen Filipescu
- Danielle Hacking
- Danil Baskakov
- Daria Rabarova
- Dassy Levy
- David De Bels
- David Higgins
- David Perez-Torres
- David Shaw
- Davide Massimo Ghioldi
- Dea Mahanes
- Debbie Noblezada-Uy
- Deborah Jibrin
- DeHong Lei
- Deirdre Doyle
- Dejan Veličković
- Delmiro Becker
- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim Akdağ
- Deyan Cao
- Diana Alvarez
- Diane Barkas
- Dianne Figaro-Barclay
- Dick Nahar
- Diego Rolando Morocho Tutillo
- Dimitra Lepida
- Dimitrios Papadopoulos
- Dinko Tonkovic
- Dirk von Lewinski
- Dmitriy Galishevskiy
- Dmitry Sergeev
- Dolly Mabel Bordon Cabral
- Dominic Carney
- Donaldo S Arteta Arteta
- Dongfang Wei
- Dongliang Lin
- Dongmei Bai
- Dongshu Ni
- Donna Cummings
- Dorel Sandesc
- Dorothee Mueller
- Dorothy Terry
- Drammen Sykehus
- Dritan Muzha
- Dritan Muzha
- Duygu Kayar Calili
- Dylan De Lange
- Dylan De Lange
- Edda Johansen
- Edwin Chapeta
- Egide Buregeya
- Egidija Bielskute
- Eileen Gilder
- Eirini Pantiora
- Eirini Papageorgiou
- Eirini-Chysovalanto Patsiou
- Ekaterina Tokareva
- Elaine Barros
- Elaine Thorpe
- Eleanor Santiago
- Elena Molinos
- Eleni Achilleos
- Eliane Mazocoli
- Elie Gharios
- Elif Erdogan
- Elif Erdogan
- Elin Kristoffersen
- Elin Mari Skorstad
- Elin Steffenak
- Elina Karjula
- Elisabet Gallart
- Elisabeth Wiborg
- Elisabetta Brizio
- Elizabeth Campbell
- Elizabeth Maidana
- Elizabeth Stones
- Ella Rokosh
- Elsa Afonso
- Elsa Afonso
- Emanuel Valgolio
- Emiliano Dean
- Emilio Maseda
- Emma Aves
- Emma Moreno Barreiro
- Emma Parkin
- Enas Soula
- Eneli Anvelt
- Enora Atchade
- Epaminontas Farmakis
- Erik Roman-Pognuz
- Erika Backlund Jansson
- Eryun Tian
- Esben Straede
- Esteban Milioto
- Estefania Orozco
- Estefanía Prol-Silva
- Estevão Lafuente
- Etienne De Montmollin
- Eugenio Garofalo
- Eugenio Martinez-Hurtado
- Eugeniya Larina
- Eulália Luis
- Eumorfia Kondili
- Eunice Tole
- Eva Joelsson-Alm
- Eva Joelsson-Alm
- Eva Åkerman
- Eva Åkerman
- Evangelia Michailidou
- Evdokia Sourla
- Evellyn Oliveira
- Evgeniy Zuev
- Evren Şentürk
- Ewa Wahlbom
- Ewa Wallin
- Fabienne Etourneau
- Fabio Capuzzi
- Fabio Guarracino
- Fan Yang
- Fanglan Wang
- Farid Zand
- Farshad Heidari
- Fatema Salman
- Fateme Jafaraghaee
- Fatemeh Zarei
- Fatiha Essardy
- Fatima Fernandes
- Fatima Ferreira
- Fatima Kasem El Ahmad
- Fatime Hawchar
- Faustina Excel Adipa
- Fausto Guerrero
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- Simona Casaioli
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- Stephanie Harris
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- Stephen J Brett
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- Stijn I Blot
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- Styliani Bastani
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- Volodymyr Babych
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- Wei Zhang
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- Wendy Chaboyer
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- Wenmei Wang
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- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
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- Birgisdottir Hrönn
- Birgisdóttir Hrönn
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- Bo Qi
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- Bormans Laura
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- Boulton Karen
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- Bratsberg Bjorn
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- Broadhurst Phil
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- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
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- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
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- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
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- Castiglione Giacomo
- Cata Juan
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- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
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- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
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- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
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- Chen Jingfang
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- Chen Wenmin
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- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
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- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
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- Coyer Fiona
- Craig Geraldine
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- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
- Cummings Donna
- Cupitt Jason
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- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
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- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
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- Delgado Carlos Castro
- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
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- Derbyshire Claire
- Derrick Helen
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- Deva Shanti Rudra
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- Di Yanhong
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- Dimski Thomas
- Ding Min
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- Dobric Milena
- Dolenc Simon
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- Dong Jingwen
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- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
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- Dugernier Thierry
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- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
- Essardy Fatiha
- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
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- Farmakis Epaminontas
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- Fei Qin
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- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
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- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
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- Filipović-Grčić Ina
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- Finnstrom Inger Johanne
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- Günther Silvia Calvino
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- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
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- Avogadro Prune
- Avramopoulou Lamprini
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- Aydemir Semih
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- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
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- Balbay Abidin Oner
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- Barrueco-Francioni Jesus Emilio
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- Elhadi Ahmed
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- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
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- Eng Timothy
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- Lee Jongmin
- Lee Sang-Miin
- Lee Sang-Min
- Lee Seok Jeong
- Lee Won-Yeon
- Legorburo Maria Schofield
- Lei DeHong
- Lei Lei
- Lei Yang
- Leong Thomas
- Leonova Anna
- Lepida Dimitra
- Leslie Gavin D.
- Lestari Mayang Indah
- Levy Dassy
- Lewis Abby
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- Li Zhuqing
- Liang Jinxian
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- Liarmakopoulou Antonia
- Lijuan Sun
- Lima Ângela
- Lin Dongliang
- Lin Frances
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- Lin Xue
- Lind Ranveig
- Lipovestky Fernando
- Lipovesty Fernando
- Liu Congcong
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- Liu Kewei
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- Liu Lu
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- Llaurado-Serra Mireia
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- Pastore Beatrice
- Pastores Stephen M.
- Pathak Sabina Dhakal
- Patrichi Tatiana
- Patsalos Artemis
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- Pedersen Anne Sofie Bomholt
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- Romero-Gonzalez Juan P.
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- Tribulev Maksim
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- Triki Ahmed Ramadan
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- Trongtratul Konlawij
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- Trudvang Siw
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- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
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- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Thigh-length compression stockings and DVT after stroke
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
- Ali S
- Ali S
- Ali S
- Alkhusheh M
- Alkhusheh M
- Allanson A
- Allen L
- Allen R
- Allen S
- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
- Amosun V
- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
- Anderson R
- Andreou P
- Andrews A
- Andrews J
- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
- Appleby S
- Appleyard D
- Archer A
- Ardley C
- Arimoto R
- Arkley C
- Armah C
- Armstrong C
- Armstrong S
- Armtrong P
- Arnison-Newgass C
- Arora D
- Arter A
- Arter A
- Asghar A
- Ashbrook-Raby C
- Ashish A
- Ashish A
- Ashraf S
- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
- Ayaz E
- Azam J
- Aziz G
- Azzopardi G
- Babatunde F
- Babi M
- Babi M
- Babingto G
- Babs-Osibodu A Obaloluwa
- Bacon G
- Bacon J
- Bacon J
- Bagley G
- Bahadori K
- Baijiu G
- Bailey K
- Bailey K
- Bailey L
- Baillie H
- Baillie JK
- Baillie JK
- Baillie K
- Baird D
- Bajandouh A
- Baker E
- Baker-Moffatt M
- Bakoulas P
- Balachandran N
- Balachandran N
- Balan A
- Balaskas T
- Balasubramaniam M
- Balcombe A
- Baldwin A
- Baldwin D
- Baldwin L
- Balfour J
- Ball C
- Bamfo S Danso
- Bamford A
- Bamford A
- Bamford P
- Bamgboye A
- Bancroft H
- Banda J
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- Waterstone M
- Watkins L
- Watson AJR
- Watson E
- Watson E
- Watson R
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- Watterson D
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- Wayman E
- Weatherly N
- Webster I
- Webster T
- Weerasinghe T
- Weeratunga J
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- Wessex D Porter
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- West R
- Weston H
- Wetherall B
- Whileman A
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- Williams K Barker
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- Wilson A
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- Wilson K
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- Winder L
- Winder P
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- Winstanley M
- Winter H
- Winter J
- Wiselka M
- Wittes J
- Wolodimeroff E
- Wong N
- Wood C
- Wood F
- Wood J
- Wood L
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- Woosey D
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- Worton S
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- Wu P
- Wyness K
- Wynter I
- Xavier B
- Xia Z
- Yan M
- Yanney M
- Yasmin S
- Yates B
- Yates B
- Yates D
- Yates H
- Yein K
- Yelnoorkar F
- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
- Zafar A-M
- Zaher S
- Zalewska K
- Zaman M
- Zaman S
- Zammit L
- Zammit-Mangion M
- Zdanaviciene A
- Zehnde D
- Zhixin J
- Zhu D
- Zia M
- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Reduction of the coefficient of friction of niobium nitride coatings by the addition of bismuth
- Author
- Abadias
- Abril Fonseca-Garcia
- Aouadi
- Barna
- Benkahoul
- Cecilia C. Barrera-Ortega
- Celia L. Gómez
- Conté
- Donnet
- Donnet
- Duane
- Enrique Camps
- Esquivel-Gaon
- Ezirmik
- Flores-Castañeda
- Gao
- Garcia-Zarco
- Grattan
- Han
- Han
- Havey
- Jonatan Pérez-Alvarez
- Juan C. Medina
- Kelly
- Krishnan
- Lancaster
- Lengauer
- Mulligan
- Olaya
- Olaya
- Oliver
- Osmary Depablos-Rivera
- Petrov
- Ramírez
- Roberto Mirabal-Rojas
- Rodil
- Rodil
- Rodil
- Sandra E. Rodil
- Sandu
- Sanjines
- Schönberg
- Singh
- Singh
- Sneddon
- Stephen Muhl
- Stone
- Teer
- Veprek
- Voevodin
- Voevodin
- Voevodin
- Zeinert
- Zhang
- Zhitomirsky
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
3er. Coloquio: Fortalecimiento de los Colectivos de Docencia
- Author
- Acero Gutiérrez Adriana
- Acosta Fuentes Isaac
- Aguilar Montoya María Georgina
- Alatriste Martínez Yadira
- Alemán Urrea Vadim
- Ando Ashijara Luis Yoshiaki
- Arrollo Pedroza Verónica
- Barnard Amosorrutia Roberto G.
- Bernal Arciniega María Teresa
- Bernal Arciniega María Teresa
- Bernal Barrón Roberto
- Bernárdez de la Granja María del Carmen
- Bravo Villafuerte Cuauhtémoc
- Bárcenas Víctor M.
- Campos Corona Martha
- Carmona Maldonado Hugo
- Castillo Núñez David
- Cervantes Baque Alberto
- Collantes Vázquez Víctor Manuel
- Córdoba Flores Consuelo
- de la Cruz Flores Zamora Gabriel
- De La Torre Francisco
- Del Arenal Fenochio Jorge
- Delgado Coellar Alma Elisa
- Dávila Ulloa Adriana
- Díaz Arellano Guillermo
- Díaz Ávila Guadalupe
- Elizondo Carrillo Manuel Antonio
- Espinosa Dorantes Elizabeth
- Fernández Moreno Ruth Alicia
- Fuentes Villasante Milagros
- Garay Vargas Elisa
- García Armenta Gabriela
- García González Areli
- García Lory Susana
- García Malo Flores Carlos
- García Martínez Silvia Gabriela
- Garmendia Ramírez José Iván
- Gay González Mauricio Alan
- Goebel Christof
- González Bárcenas Jaime
- González Fragoso David
- González Montes Jaime
- González Montes Jaime Gregorio
- Guerra Benítez Gina Oliva
- Guerra Benítez Gina Oliva
- Gutiérrez R Francisco J
- Gutiérrez Trapero Olga Margarita
- Gutiérrez Trapero Olga Margarita
- Gómez Ochoa Mónica Elvira
- Gómez Ochoa Mónica Elvira
- Hernández Camacho Genaro
- Hernández García Carlos Enrique
- Hernández García Montserrat Paola
- Hernández García Montserrat Paola
- Herrera Batista Miguel Ángel
- Hirata Kitahara Miguel Toshihiko
- Huamán Herrera Elías
- Huerta Vázquez Verónica
- Hurtado Farfán Cesar Alejandro
- Ibarra Edrei
- Jiménez Corredor Tzindehé
- Jiménez Seade Haydeé Alejandra
- Kotásek González Eduardo
- Laguna Galindo Selene
- Lancón Rivera Laura Angélica
- Lancón Rivera Laura Angélica
- León Valle Alma Olivia
- López Arredondo Irma
- López Bracho Rocío
- Martinez Leal Luisa
- Martínez Herrera Teresa
- Martínez Silva César
- Marín Álvarez Marco Antonio
- Mejía Modesto Beatriz Irene
- Meléndez Crespo Ana
- Minaya Hernández Fernando Rafael
- Minaya Hernández Fernando Rafael
- Molina Mata Sandra
- Morales Aceves Jorge Armando
- Morales Moreno Jorge
- Moreno Tamayo Carlos H.
- Moyo Martinez Roció Elena
- Murillo Islas Martha Ivonne
- Muñoz Marañón Julio A.
- Neri Aceves Yolanda
- Olalde Ramos María Teresa
- Ortega García Clara
- Ortega García Clara
- Ortega Ochoa Martha Patricia
- Padilla Galicia Sergio
- Palacios Barrera Elvia
- Pedraza Vidal Juan Carlos
- Ponce Patrón Dulce Rosario
- Portilla Tirado Paulo César
- Pérez Sandoval Miguel Ángel
- Ramírez Lozano Alejandro
- Ramírez Sandoval Georgina
- Rangel Rodríguez Jorge Alonso
- Rangel Vázquez Lucía
- Redondo Gómez Maruja
- Revueltas José
- Reyna Iñiguez Auristela
- Ricárdez Sánchez J. Eugenio,
- Rivas Cruces Alfonso
- Rocha C. Víctor J.
- Sahagún Angulo Rubén
- Sahagún Angulo Rubén
- Sainz González María Itzel
- Salazar Contreras Gabriel
- Salinas Rocha Javier Eduardo
- Santos Zertuche Francisco
- Serratos Zavala Laura Elvira
- Solís Arturo
- Suarez Santacruz Julio
- Suarez Yáñez Andrés
- Sánchez De Carmona Manuel
- Sánchez Martínez María Esther
- Sánchez Paredes Torres Alinne
- Sánchez Parredes Torres Alinne
- Sánchez Ruiz Gerardo
- Toledo Ramírez Francisco Gerardo
- Tovar Romero Iarene Argelia
- Valdez Vargas Celso
- Valenzuela Romero Jocelyn Dafne
- Vanden Broeck Fabricio
- Vargas Serrano María Georgina
- Vassis Christos
- Velarde Gutiérrez Bárbara
- Velarde Gutiérrez Bárbara Paulina
- Vielma Moreno Jaime
- Villeda Ayala Rafael
- Zaragoza Contreras Araceli
- Álvarez Martínez Rosa Elena
- Álvarez Martínez Rosa Elena
- Ángeles Cañedo Juana Cecilia
- Publication venue
- Publication date
- 23/03/2021
- Field of study
Las memorias del 3er. Coloquio de Fortalecimiento de Colectivos de Docencia
deben ser entendidas como un esfuerzo colectivo de la comunidad de académicos de la División de Ciencias y Artes para el Diseño, en medio de la pandemia COVID-19, con el fin de:
• Analizar y proponer acciones concretas que promuevan el mejoramiento de la calidad docente en la División.
• Proponer acciones que permitan continuar fortaleciendo los cursos con modalidad a distancia (remotos).
• Ante un escenario que probablemente demandará en el mediano plazo, transitar del modelo remoto a un modelo híbrido, proponer acciones a considerar para la transición de los cursos.
• Planear y preparar cursos de nivelación de conocimientos, para cuando se transite a la impartición de la docencia de manera mixta o presencial, dirigidos a los alumnos que no hayan tenido oportunidad de desarrollar actividades relevantes para su formación, como prácticas de talleres y laboratorios, visitas, o alguna otra actividad relevante
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
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- Abouibrahim M
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- Ah-Chuen J
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- Ail D
- Ainsley A
- Ainsworth M
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- Akili S
- Akindolie O
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- Willis J
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- Xia Z
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- Yanney M
- Yasmin S
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- Yates D
- Yates H
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- Yelnoorkar F
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- Ynter I
- Yorke J
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- Zaher S
- Zalewska K
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- Zdanaviciene A
- Zehnde D
- Zhixin J
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- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial
- Author
- Aguirre-García Gloria Mayela
- Ahuad Guerrero Rodolfo Andres
- Ahuad Guerrero Rodolfo Andrés
- Arana-Arri Eunate
- Arancibia Luna Lesly Angela
- Arias Hoo Dommie Janneth
- Aroca Martinez Gustavo Jose
- Arredondo Saldaña Felipe
- Ascaso del Río Ana
- Balmaceda Maria Pia
- Barrera Perigault Paulo
- Bautista Toloza Leonardo
- Bobat Antonela
- Boersma Wim
- Boggia Bruno Emilio
- Bonten Marc
- Borchowiek Silvina
- Braida Ariel
- Brecx Alain
- Bustinduy Odriozola Maria Jesus
- Camacho Choza Laura Julia
- Camara Anais
- Candelario Rosalba
- Carbajal Paulet Óscar
- Castella Sofia
- Castro Castrezana Laura
- Celis Carlos R.
- Chan Milagros
- Chandler Reynaldo
- Cheatham-Seitz Darline
- Chávez Barón Jaime
- Collazos Lennis Maria Fernanda
- Cornejo Enrique
- Cornejo Rubelio E.
- Corral Gonzalo
- de Bie Jessie
- de Block Eddie Jan Louis
- de Jonge Hanna K.
- de la Flor Carolina
- de Winter Ronald Frank Jacobus
- DeAntonio Rodrigo
- Diaz-Parra Carmen
- Diez Fabián
- Dittrich Ricardo Julio
- Djamin Remco
- Donastorg Yeycy
- Durigan Virginia
- Durán Laviña María Isabel
- Eberts Sandra
- Ecker Lucie
- Escobar Johnny
- Esen Meral
- Espínola Lidia
- Fendel Rolf
- Fernandez Alberto
- Fleischmann Wim Alexander
- Flores Omar
- Foccoli Monica
- Gabor Julian Justin
- Gallego Mikel
- Ganaha Maria Cristina
- Garcia Lopez Carlos Alberto
- García Cruz Johanna Marcela
- García-de-Vicuña Aitor
- Gil Ana I.
- Gonzales Lucy
- González Limón Pablo
- Gorini Nestor
- Granados González María Angélica
- Grandez Castillo Gustavo Alberto
- Grazziani Franco
- Gregoraci Giorgia
- Grobusch Martin P.
- Guardiani Fernando Martin
- Guzman Quintanilla Fernanda
- Guzman Esperanza
- Hammerschlag Icaza Bruno
- Herrera Sanchez Javier
- Hessels Lisa
- Horn Carola
- Hrabar Adrian D.
- Huber Kristina
- Imaz-Ayo Natale
- Junker Helga
- Kimura Alan
- Koehne Erik
- Kreidenweiss Andrea
- Kremsner Peter G.
- Kroidl Arne
- Köhler Carsten
- Ladino González Margot Cecilia
- Lama Javier R.
- Lambert Sandra
- Lanata Claudio F.
- Lantigua Flavia
- Laredo Velasco Leonor
- Larrea Arranz Igor
- Lehmann Clara
- Leroux-Roels Isabel
- Longhi Andrea
- Lovesio Luciano
- Luján Palacios Juan de Dios
- Mann Philipp
- Martella Carolina
- Martinez Avendaño Alejandro
- Martinez-Reséndez Michel Fernando
- Martínez Alcorta Luis Ignacio
- Mastruzzo María
- Matta Aguirre Milagros Erika
- Mayorga Valerie
- Mazara Rosario Sonia
- Mazo Elorza Diana Patricia
- Meijide Susana
- Morales-Oliva Jose
- Nemi Sergio Andrés
- Ochoa Mayra
- Ochoa Theresa J.
- Olmos Vega Jocelyn
- Oostvogels Lidia
- Ortega Dominguez Sandra Janeth
- Pedernera Aldana
- Peña Mendez Lourdes
- Peña Bia
- Peña Moisés
- Piedimonte Fabián C. sar
- Portolés-Pérez Antonio
- Potito Roberto
- Poy Carlos Alberto
- Prieto Pradera I. igo
- Quintini Gianluca
- Ramírez Lamas Suzanne Pamela
- Rebollon Gabriel
- Reyes Fentanes Maria Jose
- Reyes Gilda
- Reynales Londoño Humberto
- Ricalde Sheby A.
- Rios Nogales Luis
- Rivera Mejia Luis Maria
- Rivera Laura
- Rodríguez Ordoñez Paula Andrea
- Rojas Marianela
- Rosario Gomez Nadia
- Ruiz Herrera Vida Veronica
- Ruiz Palacios y Santos Guillermo Miguel
- Ruiz Sergio
- Sanes Fatima
- Santorcuato Ana
- Schnyder Jenny L.
- Schunk Mirjam
- Schönborn-Kellenberger Oliver
- Seibel Tobias
- Sierra Garcia Alexandra
- Solano Mosquera Lina Marianur
- Sáez-Llorens Xavier
- Tartaglione Javier Gerardo
- Thiel Verena
- Torres Almanzar Dania
- Torres Hernandez Daniela
- Torres Quiroz Ivonne Aimee
- Vahrenhorst Dominik
- Valdiviezo Gladys
- van der Sar Simone
- Vanegas Dominguez Beatriz
- Vecchio Claudia
- Vega Orozco Karen Sofia
- Vergara Itziar
- Verstraeten Thomas
- Vico Marisa
- Vidal Jhonny
- Vázquez Saldaña Eduardo Gabriel
- Vázquez Villar Andrea
- Walz Lisa
- Webb Camille María
- Wong t Digna Y.
- Zalatnik Viviana Judith
- Zambrano Ochoa Adriana Pilar
- Zambrano Ortiz José
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2022
- Field of study
Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18–60 years and ≥61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0·6 mL doses of CVnCoV containing 12 μg of mRNA or two 0·6 mL doses of 0·9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020–003998–22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48·2 days (SE 0·2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735·29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569·87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48·2% (95·826% CI 31·0–61·4; p=0·016). Vaccine efficacy against moderate-to-severe COVID-19 was 70·7% (95% CI 42·5–86·1; CVnCoV 12 cases in 1735·29 person-years, placebo 37 cases in 1569·87 person-years). In participants aged 18–60 years, vaccine efficacy against symptomatic disease was 52·5% (95% CI 36·2–64·8; CVnCoV 71 cases in 1591·47 person-years, placebo, 136 cases in 1449·23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96·5%] of 2003) than in placebo recipients (1344 [67·9%] of 1978), with 542 (27·1%) CVnCoV recipients and 61 (3·1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83·6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80·0%] of 2003) and headache (1541 [76·9%] of 2003). 82 (0·4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0·3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0·2%) participants in the CVnCoV group and 31 (0·2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0·1%) participants in the CVnCoV group and for five (<0·1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- Author
- Aalfs Cora M.
- Adank Muriel A.
- Adenis Claude
- Adlard Julian
- Agata Simona
- Aghmesheh Morteza
- Agnarsson Bjarni A.
- Ahearn Thomas
- Aittomaki Kristiina
- Ambrosone Christine B.
- Amor David
- Andrews Lesley
- Andrulis Irene L.
- Angel Pujana Miquel
- Antill Yoland
- Anton-Culver Hoda
- Antonenkova Natalia N.
- Antoniou Antonis C.
- Armitage Shane
- Arndt Volker
- Arnold Leanne
- Arnold Norbert
- Aronson Kristan J.
- Arun Banu K.
- Asseryanis Ella
- Auber Bernd
- Auvinen Paivi
- Azzollini Jacopo
- Balleine Rosemary
- Balmana Judith
- Barkardottir Rosa B.
- Barnes Daniel R.
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barwell Julian
- Bastick Patti
- Baurand Amandine
- Baxter Robert
- Beauparlant Charles Joly
- Beckmann Matthias W.
- Beesley Jonathan
- Behrens Sabine
- Beilby John
- Belotti Muriel
- Benitez Javier
- Bennett Ian
- Berger Raanan
- Bermisheva Marina
- Berthet Pascaline
- Bertolone Geoffrey
- Bertrand Ophelie
- Bezieau Stephane
- Bignon Yves-Jean
- Birot Anne-Marie
- Blackburn Anneke
- Blanco Amie M.
- Blomqvist Carl
- Bogdanova Natalia, V
- Bogliolo Massimo
- Bogwitz Michael
- Bojesen Anders
- Bojesen Stig E.
- Bolla Manjeet K.
- Bonadona Valerie
- Bonanni Bernardo
- Bonnet Francoise
- Borg Ake
- Botes Leon
- Bourdon Violaine
- Boutry-Kryza Nadia
- Brady Angela F.
- Brauch Hiltrud
- Braye Stephen
- Brennan Meagan
- Brenner Hermann
- Bressac-de-Paillerets Brigitte
- Bronner Myriam
- Brown Melissa
- Bruening Thomas
- Bubien Virginie
- Buckley Michael
- Buecher Bruno
- Burgess Matthew
- Burke Jo
- Burwinkel Barbara
- Butow Phyllis
- Buys Saundra S.
- Cadoo Karen
- Caldes Trinidad
- Caldon Liz
- Caleca Laura
- Calender Alain
- Caliebe Almuth
- Caligo Maria A.
- Callen David
- Campa Daniele
- Campbell Ian G.
- Canzian Federico
- Caputo Sandrine
- Caron Olivier
- Carpenter Jane
- Castelao Jose E.
- Castera Laurent
- Catucci Irene
- Chang-Claude Jenny
- Chanock Stephen J.
- Chauhan Deepa
- Chauhan Manisha
- Chenevix-Trench Georgia
- Chiesa Jean
- Christian Alice
- Chung Wendy K.
- Claes Kathleen B. M.
- Clarke Christine L.
- Cohen Paul
- Colas Chrystelle
- Collavoli Anita
- Colley Alison
- Collonge-Rame Marie-Agnes
- Conner Thomas A.
- Coron Fanny
- Couch Fergus J.
- Coulet Florence
- Coupier Isabelle
- Cox David G.
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret
- Cybulski Cezary
- Czene Kamila
- Dahlstrom Jane
- Daly Mary B.
- Damette Alexandre
- Dawson Sarah-Jane
- de la Hoya Miguel
- de Pauw Antoine
- DeFazio Anna
- Delatycki Martin
- Delnatte Capucine
- Dennis Joe
- Devilee Peter
- Dickson Rebecca
- Diez Orland
- Ding Yuan Chun
- Dite Gillian S.
- Ditsch Nina
- Dixon Joanne
- Dobrovic Alexander
- Doerk Thilo
- Domchek Susan M.
- Dorfling Cecilia M.
- dos-Santos-Silva Isabel
- Dreyfus Helene
- Dudding Tracy
- Dumont Aurelie
- Dunning Alison M.
- Dupre Anais
- Durda Katarzyna
- Dwek Miriam
- Easton Douglas F.
- Eccles Diana M.
- Edkins Ted
- Edwards Stacey
- Eisenbruch Maurice
- Ekici Arif B.
- Eliassen A. Heather
- Ellberg Carolina
- Eriksson Mikael
- Evans D. Gareth
- Faivre Laurence
- Farshid Gelareh
- Fasching Peter A.
- Feillel Viviane
- Fellows Andrew
- Fenton Georgina
- Fert-Ferrer Sandra
- Field Michael
- Figlioli Gisella
- Figueroa Jonine
- Flanagan James
- Flyger Henrik
- Fong Peter
- Forbes John
- Forrest Laura
- Fostira Florentia
- Foulkes William D.
- Fourme Emmanuelle
- Fox Stephen
- Freeman Laura E. Beane
- French Juliet
- Friebel Tara M.
- Friedlander Michael
- Friedman Eitan
- Gabrielson Marike
- Gaddam Pragna
- Gaff Clara
- Gago-Dominguez Manuela
- Gallego-Ortega David
- Gao Chi
- Gapstur Susan M.
- Garber Judy
- Garcia-Closas Montserrat
- Garcia-Saenz Jose A.
- Gattas Mike
- Gaudet Mia M.
- Gauthier-Villars Marion
- Gayther Simon A.
- George Peter
- Gesta Paul
- Giles Graham G.
- Gill Grantley
- Giraud Sophie
- Gladieff Laurence
- Glendon Gord
- Godwin Andrew K.
- Goldberg Mark S.
- Goldgar David E.
- Golmard Lisa
- Greene Mark H.
- Greening Sian
- Guenel Pascal
- Guillaud-Bataille Marine
- Guimbaud Rosine
- Gutierrez-Barrera Angelica M.
- Haan Eric
- Haeberle Lothar
- Hahnen Eric
- Haiman Christopher A.
- Hakansson Niclas
- Hall Per
- Hamann Ute
- Harrington Patricia A.
- Harris Marion
- Hart Stewart
- Hayward Nick
- Hein Alexander
- Heiniger Louise
- Heyworth Jane
- Hillemanns Peter
- Hollestelle Antoinette
- Hopper John L.
- Hosgood H. Dean, III
- Howell Anthony
- Hu Chunling
- Hulick Peter J.
- Hunt Clare
- Hunter David J.
- Imyanitov Evgeny N.
- Ingster Olivier
- Isaacs Claudine
- Jacquot Caroline
- Jakimovska Milena
- Jakubowska Anna
- James Paul
- Janavicius Ramunas
- Janni Wolfgang
- Jenkins Mark
- John Esther M.
- Jones Michael E.
- Jung Audrey
- Kaaks Rudolf
- Karlan Beth Y.
- Kefford Rick
- Khusnutdinova Elza
- Kidd Alexa
- Kientz Caroline
- Kiiski Johanna, I
- Kirk Judy
- Kitahara Cari M.
- Koehler Jessica
- Kollias James
- Konstantopoulou Irene
- Koutros Stella
- Kraft Peter
- Lakhani Sunil
- Lallaoui Hakima
- Lambrechts Diether
- Lasset Christine
- Lazaro Conxi
- Le Marchand Loic
- Le Mentec Marine
- Lebrun Marine
- Lee C. Soon
- Legrand Clementine
- Lejbkowicz Flavio
- Lejeune Sophie
- Leone Mlanie
- Leroux Christine Dominique
- Leslie Goska
- Lester Jenny
- Lesueur Fabienne
- Lilyquist Jenna
- Lindeman Geoff
- Lipton Lara
- Lizard Sarab
- Lobb Liz
- Longy Michel
- Loud Jennifer T.
- Lu Karen H.
- Luben Robert N.
- Lubinski Jan
- Lush Michael
- Mann Graham
- Mannermaa Arto
- Manoochehri Mehdi
- Manoukian Siranoush
- Manouvrier-Hanu Sylvie
- Margolin Sara
- Mari Vronique
- Marsh Deborah
- Martens John W. M.
- Maurer Tabea
- Mavroudis Dimitrios
- McGuffog Lesley
- McLachlan Sue Anne
- Mebirouk Noura
- Meindl Alfons
- Meiser Bettina
- Menon Usha
- Michailidou Kyriaki
- Miller Austin
- Milne Roger L.
- Molina-Gomes Denise
- Moncoutier Virginie
- Montagna Marco
- Morey Adrienne
- Mortemousque Isabelle
- Muller Daniele
- Muranen Taru A.
- Nathanson Katherine L.
- Neuhausen Susan L.
- Nevanlinna Heli
- Newman William G.
- Nguyen-Dumont Tu
- Nielsen Finn Cilius
- Nielsen Sarah
- Nightingale Sophie
- Nikitina-Zake Liene
- Noguchi Tetsuro
- Nogues Catherine
- O'Connell Shona
- O'Sullivan Sarah
- Offit Kenneth
- Olah Edith
- Olopade Olufunmilayo, I
- Olshan Andrew F.
- Olson Janet E.
- Olsson Hakan
- Osorio Ana
- Ottini Laura
- Pachter Nick
- Parsons Michael T.
- Pathmanathan Nirmala
- Patterson Briony
- Peissel Bernard
- Peixoto Ana
- Peterlongo Paolo
- Peto Julian
- Peysselon Magalie
- Pharoah Paul D. P.
- Phillips Kelly
- Pieper Ellen
- Plaseska-Karanfilska Dijana
- Pocza Timea
- Popovici Cornel
- Presneau Nadege
- Prieur Fabienne
- Pujol Pascal
- Pujol Roser
- Punie Kevin
- Rack Brigitte
- Radice Paolo
- Ramus Susan J.
- Rantala Johanna
- Rashid Muhammad U.
- Rau-Murthy Rohini
- Rebischung Christine
- Remenieras Audrey
- Rennert Gad
- Revillion Francoise
- Rhenius Valerie
- Rickard Edwina
- Robinson Bridget
- Romero Atocha
- Rookus Matti A.
- Ross Eric A.
- Rossing Maria
- Rudaitis Vilius
- Ruebner Matthias
- Saleh Mona
- Salisbury Elizabeth
- Saloustros Emmanouil
- Sambrook Joe
- Sanden Kristin
- Santamarina Marta
- Saule Claire
- Saunders Christobel
- Saunus Jodi
- Scheuner Maren T.
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Schneider Michael
- Scott Christopher
- Scott Clare
- Scott Elizabeth
- Scott Rodney
- Senter Leigha
- Sevenet Nicolas
- Sexton Adrienne
- Shah Mitul
- Sharma Priyanka
- Shelling Andrew
- Shu Xiao-Ou
- Simard Jacques
- Simpson Peter
- Singer Christian F.
- Sobol Hagay
- Sohn Christof
- Sokolowska Johanna
- Soubrier Florent
- Soucy Penny
- Southey Melissa C.
- Spigelman Allan
- Spinelli John J.
- Spurdle Amanda
- Steele Linda
- Stoppa-Lyonnet Dominique
- Surralles Jordi
- Swerdlow Anthony J.
- Tapper William J.
- Taylor Jessica
- Teixeira Manuel R.
- Terry Mary Beth
- Thomassen Mads
- Thompson Jennifer
- Thorne Heather
- Thull Darcy L.
- Tischkowitz Marc
- Toland Amanda E.
- Tollenaar Rob A. E. M.
- Torres Diana
- Toulas Christine
- Trainer Alison
- Troester Melissa A.
- Truong Therese
- Tucker Kathy
- Tung Nadine
- Uhrhammer Nancy
- Untch Michael
- Vachon Celine M.
- van Rensburg Elizabeth J.
- van Veen Elke M.
- Vaur Dominique
- Vega Ana
- Venat-Bouvet Laurence
- Viel Alessandra
- Visvader Jane
- Viz Lasheras Sandra
- Walker Logan
- Wang Qin
- Wappenschmidt Barbara
- Warcoin Mathilde
- Weitzel Jeffrey N.
- Wendt Camilla
- Wieme Greet
- Wilcken Nicholas
- Williams Rachael
- Winship Ingrid
- Wolk Alicja
- Yang Xiaohong R.
- Yip Desmond
- Young Mary Ann
- Zeps Nikolajs
- Zheng Wei
- Ziogas Argyrios
- Zorn Kristin K.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PAM, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and pArg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM(-/-) patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors