Planeación estratégica de las pymes del sector metalmecánico

La asimilación del Direccionamiento Estratégico en el sector metalmecánico para las pequeñas y medianas empresas es fundamental para el desarrollo económico propio y de la nación, ya que potencializa la productividad mediante la fijación de objetivos y planes estratégicos enfocados en el mejoramiento de la calidad, del servicio y de las actividades complementarias para cumplir dichos objetivos. La importancia de la implementación del Direccionamiento Estratégico en este sector radica en la relevancia que tiene para contribuir al país con la generación de empleo, y en gran medida a la economía nacional y una formalización de la industria que conlleve a grandes ventajas competitivas a nivel internacional. El presente artículo es una revisión bibliográfica acerca del Direccionamiento Estratégico de las pymes del sector metalmecánico cuyos objetivos fueron: identificar el direccionamiento estratégico de las pymes del sector metalmecánico, describir los factores del Direccionamiento Estratégico, establecer las estrategias del direccionamiento de las pymes y examinar los procesos estratégicos del sector metalmecánico así como la metodología se realizó en tres etapas: comprensión lectora, análisis de la información recopilada y síntesis. Para concluir el direccionamiento estratégico define la orientación de los productos y servicios hacia el mercado de las pymes del sector metalmecánico el cual permite determinar el crecimiento de las pequeñas y mediana empresas.Theassimilation of the Strategic Direction in the metal-mechanic sector for small and medium enterprises is fundamental for the economic development of the nation and itself, since it potentiates productivity through the establishment of objectives and strategic plans focused on the improvement of quality, of service and complementary activities to meet these objectives. The importance of the implementation of the Strategic Direction in this sector lies in the relevance that has to contribute to the country with the employment generation, and largely to the national economy and a formalization of the industry that leads to great competitive advantages at the international level. This article is a bibliographic review about the Strategic Direction of SMEs in the metalworking sector whose objectives were: to identify the strategic direction of SMEs in the metal-mechanic sector, describe the factors of Strategic Management, establish SME targeting strategies and examine the strategic processes of the metalworking sector as well as the methodology was carried out in three stages: reading comprehension, analysis of the information collected and synthesis. To conclude the strategic direction defines the orientation of products and services to the market of SMEs in the metalworking sector which allows to determine the growth of small and medium enterprises

Propuesta en Supply Chain Management y Logística en la empresa Clarios Andina S.A.S

Este trabajo contiene el análisis realizado en la cadena de suministro y logística de la empresa Clarios Andina SAS en el cual se detallan los proceso ejecutados por la empresa mediante métodos estratégicos, permitiendo evidenciar buenas prácticas en sus ejecuciones, pero también oportunidades de mejora en algunos puntos del proceso, mediante la investigación de toda la cadena de suministro de esta empresa este documento propone mejoras en los procesos de gestión de inventarios, relación con sus clientes y proveedores las cuales permitirán disminuir costos, mejorar su eficiencia económica utilidades y realizar una mejora continua a sus proceso que ayudara a que la empresa se sostenga en el tiempo como una empresa competitiva, además se detallan los medios de transporte usados por la empresa para su abastecimiento y despacho de mercancía hacia sus clientes.This work contains the analysis supply chain and logistics of the company Clarios Andina SAS in which the processes executed by the company are detailed through strategic methods, allowing to demonstrate good practices in their executions, but also opportunities for improvement in some points of the process, through the investigation of the entire supply chain of this company, this document proposes improvements in the processes of inventory management, relationship with its clients and suppliers which will allow to reduce costs, improve its economic efficiency, profits and make a continuous improvement to Its process that will help the company to sustain itself over time as a competitive company, also details the means of transport used by the company for its supply and dispatch of merchandise to its customers

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons

Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). There is compelling evidence that mouse and human ALS and ALS/FTD astrocytes can reduce the number of healthy wild-type motoneurons (MNs) in co-cultures or after treatment with astrocyte conditioned media (ACM), independently of their genotype. A growing number of studies have shown that soluble toxic factor(s) in the ACM cause non-cell autonomous MN death, including our recent identification of inorganic polyphosphate (polyP) that is excessively released from mouse primary astrocytes (SOD1, TARDBP, and C9ORF72) and human induced pluripotent stem cells (iPSC)-derived astrocytes (TARDBP) to kill MNs. However, others have reported that astrocytes carrying mutant TDP43 do not produce detectable MN toxicity. This controversy is likely to arise from the findings that human iPSC-derived astrocytes exhibit a rather immature and/or reactive phenotype in a number of studies. Here, we have succeeded in generating a highly homogenous population of functional quiescent mature astrocytes from control subject iPSCs. Using identical conditions, we also generated mature astrocytes from an ALS/FTD patient carrying the TDP43A90V mutation. These mutant TDP43 patient-derived astrocytes exhibit key pathological hallmarks, including enhanced cytoplasmic TDP-43 and polyP levels. Additionally, mutant TDP43 astrocytes displayed a mild reactive signature and an aberrant function as they were unable to promote synaptogenesis of hippocampal neurons. The polyP-dependent neurotoxic nature of the TDP43A90V mutation was further confirmed as neutralization of polyP in ACM derived from mutant TDP43 astrocytes prevented MN death. Our results establish that human astrocytes carrying the TDP43A90V mutation exhibit a cell-autonomous pathological signature, hence providing an experimental model to decipher the molecular mechanisms underlying the generation of the neurotoxic phenotype

Reto logístico en el tiempo de entrega del material "tetra pak" a las diferentes plantas de productos lácteos en la república mexicana

Tesis (Ingeniería Industrial), Instituto Politécnico Nacional, UPIICSA, 2010, 1 archivo PDF, (116 páginas). tesis.ipn.m