Women Give 2012: New Research about Women and Giving

Women Give 2012 focuses on the effect of age and gender on charitable giving, with a spotlight on giving by Baby Boomers (born between 1946 and 1964) and older Americans. The new report is the third in a series of research reports by the Women's Philanthropy Institute at the Center on Philanthropy at Indiana University that offers deeper insights as to how gender differences affect philanthropy.The Women Give studies complement a growing body of research that affirms women's growing importance as donors in the nonprofit sector. They also benefit decision-makers and fundraisers seeking to expand their donor base and attract more volunteers by providing key insights to inform their strategic efforts to more deeply engage women

Women and Philanthropy: A Literature Review (2009)

Over the past 30 years, women have emerged on the philanthropic landscape as a visible and bold presence. They are changing the face of philanthropy and are transforming society around the world. Today’s reality is that women, strengthened by increasing economic power and education, are as likely as men to be philanthropists. Yet, the body of research literature on women’s philanthropic giving is lagging behind the reality of what is happening in practice around the world. Recently, however, interest in understanding how and why women give has gotten underway—particularly over the past decade--prompting researchers to examine gender issues in philanthropy from new angles. These research findings suggest that a more proactive, strategic engagement of women in philanthropy will unleash new human and financial resources for the public good

Women Give 2012

Women Give 2012 focuses on the effect of age and gender on charitable giving, with a spotlight on giving by Baby Boomers (born between 1946 and 1964) and older Americans

Synthesis and biological evaluation of carbohydrate-mimetics as ligands for Siglecs

Sialic acid binding immunoglobulin-like lectins (Siglecs) play an important role in the mediation of cell-cell interactions as well as in the regulation of signaling pathways. They are mainly expressed in the haematopoietic and immune system, with exception of Siglec-4, also called myelin-associated glycoprotein (MAG). It was identified as one of neurite outgrowth inhibitors, playing a crucial role in paraplegia, which is caused by injuries of the central nervous system (CNS) and especially young people suffer from these severe consequences as, for example, the loss of motor functions. The lack of repair of the injured nerve strands originates from the inhibitory environment for axon regeneration in the CNS. SpeciÞc inhibitory proteins, such as MAG block the regrowth of nerve roots. We identiÞed potent small molecule MAG antagonists modifies in the 2- and 5-position. Furthermore, we investigated new neuraminic acid derivatives modiÞed in the 4-position, and the inßuence of various structural modiÞcations on their kinetic and thermodynamic binding properties. In a next step we presented high affinity ligands, which were identified in second-site screenings and optimized them according to medicinal chemistry aspects. All ligands were elucidated with respect to their binding affinity as well as their kinetic and thermodynamic profile. Siglec-2, also known as CD22, is involved in the regulation and survival of B-cells and has been successfully targeted in cell depletion therapies with antibody-based approaches. Sialic acid derivatives, already known to bind with high affinity to myelin-associated glycoprotein (MAG, Siglec-4), were screened for their binding affinity for CD22 by surface plasmon resonance. The best compound identified was further modified with various hydrophobic substituents at the 2-, 5-, and 9-positions of the sialic acid scaffold, leading to nanomolar derivatives. Furthermore, initial tests regarding drug-like properties of these antagonists demonstrate the required high plasma protein binding yet a lack of oral availability, although its distribution coefficient (log D) is in the required range. Finally, we investigated a library of sialic acid mimetics with respect to binding towards another member of the Siglec family, namely Sialadhesin and discuss the influence of various structural moieties with regard to the arising selectivity towards these three proteins

The Effects of Platelet-Rich Plasma Injections on Patellar Tendinopathy

Physical therapy is often a very successful tool in the treatment of patellar tendinopathy and should be followed and implemented for at least 3 to 6 months as a first line of treatment. For those individuals suffering from recalcitrant patellar tendinopathy that have failed more conservative treatments, it may be worthwhile to include PRP injection therapy as a recommendation. Studies have shown decreases in tendon irregularities and results of pain reduction and/or increased function after PRP injection. Although current research is of lower quality and confers no clear benefit that can be stated with certainty, we can say PRP injection is a very safe and minimally invasive procedure that almost always provided patients with some sort of pain reduction and allowed many of the subjects to return to sport and play to full capacity. Further high quality research is needed in this area

Variations in tactile signing – the case of one-handed signing

Tactile sign language is a variety of a national sign language. Tactile signing among persons with deafblindness also includes some minor variations. Early analyses of tactile Swedish Sign Language (e.g. Mesch 1998, 2001) show how interactants use both their hands in tactile communication in two different positions: dialogue position and monologue position. This paper examines the signing variations that partially or functionally blind signers encounter when using one hand to communicate with each other in a conversation dyad in what is one of the most advanced types of sign language communication. In tactile one-handed signing, the signer uses her right hand both for producing and receiving signs, while the addressee uses her left hand not only for receiving but also for producing signs after turn-taking, even though it is the non-dominant hand and, therefore, is not normally used to produce one-handed signs. In this study, conversation analysis was conducted on the discourse of four groups.The results show that some variations depend on the linguistic background of individuals and their everyday communication. A com-parative study of a two-handed and a one-handed system is then presented, focusing on issues of simplicity, flexibility, turn-taking, and feedback. Some results showing changes in the sign structures of both communication types are also presente

Women Give 2020

By focusing on technology, Women Give 2020 seeks to understand how women’s greater use of social networks and greater presence in key online spaces might influence philanthropy. This subject resonates in particular with women donors who are often drawn to philanthropy through collective giving and the sense of community they build when giving together. Women are inclined to give more than money, combining charitable donations with volunteer or board service, or with more informal giving and helping. Moreover, women donors tend to be drawn to some causes in particular, such as women’s and girls’ issues, or other organizations to which they are connected personally