XMM-Newton Observations Reveal Very High X-ray Luminosity from the Carbon-rich Wolf-Rayet Star WR 48a

We present XMM-Newton observations of the dusty Wolf-Rayet star WR 48a. This is the first detection of this object in X-rays. The XMM-Newton EPIC spectra are heavily absorbed and the presence of numerous strong emission lines indicates a thermal origin of the WR 48a X-ray emission, with dominant temperature components at kT_cool approx. 1 keV and kT_hot approx. 3~keV, the hotter component dominating the observed flux. No significant X-ray variability was detected on time scales < 1 day. Although the distance to WR 48a is uncertain, if it is physically associated with the open clusters Danks 1 and 2 at d ~ 4 kpc, then the resultant X-ray luminosity L_X ~ 10^(35) ergs/s makes it the most X-ray luminous Wolf-Rayet star in the Galaxy detected so far, after the black-hole candidate Cyg X-3. We assume the following scenarios as the most likely explanation for the X-ray properties of WR 48a: (1) colliding stellar winds in a wide WR+O binary system, or in a hierarchical triple system with non-degenerate stellar components; (2) accretion shocks from the WR 48a wind onto a close companion (possibly a neutron star). More specific information about WR48a and its wind properties will be needed to distinguish between the above possibilities.Comment: 10 pages, 3 figures, 1 table, accepted for publication in The Astrophysical Journal Letter

Cultural flies:Conformist social learning in fruitflies predicts long-lasting mate-choice traditions

Despite theoretical justification for the evolution of animal culture, empirical evidence for it beyond mammals and birds remains scant, and we still know little about the process of cultural inheritance. In this study, we propose a mechanism-driven definition of animal culture and test it in the fruitfly. We found that fruitflies have five cognitive capacities that enable them to transmit mating preferences culturally across generations, potentially fostering persistent traditions (the main marker of culture) in mating preference. A transmission chain experiment validates a model of the emergence of local traditions, indicating that such social transmission may lead initially neutral traits to become adaptive, hence strongly selecting for copying and conformity. Although this situation was suggested decades ago, it previously had little empirical support.</p

The XMM-Newton view of PG quasars I. X-ray continuum and absorption

We present results of a systematic analysis of the XMM-Newton spectra of 40 quasars (QSOs) (z<1.72) from the Palomar-Green (PG) Bright Quasar Survey sample (M_B<-23). The sample includes 35 radio-quiet quasars (RQQs) and 5 radio-loud quasars (RLQs). The analysis of the spectra above 2 keV reveals that the hard X-ray continuum emission can be modeled with a power law component with = 1.89+/-0.11 and = 1.63^(+0.02)_(-0.01) for the RQQs and RLQs, respectively. Below 2 keV, a strong, broad excess is present in most QSO spectra. This feature has been fitted with four different models assuming several physical scenarios. All tested models (blackbody, multicolor blackbody, bremsstrahlung and power law) satisfactorily fitted the majority of the spectra. However, none of them is able to provide an adequate parameterization for the soft excess emission in all QSOs, indicating the absence of an universal shape for this spectral feature. An additional cold absorption component was required only in three sources. On the other hand, as recently pointed out by Porquet et al. (2004) for a smaller sample of PG QSOs, warm absorber features are present in ~50% of the QSO spectra in contrast with their rare occurrence (~5-10%) found in previous studies. The XMM-Newton view of optically-selected bright QSOs therefore suggests that there are no significant difference in the X-ray spectral properties once compared with the low-luminosity Seyfert 1 galaxies. Properties of the Fe Kalpha emission lines are presented in a companion paper.Comment: To be published in A&

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Ni stuc, ni peinture : un traitement illusionniste des enduits

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Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis

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The importance of new collection efficiency values including the effect of rear capture for the below-cloud scavenging of aerosol particles

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