Novel cobalt complexes with glyoximes : synthesis, physicochemical analysis and biological study

Azomethine derivatives have several applications, especially as reagents for the determination of transition metal ions. Furthermore these ligands and their cobalt complexes were also reported to possess biological activities, such as antimicrobial, anti-tubercular, anticonvulsant, anti-inflammatory, anti-proliferative activities as well as antifungal inhibition potential [1]. Another reason for using metal-containing compounds as structural scaffolds is related to the kinetic stability of their coordination spheres in the biological environment. Metallic ions have been shown to play important role in the biological activity of different compounds in such away that, in some cases, activity is enhanced or only takes place in the presence of these ions [2]. In our research new cobalt(III) complexes were synthesized with -glyoximes, azides, amines, thiocyanate and halogens, such as [Co(Me-propyl-GlyoxH)2(N3)(amine)], [Co(Mepentyl-GlyoxH)2(N3)(amine)], [Co(Et-propyl-GlyoxH)2(N3)(amine)], [Co(Et-propylGlyoxH)2(Br)(amine)], [Co(Et-propyl-GlyoxH)2(SCN)(amine)], H[Co(Et-propylGlyoxH)2(SCN)2], [Co(phenyl-Me-GlyoxH)2(amine)2]I, [Co(Et-propyl-GlyoxH)2(amine)2]I, [Co(Et-Bu-GlyoxH)2(amine)2]I, where GlyoxH = mono deprotonated glyoxime, and the used amines: imidazole, 3-hydroxy-aniline, lepidine, 3,5-dimethyl-pyridine, di(n-butyl)-amine, diisopropyl-amine, 2-amino-pyrimidine, diphenyl-amine, 2-picoline, 3-picoline. The Co(II)- acetate salt dissolved in water and mixed with the glyoxime alcoholic solution was oxidized by air bubbling, then the corresponding diamines and the other complexing agents were added. The molecular structure of our products was investigated by IR, UV–VIS spectroscopy, mass spectrometry (MS), thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity, like antimicrobial effect, was studied for a few bacteria

Novel platinum complexes with schiff bases and α-Dioximes, their physico-chemical and biological study

In our research project we prepared the following platinum(II) complexes with Schiff bases and -dioximes, such as [Pt(ketone)2A(L2)], (ketone: 2-heptanone, 2-octanone, 3-octanone; A: hydrazine, phenylhydrazine, o-phenylene-diamine; L: 1-naphthylamine, 2-aminopyrimidine, 2-methylimidazole, 2-amino-4-methylpyridine) and [Pt(DioxH)2L2], (DioxH2: methyl-phenyl-dioxime, butyl-methyl-dioxime; L: 1-naphthylamine, 2-methylimidazole, 2-amino-4-methylpyridine, lepidine, 2-methylpyridine, m-toluidine, dicyclohexylamine, 4-isopropylamine, cyclohexylamine), by the reaction of PtCl2 in suitable solvent. After a short bibliographical survey, involving the classification and evolution of platinum complexes with possible applications, we analyzed their physico-chemical properties using FTIR, Raman, NMR, UV-VIS spectroscopy, powder X-ray diffraction (XRD), mass spectrometry, thermal analysis (TG, DTG, DTA) and SEM. We also studied the antibacterial effect of complexes on different strains of bacteria. This class of compounds has relevance in biochemistry, some of them are antibacterial agents and potential anti-tumor drugs

Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study

Iron(II) clathrochelate complexes obtained with glyoximes are macrobicyclic ligand systems, which completely encapsulate the metal ion, and are formed under mild conditions with high yields [1]. In particular, the riblike-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -glyoximes, boric acid derivatives, amines, Schiff bases, such as [Fe(Me-Pr-Glyox)3(BO–Et)2], [Fe(Et-BuGlyox)3(BO–R)2] (R = methyl, propyl, butyl), [Fe(phenyl-Me-GlyoxH)2(amine)2], [Fe(Et-BuGlyoxH)2(amine)2], [Fe(2-heptanone)2(en)(amine)2], where GlyoxH, Glyox = mono- or bideprotonated glyoxime, en = ethylenediamine and the used amines: dibutylamine, 3-picoline, 4-aminopyridine, 6-amino-3-picoline, 3-amino-1-propanol, imidazole, 2-aminopyrimidine, 3- methylpiperidine, 3-amino-1H-1,2,4-triazole. For preparation ironII -sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines and the other complexing agents were added. The mixture so obtained was refluxed under inert atmosphere. The molecular structures of our products were studied by IR, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). The biological activity, like antimicrobial effect, was studied for a few bacteria

Mössbauer study of some novel iron-bis-glyoxime and iron-tris-glyoxime complexes

Dioximes as ligands are used as analytical reagents and serve as models for biological systems as well as catalysts in chemical processes. A number of novel mixed complexes of the type [Fe(DioxH)2(amine)2] have been prepared and characterised by FTIR, 57Fe Mössbauer and mass spectroscopy by us. We have found strong Fe–N donor acceptor interactions and iron occurred in low-spin FeII state in all complexes. Later, we have also found that the incorporation of branching alkyl chains (isopropyl) in the complexes alters the Fe–N bond length and results in high-spin iron(II) state [1, 2]. The question arises: can the spin state of iron be manipulated generally by replacing the short alkyl chains with high volume demand ones in Fe-azomethine-amine complexes? To answer the question we have synthetized novel iron-bis-glioxime and iron-tris-gloxime complexes when long chain alkyl or aromatic ligands replaced the short alkyl ones and studied by 57Fe Mössbauer spectroscopy, MS, FTIR, UV-VIS, TG-DTA-DTG and XRD methods. Novel iron-bis-glyoxime and iron-tris-glyoxime type complexes, [Fe(Diethyl-Diox)3(BOH)2], [Fe(Diethyl-Diox)3(BOEt)2] and [Fe(phenyl-Me-Diox)3(BOEt)2], were synthesized similarly as described in [2]. The FTIR, UV-VIS, TG-DTA-DTG and MS measurements indicated that the expected novel complexes could be successfully synthesized

Novel copper complexes with glyoximes, amines, schiff bases, semi-and thiosemicarbazones ; synthesis and physico-chemical analysis

In our research project new copper(II) complexes were synthesized with -dioximes, amines, Schiff bases, semi- and thiosemicarbazones such as [Cu(DioxH)2L2], (DioxH2: methyl-butylglyoxime, ethyl-butyl-glyoxime, methyl-phenyl-glyoxime; L: diphenyl-amine, 2-methylimidazole, dibutyl-amine, 2-amino-4-methylpyridine, imidazole, 1-aminonaphthaline), [Cu(octan-2-one)2AL2], (A: hydrazine, phenylhydrazine, o-phenylene-diamine; L: 3-amino1H-1,2,4-triazole, 2-aminopyrimidine, 2-methylimidazole), [Cu(ketone-SC)2], [Cu(ketoneTSC)2], (ketone: propiophenone, butyrophenone; SC: semicarbazone; TSC: thiosemicarbazone), by the reaction of copper(II)-acetate in suitable solvent. After a short bibliographical survey, involving the classification and evolution of copper complexes with possible applications, we analyzed their physicochemical properties using FTIR, Raman, ESR, UV-VIS, powder X-ray diffraction (XRD), mass spectrometry, thermal analysis (TG, DTG, DTA) and SEM. The importance of this class of compounds lies in biochemistry as some of them are antibacterial agents and potential anti-tumour drugs

Fault Type Diagnosis of the WWTP Dissolved Oxygen Sensor Based on Fisher Discriminant Analysis and Assessment of Associated Environmental and Economic Impact

Sensor failures are common events in wastewater treatment plant (WWTP) operations, resulting in ineffective monitoring and inappropriate plant management. Efficient aeration control is typically achieved by the dissolved oxygen (DO) control, and its associated sensor becomes critical to the whole WWTP’s reliable and economical operation. This study presents the Fisher discriminant analysis (FDA) used for fault diagnosis of the DO sensor of a currently operating municipal WWTP. Identification of the bias, drift, wrong gain, loss of accuracy, fixed value, complete failure minimum and maximum types of DO sensor fault was investigated. The FDA-proposed methodology proved efficiency and promptitude in obtaining the diagnosis decision. The consolidated fault identification showed an accuracy of 87.5% correct identification of the seven faulty and normal considered classes. Depending on the fault type, the results of the diagnosing time varied from 2.5 h to 16.5 h during the very first day of the fault appearance and were only based on observation data not included in the training data set. The latter aspect reveals the potential of the methodology to learn from incomplete data describing the faults. The rank of the fault type detection promptitude was: bias, fixed value, complete failure minimum, complete failure maximum, drift, wrong gain and loss of accuracy. Greenhouse gases (GHGs) such as nitrous oxide (N2O) and carbon dioxide (CO2) emitted during wastewater treatment, electrical energy quantity in association with costs spent in the WWTP water line and clean water effluent quality were ranked and assessed for the normal operation and for each of the DO sensor faulty regimes. Both for CO2 and N2O, the on-site emissions showed the most significant GHG contribution, accounting for about three-quarters of the total emissions. The complete failure maximum, fixed value and loss of accuracy were the DO sensor faults with the highest detrimental impact on GHG-released emissions. The environmental and economic study reveals the incentives of the proposed DO sensor faults identification for the WWTP efficient and environmentally friendly operation