Microbial Biosurfactants: Antimicrobial Activity and Potential Biomedical and Therapeutic Exploits

The rapid emergence of multidrug-resistant pathogens worldwide has raised concerns regarding the effectiveness of conventional antibiotics. This can be observed in ESKAPE pathogens, among others, whose multiple resistance mechanisms have led to a reduction in effective treatment options. Innovative strategies aimed at mitigating the incidence of antibiotic-resistant pathogens encompass the potential use of biosurfactants. These surface-active agents comprise a group of unique amphiphilic molecules of microbial origin that are capable of interacting with the lipidic components of microorganisms. Biosurfactant interactions with different surfaces can affect their hydrophobic properties and as a result, their ability to alter microorganisms’ adhesion abilities and consequent biofilm formation. Unlike synthetic surfactants, biosurfactants present low toxicity and high biodegradability and remain stable under temperature and pH extremes, making them potentially suitable for targeted use in medical and pharmaceutical applications. This review discusses the development of biosurfactants in biomedical and therapeutic uses as antimicrobial and antibiofilm agents, in addition to considering the potential synergistic effect of biosurfactants in combination with antibiotics. Furthermore, the anti-cancer and anti-viral potential of biosurfactants in relation to COVID-19 is also discussed

Alarm therapy for nocturnal enuresis in children: A literature review

Nocturnal enuresis is a common childhood problem impacting the quality of life of children and families. Treatment with an enuresis alarm is recommended for 8–12 weeks by the International Children's Continence Society as first line management of monosymptomatic nocturnal enuresis. However, the effectiveness of alarm therapy varies between 80% and 45.9%. There is minimal evidence within the literature exploring the factors impacting this varying response to alarm therapy. Therefore, this literature review aims to explore factors that impact the effectiveness of the enuresis alarm as a treatment for nocturnal enuresis, in children aged 5–17 years. Literature searches were conducted on MEDLINE (Ovid), SCOPUS and CINAHL Databases. The PRISMA tool was used to report the data in the search strategy. The inclusion criteria of children aged 5 to 17 years was chosen based on International Children's Continence Society Guidelines. English language, academic journals and studies in the past 10 years were selected as additional inclusion criterion to identify the most recent, robust literature for the review. All 13 primary research articles were critiqued using the Caldwell Framework. Data were extracted and presented in table format highlighting study methodology, sample, duration of treatment, relevance to review topic and key findings. The findings highlight factors influencing the effectiveness of alarm therapy related to the impact on the child and family, heighten arousal to the alarm, the duration of therapy, age of child and the impact of overlearning. This review provides health professionals with an insight into strategies that may help children and their family to respond successfully to enuresis alarm treatment

The role of resilience in the relationship between intimate partner violence severity and ICD-11 CPTSD severity

Background: Resilience is a modulating factor in the development of PTSD and CPTSD after exposure to traumatic events. However, the relationship between resilience and ICD-11 CPTSD is not adequately understood in survivors of intimate partner violence (IPV).Objective: The aim of this study is to determine whether resilience has a mediating role in the relationship between severity of violence and severity of CPTSD symptoms.Method: A sample of 202 women IPV survivors completed self-rated questionnaires to assess CPTSD, severity of violence and resilience.Results: Mediation analyses indicated that there was a direct relationship between the severity of violence and the severity of CPTSD symptoms (β = .113, p < .001) and that there was a significantly inverse relationship between levels of resilience and the severity of CPTSD symptoms (β = −.248, p < .001). At the same time, there was no significant relationship between the severity of violence and resilience (β = −.061, p = .254).Conclusions: These findings suggest that resilience does not mediate the relationship between violence severity and CPTSD severity. Directions for future research are discussed

Molecular determinants and intracellular targets of taurine signalling in pancreatic islet β‐cells

AbstractAimDespite its abundance in pancreatic islets of Langerhans and proven antihyperglycemic effects, the impact of the essential amino acid, taurine, on islet β‐cell biology has not yet received due consideration, which prompted the current studies exploring the molecular selectivity of taurine import into β‐cells and its acute and chronic intracellular interactions.MethodsThe molecular aspects of taurine transport were probed by exposing the clonal pancreatic BRIN BD11 β‐cells and primary mouse and human islets to a range of the homologs of the amino acid (assayed at 2–20 mM), using the hormone release and imaging of intracellular signals as surrogate read‐outs. Known secretagogues were employed to profile the interaction of taurine with acute and chronic intracellular signals.ResultsTaurine transporter TauT was expressed in the islet β‐cells, with the transport of taurine and homologs having a weak sulfonate specificity but significant sensitivity to the molecular weight of the transporter. Taurine, hypotaurine, homotaurine, and β‐alanine enhanced insulin secretion in a glucose‐dependent manner, an action potentiated by cytosolic Ca2+ and cAMP. Acute and chronic β‐cell insulinotropic effects of taurine were highly sensitive to co‐agonism with GLP‐1, forskolin, tolbutamide, and membrane depolarization, with an unanticipated indifference to the activation of PKC and CCK8 receptors. Pre‐culturing with GLP‐1 or KATP channel inhibitors sensitized or, respectively, desensitized β‐cells to the acute taurine stimulus.ConclusionTogether, these data demonstrate the pathways whereby taurine exhibits a range of beneficial effects on insulin secretion and β‐cell function, consistent with the antidiabetic potential of its dietary low‐dose supplementation

Experimental comparative study on thermal performance of latent heat storage tanks with pin, perforated, and rectangular fins at different orientations

The low thermal conductivity of phase change materials (PCMs) has limited their widespread use in practical applications. In the present study, different fin structures, namely, rectangular, perforated, and pin were examined to analyze the thermal performance of the melting process in rectangular latent heat storage tanks. Experiments were performed at both horizontal and vertical orientations to evaluate the effectiveness of different fin configurations. Visual observation of the phase change evolution at different time intervals was enabled through a transparent plexiglass shell. Instantaneous heat transfer rate and energy storage were measured using thermocouple readings and melting photographs. The results show that the maximum heat transfer coefficient between the heated wall and PCM is obtained by the pin-finned tank followed by perforated and rectangular-finned tanks. This thermal behavior is justified by the intensification of the upward convection flows through the voids provided by pin fins or perforated fins. Although the rectangular fin structure has the lowest convective heat transfer coefficient, its heat transfer rate is slightly higher than the other structures due to its larger heat transfer area. At a wall temperature of 70℃, the convective heat transfer coefficient and heat transfer rate obtained by the pin fin configuration are respectively 25% higher and 4% less than those of the rectangular fin. It reveals that the pin fin structure provides the most effective heat transfer area compared to its counterparts which have a significantly larger fin volume. In addition, it was found that regardless of the fin configuration, the melting rate in the horizontal tank was significantly higher than in the vertical tank due to the formation of more vortical flow structures within the molten PCM. The melting time in the unfinned horizontal tank was less than those of the vertical finned tanks implying that the tank orientation should be well-chosen to minimize the melting time along with adding fins of various configurations

Quantifying Temporal Entropy in Neuromorphic Memory Forgetting: Exploring Advanced Forgetting Models for Robust Long-term Information Storage

This paper presents a progression of a popular neuromorphic memory structure by exploring advanced forgetting models for robust long-term information storage. Inspired by biological neuronal systems, neuromorphic sensors efficiently capture and transmit sensory information using event-based communication. Managing the decay of information over time is a critical aspect, and forgetting models play a vital role in this process. Building upon the foundation of an existing popular neuromorphic memory structure, this study introduces and evaluates four advanced forgetting models: ROT, adaptive, emotional memory enhancement, and context-dependent memory forgetting models. Each model incorporates different factors to modulate the rate of decay or forgetting. Through rigorous experimentation and analysis, these models are compared with the original ROT forgetting model to assess their effectiveness in retaining relevant information while discarding irrelevant or outdated data. The results provide insights into the strengths, limitations, and potential applications of these advanced forgetting models in the context of neuromorphic memory systems, thereby contributing to the progression of this popular neuromorphic memory structure

Assessing the clinical and cost-effectiveness of inpatient mental health rehabilitation services provided by the NHS and independent sector (ACER): protocol

Background: Mental health rehabilitation services provide specialist treatment to people with particularly severe and complex problems. In 2018, the Care Quality Commission reported that over half the 4,400 mental health inpatient rehabilitation beds in England were provided by the independent sector. They raised concerns that the length of stay and cost of independent sector care was double that of the NHS and that their services tended to be provided much further from people’s homes. However, there has been no research comparing the two sectors and we therefore do not know if these concerns are justified. The ACER Study (Assessing the Clinical and cost-Effectiveness of inpatient mental health Rehabilitation services provided by the NHS and independent sector) is a national programme of research in England, funded from 2021 to 2026, that aims to investigate differences in inpatient mental health rehabilitation provided by the NHS and independent sector in terms of: patient characteristics; service quality; patient, carer and staff experiences; clinical and cost effectiveness. Methods: ACER comprises a:1) detailed survey of NHS and independent sector inpatient mental health rehabilitation services across England; 2) qualitative investigation of patient, family, staff and commissioners’ experiences of the two sectors; 3) cohort study comparing clinical outcomes in the two sectors over 18 months; 4) comprehensive national comparison of inpatient service use in the two sectors, using instrumental variable analysis of routinely collected healthcare data over 18 months; 5) health economic evaluation of the relative cost-effectiveness of the two sectors. In Components 3 and 4, our primary outcome is ‘successful rehabilitation’ defined as a) being discharged from the inpatient rehabilitation unit without readmission and b) inpatient service use over the 18 months. Discussion: The ACER study will deliver the first empirical comparison of the clinical and cost-effectiveness of NHS and independent sector inpatient mental health rehabilitation services. Trial registration: ISRCTN17381762 retrospectively registered

Of rodents and primates: Time-variant gain in drift-diffusion decision models

Sequential sampling models of decision-making involve evidence accumulation over time and have been successful in capturing choice behaviour. A popular model is the drift-diffusion model (DDM). To capture the finer aspects of choice reaction times (RTs), time-variant gain features representing urgency signals have been implemented in DDM that can exhibit slower error RTs than correct RTs. However, time-variant gain is often implemented on both DDM’s signal and noise features, with the assumption that increasing gain on the drift rate (due to urgency) is similar to DDM with collapsing decision bounds. Hence, it is unclear whether gain effects on just the signal or noise feature can lead to different choice behaviour. This work presents an alternative DDM variant, focusing on the implications of time-variant gain mechanisms, constrained by model parsimony. Specifically, using computational modelling of choice behaviour of rats, monkeys and humans, we systematically showed that time-variant gain only on the DDM’s noise was sufficient to produce slower error RTs, as in monkeys, while time-variant gain only on drift rate leads to faster error RTs, as in rodents. We also found minimal effects of time-variant gain in humans. By highlighting these patterns, this study underscores the utility of group-level modelling in capturing general trends and effects consistent across species. Thus, time-variant gain on DDM’s different components can lead to different choice behaviour, shed light on the underlying time-variant gain mechanisms for different species, and can be used for systematic data fitting

International consensus statement on the design, delivery and evaluation of sport-based interventions aimed at promoting social, psychological and physical well-being in prison

Objective: To develop an international consensus statement to advise on designing, delivering and evaluating sport-based interventions (SBIs) aimed at promoting social, psychological and physical well-being in prison.Design: Modified Delphi using two rounds of survey questionnaires and two consensus workshops.Participants: A multidisciplinary panel of more than 40 experts from 15 international jurisdictions was formed, including representation from the following groups and stakeholders: professionals working in the justice system; officials from sport federations and organisations; academics with research experience of prisons, secure forensic mental health settings and SBIs; and policy-makers in criminal justice and sport.Results: A core research team and advisory board developed the initial rationale, statement and survey. This survey produced qualitative data which was analysed thematically. The findings were presented at an in-person workshop. Panellists discussed the findings, and, using a modified nominal group technique, reached a consensus on objectives to be included in a revised statement. The core research team and advisory board revised the statement and recirculated it with a second survey. Findings from the second survey were discussed at a second, virtual, workshop. The core research team and advisory board further revised the consensus statement and recirculated it asking panellists for further comments. This iterative process resulted in seven final statement items; all participants have confirmed that they agreed with the content, objectives and recommendations of the final statement.Conclusions: The statement can be used to assist those that design, deliver and evaluate SBIs by providing guidance on: (1) minimum levels of competence for those designing and delivering SBIs; (2) the design and delivery of inclusive programmes prioritising disadvantaged groups; and (3) evaluation measures which are carefully calibrated both to capture proposed programme outcomes and to advance an understanding of the systems, processes and experiences of sport engagement in prison

Edge-Enabled Metaverse: The Convergence of Metaverse and Mobile Edge Computing

Metaverse is a virtual environment where users are represented by their avatars to navigate a virtual world having strong links with its physical counterpart. The state-of-the-art Metaverse architectures rely on a cloud-based approach for avatar physics emulation and graphics rendering computation. The current centralized architecture of such systems is unfavorable as it suffers from several drawbacks caused by the long latency of cloud access, such as low-quality visualization. To this end, we propose a Fog-Edge hybrid computing architecture for Metaverse applications that leverage an edge-enabled distributed computing paradigm. Metaverse applications leverage edge devices' computing power to perform the required computations for heavy tasks, such as collision detection in the virtual universe and high-computational 3D physics in virtual simulations. The computational costs of a Metaverse entity, such as collision detection or physics emulation, are performed at the device of the associated physical entity. To validate the effectiveness of the proposed architecture, we simulate a distributed social Metaverse application. The simulation results show that the proposed architecture can reduce the latency by 50% when compared with cloud-based Metaverse applications