10 research outputs found
Methotrexate-Induced Vasculitis in a Child with Systemic Onset Juvenile Idiopathic Arthritis
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Microarray Comparative Genomic Hybridization for the Analysis of Bacterial Population Genetics and Evolution
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
Escherichia albertii in Wild and Domestic Birds
- Author
- Publication venue
- Centers for Disease Control and Prevention
- Publication date
- 01/04/2010
- Field of study
The isolates were similar to those that cause disease in humans.
Escherichia albertii
has been associated with diarrhea in humans but not with disease or infection in animals. However, in December 2004,
E. albertii
was found, by biochemical and genetic methods, to be the probable cause of death for redpoll finches (
Carduelis flammea
) in Alaska. Subsequent investigation found this organism in dead and subclinically infected birds of other species from North America and Australia. Isolates from dead finches in Scotland, previously identified as
Escherichia coli
O86:K61, also were shown to be
E. albertii
. Similar to the isolates from humans,
E. albertii
isolates from birds possessed intimin (
eae
) and cytolethal distending toxin (
cdtB
) genes but lacked Shiga toxin (s
tx
) genes. Genetic analysis of
eae
and
cdtB
sequences, multilocus sequence typing, and pulsed-field gel electrophoresis patterns showed that the
E. albertii
strains from birds are heterogeneous but similar to isolates that cause disease in humans
Thigh-length compression stockings and DVT after stroke
- Author
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- Watson E
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- Yelnoorkar F
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- Yorke J
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- Zdanaviciene A
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial
- Author
- Abhishek Abhishek
- Alcorn Nicola
- Altmann Daniel M
- Appelbe Duncan
- Barber Vicki
- Batty Thomas
- Bingham Sarah
- Bluett James
- Boyton Rosemary J
- Brooks Tim
- Coates Laura C
- Cook Jonathan A
- Crowder Rory
- Cureton Lucy
- Douglas Karen
- Eldridge Lucy
- Ellis Rob
- Francis Anne
- Gaffney Karl
- George Emmanuel
- Gibbons Joseph M
- Green Mike
- Gullick Nicola
- Gwynne Catherine
- Hassan Ala
- Hider Samantha
- Ho Gen Nen
- Holroyd Chris
- Horton Sarah
- Hunt Laura
- Huws Gwenan
- Jones Catrin
- Joseph Theresa
- Julier Patrick
- Khalid Salema
- Lapin Agnieszka
- Layton Alison
- Levasseur Kirsty
- Lwin May
- Madan Ayesha
- Mathew Rengi
- McKnight Áine
- Mustafa Alaa
- Nguyen-Van-Tam Jonathan S
- Oikonomou Stamatios
- Otter Ashley
- Pade Corinna
- Pande Ira
- Peckham Nicholas
- Pradeep John
- Pratt Arthur
- Price Elizabeth
- Reynolds Nick J
- Rhys-Dillon Ceril
- Rombach Ines
- Saravanan Vadivelu
- Semper Amanda
- Soni Anushka
- Tacu Cristina
- Tang Ting Seng
- Tran Gui
- Valdes Ana M
- Venkatachalam Srinivasan
- Walsh David A
- Whittam Lindsay
- Williams Hywel C
- Williams Jennifer A E
- Youngstein Taryn
- Publication venue
- Elsevier
- Publication date
- 01/02/2024
- Field of study
The Contribution of Pathogenicity Islands to the Evolution of Bacterial Pathogens
- Author
- Achtman
- Adhikari
- Alfano
- Amavisit
- Antoine
- Bach
- Bach
- Beaber
- Bell
- Billington
- Billington
- Blanc-Potard
- Bloomfield
- Blum
- Boyd
- Boyd
- Braun
- Brown
- Buchrieser
- Buchrieser
- Buchrieser
- Burns
- Burrus
- Buttner
- Böltner
- Carniel
- Carniel
- Censini
- Cheetham
- Christie
- Cieslewicz
- Collmer
- Craig
- Deng
- Dillard
- Dobrindt
- Dobrindt
- Dobrindt
- Dobrindt
- Dobrindt
- Elliott
- Falkow
- Fitzgerald
- Fleckenstein
- Girardeau
- Groisman
- Guyer
- Hacker
- Hacker
- Hacker
- Hacker
- Hacker
- Hall
- Hare
- Haring
- Hensel
- Hiramatsu
- Hochhut
- Hong
- Houdouin
- Ito
- Ito
- Jackson
- Jermyn
- Jin
- Johnson
- Johnson
- Jores
- Kao
- Kaper
- Kaper
- Karaolis
- Karch
- Keller
- Kim
- Klose
- Kreft
- Kuroda
- Lalioui
- Liang
- Lindqvist
- Lindsay
- Lostroh
- Lucas
- Luck
- Marie
- Maurelli
- Mazel
- McClelland
- McDaniel
- Meer
- Mellies
- Middendorf
- Mills
- Mirold
- Morschhäuser
- Moss
- Noel
- Novick
- O'Shea
- Ochman
- Odenbreit
- Parkhill
- Perna
- Piechaczek
- Podbielski
- Preston
- Rajakumar
- Rakin
- Rasko
- Ravatn
- Redford
- Reiter
- Ritter
- Rowe-Magnus
- Ruzin
- Salanoubat
- Salyers
- Schmidt
- Schmidt
- Schneider
- Schubert
- Schubert
- Scott
- Selbach
- Shankar
- Silva
- So
- Sperandio
- Stein
- Sullivan
- Sullivan
- Swenson
- Tauschek
- Tinker
- Van Sluys
- Vokes
- Waldor
- Welch
- Whittam
- Whittle
- Williams
- Wong
- Wood
- Yamaguchi
- Yarwood
- Zhu
- Ölschläger
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Four Crises of Democracy: Representation, Mastery, Discipline, Anticipation
- Author
- Alasdair Roberts
- Alasdair Roberts
- Alasdair Roberts
- Alasdair S. Roberts
- Bruce Smith
- Charles A Kupchan
- Charles H Heatherly
- Charles Kupchan
- Charles P Stewart
- Chrystia Freeland
- Clinton Rossiter
- Crozier
- Daniel R Ernst
- David B Robertson
- David H Rosenbloom
- David Runciman
- Dennis F Thompson
- Department Of Justice
- Donella H Meadows
- E J Shriver
- Edwin F Gay
- Elena Kagan
- Ernest Crosby
- Francis Fukuyama
- Franklin D Roosevelt
- Gabriel Wildau
- Gavin Hewitt
- Geoff Dyer
- George Soros
- Georgios Georgiadis
- Gilbert H Montague
- Ha-Joon Chang
- Hamlin Garland
- Harold Laski
- Heniff
- Herman Kahn
- Ian Buruma
- Ida H Harper
- Inez Gillmore
- James Bryce
- James Bryce
- James C Scott
- James M Buchanan
- James Pfiffner
- James Reston
- Jane Seaberry
- Janet Beer
- Jeff Manza
- Jeremy Brecher
- Jimmy Carter
- Jo Guldi
- John Dunn
- John Dunn
- John J Diiulio
- John M Mecklin
- John Micklethwait
- John Moody
- John R Macarthur
- John Reed
- Jon Hovi
- Jonathan Boston
- Joseph E Stiglitz
- Joshua Kurlantzick
- Jurgen Habermas
- Karl R Popper
- Kurt Weyland
- Lawrence Lessig
- Leon Fuerth
- Lindsay Rogers
- Luther H Gulick
- Mancur Olson
- Martin Jacques
- Matthew Flinders
- Michael Flamm
- Michael J Glennon
- Michael J Hogan
- Michael Witt
- Morton Sosna
- Niall Ferguson
- Outlook
- Paul Bowles
- Paul Krugman
- Pendleton Herring
- Peter G Peterson
- Peter H Schuck
- Peter Mair
- Peter Orzag
- Philip Coggan
- Ralph Nader
- Richard E B Simeon
- Richard Katz
- Richard Polenberg
- Richard W Waterman
- Robert Strausz-Hup�
- Robert W Staiger
- Samuel Brittan
- Sanford Levinson
- Shailer Mathews
- Simon J Evenett
- Simon Johnson
- Spencer Overton
- Thomas Borstelmann
- Thomas E Mann
- Thomas F Cargill
- Thomas L Friedman
- Timothy Mitchell
- Victor Zarnowitz
- Von Uexkull
- Walter Kickert
- Walter Lippmann
- Walter Lippmann
- Walter Weyl
- Whittam Smith
- William C Mitchell
- William Galston
- Wolfgang Schivelbusch
- X
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
How American Democracy Learns from Crisis (((( )
- Author
- Alasdair Roberts
- Alasdair Roberts
- Alasdair Roberts
- Alasdair S. Roberts
- Albert O Hirschman
- Albert O Hirschman
- Bruce Smith
- Charles A Kupchan
- Charles H Heatherly
- Charles H Heatherly
- Charles Kupchan
- Charles M Tiebout
- Christopher K Ansell
- Crozier
- Daniel R Ernst
- David H Rosenbloom
- Deal
- Dennis F Thompson
- E J Shriver
- Edwin F Gay
- Edwin F Gay
- Francis Fukuyama
- Francis Fukuyama
- Franklin D Roosevelt
- Gavin Hewitt
- Gavin Hewitt
- Geoff Dyer
- George Soros
- Ha-Joon Chang
- Hamlin Garland
- Hamlin Garland
- Heniff
- Heniff
- Ian Buruma
- Ida H Harper
- Ida H Harper
- Jack Knight
- Jack Knight
- James Bryce
- James C Scott
- James M Buchanan
- James Pfiffner
- James Reston
- Janet Beer
- Jeff Manza
- Jimmy Carter
- Jo Guldi
- Jo Guldi
- John Dunn
- John J Diiulio
- John M Mecklin
- John Micklethwait
- John Moody
- John R Macarthur
- John Reed
- Jon Hovi
- Jon Hovi
- Jonathan Boston
- Joseph E Stiglitz
- Joseph S Nye
- Joseph Schneider
- Karl R Popper
- Kurt Weyland
- Lawrence Lessig
- Leon Fuerth
- Leon Fuerth
- Lindsay Rogers
- Luther H Gulick
- Luther H Gulick
- Martin Jacques
- Martin Jacques
- Matthew Flinders
- Matthew Flinders
- Michael Flamm
- Michael Flamm
- Michael J Glennon
- Michael J Glennon
- Michael J Hogan
- Michael J Hogan
- Michael Mandelbaum
- Michael Witt
- Michelle Alexander
- Niall Ferguson
- Outlook
- Paul Bowles
- Paul Krugman
- Pendleton Herring
- Pendleton Herring
- Peter G Peterson
- Peter H Schuck
- Peter Orzag
- Philip Coggan
- Ralph Nader
- Richard E Neustadt
- Richard Katz
- Richard Katz
- Richard Polenberg
- Robert ??????? ??????? Strausz-Hup�
- Robert W Staiger
- Roy F Nichols
- Samuel Brittan
- Sanford Levinson
- Shailer Mathews
- Simon Johnson
- Simon Johnson
- Spencer Overton
- Tariq Ali
- Thomas Borstelmann
- Thomas E Mann
- Thomas L Friedman
- Thomas L Friedman
- Timothy Mitchell
- Tova Wang
- Victor Zarnowitz
- Walter Lippmann
- Whittam Smith
- Wolfgang Schivelbusch
- X
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
- Ali S
- Ali S
- Ali S
- Alkhusheh M
- Alkhusheh M
- Allanson A
- Allen L
- Allen R
- Allen S
- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
- Amosun V
- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
- Anderson R
- Andreou P
- Andrews A
- Andrews J
- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
- Appleby S
- Appleyard D
- Archer A
- Ardley C
- Arimoto R
- Arkley C
- Armah C
- Armstrong C
- Armstrong S
- Armtrong P
- Arnison-Newgass C
- Arora D
- Arter A
- Arter A
- Asghar A
- Ashbrook-Raby C
- Ashish A
- Ashish A
- Ashraf S
- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
- Ayaz E
- Azam J
- Aziz G
- Azzopardi G
- Babatunde F
- Babi M
- Babi M
- Babingto G
- Babs-Osibodu A Obaloluwa
- Bacon G
- Bacon J
- Bacon J
- Bagley G
- Bahadori K
- Baijiu G
- Bailey K
- Bailey K
- Bailey L
- Baillie H
- Baillie JK
- Baillie JK
- Baillie K
- Baird D
- Bajandouh A
- Baker E
- Baker-Moffatt M
- Bakoulas P
- Balachandran N
- Balachandran N
- Balan A
- Balaskas T
- Balasubramaniam M
- Balcombe A
- Baldwin A
- Baldwin D
- Baldwin L
- Balfour J
- Ball C
- Bamfo S Danso
- Bamford A
- Bamford A
- Bamford P
- Bamgboye A
- Bancroft H
- Banda J
- Bandi S
- Bandi S
- Bandla N
- Bandyopadhyam S
- Bandyopadhyam S
- Banerjee R
- Banerjee S
- Banks H
- Banks L
- Banks L
- Bannister O
- Baptist M
- Baqai T
- Barclay A
- Bari S
- Barker D
- Barker J
- Barker L
- Barker-Williams K
- Barla J
- Barla J
- Barlow G
- Barnard A
- Barnes D
- Barnes N
- Barnett A
- Barnett D
- Barnsley W
- Barr D
- Barrera M
- Barrett J
- Bartholomew J
- Bartholomew S
- Bartlett C
- Bartlett G
- Barton J
- Barton R
- Baryschpolec S
- Bashyal A
- Basker B
- Basoglu A
- Bassoy B
- Basumatary A
- Bataineh A
- Bateman K
- Bates M
- Batha R
- Batham S
- Batla A
- Batra D
- Batty H
- Batty T
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- Bax S
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- Baxter M
- Bazaz R
- Bazli A
- Beacham L
- Beale A
- Beaver T
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- Beckett V
- Beddall H
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- Beeby D
- Beer S
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- Begum S
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- Belcher J
- Belfield K
- Belgaumkar A
- Belgaumkar A
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- Bell JL
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- Bellamy M
- Bendall L
- Benesh N
- Benetti N
- Benham L
- Benison-Horner G
- Benison-Horner G
- Bennett A
- Benson V
- Bentley A
- Benton I
- Beranova E
- Beresford M
- Bergin C
- Bergstrom M
- Bernatoniene J
- Bernatoniene J
- Berriman T
- Best K
- Beuvink Y
- Bexhell H
- Bhadi A
- Bhakta S
- Bhalla R
- Bhalme M
- Bhandal K
- Bhandal K
- Bhatia N
- Bhayani J
- Bhojwani D
- Bhuiyan S
- Bhushan A Kala
- Bibi N
- Biggs S
- Biju A
- Bikov A
- Billingham S
- Billings J
- Birch C
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- Birt M
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- Blackstock C
- Blamey H
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- Blazeby J
- Blencowe N
- Bloom B
- Bloss A
- Blundell L
- Bobruk K
- Bodasing N
- Boehmer G
- Bokhari S
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- Bokhari S Owais
- Boles A
- Boles A
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- Bond T
- Boniface G
- Borbone J
- Borra C
- Boughton H
- Boult Z
- Bourne M
- Bowker P
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- Boyapati G
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- Bradder J
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- Bradshaw Z
- Brady S
- Branch M
- Brandl-Salutz E
- Brannigan J
- Brassington L
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- Segovia M
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- Sohail B
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- Thozthumparambil P
- Thrasyvoulou L
- Thraves H
- Thwaites G
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- Tyagi B
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- Umaipalan A
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- Vaccari L Cheyenne
- Valeria B
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- van Someren C
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- Vasadi V
- Vasu V
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- Venables I
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- Vergnano S
- Verma A
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- Vethanayagam N
- Vilimiene N
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- Visentin E
- Vithian K
- Vyras E
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- Wadsworth K
- Wafa SEI
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- Wahbi Z
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- Weeratunga J
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- Willis J
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- Wilson J
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- Wiselka M
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- Xia Z
- Yan M
- Yanney M
- Yasmin S
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- Yelnoorkar F
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- Youssouf S
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- Zehnde D
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- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2021
- Field of study
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research