41 research outputs found
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/07/2021
- Field of study
Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of anticancer drug discovery. However, lack of inhibitors that possess high selectivity toward certain HDACs isozymes is associated with adverse side effects that limits their clinical applications. We have initiated a collaborative initiatives between multi-institutions aimed at the discovery of novel and selective HDACs inhibitors. To this end, a phenotypic screening of an in-house pilot library of about 70 small molecules against various HDAC isozymes led to the discovery of five compounds that displayed varying degrees of HDAC isozyme selectivity. The anticancer activities of these molecules were validated using various biological assays including transcriptomic studies. Compounds 15, 14, and 19 possessed selective inhibitory activity against HDAC5, while 28 displayed selective inhibition of HDAC1 and HDAC2. Compound 22 was found to be a selective inhibitor for HDAC3 and HDAC9. Importantly, we discovered a none-hydroxamate based HDAC inhibitor, compound 28, representing a distinct chemical probe of HDAC inhibitors. It contains a trifluoromethyloxadiazolyl moiety (TFMO) as a non-chelating metal-binding group. The new compounds showed potent anti-proliferative activity when tested against MCF7 breast cancer cell line, as well as increased acetylation of histones and induce cells apoptosis. The new compounds apoptotic effects were validated through the upregulation of proapoptotic proteins caspases3 and 7 and downregulation of the antiapoptotic biomarkers C-MYC, BCL2, BCL3 and NFĸB genes. Furthermore, the new compounds arrested cell cycle at different phases, which was confirmed through downregulation of the CDK1, 2, 4, 6, E2F1 and RB1 proteins. Taken together, our findings provide the foundation for the development of new chemical probes as potential lead drug candidates for the treatment of cancer
Current and prospective pharmacological targets in relation to antimigraine action
- Author
- A Bergerot
- A Buchwalder
- A Carlsson
- A Carlsson
- A Hughes
- A MaassenVanDenBrink
- A MaassenVanDenBrink
- A May
- A May
- A May
- A Pindon
- A Rouleau
- A Srikiatkhachorn
- A Sudilovsky
- A Tanoue
- A Wackenfors
- AC Honey
- AD Bennett
- AD Medhurst
- AD Michel
- AE Luebke
- AH Bom
- AH Calhoun
- AJ Kaumann
- AL Magos
- AM Aloisi
- AM Carruthers
- AM Lands
- AM Maagdenberg van den
- Antoinette MaassenVanDenBrink
- AP Ford
- AP Silva
- B Forssman
- B Gómez-Mancilla
- B Pouzet
- B Schaerlinger
- B Weiss
- BB Fredholm
- BB Hoffman
- BJ Francken
- BK Kobilka
- BK Rasmussen
- BW Somerville
- BW Somerville
- C Hofmann
- C Hohoff
- C Lampl
- C Tzourio
- CA Salvatore
- Carlos M. Villalón
- CG Dahlöf
- CM Villalón
- CM Villalón
- CM Villalón
- CM Villalón
- CN Sang
- CY Yu
- D Centurión
- D Hoyer
- D Hoyer
- D Sarsero
- DA Curran
- David Centurión
- DB Bylund
- DB Bylund
- DB Bylund
- DB Bylund
- DB Bylund
- DD Mitsikostas
- DD Mitsikostas
- DE Dluzen
- DJ Goldstein
- DJ Goldstein
- DJ Goldstein
- DL Jackson
- DM Pérez
- DR Poyner
- DR Thomas
- DR Thomas
- DS Millson
- DW Dodick
- E Del Bene
- E Enmark
- E Fabbretti
- E Fusayasu
- E Tronvik
- EA Barnard
- EA MacGregor
- EA MacGregor
- EA MacGregor
- EA MacGregor
- EM Cassidy
- EW Willems
- EW Willems
- EW Willems
- EW Willems
- F Facchinetti
- F Facchinetti
- F Marceau
- F Martínez
- FG Freitag
- FM Cutrer
- FM Cutrer
- FM Cutrer
- G Attali
- G Burnstock
- G D’Andrea
- G Trapani Di
- GA Lambert
- GA Michelotti
- GL Stiles
- GM Terwindt
- GW Price
- GW Smith
- H Doods
- H Heyck
- H Kaube
- H Kowa
- H Schrader
- HC Diener
- HM Vargas
- HO Kalkman
- HS Blaxall
- I Jansen-Olesen
- I Mody
- IH Page
- IT Forbes
- J Galitzky
- J Honkaniemi
- J Olesen
- J Olesen
- JA Charles
- JA Terrón
- JB Becker
- JC Jen
- JC Shih
- JD Carroll
- JD Classey
- JE Palmer
- JJ Fernández-Ruíz
- JL Brandes
- JM Brundege
- JM Cruickshank
- JM Orshal
- JP Dreier
- JP Hieble
- JP Hieble
- JR Arch
- JR Clements
- JR Docherty
- JR Fozard
- JW Lomasney
- JW Regan
- K Kapoor
- K Schmuck
- K Zimmermann
- KA Krobert
- KA Petersen
- KA Petersen
- Kayi Y. Chan
- KI Roon
- KJ Powell
- KL Hoskin
- KMA Welch
- KP Lesch
- KR Oliver
- KW Johnson
- L Edvinsson
- L Edvinsson
- L Hein
- LA Phebus
- LE Limbird
- LH Lassen
- LH Lassen
- LH Lassen
- LJ Smith
- LL Ven van de
- LM McLatchie
- M Anthony
- M Anthony
- M Boccuni
- M Cyr
- M Farkkila
- M Gasparo De
- M Hasselblatt
- M Iovino
- M Kallela
- M Mochi
- M Oshita
- M Peeters
- M Quartu
- M Spedding
- M Yanagisawa
- MA Moskowitz
- MA Moskowitz
- MD Ferrari
- MD Ferrari
- ME Bigal
- ME Erdal
- ME Moreau
- MG Garry
- MG Hanna
- MJ Kelly
- ML Hernández
- MM Rapport
- MT Piascik
- NG Bowery
- NJ Colson
- NJ Colson
- NJ Giffin
- NM Barnes
- NM Ramadan
- NM Ramadan
- NM Ramadan
- NT Mathew
- O Blin
- P Barbanti
- P Barbanti
- P Geppetti
- P Kastner
- P Roffey
- P Sarchielli
- P Sarchielli
- P Tfelt-Hansen
- P Tfelt-Hansen
- P Vries De
- P Vries De
- PD Drummond
- PD Drummond
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PJ Goadsby
- PL Durham
- PP Lakhlani
- PR Saxena
- PR Saxena
- PR Saxena
- PR Saxena
- Pramod R. Saxena
- PT Hurley
- QP Ma
- R Burstein
- R Cerbo
- R Hering-Hanit
- R Lodi
- R Quirion
- R Rabkin
- R Uddman
- R Würz
- RA Bond
- RA Ophoff
- RB Lipton
- RB McCall
- RE Widdop
- RJ Storer
- RJ Storer
- RJ Storer
- RL Weinshank
- RO Millán-Guerrero
- RO Millán-Guerrero
- RP Ahlquist
- RW Kimball
- RWM Broek van den
- S Akerman
- S Akerman
- S Akerman
- S Akerman
- S Akerman
- S Cotecchia
- S Ghelardoni
- S Gupta
- S Gupta
- S Gupta
- S Maude
- S Mehrotra
- S Mehrotra
- S Nag
- S Paterna
- S Shepheard
- S Stellar
- Saurabh Gupta
- SD Brain
- SD Silberstein
- SD Silberstein
- SD Silberstein
- SG Hamilton
- SJ Hill
- SJ Peroutka
- SJ Peroutka
- SJ Peroutka
- SJ Peroutka
- SJ Peroutka
- SJ Peroutka
- SJ Tallaksen-Greene
- SJ Tepper
- SM Lanier
- SP Alexander
- SP Cook
- SP Cook
- ST Lee
- Suneet Mehrotra
- T Attina
- T Ishida
- T Ishida
- T Matsubara
- T Takenaka
- TJ Murphy
- TM Buchanan
- TW Ho
- U Arulmani
- U Arulmani
- U Arulmani
- V Erspamer
- V Erspamer
- V Johannsson
- V Limmroth
- V Shaygannejad
- V Simonneaux
- VT Martin
- W Chai
- WF Stewart
- WI Bender
- WL Hasler
- WM Herrmann
- WS Lee
- Y Dumont
- Y Sahara
- Y Zhang
- YT Lau
- Z Cohen
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon
Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
- Author
- A Csiszar
- A Hartmann
- A Kasdallah-Grissa
- A Kode
- A Kumar
- A Kunwar
- A Picchi
- A Singhal
- A Yavari
- A Zittermann
- A-L Khoo
- A-T McGill
- AC Carr
- AC Montezano
- AE Civitarese
- AH Goldfarb
- AS Kelly
- AZ Caron
- B Halliwell
- B Li
- C Berry
- C Brinkmann
- C Cantó
- C Goto
- C Goto
- C Groussard
- C Hamilton
- C Manach
- C Murr
- C Ruggiero
- C-C Wu
- CF Nathan
- CG McCarthy
- CK Roberts
- CN Lumeng
- CW Nemerovski
- D Feskanich
- D-H Hyun
- D-W Zhang
- DA Mowry
- DM Bailey
- DM Bailey
- DS Moran
- DT Villareal
- E Garcion
- E Nisoli
- EJ Anderson
- EJ Masoro
- EL Goldberg
- F Amiri
- F Giacco
- F Maingrette
- F Perticone
- G Arcaro
- H Miyazaki
- H Sies
- H Sies
- H Wiseman
- H Youssef
- H Zarkesh-Esfahani
- H Zhang
- H-P Kopp
- HK Vincent
- HK Vincent
- HK Vincent
- I S-i
- I Samjoo
- I Urquiaga
- J Chen
- J Vider
- J Wortsman
- J-Y Youn
- JB Johnson
- JF Keaney
- JF Trepanowski
- JF Trepanowski
- JG Neels
- JH O’Keefe
- JJ Cannell
- JL Tarry-Adkins
- JM Bruun
- K Fisher-Wellman
- K Hagopian
- K-H Jung
- KH Fisher-Wellman
- KJ Davies
- KK Griendling
- KK Nickander
- KM Flegal
- L Bevilacqua
- L Wang
- LI Mennen
- LK Forsythe
- LL Ji
- M Bougoulia
- M Cojocaru
- M Hey-Mogensen
- M Jové
- M Kitada
- M Kondo
- M Korda
- M Lagouge
- M Martinesi
- M Monda
- M Ramezanipour
- M Reid
- MC Devries
- MD Phillips
- MH Eftekhari
- MN Stanković
- MS Cohen
- MS Zumbach
- MT Borra
- N Gletsu‐Miller
- NM Fletcher
- O Ozcelik
- O Rebolledo
- P Dallaire
- P Pacher
- P Plomgaard
- P Tuso
- P Valcheva
- P Wilcox
- P Zhang
- Q Wang
- R Bloomer
- R Gredilla
- R Ramadan
- R Rosenheck
- RA Kremsdorf
- RH Liu
- RJ Bloomer
- RJ Bloomer
- RJ Bloomer
- RJ Bloomer
- RJ Bloomer
- RJ Bloomer
- RS Rector
- RS Sohal
- RS Sohal
- S Blankenberg
- S Konradsen
- S Oh
- S Olusi
- S Pastromas
- S Touati
- S Verma
- S Yan
- SB Lotito
- SG Wannamethee
- SJ Parikh
- SR McAnulty
- SS Ulasli
- T Ashton
- T Ashton
- T Fukai
- T Inoguchi
- T Tzotzas
- TA Zainal
- TD Noakes
- TN Hilton
- TP Wycherley
- WL Knez
- WS Cheang
- Y Jiang
- Y Liu
- Y S-i
- Y S-i
- Y Sato
- Y Takahashi
- Y-A Shin
- Y-P Li
- Z Ungvari
- Publication venue
- VCU Scholars Compass
- Publication date
- 01/01/2015
- Field of study
Obesity-related oxidative stress, the imbalance between pro-oxidants and antioxidants (e.g., nitric oxide), has been linked to metabolic and cardiovascular disease, including endothelial dysfunction and atherosclerosis. Reactive oxygen species (ROS) are essential for physiological functions including gene expression, cellular growth, infection defense, and modulating endothelial function. However, elevated ROS and/or diminished antioxidant capacity leading to oxidative stress can lead to dysfunction. Physical activity also results in an acute state of oxidative stress. However, it is likely that chronic physical activity provides a stimulus for favorable oxidative adaptations and enhanced physiological performance and physical health, although distinct responses between aerobic and anaerobic activities warrant further investigation. Studies support the benefits of dietary modification as well as exercise interventions in alleviating oxidative stress susceptibility. Since obese individuals tend to demonstrate elevated markers of oxidative stress, the implications for this population are significant. Therefore, in this review our aim is to discuss (i) the role of oxidative stress and inflammation as associated with obesity-related diseases, (ii) the potential concerns and benefits of exercise-mediated oxidative stress, and (iii) the advantageous role of dietary modification, including acute or chronic caloric restriction and vitamin D supplementation
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Adeniji K
- Afifi S
- Aggarwal D
- Agranoff D
- Agwuh K
- Ahmad SSY
- Ahmed KA
- Aigrain L
- Ail D
- Alcolea-Medina A
- Aldera EL
- Alegria A
- Alex B
- Alikhan N-F
- Allara E
- Allen S
- Amato R
- Andrikopoulos P
- Angus B
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Armstrong JA
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Ashish A
- Ashworth M
- Asiimwe IG
- Atkinson D
- Atkinson L
- Attwood SW
- Auckland C
- Aydin A
- Bach B
- Baillie JK
- Baker DJ
- Baker P
- Bakshi S
- Balcazar CE
- Ball J
- Barclay WS
- Bari S
- Barlow G
- Barlow SL
- Barnass S
- Barrett JC
- Barrett N
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Bassford C
- Basude S
- Batra R
- Baxter C
- Baxter D
- Bayzid N
- Beadsworth M
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Bernatoniene J
- Berridge J
- Berry C
- Berry L
- Bertolusso B
- Best A
- Best N
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bogaert D
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Booth L
- Boswell T
- Bosworth A
- Bothma P
- Bourgeois Y
- Boyd O
- Bradley DT
- Breen C
- Brennan B
- Bresner C
- Breuer J
- Bridgett S
- Brittain-Long R
- Bronner IF
- Brooks E
- Broos A
- Brown JR
- Brown R
- Bucca G
- Buchan SL
- Buck D
- Bull M
- Bullock K
- Bulteel N
- Burden T
- Burns PJ
- Burtenshaw A
- Burton-Fanning S
- Byaruhanga T
- Byott M
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carlucci N
- Carracedo AD
- Carson G
- Caruth V
- Carvalho SF
- Casey A
- Cass E
- Castigador A
- Catalan J
- Catterall BWA
- Chadwick D
- Chadwick D
- Chalker V
- Chaloner NJ
- Chambler D
- Chand M
- Chand M
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Chechi K
- Chee N
- Child J
- Chukkambotla S
- Churcher CM
- Clark G
- Clark JJ
- Clark T
- Clarke EA
- Clarke P
- Clohisey S
- Cogger BJ
- Cole K
- Cole S
- Cole S
- Collini P
- Collins J
- Colquhoun R
- Connor M
- Connor TR
- Cook KF
- Cooke GS
- Coombes J
- Cooper L
- Corden S
- Cormie C
- Correia GDS
- Cortes N
- Cosgrove C
- Cotic M
- Cotton S
- Cottrell S
- Coupland L
- Cox A
- Cox H
- Cox M
- Craine N
- Crawford L
- Cross A
- Crown MR
- Crudgington D
- Cumley N
- Cupitt J
- Curran MD
- Curran T
- Cutino-Moguel M-T
- da Silva Filipe A
- da Silva Filipe A
- Dabrera G
- Dalton J
- Darby AC
- Dark P
- Davidson RK
- Davies A
- Davies RM
- Davis C
- Davis T
- Dawson C
- de Angelis D
- De Lacy E
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Denton-Smith R
- Dervisevic S
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dincarslan O
- Dobie D
- Docherty AB
- Donegan C
- Dong D
- Dong T
- Donnison P
- Donohue C
- Dorman MJ
- Douthwaite S
- Downing F
- Driscoll M
- Drummond A
- du Plessis L
- Duckworth N
- Dumas M-E
- Dunachie S
- Dunn C
- Dunning J
- DuRand I
- Durham J
- Dushianthan A
- Dyer P
- Dyer T
- Eastick K
- Easton LJ
- Eccles R
- Edgeworth J
- Edwards S
- El Bouzidi K
- Eldirdiri S
- Ellaby N
- Elliott A
- Elliott S
- Eltringham G
- Ensell L
- Erkiert MJ
- Essex S
- Evans A
- Evans C
- Evans C
- Evans JM
- Everson W
- Eziefula C
- Fairley DJ
- Fallon K
- Fanaie A
- Farr BW
- Fearn C
- Fegan C
- Feltwell T
- Ferguson L
- Fina L
- Finch L
- Finn A
- Fisher LWS
- Flaherty L
- Flaviani F
- Fleming VM
- Fletcher T
- Forrest S
- Foster T
- Foster-Nyarko E
- Foulkes BH
- Foulser L
- Fragakis M
- Frampton D
- Francois S
- Fraser C
- Freeman TM
- Fryer H
- Fuchs M
- Fuller W
- Fullerton D
- Gajee K
- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
- Gallis M
- Gamble C
- Garcia-Dorival I
- Garg A
- Garg S
- Garg S
- Gaskin A
- Gatica-Wilcox B
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Gifford L
- Gilbert L
- Girgis ST
- Girvan M
- Gkrania-Klotsas E
- Glaysher S
- Godden J
- Goldsmith A
- Goldstein EJ
- Golubchik T
- Gomes AN
- Gonçalves S
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gourtovaia M
- Graham C
- Graham C
- Graham L
- Grant PR
- Green A
- Green CA
- Green LR
- Greenaway J
- Greenhalf W
- Gregory R
- Griffin JL
- Griffiths F
- Guest M
- Gunning P
- Gunson RN
- Gupta RK
- Gupta RK
- Gutierrez B
- Haldenby ST
- Halpin S
- Hamilton WL
- Hansford SE
- Haque T
- Hardwick H
- Hardy E
- Harris KA
- Harrison EM
- Harrison EM
- Harrison I
- Harrison J
- Hart J
- Hartley C
- Hartley JA
- Hartshorn S
- Harvey D
- Harvey M
- Harvey WT
- Hassan-Ibrahim MO
- Havalda P
- Hawcutt DB
- Heaney J
- Helmer T
- Henderson JH
- Hendry R
- Hesketh AR
- Hey J
- Heyburn D
- Higginson EE
- Hill JD
- Hill V
- Hilson RA
- Hilvers E
- Hiscox JA
- Hobrok M
- Hodgson L
- Holden MTG
- Hollis A
- Holmes A
- Holmes AH
- Holmes CW
- Holmes N
- Hopes R
- Horby PW
- Hormis A
- Hornsby HR
- Hosmillo M
- Houlihan C
- Howson-Wells HC
- Hsu NS
- Hubb J
- Huckson H
- Hughes J
- Hughes M
- Hughes W
- Hutchings S
- Idle G
- Ijaz S
- Illingworth CJ
- Impey R
- Irish-Tavares D
- Iturriza-Gomara M
- Izuagbe R
- Jackson B
- Jackson C
- Jackson C
- Jackson DK
- Jackson KA
- Jackson LM
- Jacobs M
- Jahun AS
- Jain S
- James K
- James V
- Jeanes C
- Jeffries AR
- Jennings P
- Jensen RL
- Jeremiah S
- Jermy A
- John M
- Johnson K
- Johnson R
- Johnston I
- Jones CB
- Jones CR
- Jones H
- Jones N
- Jones O
- Jones S
- Jones TR
- Joseph A
- Judges S
- Kaliappan A
- Kasipandian V
- Kay GL
- Kay S
- Keating S
- Keatley J-P
- Keeley AJ
- Kegg S
- Kelsey M
- Kendall J
- Kenyon A
- Kermack LM
- Kerrison C
- Kerslake I
- Khakh M
- Khandaker S
- Khoo S
- Kidd SP
- Kimuli M
- King K
- Kirk S
- Kitchen C
- Kitchman K
- Kiy RT
- Klenerman P
- Knight BA
- Knight JC
- Koch O
- Koduri G
- Koshy C
- Koshy G
- Koukorava C
- Kraemer MUG
- Kumziene-Summerhayes S
- Kwiatkowski D
- Lackenby A
- Laha S
- Laing KG
- Laird S
- Lake A
- Lampejo T
- Langford CF
- Lant S
- Larkin S
- Latawiec D
- Lavelle-Langham L
- Lavin D
- Law A
- Law A
- Lawton AI
- Le-Viet T
- Lee D
- Lee J
- Lee J
- Leeming G
- Lefteri D
- Leiner T
- Lensing SV
- Leonard S
- Lett L
- Levett LJ
- Lewis J
- Lewis K
- Lewis MR
- Liddle J
- Liggett S
- Liggi S
- Lillie P
- Lillie PJ
- Lim WS
- Limb J
- Lindsey BB
- Linnett V
- Lister MM
- Little J
- Liu G
- Livett R
- Livoti LA
- Lo S
- Loman NJ
- Loose MW
- Louka SF
- Loveson KF
- Lowdon S
- Lowe H
- Lowe HL
- Lucaci AO
- Ludden C
- Lynch J
- Lyons RA
- Lythgoe K
- Lyttle M
- Machin NW
- MacIntyre-Cockett G
- Mack A
- Macklin B
- Maclean A
- MacLean A
- MacMahon M
- Macnaughton E
- MacNaughton E
- Madona P
- Maes M
- Maftei L
- Mahanama AIK
- Mahungu TW
- Maini MK
- Mair D
- Maksimovic J
- Malone CS
- Maloney D
- Mancini M
- Manesis N
- Mankregod R
- Manley R
- Mantzouratou A
- Marchbank A
- Mariappan A
- Marsh L
- Martincorena I
- Martinez Nunez RT
- Maslen L
- Massey H
- Masson H
- Mather AE
- Matovu E
- Maxwell P
- Mayhew M
- Maziere N
- Mbisa T
- McCafferty S
- McCann CM
- McCarthy SA
- McCluggage K
- McClure PC
- McCrone JT
- McCullough K
- McDonald S
- McDonald SE
- McEvoy L
- McEwen R
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- Publication venue
- iScience
- Publication date
- 01/01/2021
- Field of study
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Aaniana K
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- Abantanga F
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- Abbasy J
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- Abd El Hameed OS
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- Abd El-Salam F
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- Abdel-Kader SM
- Abdel-Wahab NYE
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- Mohamed M
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- Sutanto EPR
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
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- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
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- Tan CY
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- Tan JK
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- Tan YW
- Tanase A
- Tanase A
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- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
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- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
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- To K
- To K
- Todd KO
- Toeema AG
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- Tomas K
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- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
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- Tselos A
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- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
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- Tutino R
- Tverskis Z
- Tyler R
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- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
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- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
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- Urbonas T
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- Urniezius Z
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- Usaityte A
- Uscinas L
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- Wold TB
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- Yildirim R
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- Yoganathan P
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- Yong CO
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- Zapata Ponze De Leon M
- Zapata F
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- Zardab A
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- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
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- Zohair A
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- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Primary neural leprosy: systematic review
- Author
- Almeida EC
- Amilton Antunes Barreira
- Andrade GB
- Barreto JA
- Bezerra da Cunha FM
- Brown TR
- Browne SG
- Buhrer-Sekula HL
- Cairns WS
- Capadia GD
- Capadia GD
- Carlos Otto Heise
- Cleverson Teixeira Soares
- De Faria CR
- De Freitas MRG
- Dharmendra RK
- Dongre VV
- Dos Santos CBA
- Garbino JA
- Garbino JA
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- Garbino JA
- Grossi MA
- Guilloton L
- Husain S
- Jaison Antonio Barreto
- Jardim MR
- Jardim MR
- Jardim MR
- Jardim MR
- Jose Antonio Garbino
- Jose Augusto Nery
- Kaur G
- Khambati FA
- Kumar B
- Lal H
- Laxmisha C
- Maeda SM
- Marcia Maria Jardim Rodrigues
- Marcos Cesar Floriano
- Marcos da Cunha Lopes Virmond
- Maria Angela Bianconcini Trindade
- Martinez AN
- McDougall AC
- Menicucci LA
- Mishra B
- Mitsuda K
- Moura RS
- Murray CK
- Nathalia Carvalho de Andrada
- Noemia Barbosa Carvalho
- Ramadan W
- Rao NP
- Rao SP
- Ridley DS
- Rotberg A
- Sanderson P
- Sergio L. Antunes
- Singh G
- Suneetha S
- Suneetha S
- Uplekar MW
- Van Brakel WH
- Van Brakel WH
- Van Brakel WH
- Van Brakel WH
- Van Brakel WH
- Wade HW
- Wilson Marques Jr
- Zenha EM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Aahlin Ek
- Aamer A
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- Aboelsoud Mr
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- Adebanjo A
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- Adedeji A
- Adekoya A
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- Ademuyiwa Ao
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- Ademuyiwa Ao
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
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- Adhitama N
- Adil M
- Adisa Ao
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- Agius M
- Aglan A
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- Aguilera M
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- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag Aa
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- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
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- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
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- Al-Obaedi O
- Al-Saqqa S
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- Al-Slaibi I
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- Alaael-Dein S
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- Alahmady O
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- Alhady K
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- Alhazmi W
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- Ali A
- Ali A
- Ali A
- Ali Cdm
- Ali E
- Ali Fm
- Ali H
- Ali S
- Ali Sawew
- Ali Ss
- Ali Tha
- Ali W
- Alihonou T
- Alimi Q
- Alimi Q
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- Aliyu H
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- Alkaaki A
- Alkammash A
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- Alnaby Mh
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- Alnusairat A
- Alomar In
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- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
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- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
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- Alzahrani M
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- Aman Nf
- Amandito R
- Amandito R
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- Ambrozeviciute V
- Ameen M
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- Amole I
- Amreia M
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- Andika Ffa
- Andreotti D
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- Andriola V
- Ang Yl
- Angelieri D
- Anis E
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- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
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- Arachchige Lajj
- Arafa O
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- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
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- Arnaud Ap
- Arnaud Ap
- Arshad Mm
- Arslan E
- Arsyad Hm
- Arthur T
- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
- Ashton A
- Asi F
- Asilah Smd
- Assal A
- Assouto Pa
- Asturias S
- Asumah H
- Ata A
- Ata Aaa
- Ata Ay
- Atiyeh A
- Atkins Et
- Atkinson K
- Atobatele K
- Attallah Na
- Attard M
- Attia A
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- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
- Azmitia Jra
- Azodo Ia
- Azzie G
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- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki Ma
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- Badr A
- Badr Mfm
- Badwi Nm
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- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila Rmh
- Balkan Aza
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis Vj
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal Gs
- Baraka H
- Barakat Sae
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas Gn
- Barnacle J
- Barneo L
- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
- Barrios E
- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
- Basto Caa
- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada Ag
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet Ah
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- Beleñ
- Belkouchi A
- Belli A
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- Benammi S
- Benevento A
- Benevento A
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- Bennai Rm
- Benons N
- Bentounsi Z
- Benyaiche C
- Bermú
- Bernardo Cg
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezzina M
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj Is
- Bhat S
- Bhatnagar A
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- Bhopal Kf
- Bhopal Kf
- Bianco F
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- Birindelli A
- Birring A
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- Bjö
- Blacker S
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- Blencowe N
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- Blower E
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- Boal M
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- Burmistrovas A
- Burns H
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- Cabrera Ccrr
- Cacurri A
- Cadogan Dd
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- Cameron B
- Camilleri Gm
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- Camilleri-Brennan J
- Camilleri-Brennan Jf
- Campagnaro T
- Canto Md
- Capito C
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- Careta Mc
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- Carmona Jm
- Carneros Vj
- Carpio J
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- Carreira Ja
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- Castillo Vdp
- Castro Mr
- Catani M
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- Cecilia T
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- Cengiz Y
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- Cevik M
- Chabok A
- Chachulski W
- Chai Ca
- Chai Fy
- Chambers A
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- Chan Tk
- Chan Xw
- Chan Z
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- Chang Ky
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- Chapman Sj
- Charles A
- Cheah Aez
- Chen Cy
- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
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- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
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- Chin Yr
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- Chiu Smy
- Choi J
- Choi P
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- Chong Cl
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- Chong Cs
- Chong Hy
- Chong Hy
- Choudhry A
- Chow Cyn
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- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung Kj
- Chung S
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- Cirocchi R
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- Claire R
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- Clegg-Lampety Jn
- Clegg-Lamptey Jn
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- Corro-Diaz S
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- Dé
- D&apos
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- Da Silva LA
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- Dainius E
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- Daniyan M
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- Daqeeq A
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- Darweesh M
- Darwish Ak
- Das A
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- Dasari M
- Dashnyam E
- Dassah V
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- Davies J
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- De Bono P
- De Bono P
- De Castro Segundo LCB
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- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
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- Deichsel F
- Del Basso C
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- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
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- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
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- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
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- Drake Tm
- Driscoll A
- Drungilas M
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- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
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- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
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- Eduard P
- Edwards J
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- El Ashal G
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- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
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- El Salam YA
- El Sayed GS
- El Sayed IM
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- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
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- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
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- Elazab A
- Elazayem Aa
- Elazoul M
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- Elbanby Es
- Elbatahgy A
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- Eldin Mab
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- Elfeki H
- Elfiky M
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- Elgendy Fi
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- Elkholy A
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- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
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- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
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- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
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- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
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- Elshami M
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- Elsherbiney S
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- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
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- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
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- Espinoza Kt
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- Essam A
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- Essam M
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- Estupinian S
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- Etchill E
- Etienne S
- Etman M
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- Fahiem A
- Fahim M
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- Fairfield C
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- Fakher R
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- Farahat Mm
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- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
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- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
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- Fontana T
- Foo Cc
- Forlin L
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- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
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- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
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- Ghanem S
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- Ghazy Aa
- Gheith A
- Ghetia M
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- Giardino Fr
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- Giuriato Tf
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- Gomaa A
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- Griffiths E
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- Grizhja B
- Grobler Dc
- Grosos C
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- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
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- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gunnarsson U
- Guo W
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- Gustafsson U
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- Gyedu A
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- Habeeb O
- Habeebullah A
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- Haddad N
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- Hafiz S
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- Hagar A
- Haines M
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- Halhouli O
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- Halicioglu I
- Hall E
- Hall N
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- Hamaguchi Jlh
- Hamarshi A
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- Hamdan A
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- Hamill D
- Hammad A
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- Hanoun S
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- Hanrahan M
- Hanrahan M
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- Hany E
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- Har Pa
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- Haroun A
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- Harrison N
- Harrison P
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- Harvey N
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- Hasanah A
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- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Omm
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- Hassan Z
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- Hassanein Ab
- Havemann I
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- Helguero-Santin Lm
- Hemeda D
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- Hoogakker E
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- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
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- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
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- Irwin G
- Irwin G
- Irwin G
- Irwin G
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- Iskandar F
- Ismaï
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- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
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- Jabbar A
- Jaber S
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- Javed O
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- Kabariti R
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- Kabba J
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- Kache S
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- Kalles V
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- Kamarajah Sk
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- Kamil R
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- Kanani A
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- Karabelias G
- Karabulut K
- Karahan Sr
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- Karjiker P
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- Karlo R
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- Karousos D
- Karumnas P
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- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
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- Kennedy Ed
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- Khamajeet A
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- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
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- Khokha D
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- Khosla S
- Khreishi R
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- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
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- Kim My
- Kim Sb
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- King R
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- Kirishnan A
- Kirupagaran A
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- Kjellin A
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- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
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- Komolafe O
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- Kong C
- Kong Sn
- Kong V
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- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
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- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
- Leppä
- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
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- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
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- Lundgren Po
- Luque Gb
- Luque L
- Luque L
- Lytras D
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- Má
- Mé
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- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
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- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
- Majid K
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- Major P
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- Mak T
- Mak T
- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
- McCullagh D
- Mcdonald R
- McGarvie S
- Mcguigan A
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- Mcintosh R
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- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
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- Mehrez S
- Mejia Agv
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Mitul Ar
- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
- Nasr A
- Nasr M
- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
- Nawawi A
- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
- Ngayu N
- Ngwa Te
- Niazi Ak
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
- Nikoloudis N
- Niragire A
- Niranjan N
- Nirumal Mk
- Niska K
- Nita Ge
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
- Normile C
- North As
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- Obute Rd
- Occhionorelli S
- Odeyemi B
- Odeyemi B
- Odutola O
- Ogunsua O
- Ogunyemi A
- Oh J
- Oh J
- Ohene-Yeboah M
- Ojeda Rrb
- Okenabirhie O
- Olajide To
- Olaolorun A
- Olivier J
- Olori S
- Olori S
- Oludara M
- Oludara M
- Olugbemi M
- Omar Aa
- Omar Me
- Omar Mfw
- Omara S
- Omer Oa
- Onimowo J
- Onuoha C
- Oosterkamp A
- Opoku-Agyeman R
- Oram S
- Orbegozo Pat
- Orchard M
- Ortega I
- Ortega I
- Ortega-Vazquez I
- Ortiz N
- Orton P
- Osagie O
- Osei-Nketiah S
- Oshati O
- Oshodi O
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- Osinowo A
- Osman M
- Osman N
- Osman O
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- Oswald D
- Otero-Dí
- Othman M
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- Oumer R
- Owen C
- Owusu F
- Owusu F
- Ozben V
- Ozkan Bb
- Ozkan Bb
- Ozkan Bb
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- Paž
- Pabla G
- Pacheco Rda
- Padmore G
- Pagano G
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- Pagnozzi J
- Pahlsson Hi
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- Palayan K
- Palkhi Eya
- Palliyil M
- Palliyil Mm
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- Palma Af
- Paludi Ma
- Paludi Ma
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- Panez Wr
- Panieri E
- Panteli C
- Papageorgiou D
- Papailia A
- Papandrea M
- Papaskarlatos Ia
- Pape J
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- Parakh J
- Paramasivan A
- Parasyris S
- Pardo G
- Parent V
- Park Eh
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- Parmentier B
- Parpoudi S
- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
- Pascale G
- Pascale Mm
- Pasini M
- Pasquali S
- Pastora J
- Pata D
- Pata D
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata G
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- Patel K
- Patel P
- Patel P
- Patel S
- Patel V
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- Patoulias I
- Paul M
- Paul S
- Paulouski D
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- Pektaş
- Pellino G
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- Perera J
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- Perino M
- Peros G
- Perrotta G
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pineñ
- Pinkney T
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- Pinnagoda K
- Pino W
- Pitt Sk
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- Pluke K
- Poš
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- Poskus T
- Poskus T
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- Powell A
- Pozo Dar
- Prabhudesai A
- Pranevicius R
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- Preckailaite E
- Primavesi F
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- Proctor Vk
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
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- Puma Cmh
- Punja V
- Purwaningsih Na
- Puttick M
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- Qawasmi I
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- Quayle J
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- Qumbos Aa
- Qureshi Au
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- Rahantasoa Fcfp
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- Rasoaherinomenjanahary F
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- Raza A
- Raza I
- Raza I
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- Razmdjou S
- Razuri C
- Razzaque J
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- Recinos G
- Recinos G
- Recinos G
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- Redgrave N
- Redota Map
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- Renaux-Petel M
- Restrepo Im
- Restrepo J
- Reunis E
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- Roche Mo
- Rocke A
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- Rodriguez X
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- Rudzenskaite A
- Ruiz-Tovar J
- Rulie As
- Runigamugabo E
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- Saad Ha
- Saad M
- Saad Mm
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- Saar S
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- Sabour Fa
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- Sahel S
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- Salah O
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- Salama M
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- Saleh O
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- Sallam Ae
- Salleh A
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- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
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- Sam Zh
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- Samaniego Cs
- Samaraweera Di
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- Sammarco G
- Sammut K
- Sampson C
- Samson G
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- Sanz S
- Sapci I
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- Sarafilovic H
- Saraste D
- Saravia F
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- Sasia D
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- Sauvat F
- Sava J
- Saw Je
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- Sayed F
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- Sayma Ea
- Scalabre A
- Scalabre A
- Schadde E
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- Schiavone R
- Schivo D
- Schmid R
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- Schuetz T
- Schultz Jk
- Scicluna R
- Scott M
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- Semeda N
- Semiz A
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- Senanayake Kj
- Senanayake Mkj
- Senanayake W
- Septiem Jg
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- Setiawan J
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- Sfougaris D
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- Shah A
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- Shah R
- Shaharuddin S
- Shahbaz Ar
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- Shahzad N
- Shaikh N
- Shaikh S
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- Shalabi A
- Shalaby A
- Shalaby M
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- Shamasneh A
- Shamsedine Aw
- Shamsi G
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- Shariffuddin Am
- Sharma A
- Sharpin C
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- Shaw Ca
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- Shawki M
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- Shawqi M
- Sheehan J
- Shehata S
- Sherif Ma
- Sherman T
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- Sheshe A
- Sheta A
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- Shillito S
- Shimy G
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- Sholadoye T
- Shrimanker N
- Shu S
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- Shu S
- Shubianok M
- Shukla J
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- Siguantay M
- Sigurdadottir J
- Sii Ssy
- Sila Gcm
- Sila Gm
- Sila Gm
- Sileri P
- Silvani P
- Silvestri V
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- Simoes Rl
- Simutis G
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- Sinha Y
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- Sivaganesh S
- Skardž
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- Sleem As
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- Smart N
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- Smart Nj
- Smedley A
- Smith C
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
- Solaini L
- Soldevila-Verdeguer C
- Soley R
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- Soliman N
- Soliman Na
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- Sollazzo V
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- Souaibou Yi
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- Soulou V
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- Srinivasan R
- Sriram A
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- Suarez A
- Suarez Aab
- Subocius A
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- Summerour V
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- Sundstrom Sm
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- Sutton P
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- Sykes M
- Szczap A
- Szeto Ccl
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- Tabiri S
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- Taddei A
- Tade A
- Tafazal H
- Taha Ems
- Tahboub H
- Taher Aa
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- Taher Mm
- Taieb C
- Taiwo A
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- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
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- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
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- Telfah Mm
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- Temoche E
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- Usaityte A
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- Vaicius A
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- Zuber M
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- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
LDHA gene is associated with pigeon survivability during racing competitions
- Author
- A Dixon
- A Dybus
- A Palleroni
- B Riviere
- C Darwin
- C Herold
- C Jerolmack
- CD Santos
- CJ Valvona
- D Biro
- D Sorensen
- D-H Shin
- David A Lightfoot
- G Van Hall
- G Van Hall
- H Lipp
- H Oki
- HJ Huson
- JC Mueller
- Junichi Yamaura
- LA Newman
- M Sobczynska
- MD Shapiro
- Miho Inoue-Murayama
- N Yang
- NC Rattenborg
- P Proia
- R Rohe
- S Mercieca
- S Ramadan
- S Ramadan
- S Ruefenacht
- Sherif Ramadan
- SSL Li
- T Smith
- T Tozaki
- T Tozaki
- Takeshi Miyake
- WM Levi
- WS Proskura
- WS Proskura
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Thigh-length compression stockings and DVT after stroke
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- Sohail B
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- Solesbury A
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- Willis J
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- Wiselka M
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- Wood F
- Wood J
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- Wyness K
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- Yanney M
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- Yates D
- Yates H
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- Yelnoorkar F
- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
- Zafar A-M
- Zaher S
- Zalewska K
- Zaman M
- Zaman S
- Zammit L
- Zammit-Mangion M
- Zdanaviciene A
- Zehnde D
- Zhixin J
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- Zia M
- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Multiple Quantum NMR Spectroscopy in Orientationally Ordered Fluids
- Author
- A Bax
- A Minoretti
- A Wokaun
- AA Maudsley
- AG Avent
- CP Slichter
- D Jaffe
- D Jaffe
- D Jaffe
- D Sandström
- D Zax
- DN Shykind
- DP Weitekamp
- DP Weitekamp
- DP Weitekamp
- E Ciampi
- EE Burnell
- EO Stejskal
- F Castiglione
- F Castiglione
- G Bodenhausen
- G Bodenhausen
- G Celebre
- G Drobny
- G Drobny
- G Drobny
- GK Pierens
- GP Drobny
- I Furo
- JA Ferretti
- JB Murdoch
- JCT Rendell
- JCT Rendell
- JF Martin
- JM Polson
- JW Emsley
- JW Emsley
- L Braunschweiler
- LD Field
- LD Field
- LD Field
- LD Field
- M Carravetta
- M Gochin
- M Gochin
- M Gochin
- M Gochin
- M Munowitz
- ME Rosen
- MH Levitt
- MH Levitt
- OW Sorenson
- P Diehl
- P Diehl
- P Diehl
- R Poupko
- RL Vold
- RR Ernst
- RR Vold
- RR Vold
- RR Vold
- RT Syvitski
- RT Syvitsky
- RT Syvitsky
- S Castellano
- S Ramadan
- S Wimperis
- SW Sinton
- SW Sinton
- T Chandrakumar
- TM Barbara
- WP Aue
- WS Warren
- WS Warren
- WS Warren
- WS Warren
- WS Warren
- WS Warren
- YS Yen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2003
- Field of study