Methods for intraoperative, sterile pose-setting of patient-specific microstereotactic frames

This work proposes new methods for a microstereotactic frame based on bone cement fixation. Microstereotactic frames are under investigation for minimal invasive temporal bone surgery, e.g. cochlear implantation, or for deep brain stimulation, where products are already on the market. The correct pose of the microstereotactic frame is either adjusted outside or inside the operating room and the frame is used for e.g. drill or electrode guidance. We present a patientspecific, disposable frame that allows intraoperative, sterile pose-setting. Key idea of our approach is bone cement between two plates that cures while the plates are positioned with a mechatronics system in the desired pose. This paper includes new designs of microstereotactic frames, a system for alignment and first measurements to analyze accuracy and applicable load. © 2015 SPIE

withdrawn 2017 hrs ehra ecas aphrs solaece expert consensus statement on catheter and surgical ablation of atrial fibrillation

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EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas

Early growth response-1 (EGR-1) is considered a central regulator in tumor cell proliferation, migration and angiogenesis and a promising candidate for gene therapy in human astrocytomas. However, conflicting data have been reported suggesting that both tumor promoting and anti-tumor activity of EGR-1 and its regulation, expression and prognostic significance still remain enigmatic. Our study explored EGR-1 expression and regulation in astrocytomas and its association with patient survival. As we detected two EGR-1 mRNA variants, one containing a N-methyl-D-aspartate-receptor (NMDA-R) responsive cytoplasmic polyadenylation element (CPE), further experiments were performed to determine the functional role of this pathway. After NMDA stimulation of SV-FHAS and neoplastic astrocytes, real-time polymerase chain reaction showed an increase of the CPE, containing EGR-1 splice variant only in astrocytoma cells. The surface expression and functionality of NMDA-R were demonstrated by flow cytometric analysis and measurement of increased intracellular Ca(2+). EGR-1 was mainly restricted to tumor cells expressing NMDA-R and significantly up-regulated in astrocytic tumors compared with normal brain. Further, EGR-1 expression was significantly (P < 0.007) associated with enhanced patient survival and was an independent prognostic factor in multivariate analysis in high grade astrocytomas. The NMDA-R-mediated EGR-1 expression, therefore, seems to be a promising target for novel clinical approaches to astrocytoma treatment

The Great Dimming of the Hypergiant Star RW Cephei: CHARA Array Images and Spectral Analysis

The cool hypergiant star RW Cephei is currently in a deep photometric minimum that began several years ago. This event bears a strong similarity to the Great Dimming of the red supergiant Betelgeuse that occurred in 2019–2020. We present the first resolved images of RW Cephei that we obtained with the CHARA Array interferometer. The angular diameter and Gaia distance estimates indicate a stellar radius of 900–1760 R _⊙ , which makes RW Cephei one of the largest stars known in the Milky Way. The reconstructed, near-infrared images show a striking asymmetry in the disk illumination with a bright patch offset from the center and a darker zone to the west. The imaging results depend on assumptions made about the extended flux, and we present two cases with and without allowing extended emission. We also present a recent near-infrared spectrum of RW Cep that demonstrates that the fading is much larger at visual wavelengths compared to that at near-infrared wavelengths as expected for extinction by dust. We suggest that the star’s dimming is the result of a recent surface mass ejection event that created a dust cloud that now partially blocks the stellar photosphere