Insights into the explosive eruption history of the Campanian volcanoes prior to the Campanian Ignimbrite eruption

The Campanian Volcanic Zone (CVZ) comprises multiple active volcanoes and includes the highly productive Campi Flegrei and Ischia caldera systems. These caldera volcanoes have produced probably the largest eruptions in Europe in the past 200 ka, such as the Monte Epomeo Green Tuff (MEGT; Ischia) at ca. 56 ka and the Campanian Ignimbrite (CI; Campi Flegrei) at ca. 40 ka, which form widespread isochrons across the Mediterranean region. These closely-spaced volcanic centres erupt phonolitic to trachytic glass compositions that are similar, and thus it can be challenging to correlate tephra deposits to specific volcanic sources. Here we present a detailed tephrostratigraphy for pre-CI eruption activity using the units preserved within a sequence at the coastal Acquamorta outcrop, on the western side of the CI caldera rim. Both the MEGT and CI units are present in the section, and they bracket twelve eruption units that were logged and sampled. New major and trace element glass chemistry data have been acquired for these Acquamorta tephra deposits. Three eruption deposits from Ischia and nine from Campi Flegrei are identified, which helps constrain the tempo of volcanic activity of these centres between the large caldera-forming eruptions. The three Ischia tephra deposits between the MEGT and the CI are indistinguishable based on both major and trace element glass chemistry and cannot be correlated to a specific or known eruption in this interval, such as the Schiappone tephra. The compositional variations between the Campi Flegrei eruptions reveal temporal shifts in the composition of the tephra deposits that reflect changes in the magmatic system prior to the CI eruption. These deposits indicate that there were at least nine eruptions at Campi Flegrei within 16 ka of the enormous CI eruption, and suggest that there was no significant period of repose before the caldera generating eruption

Potential for doseâ escalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and gEUDâ based cost functions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135067/1/mp6403.pd

The stubborn non-probabilist : "negation incoherence" and a new way to block the Dutch Book argument

We rigorously specify the class of nonprobabilistic agents which are, we argue, immune to the classical Dutch Book argument. We also discuss the notion of expected value used in the argument as well as sketch future research connecting our results to those concerning incoherence measures

Cyclical coronary flow reductions in conscious dogs equipped with ameroid constrictors to produce severe coronary narrowing

In conscious dogs equipped with ameroid constrictors to produce gradual coronary occlusion, coronary flow velocity was monitored prior to complete occlusion when coronary constriction was severe (resting flow velocity reduced by 10–50% from control recordings made 7–10 days after ameroid implantation). In six of the ten dogs, we observed spontaneous cyclical variations in coronary flow velocity, characterized by gradual reduction in flow followed by very abrupt restoration of flow. The cyclic coronary flow reductions were observed between 20 and 31 days after ameroid implantation. These changes in flow bear striking similarity to those observed by previous investigators using anesthetized, open-chest canine preparations, in which the role of platelets was clearly demonstrated. Consequently, we hypothesize that spontaneous platelet aggregation and de-aggregation within the severely narrowed coronary lumen (enclosed by the ameroid constrictors) could account for our observations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41746/1/395_2005_Article_BF01906748.pd

Cellular Basis of Tissue Regeneration by Omentum

The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells

Costlets: A Generalized Approach to Cost Functions for Automated Optimization of IMRT Treatment Plans

We present the creation and use of a generalized cost function methodology based on costlets for automated optimization for conformal and intensity modulated radiotherapy treatment plans. In our approach, cost functions are created by combining clinically relevant “costlets”. Each costlet is created by the user, using an “evaluator” of the plan or dose distribution which is incorporated into a function or “modifier” to create an individual costlet. Dose statistics, dose-volume points, biological model results, non-dosimetric parameters, and any other information can be converted into a costlet. A wide variety of different types of costlets can be used concurrently. Individual costlet changes affect not only the results for that structure, but also all the other structures in the plan (e.g., a change in a normal tissue costlet can have large effects on target volume results as well as the normal tissue). Effective cost functions can be created from combinations of dose-based costlets, dose-volume costlets, biological model costlets, and other parameters. Generalized cost functions based on costlets have been demonstrated, and show potential for allowing input of numerous clinical issues into the optimization process, thereby helping to achieve clinically useful optimized plans. In this paper, we describe and illustrate the use of the costlets in an automated planning system developed and used clinically at the University of Michigan Medical Center. We place particular emphasis on the flexibility of the system, and its ability to discover a variety of plans making various trade-offs between clinical goals of the treatment that may be difficult to meet simultaneously.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47484/1/11081_2005_Article_2066.pd

On the Mathematical Constitution and Explanation of Physical Facts

The mathematical nature of modern physics suggests that mathematics is bound to play some role in explaining physical reality. Yet, there is an ongoing controversy about the prospects of mathematical explanations of physical facts and their nature. A common view has it that mathematics provides a rich and indispensable language for representing physical reality but that, ontologically, physical facts are not mathematical and, accordingly, mathematical facts cannot really explain physical facts. In what follows, I challenge this common view. I argue that, in addition to its representational role, in modern physics mathematics is constitutive of the physical. Granted the mathematical constitution of the physical, I propose an account of explanation in which mathematical frameworks, structures, and facts explain physical facts. In this account, mathematical explanations of physical facts are either species of physical explanations of physical facts in which the mathematical constitution of some physical facts in the explanans are highlighted, or simply explanations in which the mathematical constitution of physical facts are highlighted. In highlighting the mathematical constitution of physical facts, mathematical explanations of physical facts deepen and increase the scope of the understanding of the explained physical facts. I argue that, unlike other accounts of mathematical explanations of physical facts, the proposed account is not subject to the objection that mathematics only represents the physical facts that actually do the explanation. I conclude by briefly considering the implications that the mathematical constitution of the physical has for the question of the unreasonable effectiveness of the use of mathematics in physics

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease

The recommendations listed in this document are, whenever possible, evidence based. An extensive evidence review was conducted as the document was compiled through December 2008. Repeated literature searches were performed by the guideline development staff and writing committee members as new issues were considered. New clinical trials published in peer-reviewed journals and articles through December 2011 were also reviewed and incorporated when relevant. Furthermore, because of the extended development time period for this guideline, peer review comments indicated that the sections focused on imaging technologies required additional updating, which occurred during 2011. Therefore, the evidence review for the imaging sections includes published literature through December 2011