172 research outputs found
Piperine as a phytogenic additive in broiler diets
- Author
- AraÚjo‑jÚnior J.X.
- BAJAD S.
- Bhat B.G.
- Botsoglou N.A.
- CAMPBELL T.W.
- Cardoso V. da S.
- CASTANON J.I.R.
- COLES E.H.
- Cristina Amorim Ribeiro de Lima
- Cross D.E.
- Dogra R.K.S.
- Ertas O.N.
- Gagini T.B.
- Ikan R.
- JAIN N.C.
- KANEKO J.J.
- Karan R.S.
- Khajuria A.
- Kohlert C.
- Luis Eduardo Gomes Dorneles
- Marco Edílson Freire de Lima
- Maria das Graças Miranda Danelli
- Miles R.D.
- Mittal R.
- Ocak N.
- Perić L.
- Pradeep C.R.
- Reddy S.V.
- Reen R.K.
- ROSTAGNO H.S.
- Samanya M.
- Scheuermann G.N.
- SCHMIDT E.M.S.
- Siddiqui B.S.
- Singh Y.N.
- SRINIVASAN K.
- TAKAKI M.
- TROBE M.M.
- Verônica da Silva Cardoso
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
- Author
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
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- Abbadessa F.
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- Abbott T.
- Abd Elazeem H. A. S.
- Abdalla M.
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
- Author
- Aawsaj Y.
- Abad Gurumeta A.
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
- Author
- Abrams Simon
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W A
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Cupitt Jason
- Cutino-moguel Maria-teresa
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- De Silva Thushan
- De Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donnison Phil
- Donohue Chloe
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Dunn Chris
- Dunning Jake
- Durand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Eunice Zhang J
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fegan Christopher
- Filipe Ana Da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W S
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Girvan Michelle
- Gkrania-klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Greenhalf William
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
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- Ho Antonia
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- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
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- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
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- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-langham Lara
- Law Andrew
- Law Andrew
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lillie Patrick
- Lim Wei Shen
- Limb James
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- Little Jeff
- Livoti Lucia A
- Lyons Ruth
- Lyttle Mark
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- Macmahon Michael
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- Marsh Laura
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- Miah Nahida S
- Middleton Joanna
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- Mitchell Joyce
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- Pais Mark
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- Pintus Stefania
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- Post Frank
- Price David
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- Subramaniam Krishanthi S
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- Summers Charlotte
- Szakmany Tamas
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- Taggart Aislynn
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- Thomas Jo
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- Thwaites Ryan S
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- Tridente Ascanio
- Trochu Erwan
- Tupper-carey Darell
- Turtle Lance
- Turtle Lance C W
- Twagira Mary
- Ustianowski Andrew
- Vallotton Nick
- Van Tonder Libby
- Vincent-smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/04/2022
- Field of study
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p
Mixed-Monolayer-Protected Au 25
- Author
- Akola J.
- Arduini A.
- Arduini A.
- Arora V.
- Astruc D.
- Casnati A.
- Chen X.
- Ciesa F.
- de Silva N.
- Dionisio M.
- Díez I.
- Elina Kalenius
- Ghosh P.
- Gutsche C. D.
- Ha J.-M.
- Ha J.-M.
- Hannu Häkkinen
- Heaven M. W.
- Heikki Tenhu
- Hudrlik P. F.
- Häkkinen H.
- Jin R.
- Jukka Hassinen
- Knoppe S.
- Lu F.
- Maity P.
- Mokhtari B.
- Niihori Y.
- Parker J. F.
- Pescatori L.
- Petri Pulkkinen
- Pulkkinen P. M. S.
- Qian H.
- Qian H.
- Robin H. A. Ras
- Saha K.
- Scheerder J.
- Shibu E. S.
- Tang Z.
- Templeton A. C.
- Thalappil Pradeep
- Wu Z.
- Zheng J.
- Zhu M.
- Zhu M.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abbas Dehghan
- Abdonas Tamosiunas
- Abdullatif S Husseini
- Abhijit Sen
- Abla M Sibai
- Adela Chirita-Emandi
- Adolfo Rubinstein
- Afshin Ostovar
- Ahmad Ali Noorbala
- Ahmad Ali Zainuddin
- Ahmad Faudzi Yusoff
- Aicha Soumare
- Aida Pilav
- Akihiro Yoshihara
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Albert Hofman
- Albertino Damasceno
- Alberto Barceló
- Alejandro Diaz
- Aleksandar Džakula
- Aleksander Giwercman Wu
- Aleksandra Piwonska
- Alet H Wijga
- Aletta E Schutte
- Alexandre C Pereira
- Alicia Matijasevich
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline Wagner
- Alireza Ahmadvand
- Alisha N Wade
- Alison J Hayes
- Allan Linneberg
- Altan Onat
- Aluisio J D Barros
- Alun Evans
- Ambady Ramachandran
- Amina Barkat
- Amir Kasaeian
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Henriques
- Ana Jelaković
- Ana Maria B Menezes
- Ana Paula C Cândido
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andre Pascal Kengne
- Andrea R V R Horimoto
- Andres Metspalu
- Andrzej Pajak
- Andrzej Wiecek
- Aneta Grajda
- Angela Chetrit
- Angela Döring
- Angelique W Chan
- Ann-Sofie Forslund
- Anna Bugge
- Anna G Iannone
- Annamari Lundqvist
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette Peters
- Annika Rosengren
- Anoosheh Ghasemian
- Anselmo J Mc Donald Posso
- Anthony Kafatos
- Antoinette Amuzu
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonis Zampelas
- Anup Ghimire
- Anwar M Batieha
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Aryeh D Stein
- Assembekov Batyrbek
- Astrid Petersmann
- Atul Trivedi
- Augusto F Di Castelnuovo
- Aung Soe Htet
- Avula Laxmaiah
- Avula Laxmaiah
- Axel C Carlsson
- Aya Mostafa
- Aye Aye Sein
- Aziz al-Safi Ismail
- Bagher Larijani
- Balkish M Naidu
- Baurzhan Zhussupov
- Beata Gurzkowska
- Belong Cho
- Ben Schöttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Bernardo L Horta
- Bernhard Föger
- Betina H Thuesen
- Bharathi Viswanathan
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Blanca Sandra Ruiz-Betancourt
- Bogdan Wojtyniak
- Bojan Jelaković
- Bontha V Babu
- Breige A McNulty
- Carl Lachat
- Carlo M Barbagallo
- Carlos A Aguilar-Salinas
- Carlos P Boissonnet
- Carmelo A Caserta
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Carsten O Schmidt
- Catherine Kyobutungi
- Catherine Leclercq
- Catterina Ferreccio
- Cecilia Björkelund
- Cesar G Victora
- Chao Qiang Jiang
- Charles Agyemang
- Charles K Mondo
- Charles Lugero
- Charles Sossa Jérome
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
- Ching-Yu Cheng
- Chris Cowell
- Christa L Lilly
- Christa Meisinger
- Christina Howitt
- Christine Cameron
- Christophe Tzourio
- Chung T Nguyen
- Cihangir Erem
- Claudia M Hormiga
- Clive Osmond
- Cláudia S Minderico
- Con Burns
- Constance Schultsz
- Cora L Craig
- Cristina Padez
- Cristina Taddei
- Cynthia Robitaille
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damaskini Valvi
- Damian K Francis
- Dan Zhu
- Daniel A Rangel Reina
- Daniel Ansong
- Daniel Fernández-Bergés
- Daniel Ferrante
- David Faeh
- Davide Noto
- Davood Khalili
- Deepa Weerasekera
- Deepak N Amarapurkar
- Delphine De Smedt
- Dermot O'Reilly
- Diana A Santos
- Diana Kuh
- Dianna J Magliano
- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego Salmerón
- Diego Vanuzzo
- Dimitrios Papandreou
- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Domenico Palli
- Dominique Arveiler
- Dominique Cottel
- Dong Wook Shin
- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris Stöckl
- Dušan Grafnetter
- Dénes Molnár
- E Shyong Tai
- Eduardo Salazar Martinez
- Eero O Kajantie
- Ei Ei K Nang
- Eiji Oda
- Eira Viikari-Juntura
- Elena Pahomova
- Eleonora d'Orsi
- Elias F Gudmundsson
- Elin Kolle
- Elio Riboli
- Elisabete Ramos
- Eliza Cinteza
- Ellis Owusu-Dabo
- Ellisiv B Mathiesen
- Els Clays
- Elzbieta Dziankowska-Zaborszczyk
- Eman Aly
- Emily Sonestedt
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- Emmanuella Magriplis
- Eng Joo Tan
- Enzo Manzato
- Erkin Mirrakhimov
- Espen Bjertness
- Esther Zimmermann
- Eugène Sobngwi
- Eunice E Ugel
- Eva Maria Navarrete-Muñoz
- Fabio Galvano
- Fangfang Chen
- Farshad Farzadfar
- Farzad Hadaegh
- Felipe F Casanueva
- Felix Gutzwiller
- Felix K Assah
- Fereidoun Azizi
- Fernando Rigo
- Fernando Rodríguez-Artalejo
- Fikru Tullu
- Flavio D Fuchs
- Flavio Nervi
- Francesco Branca
- Francesco Gianfagna
- Francesco Panza
- Francisco J Felix-Redondo
- Frank Claessens
- Frank Tanser
- Fred Michel Paccaud
- Freda Pitakaka
- Frederic Gottrand
- Frederick C Wu
- Gabriele Nagel
- Gabriella Gruden
- Gailute Bernotiene
- Garry Jennings
- Geetha R Menon
- Georg Lappas
- George L L Machado-Coelho
- George Moschonis
- George S Stergiou
- Giovanni de Gaetano
- Giovanni Veronesi
- Giselle Sarganas
- Giuseppe Grosso
- Glenn Oehlers
- Gonul Horasan Dinc
- Gonzalo Valdivia
- Goodarz Danaei
- Goodarz Danaei
- Graziella Bruno
- Graziella D'Arrigo
- Grazyna Jasienska
- Gregor Jurak
- Gregor Starc
- Gregor Starc
- Gretchen A Stevens
- Guang Ning
- Guansheng Ma
- Guillermo Frontera
- Gustavo Velasquez-Melendez
- Guy De Backer
- Gyulli Kazakbaeva
- Günay Can
- H B(as) Bueno-de-Mesquita
- Ha T P Do
- Haakon E Meyer
- Habiba Ben Romdhane
- Haiquan Xu
- Hajer Aounallah-Skhiri
- Han C G Kemper
- Hanna K Tolonen
- Hannelore K Neuhauser
- Hannelore K Neuhauser
- Hanno Ulmer
- Hannu M T Uusitalo
- Hans Concin
- Harshpal S Sachdev
- Harunobu Nakamura
- Hashem Jaddou
- Heba M Fouad
- Heiner Boeing
- Helen Gonçalves
- Heloisa Bettiol
- Herculina S Kruger
- Herman Schargrodsky
- Hermann Brenner
- Himanshu K Chaturvedi
- Hoang Van Minh
- Holger Theobald
- Honor Bixby
- Hossein Poustchi
- Hsien-Ho Lin
- Huashuai Chen
- Hui Cai
- Hung-Kwan So
- Hynek Pikhart
- Hélène Delisle
- Ian R Hambleton
- Ian R Hambleton
- Idowu O Senbanjo
- Idris Guessous
- Ilona Nenko
- Ilpo Tapani Hihtaniemi
- Imane Cherkaoui Dekkaki
- Imperia Brajkovich
- Imre Janszky
- Ina S Santos
- Indah S Widyahening
- Indrapal I Meshram
- Inge Huybrechts
- Inger Ariansen
- Iqbal Bata
- Iraj Nabipour
- Irene G M van Valkengoed
- Iris Pigeot
- Isabel O Oliveira
- Ivan Pecin
- Ivana Radic
- J Jaime Miranda
- Jaakko Mursu
- Jaakko Tuomilehto
- Jacek Jóźwiak
- Jacqueline F Price
- Jakub Stokwiszewski
- Jalila El Ati
- James Bennett
- James Bentham
- Jan A Staessen
- Jana Námešná
- Janette Walton
- Janina Petkeviciene
- Janne S Tolstrup
- Japhet Killewo
- Jardena J Puder
- Jari J Jokelainen
- Jaume Marrugat
- Jean Claude N Mbanya
- Jean Dallongeville
- Jean Ferrieres
- Jean Woo
- Jean-Michel Gaspoz
- Jeannette Lee
- Jeonghee Lee
- Jeongseon Kim
- Jeremy M Jacobs
- Jerzy Chudek
- Jesus Vioque
- Jiang He
- Jie Mi
- Jim I Mann
- Jin Soo Moon
- Jing Liu
- Jing Liu
- Joana Araújo
- Joanne Katz
- Jochanan Stessman
- Jody C Miller
- Joel G R Roy
- Johan G Eriksson
- Johan Sundström
- Johan Sundström
- Johann Willeit
- Johanna A Otero
- Johanna Gunnlaugsdottir
- Johanna M Geleijnse
- Jolanta Slowikowska-Hilczer
- Jonathan E Shaw
- Jonathan Giovannelli
- Jorge Escobedo-de la Peña
- Jorge Mota
- Jorge Motta
- Jose G Boggia
- Jose Sánchez-Abanto
- Josep Redon
- Joseph Cacciottolo
- Joseph D Finn
- Jost B Jonas
- Jostein Steene-Johannessen
- José Eugenio Lozano
- José María Huerta
- José R Banegas
- Jouko L Saramies
- Juan Francisco
- Juan J Cruz
- Juan P González-Rivas
- Juan-Pablo Casas
- Judith Simons
- Juergen Breckenkamp
- Jukka T Salonen
- Julio Zuñiga Cisneros
- Jun Hata
- Jun Ma
- Jurate Klumbiene
- Jurate Medzioniene
- Jussi Kauhanen
- Justin Y Y Wong
- Jutta Stieber
- Juvenal Soares Dias-da-Costa
- Jyrki K Virtanen
- Jytte Halkjær
- Kai-Uwe Saum
- Kairat Davletov
- Kairit Mikkel
- Kamel Ajlouni
- Kaosar Afsana
- Karen Morgan
- Kari Kuulasmaa
- Karien Stronks
- Katsuyasu Kouda
- Kaveh Hajifathalian
- Kay-Tee Khaw
- Kazem Mohammad
- Kelias P Msyamboza
- Kenji Shibuya
- Khairil Si-Ramlee
- Khanh Le Nguyen Bao
- Khem B Karki
- Kim Overvad
- Kimmo Ronkainen
- Klodian Dhana
- Kodavanti Mallikharjuna Rao
- Koen Van Herck
- Konrad Jamrozik
- Kotsedi Daniel K Monyeki
- Kouamelan Doua
- Krishna K Aryal
- Krista Fischer
- Kumiko Ohara
- Kurt Widhalm
- Kyungwon Oh
- Lariane M Ono
- Larissa Pruner Marques
- Lars Bo Andersen
- Lars E Laugsand
- Lars H Ängquist
- Lars Lind
- Lars Vatten
- Laura A Rodríguez-Villamizar
- Laura Gutierrez
- Lauren Lissner
- Leandra Abarca-Gómez
- Leanne M Riley
- Lechaba Tshepo
- Leila B Moreira
- Leila Houti
- Lekhraj Rampal
- Leng Huat Foo
- Lenie van Rossem
- Leon A Simons
- Leticia Hernandez Cadena
- Liam Smeeth
- Licia Iacoviello
- Line T Møllehave
- Lital Keinan Boker
- Lizzy M Brewster
- Lorenza Pilotto
- Louise A Baur
- Louise Eriksen
- Louise Gates
- Lowell S Benson
- Luc Dauchet
- Lucie Viet
- Luigi Palmieri
- Luis A Moreno
- Luis B Sardinha
- Lutgarde Thijs
- Lutgart Braeckman
- Luz M León-Muñoz
- M Arfan Ikram
- M Fernanda Lima-Costa
- Maciej Banach
- Magda Gasull
- Mahboubeh Parsaeian
- Mahfuzar Rahman
- Majid Ezzati
- Malgorzata Mossakowska
- Mangesh S Pednekar
- Manoli Garcia-de-la-Hera
- Manu Raj
- Marc Gunter
- Marcela Gonzalez-Gross
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- Margus Punab
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- Maria Cecília F Assunção
- Maria do Carmo Franco
- Maria Dorobantu
- Maria Forsner
- Maria G Grammatikopoulou
- Maria G Stathopoulou
- Maria J Carvalho
- Maria L Muiesan
- Maria L Turley
- Maria Puiu
- Maria Teresa A Olinto
- Maria Wany Strufaldi
- Mariachiara Di Cesare
- Marianna Noale
- Mariano Bonet Gorbea
- Marieke B Snijder
- Marika Ferrari
- Marileen L P Portegies
- Marius B Bjertness
- Marjeta Majer
- Marjeta Mišigoj-Durakovic
- Mark Woodward
- Mark Woodward
- Markku Peltonen
- Marleen Elisabeth
- Maroje Soric
- Maroje Sorić
- Marshall K Tulloch-Reid
- Martijn Huisman
- Martin Bobak
- Martin C Gulliford
- Martin Neovius
- Martina Müller-Nurasyid
- Mary Simon
- Maryam Kavousi
- María del Cristo Rodriguez-Perez
- María José Tormo
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- Mattias Johansson
- Maung Maung Than Htike
- Mauro V Barros
- Melanie J Cowan
- Michael Bursztyn
- Michael Hobbs
- Michael Knoflach
- Michael Sjöström
- Michel Joffres
- Mieczyslaw Litwin
- Mikhail Benet
- Ming-Dong Wang
- Miquel Porta
- Mohamed Bamoshmoosh
- Mohamed M Ali
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- Mohsen M Ibrahim
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- Mostafa Qorbani
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- Nasheeta Peer
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- Nayu Ikeda
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- Niloofar Peykari
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- Noor Ani Ahmad
- Nor Azmi Kamaruddin
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- Noushin Mohammadifard
- Novie O Younger-Coleman
- null null
- Nuno Lunet
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- Oanh T H Trinh
- Ofra Kalter-Leibovici
- Olfa Saidi
- Olli Raitakari
- Ong Peng Guan
- Orlando Landrove
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- Oscar H Franco
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- Paibul Suriyawongpaisal
- Panayiotis K Yiallouros
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- Per Tynelius
- Peter Bjerregaard
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- Peter Stehle
- Peter Ueda
- Peter Vollenweider
- Peter Willeit
- Petra H Peeters
- Philippe Amouyel
- Pierre Traissac
- Pietro A Modesti
- Piotr Bandosz
- Prabhdeep Kaur
- Pradeep Joshi
- Prakash C Gupta
- Przemyslaw Slusarczyk
- Qian Wang
- Quang Ngoc Nguyen
- Quang V Nguyen
- Queenie Chan
- R Krishna Kumar
- Rachael M McLean
- Rachakulla Hari Kumar
- Rachel Cooper
- Rachel Dankner
- Radwan F Qasrawi
- Rahul Malhotra
- Rainford J Wilks
- Rajaa Al-Raddadi
- Rajeev Gupta
- Rajendra Pradeepa
- Rajiv T Erasmus
- Ramfis E Nieto-Martínez
- Ramin Heshmat
- Ramiro Guerrero
- Ranjit Mohan Anjana
- Raphael M Ritti-Dias
- Rebecca A Goldsmith
- Rebecca Hardy
- Renata Cifkova
- Renata Kuciene
- Renata Nunes dos Santos
- Reynaldo Martorell
- Reza Malekzadeh
- Reza Malekzadeh
- Ricardas Radisauskas
- Rildo S Wanderley
- Robert Beaglehole
- Robert Eggertsen
- Robert J Adams
- Roberto Elosua
- Roberto Lorbeer
- Robespierre Ribeiro
- Rod T Jackson
- Rod T Jackson
- Rodrigo M Carrillo-Larco
- Rody G Sy
- Roman Topór-Madry
- Romulo A Fernandes
- Ronald D Gregor
- Roosmarijn Verstraeten
- Rosalba Rojas-Martinez
- Rosalynn Siantar
- Rossana Borchini
- Roy A Wong-McClure
- Roya Kelishadi
- Rudolf Kaaks
- Rui Ornelas
- Rute Santos
- Ruzena Kubinova
- S Goya Wannamethee
- Sabina Zambon
- Sabine Schipf
- Sadaf G Sepanlou
- Sai Yin Ho
- Salim Mohanna
- Sameer Narake
- Sandra C Fuchs
- Sania Nishtar
- Sanjay Rampal
- Sanjib K Sharma
- Santosh K Bhargava
- Sarah P Garnett
- Sari Voutilainen
- Sauli Herrala
- Savvas Savva
- Scott B McLean
- Seppo Koskinen
- Sergej M Ostojic
- Sergio Viana Peixoto
- Seung-lyeal Jeong
- Shahab Khatibzadeh
- Shelly R McFarlane
- Shirin Djalalinia
- Shirin Djalalinia
- Shouling Wu
- Shu-Ti Chiou
- Shuohua Chen
- Sian M Robinson
- Sibel Sakarya
- Sidsel Graff-Iversen
- Sigmund A Anderssen
- Silvana P Donoso
- Simona Bo
- Simona Costanzo
- Simona Giampaoli
- Sine Skovbjerg
- Sirkka Keinänen-Kiukaanniemi
- Slawomir Koziel
- Snehalatha Chamukuttan
- Sofia Malyutina
- Sok King Ong
- Son Thai Pham
- Songhomitra Panda-Jonas
- Soon-Woo Park
- Sophie Visvikis-Siest
- Sounnia Mediene-Benchekor
- Stefaan De Henauw
- Stefan Kiechl
- Stefan Söderberg
- Stefania Maggi
- Steinar Krokstad
- Stela McLachlan
- Stephen T McGarvey
- Sudha Ramachandra Rao
- Sudhir Kowlessur
- Suhad Bahijri
- Suka Machi
- Sumit Bharadwaj
- Susana Sans
- Susi Kriemler
- Suzanne C Ho
- Tahir Aris
- Tai Hing Lam
- Takuro Furusawa
- Tandi E Matsha
- Tanja Stocks
- Tara C Coppinger
- Tazeen Jafar
- Teemu J Niiranen
- Teresa Norat
- Terho Lehtimäki
- Thein Thein Htay
- Thet Thet Mu
- Thomas M Dantoft
- Thor Aspelund
- Thorkild I A Sørensen
- Tien Yin Wong
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Vlasoff
- Timothy Key
- Tobias F Rinke de Wit
- Tom Wilsgaard
- Tomas Vega
- Tomasz Grodzicki
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Torben Jørgensen
- Toshiharu Ninomiya
- Tran Quoc Bao
- Trevor S Ferguson
- Tuyen D Le
- Ty T Dickerson
- Ulf Ekelund
- Ulrich Keil
- Urho M Kujala
- Ursula Kiechl-Kohlendorfer
- Valérie Deschamps
- Vanina Bongard
- Vanja Ivkovic
- Veikko Salomaa
- Ver Bilano
- Vera Grujic
- Vera Lanska
- Vera Musil
- Vesna Jureša
- Vilma E Irazola
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Virginija Dulskiene
- Viswanathan Mohan
- Viviane C Cardoso
- W M Monique Verschuren
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wan Zhu Zhang
- Wei Zheng
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenhua Zhao
- Wichai Aekplakorn
- William A Neal
- Winsome R Parnell
- Wojciech Drygas
- Wolfgang Ahrens
- Xenophon Theodoridis
- Xiaoguang Yang
- Xingwang Ye
- Xu Lin
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yannis Manios
- Yanping Li
- Yeon-Yong Kim
- Yi Song
- Yi Zeng
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Youchan Shin
- Young-Ho Khang
- Young-Ho Khang
- Yousef Saleh Khader
- Yufang Bi
- Yuki Fujita
- Yumi Cho
- Yuna He
- Yvonne T van der Schouw
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zhengming Chen
- Zhengming Chen
- Ziad A Abdeen
- Publication venue
- ZU Scholars
- Publication date
- 01/01/2018
- Field of study
© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Repositioning of the global epicentre of non-optimal cholesterol
- Author
- Aadahl Mette
- Abarca-Gómez Leandra
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahluwalia Tarunveer S.
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- Ahmadi Ali
- Ahmadi Naser
- Ahmed Soheir H.
- Ahrens Wolfgang
- Ajlouni Kamel
- al-Safi Ismail Aziz
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala’a
- Aly Eman
- Amarapurkar Deepak N.
- Amouyel Philippe
- Andersen Lars Bo
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- Zambon Sabina
- Zampelas Antonis
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Wenhua
- Zhen Shiqi
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhussupov Baurzhan
- Zoghlami Nada
- Publication venue
- Publication date
- 01/01/2020
- Field of study
High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
- Carroll Paul
- Carter C. Ross
- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
- Chambers Adam
- Chambers Alice
- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chhabra Alok
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
- Dennison A. R.
- Derbyshire Laura
- Devoto Laurence
- Dhillon Ajit
- Diamond Tom
- Dickson-Lowe Richard
- Digney Ruairi
- Dindyal Shiva
- Dobbins Brian
- Doe Matthew
- Dorrian Emmet
- Doulias Triantafyllos
- Downing Justine
- Drake Benjamin
- Driscoll Peter J.
- Duke Diana
- Durkin Damien
- Dwerryhouse Simon J.
- D’Costa Conrad
- Ebdewi Hamdi
- Ebied Husam
- Eisawi Abdalla
- El-Dhuwaib Yesar
- El-Hasani Shamsi S.
- Elkheir Natalie
- Elmasry Mohamed
- Elsayed Mohammed
- Elshaer Mohamed
- Emesih Sophie
- Farag Sameh F.
- Farooq Ansar
- Farouk Marwan
- Fasih Tani
- Fawole Adeshina S.
- Fenwick Stephen
- Ferguson Graeme
- Ferris Paul
- Finch David
- Finch J. G.
- Finlay Ian
- Fleming Katie
- Fletcher Ted
- Fordham Imogen J.
- Forouzanfar Amir
- Forrest Craig R.
- Forster Luke
- Fothergill Laura
- Frame Richard J.
- Francombe James
- Frank Lucinda
- Fusai Guiseppe
- Galanopoulos Giorgios
- Gallagher Paul V.
- Garcea Giuseppe
- Gardner-Thorpe James
- Geoghegan Justin G.
- Geogloma Ileana
- Gerakopoulos Stratos
- Ghareeb Essam
- Ghazanfar Mudassar A.
- Gibson Simon
- Giles Mathew
- Giovinazzo Francesco
- Giwa Lola
- Goh Yan Li
- Gopalswamy Sivakumar
- Goscimski Andrzej
- Gossage James A.
- Gough Martin
- Gould Laura
- Gould Laura
- Grant Alan J.
- Gravante Gianpiero
- Griffiths Ewen
- Griffiths Ewen A.
- Gull Sadaf
- Gunasekera Rohan T.
- Gurung Kabita
- Guthrie Graeme J. K.
- Guy Finch J.
- Hafiz Shazia
- Halkias Constantine
- Hall Claire
- Hamady Zayed
- Hamdan Alhafidz
- Hamdan Mohammed F.
- Hamilton Emma
- Hancorn Kate
- Haque Manzarul
- Haque Samer Ul
- Hardy Thomas J.
- Hargreaves Anita
- Harilingam Mohan
- Harris Andrew
- Harrison Ewen
- Hawkins Helen
- Heath Jonathan
- Hebbar Madhusoodhana
- Henderson Lucy T.
- Henley Natasha
- Heshaishi Mohamed
- Hewes James
- Hewes James C.
- Heywood Nick
- Higgs Simon M.
- Hill Arnold D. K.
- Hindley Caroline
- Hirst Natalie A.
- Hisham Elzanati
- Ho Wei-Min
- Hoban Jennifer R.
- Hodgkins Kathryn A.
- Hodson James
- Holroyd David J.
- Hooks Gareth
- Hopwood Benjamin
- Hornby Steve T.
- Hornsby Jane
- Hosie Kenneth B.
- Hosie Kenneth B.
- Hossack Martin R.
- Hossain Tanvir
- Hoti Emir
- Hou David
- Hrycaiczuk Alex
- Hughes Michael
- Hunter David I.
- Hussain Abdulzahra A.
- Hussain Adnan
- Hussain Anwar
- Hussain Najam
- Iftikhar Syed Yusuf
- Iqbal Nusrat
- Iskandar Edrin
- Issa Eyad
- Ivanovski Ivan
- Jackson Andrew
- Jackson Claire
- Jafferbhoy Sadaf F.
- Jambulingam Periyathambi
- Jamdar Saurabh
- Jamel Sara
- Janeczko Adam
- Jaunoo Shameen
- Jayanthi Naga V. G.
- Jelley Clare
- Jennings Neil A.
- Joel Abraham
- Johnpulle Michelle A.
- Johnston Dorothy
- Johnstone Marianne
- Johnstone Marianne
- Joji Nikita
- Jones Claire
- Jones Elinor
- Jones Gareth H.
- Jones M. Angharad
- Jones Michael J.
- Jones Robert P.
- Jones Steven M.
- Kadhim Abbas
- Kadirkamanathan Sritharan
- Kallaway Charlotte
- Kanakala Venkatesh
- Kanavati Osama
- Kansal Nisheeth
- Kaptanis Sarantos
- Karavadra Babu
- Karim Lawen
- Karunakaran Priyadarssini
- Kaur Parminder
- Kausar Ambareen
- Kelly Michael E.
- Kendal Chris
- Kennedy David
- Kenny Ross
- Keogh Ken
- Khalil Ahmed M.
- Khan Amarah
- Khan Mohammad A.
- Khan Muhammad A. S.
- Khan Raja Basit
- Khan Shabuddin
- Khan Shahab
- Khawaja Amir
- Khawaja Zechan
- Khogali Elmoataz
- Kimble Adam
- Kinghorn Alison
- Kirkham Amanda J.
- Knight Benjamin
- Knight Katrina
- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
- Kyriakidis Dimitrios
- Lalla Kushik
- Lambert Joel
- Lammy Simon
- Lane Risha
- Larkin David
- Law Jennifer
- Lawther Roger
- Lazim Taha
- Lee Kathryn
- Lee Matthew
- Leeder Paul
- Lennon Hannah
- Lewis Michael
- Lim Henry C. C.
- Lim Pei J.
- Lindsay David
- Lloyd David
- Lo Christina
- Lodhia Joshil
- Longbotham David A.
- Loughlin Paula
- Lovett Bryony
- Luhmann Andreas
- Luther Ali Alison
- Lyons Emma M.
- Macano Christina A. W.
- MacArtney Matthew
- Macdonald Andrew
- Madanipour Suroosh
- Madbak Khaliel
- Madurska Marta
- Magee Conor J.
- Maguire Donal
- Maharaj Geta
- Majeed Ali
- Malcolm Cathy
- Malde Deep
- Malik Nabeela S.
- Mallik Mekhlola
- Mansour Sami
- Manu Mangta
- Manzelli Antonio
- Marriott Paul
- Martin Jack
- Martin Sean T.
- Martin Serena
- Marudanayagam Ravi
- Mason Denise
- Mathur Pawan
- Mawhinney Abi
- Mbuvi James
- McAree Barry
- McCain Stephen
- McCallum Iain J. D.
- McClarey Andrew
- McCune Ken
- McDermott Frank
- McEntee Gerry P.
- McGlone Emma R.
- McGuigan Andrew
- McIlmunn Colin
- McKay Damian
- McKenzie Stephen
- McNair Angus G. K.
- Mealy Ken
- Menzies Donald
- Mercer Stuart J.
- Milburn James
- Mirza Ahmed K.
- Mirza Darius
- Miu Victor
- Mockford Justine Downing Katherine A.
- Mohamed Sarah
- Mohan Helen M.
- Mok Kam Wa Jessica
- Monk David
- Morcous Paul
- Morrison Tamsin E. M.
- Mothe Bhavani Sidhartha
- Mowbray Nicholas
- Mozolowski Kirsty L.
- Mukherjee Dipankar
- Murphy James O.
- Murtaza Ghulam
- Nally Deirdre M.
- Napetti Sara
- Nassar Ahmad H.
- Naumann David
- Nedujchelyn Yuwaraja
- Needham Paul J.
- Newton Katy
- Newton Richard C.
- Ngu Wee Sing
- Nicholson Gary A.
- Nicholson James
- Nicholson James A.
- Nicol Laura
- Nicolay Christopher R.
- Nieto Tom
- Nijjar Rajwinder S.
- Nilsen-Nunn April
- Nilsson Frida
- Noble Fergus
- Nofal Emma
- Noor Nigel
- Nunes Quentin M.
- Obeidallah Mohd Rami
- Ogedegbe Arikoge
- Old Oliver J.
- Orchard Philippa
- Orizu Mavis N.
- O’Dwyer Patrick
- O’Neill Maeve A.
- O’Neill Stephen
- O’Reilly Derek A.
- O’shea Kathryn M.
- O’Sullivan Adrian W.
- Packer Jessica R.
- Padwick Robert
- Pannu Arslan
- Panteleimonitis Sofoklis
- Parappally Ciny P.
- Parmar J.
- Pasquali Sandro
- Patel Abhilasha
- Patel Krashna
- Patel Shakira
- Pati Pradeep
- Pearce Belinda
- Pearson Katherine L.
- Peirce Colin
- Pellen Mike
- Peter Mark B.
- Peterson Mark
- Pezzuto Roberto
- Photi Evangelos
- Phull Manraj
- Pinho-Gomes Ana C.
- Pollock Sarah
- Popplewell Matthew
- Pore Naresh
- Porter Jonathan
- Prasad Abheesh R.
- Prasad Raj
- Preston Shaun R.
- Preziosi Giuseppe
- Prince Sarah
- Psica Alicja
- Puig Sonia
- Puntis Daniel J.
- Puri Yogesh
- Qandeel Haitham
- Rabie Mohamed
- Radwan Rami
- Rae David M.
- Rahman Saquib
- Rajaganeshan Rajasundaram
- Rajendran Ilayaraja
- Ramage Michael I.
- Rao Sudhindra T. V.
- Rate Anthony J.
- Raza Soulat
- Read Edward
- Reddy Marcus
- Reece-Bolton Obuobi
- Reed Joanna
- Reid Alistair
- Rengifo Carla
- Rhys Thomas
- Richards Colin H.
- Riera Manel
- Ritchie Judith
- Robb William
- Roberts Geoffrey P.
- Robinson Sarah
- Robinson Steven J.
- Robinson Stuart
- Rodriguez Dan
- Rodriguez Daniel Urriza
- Roebuck Amanda
- Rogers Paul N.
- Rolph Rachel C.
- Roy Sudipta
- Rutherford Claire L.
- Sadat Mohammed M.
- Sakai Naomi
- Sampat Keerthika
- Samuel Nehemiah
- Sarmah Piyush B.
- Sarvananthan Kas
- Sarveswaran Janahan
- Satheesan Steve
- Saunders Michael
- Sayegh Mazin
- Segaran Ashvina
- Sekhar Hema
- Sen Gourab
- Seymour Keith
- Shabo Wael
- Shah Nayab
- Shah Reena
- Shahin Yousef
- Sheel Andrea R. G.
- Shenoy Hrishikesh
- Shetty Vinutha
- Shier David
- Shingler Guy M.
- Shiwani Muhammad Hanif
- Shrestha Ashish Kiran
- Siddiqi Najaf
- Siddiqui Midhat N.
- Siddiqui Zohaib
- Sillo Toritseju O.
- Silva Michael
- Simpson Duncan J.
- Singh Shailendra
- Singh-Ranger Deepak
- Sinha Sidhartha
- Skelly Brendan L.
- Slavin John P.
- Slawinski Corinna
- Sloane Jake
- Smith Stella R.
- Smith Stella R.
- Sonsale Aniket
- Spearman John
- Spence Gary
- Spreadborough Philip
- Spreadborough Philip
- Starmer Benjamin Z.
- Stevenson Thomas E. J.
- Stewart Duncan J.
- Stirland E.
- Subramanium Dhivya
- Sufi Pratik A.
- Sukha Anisha
- Sutcliffe Robert
- Suttie Stuart
- Sutton Cherith M. L. R.
- Szentpali Karoly
- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
- Taylor Christopher
- Taylor Greg W.
- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
- Thomas George
- Thompson Ronald L. E.
- Tilston Michael P.
- Toh Simon K. C.
- Tolofari Sotonye
- Tomlinson Mark A.
- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
- Tsavellas George
- Tuck Liz
- Turner Paul
- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
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- Cooper Debbie
- Copland Robert F
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- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
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- Crisp John C
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- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
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- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
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- Donovan Jenny L
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- Duffy Peter
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- Dunsmuir W D
- Durkan Garrett
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- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
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- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
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- Emberton Mark
- Emmerson Louise
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- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
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- Feggetter Jeremy
- Ferguson C
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- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
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- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
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- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Government ownership, informed trading, and private information
- Author
- Affleck-Graves
- Bailey
- Bardong
- Barron
- Ben-Nasr
- Ben-Nasr
- Ben-Nasr
- Bessembinder
- Bloomfield
- Borisova
- Borisova
- Bortolotti
- Bortolotti
- Botosan
- Boubaker
- Boubakri
- Bris
- Brockman
- Bushman
- Chan
- Choi
- Copeland
- De Winne
- Denis
- Dharwadkar
- Djankov
- Duarte
- Duarte-Silva
- Easley
- Easley
- Euronext rule book Book I: Harmonized rules
- Euronext: Organization and procedures
- Fan
- Finnerty
- Ginka Borisova
- Glosten
- Greenhouse
- Grullon
- Gul
- Hansch
- He
- Heflin
- Huang
- Hughes
- Khang
- Kim
- Kim
- Korczak
- Krinsky
- Lee
- Leuz
- Megginson
- Megginson
- Mohanram
- Parkinson
- Peng
- Perotti
- Piotroski
- Pradeep K. Yadav
- Rindi
- Shleifer
- Shleifer
- Su
- Ziobrowski
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
- …