An electrophysiological index of perceptual goodness

A traditional line of work starting with the Gestalt school has shown that patterns vary in strength and salience, a difference in ‘Perceptual goodness’. The Holographic weight of evidence model quantified goodness of visual regularities (van der Helm and Leeuwenberg, 1996). The key formula states that W = E/N, where E is number of holographic identities in a pattern, and N is number of elements. We tested whether W predicts the amplitude of the neural response to regularity in an extrastriate symmetry-sensitive network. We recorded a symmetry related ERP component called the Sustained Posterior Negativity (SPN). First we reanalysed published work and found that W explained most variance in SPN amplitude. Then in four new studies, we confirmed specific predictions of the holographic model regarding 1) the differential effects of numerosity on reflection and repetition, 2) the similarity between reflection and Glass patterns 3) multiple symmetries, and 4) symmetry and anti-symmetry. In all cases, the holographic approach predicted SPN amplitude remarkably well; particularly in an early window around 300-400 ms post stimulus onset. Although the holographic model was not conceived as a model of neural processing, it captures many details of the brain response to symmetry

UK Geoenergy Observatories : Glasgow baseline groundwater and surface water chemistry dataset release September 2020 - May 2021

This report describes baseline water chemistry sampling and analysis results for groundwater and surface water at the United Kingdom Geoenergy Observatory (UKGEOS) in Glasgow between September 2020 and May 2021. The report accompanies the Glasgow Observatory groundwater chemistry data release and the Glasgow Observatory surface water chemistry data release for the same periods. While the reporting period is nine months long, the global Covid-19 pandemic meant sampling was not always possible during this time. The groundwater data release contains data from six monthly sampling rounds, and the surface water data release contains data from three to five monthly sampling rounds (site dependant). The Glasgow Observatory comprises twelve boreholes drilled into the main hydrogeological units, known as target units. These are the superficial deposits, bedrock, Glasgow Upper mine workings and Glasgow Main mine workings. The ten boreholes used for groundwater sampling are located at the Cuningar Loop in South Lanarkshire. There are two additional boreholes in the Observatory, one seismic monitoring borehole in Dalmarnock in the east end of Glasgow, and one borehole used for sensor testing. Three boreholes are drilled into the superficial deposits, two into the unmined bedrock, three into the Glasgow Upper mine workings and two into the Glasgow Main mine workings. The boreholes are designed to assist geological and hydrogeological characterisation, including baseline water chemistry monitoring, and to act as mine water abstraction and reinjection wells. The aims of the Observatory are to: 1) provide baseline environmental characterisation, 2) assess changes in ambient conditions induced by mine water abstraction/re-injection cycles and, 3) provide data and evidence to de-risk low-temperature shallow mine water heat energy and heat storage in former coal mine workings. Groundwater sampling was conducted using either a submersible or bladder pump. Field parameters (pH, specific electrical conductance (SEC), redox potential (Eh) and dissolved oxygen (DO)) were measured in a flow-through cell. The flow-through cell was discharged to a plastic beaker containing a thermometer probe. Field parameters were measured for a period of 20 minutes and at least three readings were taken five minutes apart. After field parameters were taken, the flow cell was disconnected and samples were taken directly from the pump discharge tube. Field alkalinity was measured by titration against H2SO4. Groundwater samples were analysed for: major, minor, and trace elements, chromium speciation (Cr (III) and Cr (VI)), non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), volatile organic compounds (VOC), stable isotopes - deuterium (δ2H), oxygen 18 (δ18O) and carbon 13 of dissolved inorganic carbon (DIC) (δ13CDIC), ammonium (NH4), methane, ethane and carbon dioxide (CH4, C2H6, CO2), chlorofluorocarbons (CFC-12 and CFC-11), sulphur hexafluoride (SF6), and sulphide (S2-). The pH of groundwater samples (range 6.78 – 7.81) is circum-neutral to alkaline, with a similar range across all target units. Groundwater from all four lithologies is highly mineralised with median SEC values >1470 μS/cm. GGA01, installed in the Glasgow Upper mine working, had the most highly mineralised groundwater with a range of 2697 μS/cm – 3002 μS/cm. This range is significantly higher than those found in the groundwater of other boreholes screened into the Glasgow Upper mine workings: GGA04 (1597 μS/cm – 1669 μS/cm) and GGA07 (1664 μS/cm – 1756 μS/cm). The Glasgow Main mine workings boreholes, GGA05 and GGA08, had a combined SEC range of 1570 μS/cm – 1658 μS/cm. The range of recorded groundwater temperatures is largest in the superficial deposits (10.8°C – 15.1°C), reflecting the near-surface environment. The bedrock and mine workings all have similar ranges (bedrock 10.3°C – 12.6 °C, Glasgow Upper mine workings 10.6 °C – 13.3 °C, Glasgow Main mine workings 10.5 °C – 13.6 °C). In all target units the dissolved oxygen concentration is very low, the medians range from 0.23 mg/L to 0.31 mg/L. In general major elements and physio-chemical parameters measured in the groundwater samples have concentration ranges similar to those found in bedrock and mine workings across the Carboniferous sedimentary aquifers of the Midland Valley (Ó Dochartaigh et al., 2011). The water from most groundwater samples is unchanged from pumping tests conducted in early 2020 (Palumbo-Roe et al., 2021). Groundwaters are HCO3 type, with no dominant cation. However, groundwater in GGA01 has evolved since the pumping test and now has Ca-SO4 type water. Oxidation of iron sulphide minerals (e.g. pyrite) could have caused the dominance of the SO4 anion in GGA01 groundwaters. Dissolved organic carbon (as NPOC) has the largest range and the highest concentrations in the superficial deposits’ groundwaters (3.44 mg/L – 16.49 mg/L), the highest concentrations were all found in the groundwater at GGB04 (4.51 mg/L – 16.49 mg/L). Broadly similar concentrations were recorded in the bedrock (1.03 mg/L – 3.37 mg/L) and mine workings (Glasgow Upper mine workings: 1.91mg/L – 3.16 mg/L, Glasgow Main mine workings: 2.10 mg/L – 3.04 mg/L). The Ammonium (NH4) concentrations are high in all Glasgow Observatory groundwaters, with similar median values in all target units (12.9 mg/L – 13.5 mg/L). There was a large concentration range of trace elements in the Glasgow Observatory groundwaters, but there was no clear distribution. The lowest concentrations, and smallest ranges of each trace element tended to be in the Glasgow Main groundwaters, while the highest median and max concentrations of each trace element were found across the superficial deposits, bedrock and Glasgow Upper groundwaters. Some PAHs were detected in the superficial and bedrock boreholes, with TPH detected in low concentrations in all units at least once during the sampling period. VOCs were detected in the superficial deposits and Glasgow Main mine workings. Water stable isotopes, carbon 13 of DIC and residence time data were consistent with findings from the pumping test results (Palumbo-Roe et al., 2021). Groundwaters are recharged by modern recharge from local rainfall. Median concentrations of dissolved CH4 in the groundwaters range from 21 μg/L in the superficial deposits to 202 μg/L in the Glasgow Upper mine workings. These values lie within the upper range of groundwaters reported in other studies from Carboniferous sedimentary rocks in the Midland Valley of Scotland (Ó Dochartaigh et al., 2011). The highest concentration was found in borehole GGA04 (991 μg/L) and the superficial deposit borehole GGA09r, the latter being consistent with previous data (Palumbo-Roe et al., 2021). Dissolved CO2 has a median value of 116 mg/L with little variation between units. Cluster analysis revealed that the superficial deposits, the bedrock, the mine workings and the surface water samples are each clustered into statistically distinct groups. Borehole GGB04 generally clusters separately from the other boreholes drilled into the superficial deposits. GGB04 displays clear differences in concentrations and trends during the monitoring for a number of trace elements including Co, Mn, Fe, Ni and also in concentrations of NH4. It is possible that these differences are driven by migration of elements from the made ground at the site into the superficial deposits. Borehole GGA01, drilled into the Glasgow Upper mine workings is also distinct. This can be explained by the behaviour and concentrations of major and trace elements during the monitoring period. Trace elements As, Ba, Co, Fe, Li, Mn, Mo, Ni, Rb, Si, Sr, U and W, all have different concentrations to those observed in the other Glasgow Upper mine working boreholes. The packed waste that GGA01 is drilled into may act as a source for the elevated trace elements. Surface water samples were taken using an angular beaker and telescopic rod. Samples were taken from the River Clyde and the Tollcross Burn. Surface water samples were analysed for: major, minor, and trace elements, chromium species (Cr (III) and Cr (VI)), non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), and stable isotopes - deuterium (δ2H), oxygen 18 (δ18O) and carbon 13 of dissolved inorganic carbon (DIC) (δ13CDIC). While both the Clyde and Tollcross Burn have a near-neutral to alkaline pH and show a narrow range in pH values, the pH values measured at the Tollcross Burn tend to be higher (median 8.4 from the Tollcross Burn and 7.9 from the Clyde). The waters all follow a similar temporal trend, with the highest value each month measured at the Tollcross Burn. The SEC measurements are higher in the Tollcross Burn samples (median 953 μs/cm) than those measured in the River Clyde samples (median 385 μs/cm). The surface water samples all have similar major ion proportions. The River Clyde samples are Ca-HCO3 type. The samples taken from the Tollcross Burn are also Ca-HCO3 type, but can be distinguished from River Clyde samples as they have lower Ca concentrations and higher HCO3 concentrations. Most trace elements are present in higher concentrations in the River Clyde than in the Tollcross Burn; exceptions to this are Sr, B, and Rb, which are higher in the Tollcross Burn, and Co, Ni, Zn, As, Y, and Sb, which have similar concentrations in both watercourses. With the exception of Cr, the trace element concentrations are similar between all sites on the River Clyde, which would be expected given these sites are all on a relatively short stretch of the same river. The Cr concentrations are much higher at the sampling site closest to a former chemical works than elsewhere within the observatory. In general, the surface water results are consistent with findings from previous work (Fordyce et al., 2021)

UK Geoenergy Observatories : Glasgow baseline groundwater and surface water chemistry dataset release June 2021 - January 2022

This report follows the Glasgow baseline groundwater and surface-water chemistry dataset release report September 2020 – May 2021 (data release/ monitoring period 1) (Bearcock et al., 2022), and describes baseline water chemistry sampling and analysis results for groundwater and surface water at the United Kingdom Geoenergy Observatory (UKGEOS) in Glasgow between June 2021 and January 2022. The report accompanies the Glasgow Observatory groundwater chemistry data release and the Glasgow Observatory surface water chemistry data release for the same periods (data release/ monitoring period 2). The monitoring period is eight months long, with six rounds of surface water and groundwater sampling during this time. Sampling during non-consecutive months was a result of COVID-19 restrictions and construction activities at site. The Glasgow Observatory comprises twelve boreholes drilled into the main hydrogeological units, known as target horizons. These are the superficial deposits, bedrock, Glasgow Upper mine workings and Glasgow Main mine workings. The ten boreholes used for groundwater sampling are located at the Cuningar Loop in South Lanarkshire. There are two additional boreholes in the Observatory, one seismic monitoring borehole in Dalmarnock in the east end of Glasgow, and one borehole used for sensor testing. Three boreholes are drilled into the superficial deposits, two into the unmined bedrock, three into the Glasgow Upper mine workings and two into the Glasgow Main mine workings. The boreholes are designed to assist geological and hydrogeological characterisation, including baseline water chemistry monitoring, and to act as mine water abstraction and reinjection wells. The aims of the Observatory are to: 1) provide baseline environmental characterisation, 2) assess changes in ambient conditions induced by mine water abstraction/re-injection cycles and, 3) provide data and evidence to de-risk low-temperature shallow mine water heat energy and heat storage in former coal mine workings. Groundwater sampling was conducted using either a submersible or bladder pump. Field parameters (pH, specific electrical conductance (SEC), redox potential (Eh) and dissolved oxygen (DO)) were measured in a flow-through cell. The flow-through cell was discharged to a plastic beaker containing a thermometer probe. Field parameters were measured for a period of 20 minutes and at least three readings were taken five minutes apart. After field parameters were taken, the flow cell was disconnected, and samples were taken directly from the pump discharge tube. Field alkalinity was measured by titration against H2SO4. Groundwater samples were analysed for: major, minor, and trace elements, reduced iron (Fe), non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), volatile organic compounds (VOC), 2H and 18O abundance in water (δ2H and δ18O), 13C abundance in dissolved inorganic carbon (DIC) (δ13CDIC), ammonium (NH4), dissolved gases (methane, ethane and carbon dioxide (CH4, C2H6, CO2)), noble gases (helium, neon, argon, krypton, and xenon (He, Ne, Ar, Kr and Xe)), chlorofluorocarbons (CFC-12 and CFC-11), sulphur hexafluoride (SF6), and sulphide (S2-). The pH of groundwater samples (range 6.6 – 7.4) is circum-neutral, with a similar range across all target horizons. Groundwater from all four horizons is highly mineralised with median SEC values 1440 μS/cm - 1670 μS/cm. GGA01, installed in the Glasgow Upper mine working, had the most highly mineralised groundwater with a range of 2930 μS/cm – 3140 μS/cm. The range of recorded groundwater temperatures is largest in the superficial deposits (11.0°C – 16.6°C). The bedrock and mine workings groundwaters all have similar temperatures, and a narrower range of 10.1°C – 13.4 °C. In all target horizons the dissolved oxygen concentration is very low, all DO values are ≤0.81 mg/L. In general major elements and physico-chemical parameters measured in the groundwater samples have concentration ranges similar to those found in bedrock and mine workings across the Carboniferous sedimentary aquifers of the Midland Valley (Ó Dochartaigh et al., 2011). The chemistry of most groundwater samples is unchanged from pumping tests conducted in early 2020 (Palumbo-Roe et al., 2021), and the previous period of baseline monitoring that spanned the period from September 2020 to May 2021 (Bearcock et al., 2022). Groundwaters are generally HCO3 type, with no dominant cation. The exception is GGA01, where groundwaters changed from HCO3 type during the pumping test to Ca-SO4 type at the start of the previous round of monitoringThe Glasgow Observatory comprises twelve boreholes drilled into the main hydrogeological units, known as target horizons. These are the superficial deposits, bedrock, Glasgow Upper mine workings and Glasgow Main mine workings. The ten boreholes used for groundwater sampling are located at the Cuningar Loop in South Lanarkshire. There are two additional boreholes in the Observatory, one seismic monitoring borehole in Dalmarnock in the east end of Glasgow, and one borehole used for sensor testing. Three boreholes are drilled into the superficial deposits, two into the unmined bedrock, three into the Glasgow Upper mine workings and two into the Glasgow Main mine workings. The boreholes are designed to assist geological and hydrogeological characterisation, including baseline water chemistry monitoring, and to act as mine water abstraction and reinjection wells. The aims of the Observatory are to: 1) provide baseline environmental characterisation, 2) assess changes in ambient conditions induced by mine water abstraction/re-injection cycles and, 3) provide data and evidence to de-risk low-temperature shallow mine water heat energy and heat storage in former coal mine workings. Groundwater sampling was conducted using either a submersible or bladder pump. Field parameters (pH, specific electrical conductance (SEC), redox potential (Eh) and dissolved oxygen (DO)) were measured in a flow-through cell. The flow-through cell was discharged to a plastic beaker containing a thermometer probe. Field parameters were measured for a period of 20 minutes and at least three readings were taken five minutes apart. After field parameters were taken, the flow cell was disconnected, and samples were taken directly from the pump discharge tube. Field alkalinity was measured by titration against H2SO4. Groundwater samples were analysed for: major, minor, and trace elements, reduced iron (Fe), non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), volatile organic compounds (VOC), 2H and 18O abundance in water (δ2H and δ18O), 13C abundance in dissolved inorganic carbon (DIC) (δ13CDIC), ammonium (NH4), dissolved gases (methane, ethane and carbon dioxide (CH4, C2H6, CO2)), noble gases (helium, neon, argon, krypton, and xenon (He, Ne, Ar, Kr and Xe)), chlorofluorocarbons (CFC-12 and CFC-11), sulphur hexafluoride (SF6), and sulphide (S2-). The pH of groundwater samples (range 6.6 – 7.4) is circum-neutral, with a similar range across all target horizons. Groundwater from all four horizons is highly mineralised with median SEC values 1440 μS/cm - 1670 μS/cm. GGA01, installed in the Glasgow Upper mine working, had the most highly mineralised groundwater with a range of 2930 μS/cm – 3140 μS/cm. The range of recorded groundwater temperatures is largest in the superficial deposits (11.0°C – 16.6°C). The bedrock and mine workings groundwaters all have similar temperatures, and a narrower range of 10.1°C – 13.4 °C. In all target horizons the dissolved oxygen concentration is very low, all DO values are ≤0.81 mg/L. In general major elements and physico-chemical parameters measured in the groundwater samples have concentration ranges similar to those found in bedrock and mine workings across the Carboniferous sedimentary aquifers of the Midland Valley (Ó Dochartaigh et al., 2011). The chemistry of most groundwater samples is unchanged from pumping tests conducted in early 2020 (Palumbo-Roe et al., 2021), and the previous period of baseline monitoring that spanned the period from September 2020 to May 2021 (Bearcock et al., 2022). Groundwaters are generally HCO3 type, with no dominant cation. The exception is GGA01, where groundwaters changed from HCO3 type during the pumping test to Ca-SO4 type at the start of the previous round of monitoring (September 2020). During this monitoring period the concentrations of Ca and SO4 in GGA01 have continued to increase, albeit at a slowing rate, while HCO3 concentrations, which had initially fallen, are slowly increasing. Oxidation of sulphide minerals (e.g. pyrite) could have caused the dominance of the SO4 anion in GGA01 groundwaters. Dissolved organic carbon (as NPOC) is present in the range 1.05 mg/L to 5.46 mg/L, except for one outlier of 23.5 mg/L at GGA01. NPOC concentrations in the superficial deposits, with a median 4.39 mg/L, are at the upper end of this range, while all other target horizons have similar, lower, median values (medians from 2.32 mg/L to 2.54 mg/L). Groundwater samples from two boreholes have low ammonium (NH4) concentrations throughout the monitoring period (GGB04 in the superficial deposits and bedrock borehole GGA03r have a combined median of 3.15 mg/L). The remaining groundwaters in the Glasgow Observatory have high NH4 concentrations (combined median 23.2 mg/L). There was a large concentration range of trace elements in the Glasgow Observatory groundwaters. In general, the lowest concentrations were found in groundwaters from the Glasgow Main mine workings. In contrast the highest trace element concentrations were found in the groundwaters from the Glasgow Upper mine workings and the superficial deposits. TPH was detected in low concentrations in all units at some point during the sampling period. VOCs were not detected in any groundwater sample. Water stable isotopes (δ2H and δ18O), inorganic carbon δ13C and groundwater residence time data were consistent with findings from the pumping test results and previous monitoring period (Bearcock et al., 2022; Palumbo-Roe et al., 2021). Groundwaters are recharged by modern recharge from local rainfall. Median concentrations of dissolved methane (CH4) in the groundwaters range from 16.6 μg/L in the superficial deposits to 224 μg/L in the Glasgow Upper mine workings. These values lie within the upper range of groundwaters reported in other studies from Carboniferous sedimentary rocks in the Midland Valley of Scotland (Ó Dochartaigh et al., 2011). Dissolved ethane (C2H6) was below detection limits in all but one sample (5.2 μg/L at GGA01). Dissolved CO2 has a median value of 141 mg/L with little variation between units. Water chemistry cluster analysis shows that the superficial deposits, bedrock, mine working, and surface water samples cluster into statistically distinct groups. Notable exceptions are groundwaters from GGA01 which form their own separate group, and GGB05 groundwaters from the bedrock horizon which group with the mine workings. Surface water samples were taken using an angular beaker and telescopic rod. Samples were taken from the River Clyde and the Tollcross Burn. Surface water samples were analysed for: major, minor, and trace elements, non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), 2H and 18O abundance in water (δ2H and δ18O) and carbon 13 abundance in dissolved inorganic carbon (DIC) (δ13CDIC), . While both the Clyde and Tollcross Burn have a near-neutral to alkaline pH (7.3 – 8.7), the pH values measured at the Tollcross Burn tend to be higher (median 8.3 from the Tollcross Burn and 7.7 from the Clyde). The waters all follow a similar temporal trend, with the highest value each month measured at the Tollcross Burn. The SEC measurements are higher in the Tollcross Burn samples (median 872 μs/cm) than those measured in the River Clyde samples (median 372 μs/cm). Surface water samples are all generally Ca-HCO3 type. The samples taken from the Tollcross Burn tend to have a greater HCO3 proportion than the river Clyde samples. Most detected trace elements are present in higher concentrations in the River Clyde than in the Tollcross Burn. With the exception of Cr, the trace element concentrations are similar between all sites on the River Clyde, which would be expected given these sites are all on a relatively short stretch of the same river. The Cr concentrations are much higher at the sampling site closest to a former chemical works (median 4.18 μg/L) than elsewhere within the Glasgow Observatory (median 0.4 μg/L). In general, the surface water results are consistent with findings from previous work (Bearcock et al., 2022; Fordyce et al., 2021). (September 2020). During this monitoring period the concentrations of Ca and SO4 in GGA01 have continued to increase, albeit at a slowing rate, while HCO3 concentrations, which had initially fallen, are slowly increasing. Oxidation of sulphide minerals (e.g. pyrite) could have caused the dominance of the SO4 anion in GGA01 groundwaters. Dissolved organic carbon (as NPOC) is present in the range 1.05 mg/L to 5.46 mg/L, except for one outlier of 23.5 mg/L at GGA01. NPOC concentrations in the superficial deposits, with a median 4.39 mg/L, are at the upper end of this range, while all other target horizons have similar, lower, median values (medians from 2.32 mg/L to 2.54 mg/L). Groundwater samples from two boreholes have low ammonium (NH4) concentrations throughout the monitoring period (GGB04 in the superficial deposits and bedrock borehole GGA03r have a combined median of 3.15 mg/L). The remaining groundwaters in the Glasgow Observatory have high NH4 concentrations (combined median 23.2 mg/L). There was a large concentration range of trace elements in the Glasgow Observatory groundwaters. In general, the lowest concentrations were found in groundwaters from the Glasgow Main mine workings. In contrast the highest trace element concentrations were found in the groundwaters from the Glasgow Upper mine workings and the superficial deposits. TPH was detected in low concentrations in all units at some point during the sampling period. VOCs were not detected in any groundwater sample. Water stable isotopes (δ2H and δ18O), inorganic carbon δ13C and groundwater residence time data were consistent with findings from the pumping test results and previous monitoring period (Bearcock et al., 2022; Palumbo-Roe et al., 2021). Groundwaters are recharged by modern recharge from local rainfall. Median concentrations of dissolved methane (CH4) in the groundwaters range from 16.6 μg/L in the superficial deposits to 224 μg/L in the Glasgow Upper mine workings. These values lie within the upper range of groundwaters reported in other studies from Carboniferous sedimentary rocks in the Midland Valley of Scotland (Ó Dochartaigh et al., 2011). Dissolved ethane (C2H6) was below detection limits in all but one sample (5.2 μg/L at GGA01). Dissolved CO2 has a median value of 141 mg/L with little variation between units. Water chemistry cluster analysis shows that the superficial deposits, bedrock, mine working, and surface water samples cluster into statistically distinct groups. Notable exceptions are groundwaters from GGA01 which form their own separate group, and GGB05 groundwaters from the bedrock horizon which group with the mine workings. Surface water samples were taken using an angular beaker and telescopic rod. Samples were taken from the River Clyde and the Tollcross Burn. Surface water samples were analysed for: major, minor, and trace elements, non-purgeable organic carbon (NPOC) and total inorganic carbon (TIC), polycyclic aromatic hydrocarbons (PAH), total petroleum hydrocarbons (TPH), 2H and 18O abundance in water (δ2H and δ18O) and carbon 13 abundance in dissolved inorganic carbon (DIC) (δ13CDIC), . While both the Clyde and Tollcross Burn have a near-neutral to alkaline pH (7.3 – 8.7), the pH values measured at the Tollcross Burn tend to be higher (median 8.3 from the Tollcross Burn and 7.7 from the Clyde). The waters all follow a similar temporal trend, with the highest value each month measured at the Tollcross Burn. The SEC measurements are higher in the Tollcross Burn samples (median 872 μs/cm) than those measured in the River Clyde samples (median 372 μs/cm). Surface water samples are all generally Ca-HCO3 type. The samples taken from the Tollcross Burn tend to have a greater HCO3 proportion than the river Clyde samples. Most detected trace elements are present in higher concentrations in the River Clyde than in the Tollcross Burn. With the exception of Cr, the trace element concentrations are similar between all sites on the River Clyde, which would be expected given these sites are all on a relatively short stretch of the same river. The Cr concentrations are much higher at the sampling site closest to a former chemical works (median 4.18 μg/L) than elsewhere within the Glasgow Observatory (median 0.4 μg/L). In general, the surface water results are consistent with findings from previous work (Bearcock et al., 2022; Fordyce et al., 2021)

HighP–TNano-Mechanics of Polycrystalline Nickel

We have conducted highP–Tsynchrotron X-ray and time-of-flight neutron diffraction experiments as well as indentation measurements to study equation of state, constitutive properties, and hardness of nanocrystalline and bulk nickel. Our lattice volume–pressure data present a clear evidence of elastic softening in nanocrystalline Ni as compared with the bulk nickel. We show that the enhanced overall compressibility of nanocrystalline Ni is a consequence of the higher compressibility of the surface shell of Ni nanocrystals, which supports the results of molecular dynamics simulation and a generalized model of a nanocrystal with expanded surface layer. The analytical methods we developed based on the peak-profile of diffraction data allow us to identify “micro/local” yield due to high stress concentration at the grain-to-grain contacts and “macro/bulk” yield due to deviatoric stress over the entire sample. The graphic approach of our strain/stress analyses can also reveal the corresponding yield strength, grain crushing/growth, work hardening/softening, and thermal relaxation under highP–Tconditions, as well as the intrinsic residual/surface strains in the polycrystalline bulks. From micro-indentation measurements, we found that a low-temperature annealing (T < 0.4 Tm) hardens nanocrystalline Ni, leading to an inverse Hall–Petch relationship. We explain this abnormal Hall–Petch effect in terms of impurity segregation to the grain boundaries of the nanocrystalline Ni

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

peer reviewedBackground: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non–oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non–OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction. © 202

A universal power-law prescription for variability from synthetic images of black hole accretion flows

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First sagittarius A* Event Horizon Telescope results. IV. Variability, morphology, and black hole mass

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