120 research outputs found
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
- Author
- Anson James
- Applebee Jackie
- Arnold Natasha
- Awsare Ninaad
- Bambra Clare
- Banks Ian
- Bareford David
- Basarab Adriana
- Beadsworth Mike
- Beer Naomi
- Bell David
- Bell David
- Bennett-Richards Phillip
- Bhatti Osman
- Boomla Kambiz
- Bossano David
- Bostock David
- Boswell John P
- Bratty Catherine
- Brearey Steve
- Brown Kirsten
- Brown Raymond
- Buhrs Ernst
- Burgess-Allen Jilla
- Bury Bob
- Buttivant Helen
- Caan Woody
- Cabot Kate
- Camilleri-Ferrante Corinne
- Carter Lucy
- Chamberlain MA
- Chandy Rajiv
- Cheeroth Sheila
- Clark Leon
- Clarke Aileen
- Clarke Edward
- Coates Jonathan
- Cole Jim
- Coleman Michel
- Colvin Deborah
- Cook Derek
- Cripwell Michael
- Crome Peter
- Cullinan Paul
- Currie Jonny
- Daley Helen
- Danby Jude
- Darling Jonathan
- Davies David
- Davies Gerry
- Davis Jacky
- Deveson Pete
- Dickinson Jane
- Dickson Harriet
- Domizio Paola
- Duncan John AT
- Edwards Mark
- Edwards Martin
- Ehrhardt Peter
- Eisner Maggie
- Erskine Jonathan
- Etherington Robert
- Evans David
- Evans-Jones John
- Farrelly George
- Feder Gene
- Feehally John
- Fell Henry
- Fellows Griffith
- Fielding Richard
- Finer Nick
- Finer Sarah
- Fisher Brian
- Fitchett Mike
- Fitzgerald Richard
- Fleming Peter
- Fleming Peter
- Fluxman Jonathan
- Folb Jonathan
- Folb Jonathan
- Ford Amy
- Ford Steven
- Franks Andrea
- Freud Kathy McAdam
- Gawler Jeff
- Gibbs John
- Gill Alison
- Godfrey Peter
- Goodger V
- Gore Jonathan
- Gould Derek A
- Greenhalgh Trisha
- Griffiths Alun
- Grunewald Richard
- Gurling Hugh
- Hall Alyson
- Hall Peter
- Hamlyn Adrian N
- Hawkins David
- Highton Clare
- Hirst Julie
- Hobson Esther
- Holland Walter
- Holt Kim
- Holt Victoria J
- Hopkinson Nicholas
- Hotchkiss Julie
- Hughes Richard
- Ingrams Grant
- Ireland Maggie
- Irvine Louise
- Irving William L
- Jacobson Bobbie
- Jeffreys Anne
- Jenner David
- Jenner David
- Johnson Guy
- Johnston Sally
- Johnstone Chris
- Jones Anna
- Jones Coral
- Jones Phil
- Kendall Bryony
- Kinmonth Ann-Louise
- Kirwin Simon
- Klonin Hilary
- Knight David
- Koperski M
- Kraemer Sebastian
- Landers Aileen
- Lau Alice
- Lawrence David
- Lee Alan
- Lefevre Dianne
- Leigh Martha
- Lewis David
- Lewis David
- Lewis Geoffrey
- Livingstone Anna
- Lockwood Kate
- Logan Jane
- Logan Mary
- Logan Stuart
- Lowes Simon
- Lyttelton Laura
- Ma Richard
- Macfarlane Alison
- Macgibbon Robert
- Macklon AF
- Maclennan Iain
- Macpherson Jamie
- Main John
- Mann Nick
- Marlowe Gary
- Marmot Saul
- Martin P
- Maryon-Davis Alan
- Mason Rebecca
- McCartney Margaret
- McCoy David
- McEewen J
- McElderry Elisabeth
- McKee Martin
- McPherson Klim
- Michael Benedict
- Middleton John
- Miller Jo
- Mindell Jennifer
- Mitchel Sarah
- Mitchison Sally
- Moore Robert
- Morrison Richard
- Mullen Paul
- Munday Pat
- Murphy E
- Newell Jo
- Nixon Jonathan
- Noor R
- Nsutebu Emmanuel
- Ormerod Julian
- Ormerod Oliver
- Paintin David
- Patel Anita
- Paul Ashish
- Peedell Clive
- Pollock Alyson
- Pride Neil
- Puntis John
- Rainbow Daniel
- Rawaf Salman
- Reeve Joanne
- Reissman Gerard
- Ross Wendy
- Rossiter Brian
- Salim Asad
- Savage Wendy
- Sayer Mel
- Schweiger Martin
- Scott Brian
- Scott-Samuel Alex
- Sharma Ajay
- Sharp Deborah J
- Sharvill John
- Sikorski Jim
- Silverman Ruth
- Singer Ron
- Singh G
- Singh Surinder
- Smailes Alison
- Smyth Alan
- Souza Richard de
- Stevenson Nicola
- Stobbart Kate
- Suckling Ruth
- Tallis Ray
- Tebboth Louise
- Timmis Alison
- Timms Philip
- Tomlinson Jonathon
- Tomlinson Laurie
- Tomson D
- Tomson Mike
- Torabi Payam
- Tulloch Alex
- Turner Gill
- Venning Helen
- Walker Jonathan
- Waterston Tony
- Wesby Barbara
- West Andrew
- West Robert
- West Robert
- Whincup Peter
- Wolfe Ingrid
- Wortley Pam
- Wrigley David
- Young Gail
- Young Jane
- Yudkin John S
- Zinkin Pam
- Publication venue
- 'BMJ'
- Publication date
- 20/03/2013
- Field of study
Analysis of shared heritability in common disorders of the brain
- Author
- Adams Hieab H.H.
- Air Tracy
- Al-Chalabi Ammar
- Alda Martin
- Alegret Montserrat
- Alfredsson Lars
- Amouyel Philippe
- Andlauer Till F.M.
- Andreassen Ole A.
- Anjorin Adebayo
- Anney Richard
- Anttila Verneri
- Arias Vasquez Alejandro
- Arking Dan
- Arnold Paul
- Arranz Maria Jesús
- Artto Ville
- Aschauer Harald
- Attia John
- Avbersek Andreja
- Bacchelli Elena
- Bailey Anthony
- Baker Jessica H.
- Bal Vanessa
- Banaschewski Tobias
- Barnes Lisa L.
- Barr Cathy L.
- Battaglia Agatino
- Battey Thomas
- Bau Claiton H.D.
- Bauer Michael
- Baum Larry
- Baune Bernhard T.
- Bayer Anthony
- Beach Thomas G.
- Becker Felicitas
- Bedoya-Berrio Gabriel
- Beekman Aartjan TF
- Beiser Alexa
- Belin Andrea C.
- Bergen Andrew W.
- Bergen Sarah E
- Berkovic Samuel
- Berr Claudine
- Betancur Catalina
- Bevan Steve
- Bienvenu O. Joseph
- Bis Joshua C
- Blackwood Douglas
- Boada Mercè
- Boland Anne
- Bolton Patrick
- Boncoraglio Giorgio
- Boomsma Dorret
- Boraska Perica Vesna
- Borck Guntram
- Bradfield Jonathan
- Bramon Elvira
- Bras Jose
- Breen Gerome
- Brentani Helena
- Buccola Nancy
- Buitelaar Jan K.
- Bulik Cynthia M.
- Bulik-Sullivan Brendan
- Buono Russell
- Buring Julie E.
- Burton Christie
- Børglum Anders D.
- Cahn Wiepke
- Cairns Murray
- Camarena Beatriz
- Cantor Rita
- Cappi Carolina
- Casas Miguel
- Catarino Claudia B.
- Cath Danielle
- Cavallini Maria
- Celestino-Soper Patrícia
- Chasman Daniel I.
- Chen Wei-Min
- Cheng Wei
- Chong Siow A.
- Chouraki Vincent
- Churchhouse Claire
- Cichon Sven
- Clementi Maurizio
- Cloninger Robert
- Cohen David
- Cohen-Woods Sarah
- Cook Edwin
- Cormand Bru
- Corvin Aiden
- Cossette Patrick
- Cotsapas Chris
- Craddock Nick
- Crespo-Facorro Benedicto
- Crosbie Jennifer
- Crowley James
- Cruceanu Cristiana
- Cruchaga Carlos
- Cuenca-Leon Ester
- Curtis David
- Cusi Daniele
- Czerski Piotr M.
- Dalsgaard Soeren
- Daly Mark
- Danner Unna N.
- Darrow Sabrina
- Davidson Michael
- Davis Oliver S. P.
- Dawson Geraldine
- de Geus Eco
- De Jager Philip L.
- De Jonghe Peter
- De Rubeis Silvia
- De-Luca Daniel Moreno-
- Degenhardt Franziska
- Deleuze Jean-François
- DeLisi Lynn
- Delorme Richard
- Demirci F. Yesim
- Dempfle Astrid
- Denys Damiaan
- Depienne Christel
- Depondt Chantal
- Derks Eske M.
- Dichgans Martin
- Dick Danielle M.
- Dietrich Andrea
- Dinan Timothy
- Dlugos Dennis
- Docampo Elisa
- Donohoe Gary
- Doyle Alysa E.
- Drapeau Elodie
- Duan Jubao
- Duncan Laramie
- Dunn Erin
- Duque Frederico
- Duron Emmanuelle
- Edenberg Howard J.
- Ehrlich Stefan
- Elia Josephine
- Eriksson Nicholas
- Escott-Price Valentina
- Espeseth Thomas
- Falcone Guido J.
- Faraone Stephen V.
- Farh Kai-How
- Farrer Lindsay A.
- Fernandez Thomas
- Ferrari Michel D.
- Ferraro Thomas N.
- Ferrier I. Nicol
- Figee Martijn
- Finucane Hilary K.
- Fischer Sascha B.
- Forstner Andreas J.
- Forzan Monica
- Fox Nick C.
- Franke Barbara
- Freilinger Tobias
- Freimer Nelson
- Freitag Christine
- French Jacqueline
- Fullerton Janice M.
- Furlotte Nicholas
- Gasser Thomas
- Gejman Pablo V.
- Gerber Gloria
- Gershon Elliot S.
- Geschwind Daniel H.
- Gibbs Raphael
- Goate Alison M.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott D.
- Gormley Padhraig
- Grabe Hans-Jorgen
- Grados Marco
- Gratacos Monica
- Green Andrew
- Greenberg Erica
- Grenier-Boley Benjamin
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guerreiro Rita
- Guzman-Parra José
- Göbel Hartmut
- Haan Lieuwe
- Haavik Jan
- Hakonarson Hakon
- Halmi Katherine A.
- Hampel Harald
- Hanna Gregory L.
- Hannequin Didier
- Hansen Thomas
- Harold Denise
- Hartmann Andreas
- Hauser Joanna
- Head Elizabeth
- Heinzen Erin L.
- Helder Sietske G.
- Henskens Frans
- Herms Stefan
- Herpertz-Dahlmann Beate
- Hervas Amaia
- Heutink Peter
- Hickie Ian
- Hirschtritt Matthew E.
- Hjalgrim Helle
- Hoekstra Pieter J.
- Hoffmann Per
- Holliday Elizabeth
- Holmans Peter
- Homuth Georg
- Hottenga Jouke-Jan
- Hougaard David
- Hrafnsdottir Maria
- Huang Alden
- Huang Hailiang
- Huang Jie
- Huckins Laura M.
- Hudson James I.
- Huentelman Matthew J.
- Hulette Christine M.
- Huyser Chaim
- Hyman Bradley T.
- Hämäläinen Eija
- Illmann Cornelia
- Jamain Stéphane
- Jamnadas-Khoda Jennifer
- Jansen Rick
- Jenike Michael
- Jicha Gregory A.
- Johansson Stefan
- Jones Ian R.
- Julià Antonio
- Kamatani Yoichiro
- Kamboh M. Ilyas
- Kaprio Jaakko
- Karachanak-Yankova Sena
- Karwautz Andreas
- Kaunisto Mari
- Kauwe John S.K.
- Kaye Jeffrey A.
- Kaye Walter
- Kendler Kenneth S.
- Keski-Rahkonen Anna
- Khrunin Andrey
- Klauck Sabine M.
- Klovins Janis
- Knowles James A.
- Koeleman Bobby
- Konkashbaev Anuar
- Kornhuber Johannes
- Kourkoulis Christina
- Kubisch Christian
- Kukull Walter A.
- Kuntsi Jonna
- Kunz Wolfram S.
- Kuperman Samuel
- Kurki Mitja I.
- Kurth Tobias
- Kučinskas Vaidutis
- Kälviäinen Reetta
- Langley Kate
- Lanzagorta Nuria
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leboyer Marion
- Lee Chee Keong Jimmy
- Lee Phil H.
- Lehtimäki Terho
- Lerche Holger
- Lesch Klaus-Peter
- Letenneur Luc
- Leu Costin
- Leventhal Bennett
- Leverenz James B.
- Levey Allan I.
- Levitt Pat
- Lewis Cathryn M.
- Li Qingqin S.
- Lieberman Andrew P.
- Ligthart Lannie
- Limborska Svetlana
- Lindhout Dick
- Lissowska Jolanta
- Lo Warren
- Lochner Christine
- Loehrer Elizabeth
- Loo Sandra K.
- Loughland Carmel
- Lowenstein Daniel
- Lundervold Astri J.
- Lupton Michelle K.
- Lyon Gholson J.
- Lönnqvist Jouko
- Maaser Anna
- Macaya Alfons
- Macciardi Fabio
- MacIntyre Donald J.
- Madruga-Garrido Marcos
- Maestrini Elena
- Magalhaes Tiago
- Maher Brion
- Maj Mario
- Malaty Irene A.
- Malik Rainer
- Mane Shrikant
- Mannik Katrin
- Maras Athanasios
- Markus Hugh
- Marson Anthony
- Martin Nicholas G.
- Martinez Maria
- Mathews Carol A.
- Mattheisen Manuel
- Matthews Keith
- Mattingsdal Morten
- Mayoral Fermin
- McCormack Mark
- McDonald Colm
- McGough James J.
- McGrath Lauren
- McIntosh Andrew
- McLaughlin Nicole
- McQuillin Andrew
- Mead Simon
- Medland Sarah E.
- Mehta Divya
- Melle Ingrid
- Metspalu Andres
- Middeldorp Christel M.
- Miguel Eurípedes C.
- Mir Pablo
- Mitchell Braxton
- Mitchell James
- Mitchell Philip B.
- Mok Kin Y.
- Molloy Anne
- Molly Nikolas
- Monteleone Palmiero
- Montgomery Grant W.
- Morgan Kevin
- Morris Derek
- Morris Huw R.
- Muller-Myhsok Bertram
- Murphy Kieran C.
- Murray Robin
- Møller Rikke S.
- Mühleisen Thomas W.
- Nauck Matthias
- Neale Benjamin M.
- Nenadic Igor
- Nestadt Gerald
- Nestadt Paul S.
- Ng Ping-Wing
- Nicolini Humberto
- Nyholt Dale R.
- Nöthen Markus M.
- Oades Robert D.
- Oh Sang-Yun
- Okun Michael S.
- Olesen Jes
- Oliver Karen
- Ophoff Roel
- Owen Michael J.
- O’Toole Julie K.
- Padyukov Leonid
- Pakstis Andrew
- Palmason Haukur
- Palotie Aarno
- Palta Priit
- Pankratz Vernon S.
- Pantelis Christos
- Papezova Hana
- Parr Jeremy
- Paschou Peristera
- Passmore Peter
- Pato Carlos
- Pato Michele
- Patsopoulos Nikolaos A.
- Penninx Brenda
- Pera Joana
- Pergadia Michele
- Petryshen Tracey
- Piacentini John
- Pinto Dalila
- Pittenger Christopher
- Plessen Kerstin
- Poon Wayne W.
- Porteous David
- Posthuma Danielle
- Potash James B.
- Pozo-Rosich Patricia
- Price Alkes
- Privitera Michael
- Proitsi Petra
- Pulit Sara
- Quested Digby
- Quinn Joseph F.
- Rabionet Raquel
- Radtke Rodney
- Raevuori Anu
- Raffeld Miriam
- Ramensky Vasily
- Ramos Eliana M.
- Ramos-Quiroga Josep Antoni
- Ran Caroline
- Ransmayr Gerhard
- Regan Regina
- Reichborn-Kjennerud Ted
- Reichenberg Abraham
- Reif Andreas
- Reinbold Céline S.
- Reitz Christiane
- Reus Victor
- Ribasés Marta
- Rice John
- Rice Kenneth
- Richter Margaret A.
- Riddle Mark A.
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Rietschel Marcella
- Ripatti Samuli
- Ripke Stephan
- Rivera Margarita
- Rivero Olga
- Robertson Mary M.
- Robinson Elise
- Roessner Veit
- Rogaeva Ekaterina
- Rogé Bernadette
- Romanos Marcel
- Rosand Jonathan
- Rossor Martin
- Rosário Maria
- Rothenberger Aribert
- Rothwell Peter
- Rotter Jerome I
- Rouleau Guy A.
- Roussos Panos
- Rubinsztein David C.
- Ruiz Agustin
- Ruppert Ann-Kathrin
- Russo Giancarlo
- Rybakowski Filip
- Ryten Mina
- Salomaa Veikko
- Samuels Jack F.
- Sander Thomas
- Sanders Alan R.
- Sandin Sven
- Sandor Cynthia
- Sandor Paul
- Santangelo Susan
- Saykin Andrew J.
- Schachar Russell
- Schachter Steven
- Schall Ulrich
- Schalling Martin
- Schankin Christoph
- Scharf Jeremiah
- Scheffer Ingrid
- Scherer Stephen W.
- Schneider Lon S.
- Schoch Susanne
- Schoevers Robert A.
- Schofield Peter R.
- Schosser Alexandra
- Schott Jonathan M.
- Schreiber Stefan
- Schulze Thomas G.
- Schumacher Johannes
- Schwab Sibylle G.
- Schürks Markus
- Scott Rodney
- Seshadri Sudha
- Sharma Manu
- Sharma Pankaj
- Silliman Scott
- Sim Kang
- Sinnamon Grant
- Sisodiya Sanjay M.
- Sklar Pamela
- Smit Johannes H.
- Smith Amanda G.
- Smith Philip
- Smoller Jordan W.
- So Hon-Cheong
- Sonnen Joshua A.
- Sperling Michael
- St George-Hyslop Peter
- Stahl Eli
- Steen Vidar M.
- Stein Dan J.
- Stern Robert A.
- Streit Fabian
- Striano Pasquale
- Strober Michael
- Strohmaier Jana
- Stroink Hans
- Stögmann Elisabeth
- Subramaniam Mythily
- Sudlow Cathie
- Sullivan Patrick
- Surges Rainer
- Szatkiewicz Jin Peng
- Sánchez-Mora Cristina
- Terwindt Gisela M.
- The Brainstorm Consortium
- Thijs Vincent
- Thomas G. Neil
- Thompson Robert C.
- Thornton Laura M.
- Toncheva Draga
- Tortorella Alfonso
- Trace Sara E.
- Tsetsos Fotis
- Tsolaki Magda
- Turecki Gustavo
- Turley Patrick
- Tziouvas Konstantinos
- Valencia-Duarte Ana
- Van Deerlin Vivianna M.
- van den Maagdenberg Arn M.J.M.
- van der Lee Sven J.
- van Elburg Annemarie A.
- Van Eldik Linda J.
- Van Nieuwerburgh Filip
- van Os Jim
- Vardarajan Badri N.
- Vepsäläinen Salli
- Vicente Astrid
- Viktorin Alexander
- Visscher Frank
- Vorstman Jacob
- Waddington John
- Wagner Gudrun
- Waldman Irwin
- Walters James
- Walters Raymond K.
- Wassink Thomas
- Weatherall Sarah
- Webb Bradley
- Webber Caleb
- Wedenoja Juho
- Wei Zhi
- Weiser Mark
- Weiss Lauren A.
- Wendland Jens R.
- Werge Thomas
- Whelan Christopher D.
- Wijsman Ellen
- William Rayner N.
- Williams Julie
- Williams Nigel
- Wilmot Beth
- Winsvold Bendik
- Witt Stephanie H.
- Wolanczyk Tomasz
- Wood Nicholas W.
- Worbe Yulia
- Wray Naomi R.
- Yilmaz Zeynep
- Yu Dongmei
- Zai Gwyneth
- Zandi Peter P.
- Zara Federico
- Zayats Tetyana
- Zimprich Fritz
- Zwart John-Anker
- Publication venue
- American Association for the Advancement of Science
- Publication date
- 01/01/2018
- Field of study
ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
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- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
- Syvänen Ann-Christine
- Sõber Siim
- Söderlund Jenny
- Tabara Yasuharu
- Tai E Shyong
- Taliun Daniel
- Talmud Philippa J
- Tammesoo Mar-Liis
- Tan Sian-Tsung
- Tanaka Toshiko
- Tang Nelson L S
- Tarnow Lise
- Taylor Andrew
- Taylor Kira
- Tayo Bamidele
- Tenesa Albert
- Terzic Janos
- Teslovich Tanya M
- Teumer Alexander
- Thelle Dag S
- Thompson John R
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
- Troffa Chiara
- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
- van Dam Rob M
- Van den Herik Evita G
- van der Harst Pim
- van der Klauw Melanie M
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
- van Meurs Joyce B J
- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
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- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
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- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
- Bierwagen Katharina
- Biesuz Nicolo
- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
- Bindi Marcello
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bisanz Tobias
- Bittrich Carsten
- Bjergaard David
- Black James
- Black Kevin
- Blair Robert
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
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- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
- Burr Jonathan
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- Butler John
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
- Cabrera Urbán Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
- Chan Yat
- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Daneri Maria
- Dang Nguyen
- Daniells Andrew
- Dann Nicholas
- Danninger Matthias
- Dano Hoffmann Maria
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- Darbo Giovanni
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- Dassoulas James
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- Dawe Edmund
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- de Asmundis Riccardo
- De Benedetti Abraham
- De Castro Stefano
- De Cecco Sandro
- De Groot Nicolo
- De Jong Paul
- De la Torre Hector
- De Lorenzi Francesco
- De Maria Antonio
- De Pedis Daniele
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- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
- Debenedetti Chiara
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- Dehghanian Nooshin
- Deigaard Ingrid
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- Dewhurst Alastair
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- Di Bello Francesco
- Di Ciaccio Anna
- Di Ciaccio Lucia
- Di Clemente William
- Di Donato Camilla
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- Di Nardo Roberto
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- Djuvsland Julia
- Dobos Daniel
- Dobre Monica
- Dodsworth David
- Doglioni Caterina
- Dolejsi Jiri
- Dolezal Zdenek
- Donadelli Marisilvia
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- Donini Julien
- Dopke Jens
- Doria Alessandra
- Dova Maria-Teresa
- Doyle Tony
- Drechsler Eric
- Dris Manolis
- Du Yanyan
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- Dubinin Filipp
- Dubreuil Arnaud
- Duchovni Ehud
- Duckeck Guenter
- Ducourthial Audrey
- Ducu Otilia
- Duda Dominik
- Dudarev Alexey
- Dudder Andreas
- Duffield Emily
- Duflot Laurent
- Dulsen Carsten
- Dumancic Mirta
- Dumitriu Ana
- Duncan Anna
- Dunford Monica
- Duperrin Arnaud
- Duran Yildiz Hatice
- Durglishvili Archil
- Duschinger Dirk
- Dutta Baishali
- Duvnjak Damir
- Dyndal Mateusz
- Dziedzic Bartosz
- Díez Cornell Sergio
- Dührssen Michael
- Düren Michael
- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan
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- Eigen Gerald
- Einsweiler Kevin
- Ekelof Tord
- El Kacimi Mohamed
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- Ellajosyula Venugopal
- Ellert Mattias
- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
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- Elsing Markus
- Emeliyanov Dmitry
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- Ennis Joseph
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- Erdmann Johannes
- Ereditato Antonio
- Ernst Michael
- Errede Steven
- Escalier Marc
- Escobar Carlos
- Esposito Bellisario
- Estrada Pastor Oscar
- Etienvre Anne-Isabelle
- Etzion Erez
- Evans Hal
- Ezhilov Alexey
- Ezzi Mohammed
- Fabbri Federica
- Fabbri Laura
- Fabiani Veronica
- Facini Gabriel
- Fakhrutdinov Rinat
- Falciano Speranza
- Falla Rebecca
- Faltova Jana
- Fang Yaquan
- Fanti Marcello
- Farbin Amir
- Farilla Addolorata
- Farina Christian
- Farina Edoardo
- Farooque Trisha
- Farrell Steven
- Farrington Sinead
- Farthouat Philippe
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- Fassnacht Patrick
- Fassouliotis Dimitrios
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- Favareto Andrea
- Fawcett William
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- Feng Eric
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- Feremenga Last
- Fernandez Martinez Patricia
- Ferrando James
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- Norjoharuddeen Nurfikri
- Novgorodova Olga
- Nozaki Mitsuaki
- Nozka Libor
- Ntekas Konstantinos
- Nurse Emily
- Nuti Francesco
- O'connor Kelsey
- O'Neil Dugan
- O'Rourke Abigail
- O'Shea Val
- Oakham Gerald
- Oberlack Horst
- Obermann Theresa
- Ocariz Jose
- Ochi Atsuhiko
- Ochoa Ines
- Ochoa-Ricoux Juan
- Oda Susumu
- Odaka Shigeru
- Oh Alexander
- Oh Seog
- Ohm Christian
- Ohman Henrik
- Oide Hideyuki
- Okawa Hideki
- Okumura Yasuyuki
- Okuyama Toyonobu
- Olariu Albert
- Oleiro Seabra Luis
- Olivares Pino Sebastian
- Oliveira Damazio Denis
- Olsson Joakim
- Olszewski Andrzej
- Olszowska Jolanta
- Onofre António
- Onogi Kouta
- Onyisi Peter
- Oppen Henrik
- Oreglia Mark
- Oren Yona
- Orestano Domizia
- Orlando Nicola
- Orr Robert
- Osculati Bianca
- Ospanov Rustem
- Otero y Garzon Gustavo
- Otono Hidetoshi
- Ouchrif Mohamed
- Ould-Saada Farid
- Ouraou Ahmimed
- Oussoren Koen
- Ouyang Qun
- Owen Mark
- Owen Rhys
- Ozcan Veysi
- Ozturk Nurcan
- Pachal Katherine
- Pacheco Pages Andres
- Pacheco Rodriguez Laura
- Padilla Aranda Cristobal
- Pagan Griso Simone
- Paganini Michela
- Paige Frank
- Palacino Gabriel
- Palazzo Serena
- Palestini Sandro
- Palka Marek
- Pallin Dominique
- Panagiotopoulou Evgenia
- Panagoulias Ilias
- Pandini Carlo
- Panduro Vazquez William
- Pani Priscilla
- Panitkin Sergey
- Pantea Dan
- Paolozzi Lorenzo
- Papadopoulou Theodora
- Papageorgiou Konstantinos
- Paramonov Alexander
- Paredes Hernandez Daniela
- Parker Adam
- Parker Kerry
- Parker Michael
- Parodi Fabrizio
- Parsons John
- Parzefall Ulrich
- Pascuzzi Vincent
- Pasner Jacob
- Pasqualucci Enrico
- Passaggio Stefano
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- Pataraia Sophio
- Pater Joleen
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- Pearson Benjamin
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- Pedro Rute
- Peleganchuk Sergey
- Penc Ondrej
- Peng Cong
- Peng Haiping
- Penwell John
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- Perego Marta
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- Peri Francesco
- Perini Laura
- Pernegger Heinz
- Perrella Sabrina
- Peschke Richard
- Peshekhonov Vladimir
- Peters Krisztian
- Peters Yvonne
- Petersen Brian
- Petersen Troels
- Petit Elisabeth
- Petridis Andreas
- Petridou Chariclia
- Petroff Pierre
- Petrolo Emilio
- Petrov Mariyan
- Petrucci Fabrizio
- Pettersson Nora
- Peyaud Alan
- Pezoa Raquel
- Phillips Forrest
- Phillips Peter
- Piacquadio Giacinto
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- Pilcher James
- Pilkington Andrew
- Pinamonti Michele
- Pinfold James
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- Pluth Daniel
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- Pokharel Ishan
- Polesello Giacomo
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- Policicchio Antonio
- Polifka Richard
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- Pommès Kathy
- Ponomarenko Daniil
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- Pralavorio Pascal
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- Primavera Margherita
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- Proklova Nadezda
- Prokofiev Kirill
- Prokoshin Fedor
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- Proudfoot James
- Przybycien Mariusz
- Puri Akshat
- Puzo Patrick
- Qian Jianming
- Qin Gang
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- Quadt Arnulf
- Queitsch-Maitland Michaela
- Quilty Donnchadha
- Raddum Silje
- Radeka Veljko
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- Radhakrishnan Sooraj
- Radloff Peter
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- Rauch Daniel
- Rauscher Felix
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- Rawling Jacob
- Raymond Michel
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- Readioff Nathan
- Reale Marilea
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- Redelbach Andreas
- Redlinger George
- Reece Ryan
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- Rehnisch Laura
- Reichert Joseph
- Reiss Andreas
- Rembser Christoph
- Ren Huan
- Rescigno Marco
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- Reynolds Elliot
- Rezanova Olga
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- Richter Robert
- Richter Stefan
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- Rimoldi Adele
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- Ritsch Elmar
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- Roberts Rhys
- Robertson Steven
- Robichaud-Veronneau Andree
- Robinson Dave
- Robinson James
- Robson Aidan
- Rocco Elena
- Roda Chiara
- Rodina Yulia
- Rodriguez Bosca Sergi
- Rodriguez Perez Andrea
- Rodriguez Rodriguez Daniel
- Roe Shaun
- Rogan Christopher
- Roloff Jennifer
- Romaniouk Anatoli
- Romano Saez Silvestre
- Romano Marino
- Romero Adam Elena
- Rompotis Nikolaos
- Ronzani Manfredi
- Roos Lydia
- Rosati Stefano
- Rosbach Kilian
- Rose Peyton
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- Rossi Elvira
- Rossi Leonardo
- Rosten Jonatan
- Rosten Rachel
- Rotaru Marina
- Rothberg Joseph
- Rousseau David
- Roy Debarati
- Rozanov Alexandre
- Rozen Yoram
- Ruan Xifeng
- Rubbo Francesco
- Ruiz-Martinez Aranzazu
- Rurikova Zuzana
- Rusakovich Nikolai
- Russell Heather
- Rutherfoord John
- Ruthmann Nils
- Ryabov Yury
- Rybar Martin
- Rybkin Grigori
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- Ryzhov Andrey
- Rzehorz Gerhard
- Røhne Ole
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- Rüttinger Elias
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- Sadrozinski Hartmut
- Sadykov Renat
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- Saha Puja
- Sahinsoy Merve
- Saimpert Matthias
- Saito Masahiko
- Saito Tomoyuki
- Sakamoto Hiroshi
- Sakurai Yuki
- Salamanna Giuseppe
- Salazar Loyola Javier
- Salek David
- Sales De Bruin Pedro
- Salihagic Denis
- Salnikov Andrei
- Salt José
- Salvatore Daniela
- Salvatore Pasquale
- Salvucci Antonio
- Salzburger Andreas
- Sammel Dirk
- Sampsonidis Dimitrios
- Sampsonidou Despoina
- Sanchez Martinez Victoria
- Sanchez Pineda Arturo
- Sandaker Heidi
- Sandbach Ruth
- Sander Christian
- Sandhoff Marisa
- Sandoval Carlos
- Sankey Dave
- Sannino Mario
- Sano Yuta
- Sansoni Andrea
- Santiago Cerqueira Augusto
- Santoni Claudio
- Santos Helena
- Santoyo Castillo Itzebelt
- Sapronov Andrey
- Saraiva João
- Sarrazin Bjorn
- Sasaki Osamu
- Sato Koji
- Sauvan Emmanuel
- Savage Graham
- Savard Pierre
- Savic Natascha
- Sawyer Craig
- Sawyer Lee
- Saxon James
- Sbarra Carla
- Sbrizzi Antonio
- Scanlon Tim
- Scannicchio Diana
- Schaarschmidt Jana
- Schacht Peter
- Schachtner Balthasar
- Schaefer Douglas
- Schaefer Leigh
- Schaefer Ralph
- Schaeffer Jan
- Schaepe Steffen
- Schaetzel Sebastian
- Schaffer Arthur
- Schaile Dorothee
- Schamberger R
- Schegelsky Valery
- Scheirich Daniel
- Schenck Ferdinand
- Schernau Michael
- Schiavi Carlo
- Schier Sheena
- Schildgen Lara
- Schillo Christian
- Schioppa Marco
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- Schmidt-Sommerfeld Korbinian
- Schmieden Kristof
- Schmitt Christian
- Schmitt Stefan
- Schmitz Simon
- Schnoor Ulrike
- Schoeffel Laurent
- Schoening Andre
- Schoenrock Bradley
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- Schott Matthias
- Schouwenberg Jeroen
- Schovancova Jaroslava
- Schramm Steven
- Schuh Natascha
- Schulte Alexandra
- Schultens Martin
- Schultz-Coulon Hans-Christian
- Schulz Holger
- Schumacher Markus
- Schumm Bruce
- Schune Philippe
- Schwartzman Ariel
- Schwarz Thomas
- Schweiger Hansdieter
- Schwemling Philippe
- Schwienhorst Reinhard
- Schwindling Jerome
- Schäfer Uli
- Sciandra Andrea
- Sciolla Gabriella
- Scornajenghi Matteo
- Scuri Fabrizio
- Scutti Federico
- Searcy Jacob
- Seema Pienpen
- Seidel Sally
- Seiden Abraham
- Seixas José
- Sekhniaidze Givi
- Sekhon Karishma
- Sekula Stephen
- Semprini-Cesari Nicola
- Senkin Sergey
- Serfon Cedric
- Serin Laurent
- Serkin Leonid
- Sessa Marco
- Seuster Rolf
- Severini Horst
- Sforza Federico
- Sfyrla Anna
- Shabalina Elizaveta
- Shaikh Nabila
- Shan Lianyou
- Shang Ruo-yu
- Shank James
- Shapiro Marjorie
- Shatalov Pavel
- Shaw Kate
- Shaw Savanna
- SHCHERBAKOVA Anna
- Shehu Ciwake
- Shen Yu-Ting
- Sherafati Nima
- Sherman Alexander
- Sherwood Peter
- Shi Liaoshan
- Shimizu Shima
- Shimmin Chase
- Shimojima Makoto
- Shipsey Ian
- Shirabe Shohei
- Shiyakova Mariya
- Shlomi Jonathan
- Shmeleva Alevtina
- Shoaleh Saadi Diane
- Shochet Mel
- Shojaii Seyed
- Shope David
- Shrestha Suyog
- Shulga Evgeny
- Shupe Michael
- Sicho Petr
- Sickles Anne
- Sidebo Per
- Sideras Haddad Elias
- Sidiropoulou Ourania
- Sidoti Antonio
- Siegert Frank
- Sijacki Djordje
- Silva José
- Silverstein Samuel
- Simak Vladislav
- Simic Ljiljana
- Simion Stefan
- Simioni Eduard
- Simmons Brinick
- Simon Manuel
- Sinervo Pekka
- Sinev Nikolai
- Sioli Maximiliano
- Siragusa Giovanni
- Siral Ismet
- Sivoklokov Serguei
- Sjölin Jörgen
- Skinner Malcolm
- Skubic Patrick
- Slater Mark
- Slavicek Tomas
- Slawinska Magdalena
- Sliwa Krzysztof
- Slovak Radim
- Smakhtin Vladimir
- Smart Ben
- Smiesko Juraj
- Smirnov Nikita
- Smirnov Sergei
- Smirnov Yury
- Smirnova Lidia
- Smirnova Oxana
- Smith Joshua
- Smith Matthew
- Smith Russell
- Smizanska Maria
- Smolek Karel
- Snesarev Andrei
- Snyder Ian
- Snyder Scott
- Sobie Randall
- Socher Felix
- Soffer Abner
- Soh Dart-yin
- Sokhrannyi Grygorii
- Solans Sanchez Carlos
- Solar Michael
- Soldatov Evgeny
- Soldevila Urmila
- Solodkov Alexander
- Soloshenko Alexei
- Solovyanov Oleg
- Solovyev Victor
- Sommer Philip
- Son Hyungsuk
- Sopczak Andre
- Sosa David
- Sotiropoulou Calliope
- Sottocornola Simone
- Soualah Rachik
- Soukharev Andrey
- South David
- Sowden Benjamin
- Spagnolo Stefania
- Spalla Margherita
- Spangenberg Martin
- Spanò Francesco
- Sperlich Dennis
- Spettel Fabian
- Spieker Thomas
- Spighi Roberto
- Spigo Giancarlo
- Spiller Laurence
- Spousta Martin
- St Denis Richard
- Stabile Alberto
- Stamen Rainer
- Stamm Soren
- Stanecka Ewa
- Stanek Robert
- Stanescu Cristian
- Stanitzki Marcel
- Stapf Birgit
- Stapnes Steinar
- Starchenko Evgeny
- Stark Giordon
- Stark Jan
- Stark Simon
- Staroba Pavel
- Starovoitov Pavel
- Staszewski Rafal
- Stegler Martin
- Steinberg Peter
- Stelzer Bernd
- Stelzer Harald
- Stelzer-Chilton Oliver
- Stenzel Hasko
- Stevenson Thomas
- Stewart Graeme
- Stockton Mark
- Stoebe Michael
- Stoicea Gabriel
- Stolte Philipp
- Stonjek Stefan
- Stradling Alden
- Straessner Arno
- Stramaglia Maria
- Strandberg Jonas
- Strandberg Sara
- Strauss Michael
- Strizenec Pavol
- Strom David
- Stroynowski Ryszard
- Strubig Antonia
- Ströhmer Raimund
- Stucci Stefania
- Stugu Bjarne
- Styles Nicholas
- Stärz Steffen
- Su Dong
- Su Jun
- Suchek Stanislav
- Sugaya Yorihito
- Suk Michal
- Sulin Vladimir
- Sultan D
- Sultansoy Saleh
- Sumida Toshi
- Sun Siyuan
- Sun Xiaohu
- Suruliz Kerim
- Suster Carl
- Sutton Mark
- Suzuki Shota
- Svatos Michal
- Swiatlowski Maximilian
- Swift Stewart
- Sykora Ivan
- Sykora Tomas
- Sánchez Javier
- Søgaard Andreas
- Ta Duc
- Tackmann Kerstin
- Taenzer Joe
- Taffard Anyes
- Tafirout Reda
- Tahirovic Elvedin
- Taiblum Nimrod
- Takai Helio
- Takashima Ryuichi
- Takasugi Eric
- Takeda Kosuke
- Takeshita Tohru
- Takubo Yosuke
- Talby Mossadek
- Talyshev Alexey
- Tanaka Junichi
- Tanaka Masahiro
- Tanaka Reisaburo
- Tanaka Shuji
- Tanioka Ryo
- Tannenwald Benjamin
- Tapia Araya Sebastian
- Tapprogge Stefan
- Tarem Shlomit
- Tartarelli Giuseppe
- Tas Petr
- Tasevsky Marek
- Tashiro Takuya
- Tassi Enrico
- Tavares Delgado Ademar
- Tayalati Yahya
- Taylor Aaron
- Taylor Alan
- Taylor Geoffrey
- Taylor Pierre
- Taylor Wendy
- Teixeira-Dias Pedro
- Temple Darren
- Ten Kate Herman
- Teng Ping-Kun
- Teoh Jia
- Tepel Fabian-Phillipp
- Terada Susumu
- Terashi Koji
- Terron Juan
- Terzo Stefano
- Testa Marianna
- Teuscher Richard
- Thais Savannah
- Theveneaux-Pelzer Timothée
- Thiele Fabian
- Thomas Juergen
- Thomas-Wilsker Joshuha
- Thompson Paul
- Thompson Stan
- Thomsen Lotte
- Thomson Evelyn
- Tian Yun
- Tibbetts Mark
- Ticse Torres Royer
- Tikhomirov Vladimir
- Tikhonov Yury
- Timoshenko Sergey
- Tipton Paul
- Tisserant Sylvain
- Todome Kazuki
- Todorova-Nova Sharka
- Todt Stefanie
- Tojo Junji
- Tokushuku Katsuo
- Tokár Stanislav
- Tolley Emma
- Tomlinson Lee
- Tomoto Makoto
- Tompkins Lauren
- Toms Konstantin
- Tong Baojia
- Tornambe Peter
- Torrence Eric
- Torres Heberth
- Torró Pastor Emma
- Toth Jozsef
- Touchard Francois
- Tovey Daniel
- Treado Colleen
- Trefzger Thomas
- Tresoldi Fabio
- Tricoli Alessandro
- Trigger Isabel
- Trincaz-Duvoid Sophie
- Tripiana Martin
- Trischuk William
- Trocmé Benjamin
- Trofymov Artur
- Troncon Clara
- Trottier-McDonald Michel
- Trovatelli Monica
- Truong Loan
- Trzebinski Maciej
- Trzupek Adam
- Tsang Ka
- Tseng Jeffrey
- Tsiareshka Pavel
- Tsirintanis Nikolaos
- Tsiskaridze Shota
- Tsiskaridze Vakhtang
- Tskhadadze Edisher
- Tsukerman Ilya
- Tsulaia Vakhtang
- Tsuno Soshi
- Tsybychev Dmitri
- Tu Yanjun
- Tudorache Alexandra
- Tudorache Valentina
- Tulbure Traian
- Tuna Alexander
- Turchikhin Semen
- Turgeman Daniel
- Turk Cakir Ilkay
- Turra Ruggero
- Tuts Michael
- Ucchielli Giulia
- Ueda Ikuo
- Ughetto Michael
- Ukegawa Fumihiko
- Unal Guillaume
- Undrus Alexander
- Unel Gokhan
- Ungaro Francesca
- Unno Yoshinobu
- Uno Kenta
- Unverdorben Christopher
- Urban Jozef
- Urquijo Phillip
- Urrejola Pedro
- Usai Giulio
- Usui Junya
- Vacavant Laurent
- Vacek Vaclav
- Vachon Brigitte
- Vadla Knut
- Vaidya Amal
- Valderanis Chrysostomos
- Valdes Santurio Eduardo
- Valente Marco
- Valentinetti Sara
- Valero Alberto
- Valkar Stefan
- Vallier Alexis
- Valls Ferrer Juan
- Valéry Lo\"ic
- Van Den Wollenberg Wouter
- van der Graaf Harry
- van Gemmeren Peter
- Van Nieuwkoop Jacobus
- van Vulpen Ivo
- van Woerden Marius
- Vanadia Marco
- Vandelli Wainer
- Vaniachine Alexandre
- Vankov Peter
- Vardanyan Gagik
- Vari Riccardo
- Varnes Erich
- Varni Carlo
- Varol Tulin
- Varouchas Dimitris
- Vartapetian Armen
- Varvell Kevin
- Vasquez Gerardo
- Vasquez Jared
- Vazeille Francois
- Vazquez Furelos David
- Vazquez Schroeder Tamara
- Veatch Jason
- Veeraraghavan Venkatesh
- Veloce Laurelle
- Veloso Filipe
- Veneziano Stefano
- Ventura Andrea
- Venturi Manuela
- Venturi Nicola
- Venturini Alessio
- Vercesi Valerio
- Verducci Monica
- Verkerke Wouter
- Vermeulen Ambrosius
- Vermeulen Jos
- Vetterli Michel
- Viaux Maira Nicolas
- Viazlo Oleksandr
- Vichou Irene
- Vickey Boeriu Oana
- Vickey Trevor
- Viehhauser Georg
- Viel Simon
- Vigani Luigi
- Villa Mauro
- Villaplana Perez Miguel
- Vilucchi Elisabetta
- Vincter Manuella
- Vinogradov Vladimir
- Vishwakarma Akanksha
- Vittori Camilla
- Vivarelli Iacopo
- Vlachos Sotirios
- Vogel Marcelo
- Vokac Petr
- Volpi Guido
- von der Schmitt Hans
- von Toerne Eckhard
- Vorobel Vit
- Vorobev Konstantin
- Vos Marcel
- Voss Rudiger
- Vossebeld Joost
- Vranjes Milosavljevic Marija
- Vranjes Nenad
- Vrba Vaclav
- Vreeswijk Marcel
- Vuillermet Raphael
- Vukotic Ilija
- Wagner Peter
- Wagner Wolfgang
- Wagner-Kuhr Jeannine
- Wahlberg Hernan
- Wahrmund Sebastian
- Wakamiya Kotaro
- Walder James
- Walker Rodney
- Walkowiak Wolfgang
- Wallangen Veronica
- Wang Chao
- Wang Fuquan
- Wang Haichen
- Wang Hulin
- Wang Jike
- Wang Jin
- Wang Qing
- Wang Renjie
- Wang Rui
- Wang Song-Ming
- Wang Tingting
- Wang Wei
- Wang Wenxiao
- Wang Zirui
- Wanotayaroj Chaowaroj
- Warburton Andreas
- Ward Patricia
- Wardrope David
- Washbrook Andrew
- Watkins Peter
- Watson Alan
- Watson Miriam
- Watts Gordon
- Watts Stephen
- Waugh Ben
- Webb Aaron
- Webb Samuel
- Weber Michele
- Weber Sebastian
- Weber Stefan
- Weber Stephen
- Webster Jordan
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weirich Marcel
- Weiser Christian
- Weits Hartger
- Wells Phillippa
- Wenaus Torre
- Wengler Thorsten
- Wenig Siegfried
- Wermes Norbert
- Werner Michael
- Werner Per
- Wessels Martin
- Weston Thomas
- Whalen Kathleen
- Whallon Nikola
- Wharton Andrew
- White Aaron
- White Andrew
- White Martin
- White Ryan
- Whiteson Daniel
- Whitmore Ben
- Wickens Fred
- Wiedenmann Werner
- Wielers Monika
- Wiglesworth Craig
- Wiik-Fuchs Liv
- Wildauer Andreas
- Wilk Fabian
- Wilkens Henric
- Williams Hugh
- Williams Sarah
- Willis Christopher
- Willocq Stephane
- Wilson John
- Wingerter-Seez Isabelle
- Winkels Emma
- Winklmeier Frank
- Winston Oliver
- Winter Benedict
- Wittgen Matthias
- Wobisch Markus
- Wolf Anton
- Wolf Tim
- Wolff Robert
- Wolter Marcin
- Wolters Helmut
- Wong Vincent
- Woods Natasha
- Worm Steven
- Wosiek Barbara
- Wotschack Jorg
- Wozniak Krzysztof
- Wu Miles
- Wu Sau
- Wu Xin
- Wu Yusheng
- Wyatt Terry
- Wynne Benjamin
- Xella Stefania
- Xi Zhaoxu
- Xia Ligang
- Xu Da
- Xu Lailin
- Xu Tairan
- Xu Wenhao
- Yabsley Bruce
- Yacoob Sahal
- Yamaguchi Daiki
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
- Young Charles
- Young Christopher
- Yu Jaehoon
- Yu Jie
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gjesing Anette P.
- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
- Rallidis Loukianos S.
- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schwarz Peter E H
- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
- Author
- Abban Dzifa
- Abdul Nasser
- Abelson Mark
- Ackermann Alan
- Adams Fran
- Adams Luthando
- Adrag\ue3o Pedro
- Ageno Walter
- Aggarwal Rajesh
- Agosti Sergio
- Aguilar Linares Julio Alberto
- Aguilar Francisco
- Aguinaga Luis
- Ahmad Zia
- Ainsworth Paul
- Al Dallow Raed
- Al Ghalayini Kamal
- Al Ismail Saad
- Al Joundi Tammam
- Al Mahameed Soufian
- Al Obaidi Mohamed
- Al Zoebi Ayham
- Alasfar Abdelfatah
- Alawwa Abdul
- Alderson Lisa
- Alexopoulos Dimitrios
- Ali Abdullah
- Ali Malik
- Aliyar Pareed
- Almassi Hossein
- Almuti Khalid
- Alshehri Mohamed
- Altmann Ute
- Alves Alvaro Rabelo
- Amara Walid
- Amelot Mathieu
- Amjadi Nima
- Ammirati Fabrizio
- Andrawis Nabil
- Angela Koh Su Mei
- Angoulvant Denis
- Annoni Giorgio
- Ansalone Gerardo
- Antonescu Sorin Alexandru
- Ariani Mehrdad
- Arias Juan Carlos
- Armero S\ue9bastien
- Arora Chander
- Arora Rohit
- Ashcraft William
- Aslam M. Shakil
- Astesiano Alfredo
- Audouin Philippe
- Augenbraun Charles
- Aydin S.
- Azar Rabih
- Azim Abul
- Aziz Shahid
- B\uf8hmer Ellen
- Backes Luciano Marcelo
- Baig Mirza
- Bains Suchdeep
- Bakbak Asaad
- Baker Seth
- Bakhtiar Karim
- Bala Richard
- Banayan Jonathan
- Bandh Stellan
- Bando Shigenobu
- Banerjee Subhash
- Bank Alan
- Bar\uf3n Gonzalo
- Barbarash Olga
- Barr Craig
- Barrera Carlos
- Bartels Dorothee B.
- Barton John
- Baula Giovanni
- Bayeh Hamid
- Bazargani Nooshin
- Behrens Steffen
- Bell Alan
- Benezet Mazuecos Juan
- Benhalima Bouziane
- Berdagu\ue9 Philippe
- Berg van den B. J.
- Bergen van P. F. M. M.
- Berngard Edvard
- Bernstein Richard
- Berrospi Percy
- Berti Sergio
- Bertomeu Vicente
- Berz Andrea
- Bettencourt Paulo
- Betzu Robert
- Beyer Westendorf Jan
- Bhagwat Ravi
- Black Toby
- Blanco Ibaceta Jorge Hugo
- Bloom Stephen
- Blumberg Edwin
- Bo Mario
- Bockisch Valerie
- Bongiorni Maria Grazia
- Boriani Giuseppe
- Borret Mariano Ruiz
- Bosch Ralph
- Boswijk D. J.
- Bott Jochen
- Bottacchi Edo
- Brandes Axel
- Bratland Bj\uf8rn
- Brautigam Donald
- Breton Nicolas
- Briones Ignacio Rodriguez
- Brkljacic Diana Delic
- Brouwers P. J. A. M.
- Browne Kevin
- Bruguera Jordi
- Brunehaut Myriam
- Brunschwig Claude
- Bryan Yan Ping Yen
- Buathier Herv\ue9
- Buenostro Gabriel Contreras
- Buhl Aur\ue9lie
- Bullinga John
- Butcher Kenneth
- Cabrera Honorio Jose Walter
- Caccavo Alberto
- Cadinot Didier
- Cai Shanglang
- Caiedo Carolina Guevara
- Calin Podoleanu Cristian Gheorghe
- Calvi Valeria
- Camm John
- Candeias Rui
- Cao Phai G\ue9rald Phan
- Capo James
- Capucci Alessandro
- Cardoso Juliano Novaes
- Carlson Brian
- Carvalho Paula
- Cary Susanna
- Casanova Rene
- Casu Gavino
- Cattan Simon
- Cavallini Claudio
- Cayla Guillaume
- Cha Kwang Soo
- Cha Tae Joon
- Chaaban Said
- Chae Jei Keon
- Challappa Krishnan
- Chand Sunil
- Chandrashekar Harinath
- Chang Mark
- Charbel Paul
- Chartier Ludovic
- Chatterjee Kausik
- Cheema Aamir
- Chen Shih Ann
- Chevallereau Pierre
- Chiang Fu Tien
- Chiarella Francesco
- Chih Chan Lin
- Cho Yong Keun
- Choi Dong Ju
- Chouinard Guy
- Chow Hoi Fan
- Chreih Rami Mihail
- Chrysos Dimitrios
- Chumakova Galina
- Cieza Lara Tomas
- Ciobotaru Vlad
- Cislowski David
- Citerne Olivier
- Claus Matthias
- Clay Anthony
- Clifford Piers
- Cocina Emilio Gonzalez
- Cohen Andrew
- Cohen Serge
- Colivicchi Furio
- Collins R\uf3n\ue1n
- Compton Steve
- Connors Sean
- Conti Alberto
- Coodley Gregg
- Cooper Martin
- Corbett Lynn
- Corey Oran
- Coronel Juli\ue1n
- Corrigan John
- Cotrina Pereyra Rosa Ysabel
- Cottin Yves
- Coutu Benoit
- Cracan Aurel
- Crean Peter
- Crenshaw James
- Crijns H. J. G. M.
- Crump Charles
- Cucher Fred
- Cudmore David
- Cui Lianqun
- Culp John
- D'Souza Anthony
- Daniel Oh Chia Theng
- Danny Null
- Darius Harald
- Dary Patrick
- Dascotte Olivier
- Dauber Ira
- Davee Thomas
- Davies Ruth
- Davis Gershan
- Davy Jean Marc
- Dayer Mark
- De La Briolle Axel
- de Los Rios Ibarra Manuel Odin
- de Mora Manuel
- de Souza Olga Ferreira
- De Teresa Eduardo
- De Wolf Luc
- Decoulx Eric
- Deepak Sasalu
- Defaye Pascal
- Del Carpio Munoz Freddy
- Deluche Laurent
- Destrac Sylvain
- Deumite N. Joseph
- Di Legge Silvia
- Dibon Olivier
- Diemberger Igor
- Diener Hans Christoph
- Dillinger Jean
- Dion\uedsio Pedro
- Dotani Imran
- Dotcheva Elena
- Duarte Vera Yan Carlos
- Dubner Sergio J.
- Dubrey Simon
- Ducrocq Xavier
- Dupljakov Dmitry
- Duthinh Vuong
- Dutra Oscar Pereira
- Dutta Dipankar
- Duvilla Nathalie
- Dy Johnny
- Dziewas Rainer
- Eaton Charles
- Eaves William
- Ebinger Matthew
- Eck van J. W. M.
- Edwards Tim
- Egocheaga Isabel
- Ehrlich Clifford
- Eisenberg Steven
- El Hallak Abdel
- El Hamdani Mehiar
- El Jabali Adnan
- El Mahmoud Rami
- El Sayed Hassan
- El Shahawy Mahfouz
- Eldadah Zayd
- Elghelbazouri Fouad
- Elhag Omar
- Elias Darlene
- Ellery Adam
- Elsaesser Amelie
- Elvan A.
- Erickson Bernard
- Espaliat Eric
- Essandoh Louis
- Everington Tamara
- Evonich Rudolph
- Ezhov Andrey
- F\ue1cila Lorenzo
- Farsad Ramin
- Fayard Maxime
- Fedele Francesco
- Ferreira Daniel
- Ferrier Anna
- Finsen Alexandra
- First Brian
- Fisher Raymond
- Floyd John
- Folk Thomas
- Fonseca Catarina
- Fonseca Luisa
- Fonteles Ritt Luiz Eduardo
- Forman Steven
- Forsgren Magnus
- Foster Malcolm
- Foster Nathan
- Frais Michael
- Frandsen Brad
- Frapp\ue9 Thierry
- Freixa Ramon
- French William
- Freydlin Marina
- Frickel Siegfried
- Fruntelata Ana Gabriela
- Fujii Shigeru
- Fujino Yusuke
- Fukunaga Hiroshi
- Furukawa Yutaka
- G\uf6tte Andreas
- Gabelmann Matthias
- Gabris Michael
- Gadsb\uf8ll Niels
- Galin Pavel
- Galinier Michel
- Ganim Ricky
- Garcia Ronnie
- Gartenlaub Olivier
- Genz Conrad
- Georger Fr\ue9d\ue9ric
- Georges Jean Louis
- Georgeson Steven
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- Gierba Mariusz
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- Giniger Alberto
- Gkotsis Alexandros
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- Gomez Mesa Juan Esteban
- Gonzalez Efrain
- Gorbunov Vladimir
- Gordon Brian
- Gorka Herv\ue9
- Gornick Charles
- Gorog Diana
- Goss Franz
- Goube Pascal
- Goudevenos Ioannis
- Goulden Dudley
- Gr\uf6nefeld Gerian
- Graham Brett
- Grande Angel
- Greco Cesare
- Green Martin
- Greer Gerald
- Gremmler Uwe
- Grena Paul
- Grinshstein Yuriy
- Grond Martin
- Gronda Edoardo
- Grondin Francois
- Groot de J. R.
- Guardigli Gabriele
- Guarnieri Thomas
- Guignier Alexandre
- Gulizia Michele
- Gumbley Michael
- Gupta Dhiraj
- Hack Terrence
- Haerer Winfried
- Hakas Joseph
- Hall Christian
- Halperin Jonathan L.
- Hampsey James
- Hananis Georgios
- Hanbali Basel
- Handel Franklin
- Hargrove Joe
- Hargroves David
- Harris Kenneth
- Hartley David
- Haruna Tetsuya
- Hata Yoshiki
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- Healey Jeff
- Hearne Steven
- Heggelund Geir
- Hemels M. E. W.
- Hemery Yann
- Henein Sam
- Henz Benhur
- Her Sung Ho
- Hermany Paul
- Hern\ue1ndez Norberto Matadamas
- Hernandes Mauro Esteves
- Higashino Yorihiko
- Hill Michael
- Hisadome Tetsuo
- Hishida Eiji
- Hitchcock James
- Hoffer Etienne
- Hoghton Matthew
- Holmes Clare
- Hong Suk Keun
- Houppe Nousse Marie Paule
- Howard Victor
- Hsu Li Fern
- Huang Chi Hung
- Huckins David
- Huehnergarth Kier
- Huisman Menno V
- Huizenga A.
- Huntley Richard
- Hussein Gamal
- Hwang Gyo Seung
- Igbokidi Oyidie
- Iglesias Ignacio
- Ikpoh Margaret
- Imberti Davide
- Ince H\ufcseyin
- Indolfi Ciro
- Ionova Tatiana
- Ip John
- Irles Didier
- Iseki Harukazu
- Ismail Younus
- Israel Noah
- Isserman Steven
- Iteld Bruce
- Ivanchura Galina
- Iyer Ramakrishnan
- Iyer Venkat
- Iza Villanueva Ruben Omar
- J\ue4ger Frank
- Jackson Voyzey Ewart
- Jaffrani Naseem
- Jain Manish
- James Martin
- Jamon Yann
- Jang Sung Won
- Jarmukli Nabil
- Jeanfreau Robert
- Jenkins Ronald
- Jiang Heng
- Jiang Nan
- Jiang Tiemin
- Jiang Xianyan
- Jimenez Javier
- Jobe Robert
- Joffe Ian
- Johansson Bengt
- Jones Nick
- Jos\ue9 Roberto Chuquiure Valenzuela Eduardo Juli\ue1n
- Jouve Bernard
- Juanatey Carlos Gonzalez
- Jundi Mayar
- Jung Byung Chun
- Jung Kyung Tae
- Jung Werner
- K\uf6hrmann Martin
- K\ufcmler Thomas
- K\ufcppers Achim
- Kabbani Samer
- Kabour Ameer
- Kafkala Chrystalenia
- Kajiwara Koji
- Kalan Marica Bracic
- Kalinina Larisa
- Kampus Priit
- Kanda Junji
- Kapadia Shaival
- Karim Amin
- Karolyi Laszlo
- Kashou Hisham
- Kastrup Andreas
- Katsivas Apostolos
- Kaufman Elizabeth
- Kawai Kazuya
- Kawajiri Kenji
- Kazmierski John
- Keeling Phil
- Kerfes Galal Ali
- Kerr Saraiva Jos\ue9 Francisco
- Kes Vanja Basic
- Ketova Galina
- Khaira Ajit
- Khalid Muhammad
- Khludeeva Elena
- Khripun Aleksey
- Kim Dae Kyeong
- Kim Doo Il
- Kim Jeong Su
- Kim Jin bae
- Kim June Soo
- Kim Ki Seok
- Kim Nam Ho
- Kim Young Hoon
- Kinova Elena
- Klein Alexander
- Kleinschnitz Christoph
- Kmetzo James
- Kneller G. Larsen
- Knezevic Aleksandar
- Koch Stanley
- Koenig Kai
- Koons Jay
- Korabathina Ravikiran
- Korennova Olga
- Koschutnik Martin
- Kosinski Edward
- Kovacic Dragan
- Kowalczyk Jacek
- Koziolova Natalya
- Kragten J. A.
- Krause Lars Udo
- Kreidieh Imad
- Krenning B. J.
- Krishnaswamy Kannappan
- Krysiak Waldemar
- Kuck Karl Heinz
- Kumar Somnath
- Kuniss Malte
- Kuo Jen Yuan
- Kurrelmeyer Karla
- Kwan Tak
- Kyo Eisho
- L\uf3pez Send\uf3n Jos\ue9
- Labovitz Arthur
- Lacroix Alain
- Lam Andy
- Lanas Zanetti Fernando Tomas
- Landau Charles
- Landini Giancarlo
- Lang Wilfried
- Larsen Torben Bjerregaard
- Laske Volker
- Lavandier Karine
- Law Nicki
- Lawrence Wong Ka Sing
- Lee Daniel
- Lee Moon Hyoung
- Leit\ue3o Ana
- Lejay Dominique
- Lelonek Malgorzata
- Lenarczyk Radoslaw
- Leprince Patrick
- Lequeux Benoit
- Leschke Matthias
- Ley Nicolas
- Li Weihua
- Li Xiaodong
- Li Yansheng
- Li Zhanquan
- Li Zicheng
- Liang Jianqiu
- Lieber Ira
- Lillestol Michael
- Limon Rodriguez Ramon Horacio
- Lin Hailong
- Lip Gregory
- Lip Gregory Y. H.
- Litchfield Jennifer
- Liu Feng
- Liu Wenhui
- Liu Xuebo
- Liu Yalin
- Liu Zhitao
- Llamas Esperon Guillermo Antonio
- Llisterri Jose Luis
- Lo Eric
- Lo Ted
- Lobos Jose Maria
- Lodde Bernhard Paul
- Loiselet Philippe
- Lorga Filho Adalberto Menezes
- Lori Ido
- Luo Ming
- Lupovitch Steven
- Lyrer Philippe
- M\ufcgge Andreas
- Ma Chang Sheng
- Ma Changsheng
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- Ma Hong
- Madariaga Irene
- Maeno Koji
- Magnin Dominique
- Mahmood Shahid
- Mahood Karen
- Maid Gustavo
- Mainigi Sumeet
- Makaritsis Konstantinos
- Maldonado Villalon Jos\ue9 Arturo
- Malhotra Rohit
- Malik Amir
- Mallecourt Catherine
- Mallik Rajiv
- Manning Rickey
- Manolis Athanasios
- Mantas Ioannis
- Manzur Jattin Fernando Gabriel
- Mar\uedn Francisco
- Marcionni Niccolo'
- Marin Javier Aguila
- Martinez Jorge
- Martinez Luis
- Maskova Petra
- Matskeplishvili Simon
- Matsuda Katsuhiro
- Mavri Alenka
- May Erik
- Mayer Nolan
- Mazon Pilar
- Mcclure John
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- Mcguire Michael
- Mcintyre Hugh
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- Mclaurin Brent
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- Mehta Paresh
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- Michalski Dominik
- Michel Patrik
- Mikdadi Ghiath
- Mikhail Magdy
- Mikus Milan
- Milicic Davor
- Militaru Constantin
- Miller Gary
- Milonas Christos
- Minescu Bogdan
- Mintale Iveta
- Miralles Aur\ue9lien
- Mirault Tristan
- Mistry Dinesh
- Mitchell George
- Miu Nicoleta Violeta
- Miyamoto Naomasa
- Moccetti Tiziano
- Mohammed Akber
- Molina de Salazar Dora Ines
- Molon Giulio
- Molony David
- Mondillo Sergio
- Mont Lluis
- Moodley Rajendra
- Moore Roger
- Morales Oscar Saenz
- Mori Kiyoo
- Moriarty Andrew
- Morka Jacek
- Moschos Nikitas
- Mota Gomes Marco Ant\uf4nio
- Moura Jorge Jose Carlos
- Mousallem Nicolas
- Moya Angel
- Mulhearn Thomas
- Muller Jean Joseph
- Muresan Carmen Manuela
- Muse Derek
- Musial Wlodzimierz
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- Nakagawa Hidemitsu
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- Nakayama Toru
- Nam Ki Byeong
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- Nechvatal Libor
- Neiman James
- Nerheim Pamela
- Neuenschwander Fernando Carvalho
- Nica Violeta Cindea
- Nishida Kunihiro
- Nizov Alexey
- Nor Azlisham Mohd
- Novikova Tatiana
- Novo Salvatore
- Nowalany Kozielska Ewa
- Nsah Emmanuel
- Nunez Fragoso Juan Carlos
- Nyvad Ole
- O'Donnell Martin
- O'Donnell Philip
- O'Hara Gilles
- Oh Dong Jin
- Oh Yong Seog
- Oikonomou Kostas
- Olalla Juan Jose
- Olivari Zoran
- Oliver Richard
- Olympios Christoforos
- Osborne John
- Osca Joaquin
- Osman Raed
- Osunkoya Abayomi
- Padanilam Benzy
- Panchenko Elizaveta
- Pandey A. Shekhar
- Paquette Miney
- Paraschos Alexander
- Pardell Herbert
- Park Hyung Wook
- Park Jong Sung
- Parkash Ratika
- Parker Ian
- Parrens Eric
- Parris Robert
- Pascual Carlos Rodr\uedguez
- Passamonti Enrico
- Patel Jaydutt
- Patel Rajesh
- Pentz William H.
- Pereira Jardim Cesar Augusto
- Persic Viktor
- Perticone Francesco
- Peters Patrick
- Petkar Sanjiv
- Pezo Luis Felipe
- Pham David
- Phlaum Stephen
- Pineau Julien
- Pineda Velez Armando
- Pini Riccardo
- Pinter Arnold
- Pinto Fausto
- Pirelli Salvatore
- Pivac Nediljko
- Pizzini Attilia Maria
- Pocanic Darko
- Polanczyk Carisi Anne
- Polasek Petr
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- Pollock Stewart
- Polo Jose
- Poock James
- Poppert Holger
- Porro Yamile
- Pose Antonio
- Poulain Fran\ue7ois
- Poulard Jean Ernst
- Pouzar Joe
- Povolny Petr
- Pozzer Domingo
- Pras Athanasios
- Prasad Neeraj
- Prevot S\ue9bastien
- Protasov Konstantin
- Prunier Laurent
- Puleo John
- Pye Maurice
- Qaddoura Fatma
- Quedillac Jean Michel
- Quintana Antonio Garcia
- Raev Dimitar
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- Randall Katie
- Ranjith Naresh
- Raposo Nuno
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- Raters Christa
- Rauch Kroehnert Ursula
- Rebane Thomas
- Regner Stefan
- Renzi Michael
- Reyes Rocha Miguel Agustin
- Reyes Humberto Rodriguez
- Reza Shabbir
- Ria Luigi
- Ribeiro Moreira Dalmo Antonio
- Richter Dimitrios
- Rickli Hans
- Rickner Kyle
- Rieker Werner
- Rigo Fausto
- Ripoll Tomas
- Roberts Douglas
- Roelke Marc
- Roman Mark
- Romeo Francesco
- Ronner E.
- Ronziere Thomas
- Rooyer F. A.
- Rosenbaum David
- Roth Sherryn
- Rothman Kenneth J.
- Rozkova Nadezda
- Rubacek Miroslav
- Rubalcava Frank
- Rubanenko Olesya
- Rubin Andrew
- Rybak Karin
- Sabbour Hani
- Sakai Tetsuo
- Salacata Abraham
- Salecker Ilsbe
- Salem Adrien
- Salfity Marwan
- Salguero Rafael
- Salvioni Alessandro
- Samson Mercedes
- Sanchez Gregorio
- Sandesara Chirag
- Santana Antonio Mart\uedn
- Santos Jos\ue9 Ferreira
- Saporito Wladmir Faustino
- Sasaoka Taishi
- Sattar Payman
- Savard Daniel
- Scala Pierre Jean
- Scemama Jacques
- Sch\uf6n Norbert
- Schaupp Thierry
- Schellinger Peter
- Scherr Carlos
- Schmitz Bettina
- Schmitz Karl Heinz
- Schmitz Lisa
- Schnitzler Robert
- Schnupp Steffen
- Schoeniger Peter
- Schuster Stefan
- Schwimmbeck Peter
- Seamark Clare
- Seebass Ruediger
- Seidl Karl Heinz
- Seidman Barry
- Sek Jaroslaw
- Sekaran Lakshmanan
- Seko Yoshinori
- Sepulveda Varela Pablo Andres
- Sevilla Bego\uf1a
- Shah Aman
- Shah Anil
- Shah Neerav
- Shah Vinay
- Shanes Jeffrey
- Sharareh Ali
- Sharma Vijay Kumar
- Shaw Louise
- Shimizu Yutaka
- Shimomura Hideki
- Shin Dong Gu
- Shin Eun Seok
- Shite Junya
- Shoukfeh Mohammad
- Shoultz Charles
- Silver Frank
- Sime Iveta
- Simmers T. A.
- Singal Dinesh
- Singh Narendra
- Siostrzonek Peter
- Sirajuddin Mohiburrahman
- Skeppholm Mika
- Smadja Didier
- Smith David
- Smith Richard
- Soda Hassan
- Sofley C. Wilson
- Sokal Adam
- Sotolongo Rodolfo
- Sparby Jon Arne
- Spinar Jindrich
- Sprigings David
- Spyropoulos Alex
- Stakos Dimitrios
- Steinberg Alon
- Steinwender Clemens
- Stergiou Georgios
- Stites H. William
- Stoikov Anastas
- Strasser Ruth
- Streb Witold
- Styliadis Ioannis
- Su Guohai
- Su Xi
- Suarez Rafael Martin
- Sudnik Wanda
- Sueyoshi Atsushi
- Sukles Kai
- Sun Li
- Suneja Randeep
- Svensson Peter
- Szavits Nossan Janko
- Taggeselle Jens
- Takagi Yuichiro
- Takhar Amrit
- Tallet Julio
- Tamm Angelika
- Tanaka Katsumi
- Tanaka Shozo
- Tang Aylmer
- Tang Sherman
- Tassinari Tiziana
- Tayama Shinji
- Tayebjee Muzahir
- Tebbe Ulrich
- Teixeira Jose
- Tesloianu Dan Nicolae
- Tessier Pascal
- Teutsch Christine
- The S. H. K.
- Thevenin J\ue9rome
- Thomas Harold
- Timsit Serge
- Topkis Robert
- Torosoff Mikhail
- Touze Emmanuel
- Traissac Thalie
- Trendafilova Elina
- Troyan Barry
- Tsai Wenchi Kevin
- Tse Hung Fat
- Tsutsui Hiroshi
- Tsutsui Takashi
- Tuininga Y. S.
- Turakhia Minang
- Turk Samir
- Turner Wayne
- Tveit Arnljot
- Twiddy Shannon
- Tytus Richard
- Ukrainski Gerald
- Valdovinos Chavez Salvador Bruno
- Van De Graaff Eric
- Vanacker Peter
- Vardas Panagiotis
- Vargas Michael
- Vassilikos Vassilios
- Vazquez Juan
- Venkataraman Asok
- Verdecchia Paolo
- Vester Ernst G\ufcnter
- Vial Hubert
- Vicenzo de Paola Angelo Amato
- Vinereanu Dragos
- Vlastaris Anthony
- Vogel Craig
- vom Dahl J\ufcrgen
- von Mering Matthias
- Vora Kishor
- Wakefield Paul
- Walia Jasjit
- Walter Thomas
- Wang Feng
- Wang Kuo Yang
- Wang Mingsheng
- Wang Ningfu
- Wang Xinhua
- Wang Zulu
- Watanabe Kouki
- Wei Jeanne
- Weimar Christian
- Weinrich Renate
- Wen Ming Shien
- Wheelan Kevin
- Wicke Jens
- Wiemer Marcus
- Wild Beate
- Wilke Andreas
- Willems Stephan
- Williams David
- Williams Marcus
- Winkler Andreas
- Wirtz Jost Henner
- Witzenbichler Bernhard
- Wong Brian
- Wong Danny H. K.
- Wozakowska Kaplon Beata
- Wu Shulin
- Wu Zhaohui
- Wyatt Nell
- Xu Xiangdong
- Xu Yong
- Yamada Akira
- Yamamoto Kazuya
- Yamanoue Hiroki
- Yamashita Takeshi
- Yang Tianlun
- Yang Yanmin
- Yao Jing
- Yarlagadda Chakri
- Yeh Kuo Ho
- Yotov Yoto
- Yvorra Serge
- Zahn Ralf
- Zamorano Jos\ue9
- Zanini Roberto
- Zarich Stuart
- Zebrack James
- Zenin Sergei
- Zeuthen Elisabeth Louise
- Zhang Dadong
- Zhang Donghui
- Zhang Huanyi
- Zhang Quansan
- Zhang Xingwei
- Zhao Shuiping
- Zhao Xinwen
- Zheng Qiangsun
- Zheng Yang
- Zhou Jian
- Zhou Jing
- Ziekenhuis Antonius
- Zimmermann Rainer
- Zimmermann Sergio Luiz
- Zint Kristina
- Zuhairy Hamed M.
- Zukerman L. Steven
- Zwaan van der C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
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- Bellard Terell M.
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- Bemrose Richard
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- BenKahla Alia
- Benke J
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- Beugelsdijk Tony J.
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- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
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- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
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- Bülow Robin
- Bülow Robin
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- Bÿchel Christian
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- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
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- Cedarbaum Jesse
- Cellar Janet S
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- Chakravarty Mallar
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- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
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- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
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- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
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- Crespo-Facorro Benedicto
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- Dale Anders M
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- Davies Gareth E
- Davies Peter
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- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
- Author
- Ackroyd Sam
- Addada Juanah (Jo)
- Ademokun Debo
- Ahmed Alhassani Thubeena M.
- Ahmed Khalil
- Aitchison Robin
- Al-Ani Maryam
- Aldouri Maadh
- Alfred Arun
- Allford Sarah
- Alvares Caroline
- Andrews Vivienne
- Anjum Farahn
- Ardeshna Kirit
- Arnold Claire
- Arnold Claire
- Austen Belinda
- Bake Bart
- Barker Helen
- Basu Supratik
- Batten Leona M.
- Beier Ommen Hans
- Berkhan Leanne
- Betteridge Sophie
- Blombery Piers
- Bokhari Syed
- Bond Lee
- Borg Anton
- Borregaard Niels
- Bowen Angela
- Bowen David
- Bowett Peter
- Brearton Gillian
- Burgess Jordan
- Burns Sarah
- Butler Andrew
- Byrne Jenny
- Cahalin Paul
- Canham Joanna
- Carr Robert
- Cavenagh Jamie
- Chacko Joseph
- Chalmers Isobel
- Chandra Deepak
- Chapman Oliver
- Chapple Mary
- Chatterjee Poulami
- Chodhouri Senthil S.
- Chvuka Shingi
- Copplestone Adrian
- Corbett Gillian
- Corbett Timothy
- Corser Robert
- Craddock Charles
- Craig Jenny
- Craig Joanne
- Cranfield Tanya
- Crawley Charles
- Creach Desmond
- Crowe Josephine
- Culligan Dominic
- Cullis Jonathan
- Cuthbert Robert
- Cutting Robert
- Cutting Robert
- Dalley Chris
- Dang Ray
- Dasgupta Emma
- Dasgupta Ranjit
- David Marianna
- Davidson Kerri
- Davies Simon
- Dennis Mike
- Devanny Ian
- DeVos Johannes
- Dignum Helen
- Dillon Richard
- Doocey Richard
- Dungarwalla Moez
- Dyer Peter
- Eagleton Helen
- Eden Ayed
- Edwards David
- Edwards Hugh
- Ellis Lauren
- Emmett Shannon
- Eve Heather
- Evely Roger
- Everington Tamara
- Fail Tom
- Farrell Katrina
- Fenella Willis Neoh
- Ferguson Paul
- Fernandes Savio
- Fernyhough Liam
- Finnegan Damian
- Fletcher Andrew
- Fletcher Andrew
- Forsyth Peter
- Francis McMullin Mary
- Freeman Sylvie D.
- Friis Lone
- Ganczakowski Mary
- Gandhi Anna Cowley S.
- Ganly Peter
- Gelly Keith
- Gharib Maged
- Gibbons Steve
- Gibbs Simon
- Gilkes Amanda
- Gilles Julie
- Gomez Cesar
- Goodman Hugh
- Goodrick Margaret
- Grand Effie
- Grey-Davies Elisabeth
- Groch Henri
- Hada Sunil
- Hall Rachel
- Hamilton Malcolm
- Hanlon Katharine
- Harrison Beth
- Hasan Yasmin
- Haskins Lea
- Hatcliffe Faye
- Hawkins Timothy
- Heartin Earnest
- Hemmaway Claire
- Hemmaway Claire
- Hendry Louise
- Hervey Victoria
- Hinson Emily L.
- Hodson Andrew
- Holm Mette
- Horne Gillian
- Horne Gillian
- Houghton John
- Hoyle Christine
- Hunter Ann
- Hunter Hannah
- Islam Shahid
- Ismail Saad
- Jack Fergus
- Jackson Nicholas
- Jacob Abraham
- Janes Sarah
- Janmohamed Riaz
- Jenner Matthew
- Jobanputra Shailesh
- Johnson Peter
- Jones Christopher
- Joseph Joe
- Jowitt Simon
- Juul Nielsen Ove
- Kaczmarski Richard
- Kakalamudi Sudhakar
- Kallenbach Maria
- Kampmann Peter
- Kaul Stuti
- Kaur Harpreet
- Keat Sally
- Kell Jonathan
- Kelsey P.
- Kerr Paul
- Kerr Ron
- Khwaja Asim
- Kjeldsen Lars
- Knapper Steve
- Knapper Steven
- Knechtli Christopher
- Kottaridis Panagiotis
- Krishnamurthy Pramila
- Krishnamurthy Suchitra
- Krogh Jensen Morten
- Kwan Mark
- Laing Alison
- Laird Jane
- Lawes Matthew
- Linch David
- Lindsay Kathrine
- Lindsay-Holmes Srividhya Sarah
- Longmuir Karyn
- Lovell Richard
- Lush Chris
- Lush Richard
- Lykke Petersen Soeren
- Lyons Simon
- Maclean Peter
- MacWhonell Alan
- Maddams Rebecca
- Maddox Jamie
- Mamat Mohd
- Mangos Hilda
- Mannari Deepak
- Marcher Claus
- Marks David
- Marshall Scott
- Martin Murray
- Maughan Elizabeth
- Maxwell Norgaard Jan
- McCaig Alison
- McCloskey Kayleigh
- McIntyre Victoria
- McLintock Lorna
- Medd Patrick
- Mehta Priyanka
- Mehta Priyanka
- Meiklejohn David
- Micallef-Eynaud Paul
- Milligan Donald
- Mills Juliet
- Milne Alison
- Mitchell Lindsey
- Mohite Unmesh
- Moreton Paul
- Moss Paula
- Mucklow Stuart
- Munro Laura
- Murphy John
- Murray Jim
- Murrin Richard
- Narat Santosh
- Narayanan Mekkali
- Neilson Jeff
- Neylon Annette
- Ngu Loretta
- Nicholson Emma
- Nicholson Toby
- Nicolle Annette
- Niemann Carsten
- Nokes Tim
- O'Hea Anne-Marie
- Omran Asad
- Orchard Kim
- Othman Jad
- Oun Hajer
- Overgaard Ulrik Malthe
- Paneesha Shankara
- Patel Amit
- Paterson Pamela
- Patil Kavita
- Pattinson Jonathan
- Pattinson Jonathan
- Patton Nigel
- Pechey Victoria
- Pemberton Lucy
- Peniket Andy
- Peters Jayne
- Plews Diane
- Popat Rakesh
- Potter Mike
- Potter Nicola
- Pottinger Bryson
- Powell Matthew
- Pullon Humphrey
- Raafat Alaeddin
- Raj Kavita
- Reilly John
- Richardson Deborah
- Roberts Patrick
- Roddie P.H.
- Rogers Stephen
- Rose Peter
- Roy Ashok
- Rudin Claudius
- Ruell Jackie
- Rule Simon
- Russell Nigel
- Russell Nigel H.
- Rye Adam
- Rye Adam
- Rymes Nicholas
- Sadik Walid
- Sadullah Shala
- Salesh Sana
- Sampson Rebecca
- Saravanamuttu Kandeepan
- Sati Hamdi
- Severinsen Marianne
- Shafeek Salim
- Sidra Gamal
- Simpson Sylwia
- Smith Jeffery
- Smith Mark
- Smith Steve
- Snowden John
- Somerfield Sven
- Somervaille Tim
- Sorour Youssef
- Spearing Ruth
- Stanchev Atanas
- Stokley Simone
- Sud Amit
- Sugai Taku
- Tauro Sudhir
- Tholouli Eleni
- Thomas Wayne
- Thomas-Dewing Rowena
- Tighe Jane
- Tomlins Jo
- Tuegar Salah
- Udby Peter Møller Lene
- Vavyla Maria
- Virchis Andres
- Walewska Renata
- Wandoo Farooq
- Wei Bjerrum Ole
- Welch Emma
- Went Richard
- Wexler Sarah
- White Denise
- Wilhelm-Benartzi Charlotte
- Wiliams Adrian
- Williams Mark
- Williamson Peter
- Wilson-Morkeh Isaac
- Wodzinski Mark
- Wright David
- Xu Chin Kate
- Yong Kwee
- Zaman Sonya
- Zhao New Oo Rui
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 30/04/2024
- Field of study
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit
A novel Alzheimer disease locus located near the gene encoding tau protein
- Author
- A Boland
- A C Naj
- A David Smith
- A Hofman
- A L Destefano
- A L Fitzpatrick
- A M Goate
- A R Laza
- A R Winslow
- A Ramirez
- A V Smith
- Adam Boxer
- Aimee Pierce
- Alberto Llèo
- Alberto Pilotto
- Alexa Beiser
- Alexandra Stretton
- Alexis Brice
- Allan I Levey
- Amanda G Smith
- Amanda J Myers
- Amanda Partch
- Ammar Al-Chalabi
- Amy Gerrish
- Ana Mauleón
- Andre G Uitterlinden
- Andrew B Singleton
- Andrew J Saykin
- Andrew McQuillin
- Andrew N McDavid
- Andrew P Lieberman
- André Lacour
- Angharad Morgan
- Ann C McKee
- Anna Karydas
- Anna M Toeglhofer
- Anna Maria Töglhofer
- Annick Alpérovitch
- Anthony Bayer
- Antonia Germanou
- Antonio González-Perez
- Aoibhinn Lynch
- Ashok Raj
- B Grenier-Boley
- B M Psaty
- B W Kunkle
- Badri N Vardarajan
- Barry Reisberg
- Benedetta Nacmias
- Bernadette McGuinness
- Bernardino Ghetti
- Bradley F Boeve
- Bradley T Hyman
- Brian Lawlor
- Britta Schürmann
- Bruce L Miller
- C A Ibrahim-Verbaas
- C Bellenguez
- C Berr
- C Brayne
- C Cruchaga
- C Dufouil
- C Holmes
- C M van Duijn
- C Tzourio
- C Van Broeckhoven
- Carlos Cruchaga
- Carol A Miller
- Caroline Graff
- Chang-En Yu
- Charlene Thomas
- Charles DeCarli
- Chiao-Feng Lin
- Chris S Carlson
- Christiane Reitz
- Christine Herold
- Christine M Hulette
- Christopher E Shaw
- Christopher Medway
- Chuang-Kuo Wu
- Chuanhai Cao
- Claudia Satizabal
- Clinton B Wright
- Clinton T Baldwin
- Constantine G Lyketsos
- Craig S Atwood
- Cynthia M Carlsson
- D A Bennett
- D Beekly
- D Campion
- D Evans
- D Hannequin
- D Harold
- D Rujescu
- D Zelenika
- Daniel C Marson
- Daniel H Geschwind
- Daniela Galimberti
- Daniilidou Makrina
- David C Rubinsztein
- David Craig
- David G Clark
- David H Cribbs
- David Mann
- David Wallon
- Davide Seripa
- DClin Psy
- Debby W Tsuang
- Deborah Blacker
- Deborah C Mash
- Dennis W Dickson
- Dennis W Dickson
- Despoina Avramidou
- Dmitriy Drichel
- Donald R Royall
- Donald Warden
- Douglas R Galasko
- E B Larson
- E M Reiman
- E R Martin
- Edward H Koo
- Eileen H Bigio
- Ekaterina Rogaeva
- Elaine Peskind
- Eliecer Coto
- Eliezer Masliah
- Elio Scarpini
- Elizabeth A Crocco
- Elizabeth Fisher
- Elizabeth Head
- Emma Vardy
- Eric Boerwinkle
- Erik D Roberson
- F Pasquier
- F Yesim Demirci
- Fernando Rivadeneira
- Florentino Sanchez Garcia
- Francesco Panza
- Francisco J Morón
- Frank Jessen
- Frank M LaFerla
- Frank Martiniuk
- G D Schellenberg
- G Eiriksdottir
- G Jun
- G W Beecham
- Gail P Jarvik
- Ge Li
- Gerhard Ransmayr
- Giancarlo Russo
- Gianfranco Spalletta
- Gill Livingston
- Gina Bisceglio
- Gordon Wilcock
- Gregory A Jicha
- H Hampel
- H Schmidt
- H-Erich Wichmann
- Hakon Hakonarson
- Harriet Oldham
- Harry V Vinters
- Heike Kölsch
- Helena C Chui
- Hendrik van den Bussche
- Henry L Paulson
- Hlikka Soininen
- Howard J Rosen
- Hugh Gurling
- Huntington Potter
- Ignacio Mateo
- Isabel Hernández
- Isabella Heuser
- J C Bis
- J Chung
- J D Buxbaum
- J F Powell
- J Hardy
- J I Rotter
- J Jakobsdóttir
- J L Haines
- J R Wendland
- J S K Kauwe
- J Williams
- J-C Lambert
- J-F Dartigues
- Jacques Epelbaum
- Jade Chapman
- James B Leverenz
- James D Bowen
- James J Lah
- James R Burke
- James T Becker
- James T Becker
- James Turton
- James Uphill
- Jan Bressler
- Janet A Johnston
- Jason Corneveaux
- Jason D Warren
- Jean Paul Vonsattel
- Jeffrey A Kaye
- Jennifer Williamson
- Jenny Lord
- Jens Wiltfang
- Jill R Murrell
- Joan S Reisch
- Joel H Kramer
- Johannes Kornhuber
- John C Morris
- John Collinge
- John Gallacher
- John H Growdon
- John Hardy
- John M Olichney
- John M Ringman
- John Q Trojanowski
- John R Gilbert
- John SK Kauwe
- Jonathan D Glass
- Jonathan M Schott
- Jordi Clarimon
- Josef J M Marksteiner
- Joseph E Parisi
- Joseph F Quinn
- Joshua A Sonnen
- Joshua W Miller
- Juan C Troncoso
- Julie A Schneider
- K C Wilhelmsen
- K L Hamilton-Nelson
- K L Lunetta
- K Morgan
- Karl-Heinz Jöckel
- Karolien Bettens
- Kathleen A Welsh-Bohmer
- Kelley M Faber
- Kenneth B Fallon
- Kenneth Rice
- Kevin Mayo
- Kristel Sleegers
- Kristelle Brown
- L A Farrer
- L B Cantwell
- L J Launer
- L Jones
- L Letenneur
- L Tárraga
- L-S Wang
- Lars Lannfelt
- Laura Fratiglioni
- Lawrence S Honig
- Lee-Way Jin
- Lei Yu
- Lewis H Kuller
- Li Ma
- Liana G Apostolova
- Lina Keller
- Linda J Van Eldik
- Lindy E Harrell
- Lisa L Barnes
- Lon S Schneider
- Lutz Frölich
- M A Ikram
- M A Nalls
- M A Pericak-Vance
- M Boada
- M C O'Donovan
- M Carasquillo
- M Gill
- M I Kamboh
- M L Dunstan
- M Lathrop
- M M Nöthen
- M Vronskaya
- Magda Tsolaki
- Maitee Rosende Roca
- Malcolm Dick
- Manuel Mayhaus
- Marc Delepine
- Maria Bullido
- Maria Candida Deniz Naranjo
- Maria del Zampo
- Maria Koutroumani
- Marilyn S Albert
- Mark A Sager
- Marla Gearing
- Marsel Mesulam
- Martin Dichgans
- Martin Ingelsson
- Martin R Farlow
- Martin Rossor
- Mary Sano
- Matthew J Huentelman
- Matthew P Frosch
- Matthias Riemenschneider
- Michael Hüll
- Michael J Owen
- Michael Nalls
- Michelangelo Mancuso
- Michelle Lupton
- Michjael M Barmada
- Mikko Hiltunen
- Minerva M Carrasquillo
- Montserrat Alegret
- Murray Raskind
- Myriam Fornage
- N Amin
- N C Fox
- N Denning
- N Fievet
- Natalie Ryan
- Neil W Kowall
- Neill R Graff-Radford
- Neill R Graff-Radford
- Nicholas J Bass
- Nick Warner
- Nigel J Cairns
- Nigel M Hooper
- Nilufer Ertekin-Taner
- Norman Klopp
- null null
- O Hanon
- O L Lopez
- O Valladares
- Olymbia Gkatzima
- Onofre Combarros
- Oscar L Lopez
- P Amouyel
- P De Jager
- P H St George-Hyslop
- P Holmans
- P K Crane
- P Passmore
- P Pastor
- P V Jonsson
- Panagiotis Deloukas
- Paola Bossù
- Paolo Caffara
- Pascale Barberger-Gateau
- Patrick G Kehoe
- Patrizia Mecocci
- Paul Freudenberger
- Paul Hollingworth
- Per Hoffmann
- Perrie M Adams
- Peter Dal-Bianco
- Peter J Koudstaal
- Petroula Proitsi
- Philip A Wolf
- Philip L De Jager
- R Barber
- R Clarke
- R F A G de Bruijn
- R Mayeux
- R Schmidt
- R Sims
- Rachelle S Doody
- Randall L Woltjer
- Ranjan Duara
- Regina M Carney
- Reiner Heun
- Reposo Ramírez-Lorca
- Rhian Gwilliam
- Rhoda Au
- Rita Guerreiro
- Robert A Stern
- Robert C Green
- Roger L Albin
- Roger N Rosenberg
- Ronald C Petersen
- Ronald Kim
- Ronald L Hamilton
- Rudolph E Tanzi
- Ryan M Huebinger
- S G Younkin
- S J van der Lee
- S Love
- S Mead
- S Seshadri
- S-H Choi
- Sabrina Pichler
- Salvatore Spina
- Sandra Weintraub
- Sandro Sorbi
- Sanjay Asthana
- Sara Ortega-Cubero
- Sarah Wishnek
- Shubhabrata Mukherjee
- Sid O'Bryant
- Simon Lovestone
- Steffi Riedel-Heller
- Stephen Todd
- Steven E Arnold
- Steven Ferris
- Steven L Carroll
- Steven T DeKosky
- Stuart Pickering-Brown
- Susan M McCurry
- Susanne Moebus
- T Becker
- T H Mosley
- T J Montine
- T M Foroud
- Tamara B Harris
- Thomas Benke
- Thomas D Bird
- Thomas Feulner
- Thomas G Beach
- Thomas J Fairchild
- Thomas Lumley
- Tricia A Thornton-Wells
- V Chouraki
- V Deramecourt
- V Emilsson
- V Escott-Price
- V Gudnason
- Vernon S Pankratz
- Victoria Alvarez
- Vivianna M Van Deerlin
- W A Kukull
- W Maier
- Wayne C McCormick
- Wayne W Poon
- Wei Gu
- Wendy J Mack
- William Perry
- William T Longstreth Jr
- William W Seeley
- Y Kamatani
- Yoav Ben-Shlomo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/03/2015
- Field of study
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordAPOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ε4+ (10 352 cases and 9207 controls) and APOE ε4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ε4 status. Suggestive associations (P<1 × 10-4) in stage 1 were evaluated in an independent sample (stage 2) containing 4203 subjects (APOE ε4+: 1250 cases and 536 controls; APOE ε4-: 718 cases and 1699 controls). Among APOE ε4- subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 data sets (best SNP, rs2732703, P=5·8 × 10-9). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100-kilobase region that includes MAPT. Except for previously identified AD loci showing stronger association in APOE ε4+ subjects (CR1 and CLU) or APOE ε4- subjects (MS4A6A/MS4A4A/MS4A6E), no other SNPs were significantly associated with AD in a specific APOE genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6 × 10-7) is noteworthy, because TMEM106B variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3 × 10-8), frontal cortex (P≤1.3 × 10-9) and temporal cortex (P≤1.2 × 10-11). Rs113986870 is also strongly associated with a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2 × 10-6) and temporal cortex (P=2.6 × 10-6). Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking APOE ε4 compared with persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted
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