Indiana University – Purdue University Indianapolis

IUPUIScholarWorks
Not a member yet
    32000 research outputs found

    Can ChatGPT 'Think Like a Lawyer?' A Socratic Dialogue

    No full text
    A witty socratic dialogue with a language-generation model, exploring the aims of legal education in the new era of machine writing

    State Behavioral Health Workforce: Context and Opportunities

    Get PDF
    The 2023 Indiana Roundtable on Mental Health Summit held a workforce breakout session entitled State Behavioral Health Workforce: Context and Opportunities. The interactive session explored national and state level trends and strategies used to address behavioral health workforce shortages

    Innovations in Medical Education: 4th Annual Indiana University School of Medicine Education Day Program

    No full text
    Program for the 4th annual Indiana University School of Medicine Education Day held at Hine Hall Conference Center on the IUPUI campus on April 28, 2023. The IUSM Education Day is an event for faculty, staff, students, residents, and fellows from all departments and campuses to showcase their medical education research through oral presentations, workshops, poster sessions, and small group discussions

    Melatonin-MT1 Signaling Axis Ameliorates the Phenotypes of Primary Sclerosing Cholangitis

    Get PDF
    Indiana University-Purdue University Indianapolis (IUPUI)Background: Primary Sclerosing Cholangitis (PSC) is characterized by hepatic fibrosis and portal inflammation. Melatonin is synthesized by arylalkylamine N-acetyltransferase (AANAT) in cholangiocytes. We found that: (i) the MT1 receptor is primarily expressed in cholangiocytes; (ii) melatonin reduces biliary proliferation via MT1 receptor signaling; and (iii) melatonin treatment for 1 wk decreases ductular reaction (DR) and liver fibrosis in cholestatic rats by downregulation of MT1 and clock genes. Melatonin administration to male Mdr2-/- mice (PSC model) reduces angiogenesis and portal inflammation via decreased miR-200b. Downregulation of maspin triggers angiogenesis during tumorigenesis by interaction with glutathione S-transferase (GST). We aimed to evaluate the effects of long-term melatonin treatment and MT1 signaling on PSC phenotypes in Mdr2-/- mice. Methods: Male FVB/NJ and Mdr2-/- mice had access ad libitum to drinking water with/without melatonin for 3 months. Immortilized-SV40-cholangiocytes isolated from human liver samples (control and PSC) were treated with melatonin (10-3 mol/L) for 24 hr. Male C3H-Hej (WT for MT1-/-), FVB/NJ (WT for Mdr2-/-), MT1-/-, Mdr2-/- mice and MT1-/-/Mdr2-/- mice were euthanized at 12 wk. We analyzed liver damage, PSC phenotypes, angiogenesis and AANAT, melatonin receptors and clock genes by immunohistochemistry, immunofluorescence, ELISA and western blots in liver samples and isolated cholangiocytes. Melatonin signaling was evaluated in human control and PSC samples. Results: Long-term melatonin treatment and inhibition of MT1 receptor ameliorates cholestatic liver phenotypes in Mdr2-/-mice by decreasing the immunoreactivity of melatonin enzymes and clock genes. GST activity and maspin expression decreased in Mdr2-/- mice and human PSC samples compared to controls; the phenotypes were reversed by melatonin. Conclusion: Chronic melatonin treatment improves liver histology and restores biliary circadian rhythm by interaction with MT1. Suppression of MT1 ameliorates biliary/liver phenotypes through changes in clock genes and melatonin enzymes. Restoration of the circadian rhythm by modulation of melatonin/MT1 signaling may be key for PSC management

    2023 Emergency Medical Responder Occupational Flyer

    No full text
    The 2023 EMR Occupational Flyer presents key information on becoming an Emergency Medical Responder in the state of Indiana

    Plant Level IIoT Based Energy Management Framework

    No full text
    Indiana University-Purdue University Indianapolis (IUPUI)The Energy Monitoring Framework, designed and developed by IAC, IUPUI, aims to provide a cloud-based solution that combines business analytics with sensors for real-time energy management at the plant level using wireless sensor network technology. The project provides a platform where users can analyze the functioning of a plant using sensor data. The data would also help users to explore the energy usage trends and identify any energy leaks due to malfunctions or other environmental factors in their plant. Additionally, the users could check the machinery status in their plant and have the capability to control the equipment remotely. The main objectives of the project include the following: • Set up a wireless network using sensors and smart implants with a base station/ controller. • Deploy and connect the smart implants and sensors with the equipment in the plant that needs to be analyzed or controlled to improve their energy efficiency. • Set up a generalized interface to collect and process the sensor data values and store the data in a database. • Design and develop a generic database compatible with various companies irrespective of the type and size. • Design and develop a web application with a generalized structure. Hence the database can be deployed at multiple companies with minimum customization. The web app should provide the users with a platform to interact with the data to analyze the sensor data and initiate commands to control the equipment. The General Structure of the project constitutes the following components: • A wireless sensor network with a base station. • An Edge PC, that interfaces with the sensor network to collect the sensor data and sends it out to the cloud server. The system also interfaces with the sensor network to send out command signals to control the switches/ actuators. • A cloud that hosts a database and an API to collect and store information. • A web application hosted in the cloud to provide an interactive platform for users to analyze the data. The project was demonstrated in: • Lecture Hall (https://iac-lecture-hall.engr.iupui.edu/LectureHallFlask/). • Test Bed (https://iac-testbed.engr.iupui.edu/testbedflask/). • A company in Indiana. The above examples used sensors such as current sensors, temperature sensors, carbon dioxide sensors, and pressure sensors to set up the sensor network. The equipment was controlled using compactable switch nodes with the chosen sensor network protocol. The energy consumption details of each piece of equipment were measured over a few days. The data was validated, and the system worked as expected and helped the user to monitor, analyze and control the connected equipment remotely

    S'more skills for everyone: Addressing scale and access in negotiation education by developing an OER

    Get PDF
    Learn about a multi-institutional project developing open educational resources (OER) to equip academic library workers with negotiation skills within the context of academic libraries work with third party vendors. Presenters will share project learnings thus far providing insights regarding e-resource negotiations and resources to aid participants in their own negotiations.IMLS Laura Bush 21st Century Librarian Grant Progra

    Senior Design Project Report Whole House Ventilation System

    Get PDF
    Indiana University Purdue University IndianapolisThe Whole House Ventilation System was created out of the sponsor’s need to have cleaner air within their home. The system will accommodate a Ranch-style, 2000 sq ft home located in Indianapolis. A microcontroller will be used to control the fan speed and make decisions based on sensor data. Other specifications include having the fan produce noise below 65 dB, physical controls for fan speed and power, and having an Android app to view sensor data. The four system tests we conducted verified power, sensor functionality, and Auto/Manual functionality. All four tests passed. The final system met the majority of the customer’s needs. We recommend a PCB board reprint as some holes do not have pads.Electrical Engineering Technolog

    A Community-Based Occupational Therapy Program for Parkinson's

    Get PDF
    Indiana University Purdue University IndianapolisParkinson’s disease is a progressive neurological condition that causes symptoms that interrupt safety, performance, and participation in everyday life activities. The literature supports occupational therapy’s role in maximizing quality of life and preventing occupational decline in people with Parkinson’s disease. Despite the effectiveness of occupational therapy treatment with this population, occupational therapy services are under-utilized among those with Parkinson’s disease. This doctoral capstone experience and project sought to increase access to occupational therapy services to individuals with Parkinson’s within the state of Indiana through free occupation-based groups hosted by a local Parkinson’s organization. Through needs assessments and client-centered surveys, the occupational needs and interests of site stakeholders were determined. Fourteen in-person training sessions were created and delivered to two Parkinson group locations within the greater Indianapolis area. There was a total of approximately thirty participants primarily consisting of community-dwelling individuals with Parkinson’s. Post-survey results indicated a positive trend, demonstrating an overall decrease in participants’ perceived difficulty with surveyed tasks. This study supports the continued need for occupation-based education and training for individuals with Parkinson’s.Occupational Therap

    27,013

    full texts

    32,000

    metadata records
    Updated in last 30 days.
    IUPUIScholarWorks is based in United States
    Access Repository Dashboard
    Do you manage Open Research Online? Become a CORE Member to access insider analytics, issue reports and manage access to outputs from your repository in the CORE Repository Dashboard! 👇