Literature-based requirements analysis review of persuasive systems design for mental health applications

Mental health problems are becoming more common while access to treatment is often not available to everyone who needs help. Recent advances in information technology, the wide availability of the internet, the emergence of smartphones and their common usage worldwide raise hope for more treatment options for mental health disorders. Many mobile phone apps that claim to assist in treating a variety of mental health disorders are already available, and the number of such apps continues to increase. The availability of such apps raises many questions about their effectiveness, suitable treatment methods, possibilities for use alongside traditional treatment methods, possible risks and other uncertainties. Beside mobile apps, internet-based apps are also being introduced with similar sets of challenges and ambiguities. One area of research that is gaining a lot of attention recently is Persuasive System Design and Behavior Change. Persuasive System Design is considered one solution that has the potential to help solve the challenges of lack of user motivation and adherence when utilizing mental health applications. The goal of this paper is to perform a literature review, in order to determine the most essential requirements for a persuasively designed mental health application. As part of this process, the challenges and requests of the end-user will be taken into account in order to make recommendations for the future design of such applications

eSano – An eHealth Platform for Internet- and Mobile-based Interventions

The prevention and treatment of mental disorders and chronic somatic diseases is a core challenge for health care systems of the 21th century. Mental- and behavioral health interventions provide the means for lowering the public health burden. However, structural deficits, reluctance to use existing services, perceived stigma and further personal and environmental reasons restrict the uptake of these evidence-based approaches. Internet- and mobile-based interventions (IMIs) might overcome some of the limitations of on-site interventions by providing an anonymous, scalable, time- and location-independent, yet evidence-based approach. In order to implement digital mental and behavioral health concepts across the life-span into practice, a technical solution to support the design, creation, and execution of IMIs is needed. However, there are various conceptual, technical as well as legal challenges to implementing a corresponding software solution in the healthcare domain. Therefore, the work at hand (1) identifies these challenges and derives a number of respective requirements, (2) introduces the eHealth platform eSano, a software project developed by an interdisciplinary team of computer scientists, psychologists, therapists, and other domain experts, with the aim to serve as a flexible basis for mental and behavioral research and health care, and (3) provides technical insights into the developed platform and its approach to address the aforementioned requirements

Clinical and Cost-Effectiveness of PSYCHOnlineTHERAPY: Study Protocol of a Multicenter Blended Outpatient Psychotherapy Cluster Randomized Controlled Trial for Patients With Depressive and Anxiety Disorders

Introduction: Internet- and mobile-based interventions (IMIs) and their integration into routine psychotherapy (i.e., blended therapy) can offer a means of complementing psychotherapy in a flexible and resource optimized way. Objective: The present study will evaluate the non-inferiority, cost-effectiveness, and safety of two versions of integrated blended psychotherapy for depression and anxiety compared to standard cognitive behavioral therapy (CBT). Methods: A three-armed multicenter cluster-randomized controlled non-inferiority trial will be conducted comparing two implementations of blended psychotherapy (PSYCHOnlineTHERAPYfix/flex) compared to CBT. Seventy-five outpatient psychotherapists with a CBT-license will be randomized in a 1:1:1 ratio. Each of them is asked to include 12 patients on average with depressive or anxiety disorders resulting in a total sample size of N = 900. All patients receive up to a maximum of 16 psychotherapy sessions, either as routine CBT or alternating with Online self-help sessions (fix: 8/8; flex: 0–16). Assessments will be conducted at patient study inclusion (pre-treatment) and 6, 12, 18, and 24 weeks and 12 months post-inclusion. The primary outcome is depression and anxiety severity at 18 weeks post-inclusion (post-treatment) using the Patient Health Questionnaire Anxiety and Depression Scale. Secondary outcomes are depression and anxiety remission, treatment response, health-related quality of life, patient satisfaction, working alliance, psychotherapy adherence, and patient safety. Additionally, several potential moderators and mediators including patient characteristics and attitudes toward the interventions will be examined, complemented by ecological day-to-day digital behavior variables via passive smartphone sensing as part of an integrated smart-sensing sub-study. Data-analysis will be performed on an intention-to-treat basis with additional per-protocol analyses. In addition, cost-effectiveness and cost-utility analyses will be conducted from a societal and a public health care perspective. Additionally, qualitative interviews on acceptance, feasibility, and optimization potential will be conducted and analyzed. Discussion: PSYCHOnlineTHERAPY will provide evidence on blended psychotherapy in one of the largest ever conducted psychotherapy trials. If shown to be non-inferior and cost-effective, PSYCHOnlineTHERAPY has the potential to innovate psychotherapy in the near future by extending the ways of conducting psychotherapy. The rigorous health care services approach will facilitate a timely implementation of blended psychotherapy into standard care

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Backend Concept of the eSano eHealth Platform for Internet- and Mobile-based Interventions

Mental disorders represent an ongoing challenge to global health and can affect anyone at any age from any region in the world. The response of healthcare providers to mental health disorders still lags behind that of other diseases and a significant number of people who are affected by mental health disorders do not receive adequate treatment. The widespread usage of Internet-connected devices provides new opportunities to deliver treatment to more people using innovative approaches. The groundwork is being laid for the adoption of Internet- and mobile-based interventions, providing mental and behavioral health support to more people and narrowing the treatment gap. This paper discusses the main technical details of the backend API of the eSano eHealth platform as an example for a complex and comprehensive IT-framework for large-scale and flexible Internet- and mobile-based interventions. An overview of eSano is provided and the platform is compared with other technical solutions in the field. In addition, the components of eSano are described and further technical insights are elaborated in more detail. To this end, the work at hand demonstrates the main requirements of the backend API powering eSano, its concepts and the overall developed solution. It will as such inform researchers and practitioners about state-of-the-art backend API development in the eHealth context

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Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease