Erträge von Winterweizen in einem Agroforstsystem zur Energieholzgewinnung im ökologischen Landbau

The study is part of the research project "Development and testing of an agroforestry system combining organic agriculture and short rotation coppice". Cooperation partners are the Bavarian State Institute for Agriculture (LfL) and the Bavarian State Institute of Forestry (LWF). The two experimental sites are located in the northern Munich gravel plain near Freising and in the southern part of the Franconian Jurassic near Kaisheim. Aim of the study was to compare the yield of agricultural crops in an alley cropping system for woody biomass production with a standard cultivation without trees on the field. A positive effect of periodically harvested tree stripes on the yield of the agricultural crops is expected. First results show that there were no significant differences in the overall marketable yield of winter wheat in the agroforestry system compared to the reference site without trees. The spatial distribution of the yield, however, differed significantly. In close proximity to the tree stripes a significant reduction of the marketable yield could be measured. These lower yields were equalized by higher yields in bigger distances of the tree stripes

Schnellwachsende Gehölze zur Energiegewinnung im ökologischen Landbau - Etablierung und Wuchsleistung verschiedener Baumarten

So far there is only little experience with the cultivation of coppicing fast-growing tree species in German organic agriculture. The research project investigated the establishment and the performance of different tree species - black alder (Alnus glutinosa), grey alder (Alnus incana) and two hybrid poplar clones ('Max 1', 'Max 3') under organic conditions. Various strategies to reduce weed competition were examined. Different undersown crops (Medicago lupulina, Trifolium repens, Camelina sativa, Secale cereale) and a self-degradable mulch membrane were compared with an untreated control. The two experimental sites are located in Southern Bavaria (Germany). All tree species could be successfully established on both experimental sites. The results show that during the first three years the trees on self-degradable mulch membrane growd best, and reached the lowest heigth on black medic. A recommendation regarding choice of tree species and strategies of establishment can be given after tree harvest and after an economic evaluation

Libraries as Journal Publishers

Increasing library involvement in journal hosting and publishing is an important topic for serialists. This installment of "The Balance Point" column presents articles that offer descriptions and analyses of the current state of ideas and activities related to libraries as publishers. Featured authors discuss the publishing and journal hosting tasks libraries can perform, programs and activities related to journal hosting, titles hosted, challenges, next steps and the benefits or drawbacks foreseen in the current paths of the libraries they represent

Entwicklung und Erprobung eines Agroforstsystems im ökologischen Landbau zur Energieholzgewinnung

Das Projekt „Entwicklung und Erprobung eines Agroforstsystems im ökologischen Landbau zur Energieholzgewinnung“ ist eine Kooperation der beiden bayerischen Landesanstalten für Landwirtschaft (LfL) und für Wald und Forstwirtschaft (LWF). Die Versuchsstandorte liegen in der nördlichen Münchener Ebene bei Freising und im südlichen Frankenjura in der Nähe von Kaisheim. Die zentrale Frage des Projektes ist, welche Erträge und Qualitäten die landwirtschaftlichen Feldfrüchte in einem Agroforstsystem im Vergleich zur herkömmlichen Bewirtschaftung ohne Bäume auf dem Acker liefern. Es wird eine positive Wirkung von Baumstreifen im Kurzumtrieb auf den Ertrag der dazwischen liegenden landwirtschaftlichen Kulturen erwartet. Außerdem wird untersucht, ob in einem Agroforstsystem die gesamte Biomasseerzeugung im Vergleich zur reinen landwirtschaftlichen Nutzung nachhaltig höher ist. Die möglichst effiziente Etablierung von schnellwachsenden Baumarten auf Flächen des Ökolandbaus ist eine weitere Fragestellung des Projekts. Erste Beobachtungen unterschiedlicher Begründungsverfahren und zum Leistungsvergleich verschiedener Hybrid-Pappelklone mit heimischen Baumarten werden vorgestellt

Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells

Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate—the benzyl isothiocyanate (BITC)—modulates the intracellular localization of the transcription factor Forkhead box O 1 (FOXO1). FoxO transcription factors can antagonize insulin effects and trigger a variety of cellular processes involved in tumor suppression, longevity, development and metabolism. The current study evaluated the ability of BITC—extracted as intact glucosinolate from nasturtium and hydrolyzed with myrosinase—to modulate i) the insulin-signaling pathway, ii) the intracellular localization of FOXO1 and, iii) the expression of proteins involved in gluconeogenesis, antioxidant response and detoxification. Stably transfected human osteosarcoma cells (U-2 OS) with constitutive expression of FOXO1 protein labeled with GFP (green fluorescent protein) were used to evaluate the effect of BITC on FOXO1. Human hepatoma HepG2 cell cultures were selected to evaluate the effect on gluconeogenic, antioxidant and detoxification genes and protein expression. BITC reduced the phosphorylation of protein kinase B (AKT/PKB) and FOXO1; promoted FOXO1 translocation from cytoplasm into the nucleus antagonizing the insulin effect; was able to down-regulate the gene and protein expression of gluconeogenic enzymes; and induced the gene expression of antioxidant and detoxification enzymes. Knockdown analyses with specific siRNAs showed that the expression of gluconeogenic genes was dependent on nuclear factor (erythroid derived)-like2 (NRF2) and independent of FOXO1, AKT and NAD- dependent deacetylase sirtuin-1 (SIRT1). The current study provides evidence that BITC might have a role in type 2 diabetes T2D by reducing hepatic glucose production and increasing antioxidant resistance

第1090回千葉医学会例会・第7回環境生命医学研究会

<p>HepG2 cells were incubated with BITC 30 μM, insulin 100 nM and insulin + BITC for 30 min. PathScan Signaling Array Kit was used for the detection of the phosphorylated AKT (Thr308). Data shown as mean of fold phosphorylation normalized to untreated control + SEM (n = 3) *p<0.05(Unpaired Student’s t test).</p

Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia

© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despite loss of both brain volume and functional connections, there is maintenance of an efficient topological organization of the brain's functional network in the years leading up to the estimated age of frontotemporal dementia symptom onset. After this point, functional network efficiency declines markedly. Reduction in connectedness was most marked in highly connected hub regions. Measures of topological efficiency of the brain's functional network and organization predicted cognitive dysfunction in domains related to symptomatic frontotemporal dementia and connectivity correlated with brain volume loss in frontotemporal dementia. We propose that maintaining the efficient organization of the brain's functional network supports cognitive health even as atrophy and connectivity decline presymptomatically.This work was funded by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant [grant number CoEN015]. JBR was supported by the Wellcome Trust [grant number 103838]. JBR, RB, TR, and SJ were supported by the NIHR Cambridge Biomedical Research Centre and Medical Research Council [grant number G1100464]. The Dementia Research Centre at UCL is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation, NIHR Queen Square Dementia Biomedical Research Unit, NIHR UCL/H Biomedical Research Centre and Dementia Platforms UK. JDR is supported by an MRC Clinician Scientist Fellowship [grant number MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [grant number BRC149/NS/MH]. MM is supported by the Canadian Institutes of Health Research, Department of Medicine at Sunnybrook Health Sciences Centre and the University of Toronto, and the Sunnybrook Research Institute. RL is supported by Réseau de médecine génétique appliquée, Fonds de recherche du Québec—Santé [grant number FRQS]. FT is supported by the Italian Ministry of Health. DG is supported by the Fondazione Monzino and Italian Ministry of Health, Ricerca Corrente. SS is supported by Cassa di Risparmio di Firenze [grant number CRF 2013/0199] and the Ministry of Health [grant number RF-2010-2319722]. JvS is supported by The Netherlands Organisation for Health Research and Development Memorable grant [grant number 733050103] and Netherlands Alzheimer Foundation Memorable grant [grant number 733050103].info:eu-repo/semantics/publishedVersio

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

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2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

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withdrawn 2017 hrs ehra ecas aphrs solaece expert consensus statement on catheter and surgical ablation of atrial fibrillation

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