196 research outputs found
High proportion of cactus species threatened with extinction
- Author
- Abba AM
- Arias S
- Arreola-Nava HJ
- Baker MA
- Barcenas RT
- Barrios D
- Braun P
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- Butterworth CA
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- del Valle Perea M
- Demaio PH
- Duarte de Barros WA
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- Fitz-Maurice B
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- Nassar JM
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- Oakley LJ
- Ortega-Baes P
- Pin Ferreira AB
- Pinkava DJ
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- Porter JM
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- Roque Gamarra J
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- Schipper J
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- Sotomayor M del C JM
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- Taylor NP
- Terrazas T
- Terry M
- Tognelli M
- Trevisson M
- Valverde T
- Van Devender TR
- Veliz-Perez ME
- Walter HE
- Wyatt SA
- Zappi D
- Zavala-Hurtado JA
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/10/2015
- Field of study
This is the author accepted manuscript. The final version is available from Nature Publishing Group via the DOI in this record.Consejo Nacional de Ciencia y Tecnologí
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants
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- Abdeen ZA
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams R
- Aekplakorn W
- Aguilar-Salinas CA
- Agyemang C
- Ahmadvand A
- Al Nsour M
- Al-Othman AR
- Ali MK
- Alkerwi A
- Amouyel P
- Amuzu A
- Andersen LB
- Anderssen SA
- Anjana RM
- Aounallah-Skhiri H
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- Arlappa N
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- Assah FK
- Avdicova M
- Azizi F
- Balakrishna N
- Bandosz P
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- Bugge A
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- Candido APC
- Capuano V
- Carlsson AC
- Carvalho MJ
- Casanueva FF
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- Caserta CA
- Castetbon K
- Chamukuttan S
- Chaturvedi N
- Chen C-J
- Chen F
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- Chetrit A
- Chiou S-T
- Cho Y
- Chudek J
- Cifkova R
- Claessens F
- Concin H
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- Cooper R
- Costanzo S
- Cottel D
- Cowan MJ
- Cowell C
- Crujeiras AB
- D'Arrigo G
- Dallongeville J
- Danaei G
- Dankner R
- Dauchet L
- de Gaetano G
- De Henauw S
- Deepa M
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- del Cristo Rodriguez-Perez M
- Deschamps V
- Dhana K
- Di Castelnuovo AF
- Di Cesare M
- Djalalinia S
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- Egbagbe EE
- Eggertsen R
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- Erasmus RT
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- Eugenio Lozano J
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- Fall CH
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- Frontera G
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- Lim W-Y
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- Luksiene D
- Lundqvist A
- Lytsy P
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- Machado-Coelho GLL
- Machi S
- Maggi S
- Magliano DJ
- Makdisse M
- Manios Y
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- Margozzini P
- Maria Navarrete-Munoz E
- Marques-Vidal P
- Martorell R
- Masoodi SR
- Mathiesen EB
- Matsha TE
- Mbanya JCN
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- McFarlane SR
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- McLachlan S
- McNulty BA
- Mediene-Benchekor S
- Meirhaeghe A
- Menezes AMB
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- Meshram II
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- Mursu J
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- NCD Risk Factor Collaboration (NCD-RisC) .
- Ndiaye NC
- Nenko I
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- Nguyen QN
- Nieto-Martinez RSE
- Ning G
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- Noale M
- Noto D
- Ochoa-Aviles AM
- Oh K
- Onat A
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- Ordunez P
- Osmond C
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- Owusu-Dabo E
- Paciorek CJ
- Pahomova E
- Palmieri L
- Panda-Jonas S
- Panza F
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- Russo Horimoto ARV
- Rutkowski M
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- Saramies JL
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- Sarrafzadegan N
- Saum K-U
- Scazufca M
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- Scheidt-Nave C
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- Shibuya K
- Shin Y
- Shiri R
- Siantar R
- Sibai AM
- Simon M
- Simons J
- Simons LA
- Sjostrom M
- Slowikowska-Hilczer J
- Slusarczyk P
- Smeeth L
- Snijder MB
- So H-K
- Sobngwi E
- Soderberg S
- Solfrizzi V
- Sonestedt E
- Soumare A
- Staessen JA
- Stathopoulou MG
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- Stokwiszewski J
- Stronks K
- Strufaldi MW
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- Sundstrom J
- Sung Y-T
- Suriyawongpaisal P
- Sy RG
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- Tamosiunas A
- Tang L
- Tarawneh M
- Tarqui-Mamani CB
- Taylor A
- Theobald H
- Thijs L
- Thuesen BH
- Tolonen HK
- Tolstrup JS
- Topbas M
- Torrent M
- Traissac P
- Trinh OTH
- Tulloch-Reid MK
- Tuomainen T-P
- Turley ML
- Tzourio C
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- Ulmer H
- Uusitalo HMT
- Valdivia G
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- van Valkengoed IGM
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- Vanuzzo D
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- Velasquez-Melendez G
- Veronesi G
- Verschuren WMM
- Verstraeten R
- Viet L
- Vioque J
- Virtanen JK
- Viswanathan B
- Vollenweider P
- Voutilainen S
- Vrijheid M
- Wade AN
- Wagner A
- Walton J
- Wang F
- Wang M-D
- Wang Q
- Wang YX
- Wannamethee SG
- Weerasekera D
- Whincup PH
- Widhalm K
- Wijga AH
- Wilks RJ
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- Wilsgaard T
- Wojtyniak B
- Wong TY
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- Yoshihara A
- Younger-Coleman NO
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- Zheng Y
- Zhou B
- Zuniga Cisneros J
- Publication venue
- Publication date
- 09/04/2016
- Field of study
BACKGROUND: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. METHODS: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence—defined as fasting plasma glucose of 7·0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs—in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. FINDINGS: We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4·3% (95% credible interval 2·4–7·0) in 1980 to 9·0% (7·2–11·1) in 2014 in men, and from 5·0% (2·9–7·9) to 7·9% (6·4–9·7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28·5% due to the rise in prevalence, 39·7% due to population growth and ageing, and 31·8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. INTERPRETATION: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. FUNDING: Wellcome Trust
Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
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- Abolfathi B
- Aguado DS
- Albareti FD
- Alberto Vazquez J
- Allende Prieto C
- Almeida A
- Alonso Palicio P
- Alonso-Garcia J
- Anders F
- Anderson SF
- Andrews B
- Aquino-Ortiz E
- Aragon-Salamanca A
- Argudo-Fernandez M
- Armengaud E
- Aubourg E
- Avila-Reese V
- Badenes C
- Bailey S
- Barger KA
- Barrera-Ballesteros J
- Bartosz C
- Bates D
- Baumgarten F
- Bautista J
- Beaton R
- Beers TC
- Belfiore F
- Bender CF
- Berlind AA
- Bernardi M
- Bershady MA
- Beutler F
- Bird JC
- Bizyaev D
- Blanc GA
- Blanton MR
- Blomqvist M
- Bolton AS
- Boquien M
- Borissova J
- Bovy J
- Brandt WN
- Brinkmann J
- Brownstein JR
- Bundy K
- Burgasser AJ
- Burtin E
- Busca NG
- Cano-Diaz M
- Cappellari M
- Carlberg JK
- Carrera R
- Chanover NJ
- Cherinka B
- Cheung E
- Chiappini C
- Choi PD
- Chojnowski D
- Chuang C-H
- Chung H
- Cirolini RF
- Clerc N
- Cohen RE
- Comparat J
- Cousinou M-C
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- Crane JD
- Croft RAC
- Cruz-Gonzalez I
- Cunha K
- da Costa L
- Damke GJ
- Darling J
- Davies R
- Dawson K
- de Andrade Queiroz AB
- de Icaza Lizaola MAC
- de la Macorra A
- de la Torre S
- De Lee N
- de Lis SB
- Delgado Carigi ML
- Dell'Agli F
- Delubac T
- des Bourboux HDM
- Di Mille F
- Diamond-Stanic A
- do Nascimento JC
- Donor J
- Drory N
- Duckworth CJ
- Dwelly T
- Dyer J
- Ebelke G
- Eigenbrot AD
- Eisenstein DJ
- Emsellem E
- Eracleous M
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- Finoguenov A
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- Frinchaboy PM
- Fuentes CE
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- Garcia-Dias R
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- Garrido Cuadra D
- Gaulme P
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- Geisler D
- Gelfand JD
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- Gillespie BA
- Goddard D
- Gonzalez Hernandez JI
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- Holtzman JA
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- Kitaura F-S
- Klaene M
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- Lacerna I
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- Lin Y-T
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- Lundgren B
- MacDonald NK
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- Malanushenko E
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- Manchado A
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- Maqueo Chew YG
- Maraston C
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- Masseron T
- Masters KL
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- McDermid RM
- McGrath B
- McGreer ID
- Medina Pena N
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- Merloni A
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- Myers AD
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- O'Connell JE
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- Oravetz A
- Oravetz D
- Pace Z
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- Parejko JK
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- Paris I
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- Patten AY
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- Percival WJ
- Perez-Fournon I
- Petitjean P
- Pieri MM
- Pinsonneault M
- Pisani A
- Poleski R
- Prada F
- Prakash A
- Raddick MJ
- Raichoor A
- Rembold SB
- Richstein H
- Riffel R
- Riffel RA
- Rix H-W
- Robin AC
- Rockosi CM
- Rodriguez-Torres S
- Roman-Lopes A
- Roman-Zuniga C
- Rosado M
- Rosell AC
- Ross AJ
- Rossi G
- Ruan J
- Ruggeri R
- Rykoff ES
- Salazar-Albornoz S
- Salvato M
- Sanchez AG
- Sanchez-Gallego JR
- Santana FA
- Santiago BX
- Sayres C
- Schiavon RP
- Schimoia JDS
- Schlafly EF
- Schlegel DJ
- Schneider DP
- Schultheis M
- Schuster WJ
- Schwope A
- Seo H-J
- Shao Z
- Shen S
- Shetrone M
- Shull M
- Simon JD
- Skinner D
- Skrutskie MF
- Slosar A
- Smith VV
- Sobeck JS
- Sobreira F
- Somers G
- Souto D
- Stark DV
- Stassun K
- Stauffer F
- Steinmetz M
- Storchi-Bergmann T
- Streblyanska A
- Stringfellow GS
- Suarez G
- Sun J
- Suzuki N
- Szigeti L
- Taghizadeh-Popp M
- Tang B
- Tao C
- Tayar J
- Tembe M
- Teske J
- Thakar AR
- Thomas D
- Thompson BA
- Tinker JL
- Tissera P
- Tojeiro R
- Tremonti C
- Troup NW
- Valenzuela O
- Van den Bosch R
- Vargas-Gonzalez J
- Vargas-Magana M
- Villanova S
- Vivek M
- Vogt N
- Wake D
- Walterbos R
- Wang Y
- Weaver BA
- Weijmans A-M
- Weinberg DH
- Westfall KB
- Whelan DG
- Wild V
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- Wood-Vasey WM
- Wylezalek D
- Xiao T
- Yan R
- Yang M
- Ybarra JE
- Yeche C
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- Zamora O
- Zarrouk P
- Zasowski G
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- Zheng Z
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- Zhou X
- Zhou Z-M
- Zhu GB
- Zoccali M
- Zou H
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/07/2017
- Field of study
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z∼0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z∼0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July
Fluid challenges in intensive care: the FENICE study A global inception cohort study
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- Abouelala A
- Acquarolo A
- Adamik B
- Adanir T
- Aguilar G
- Al-subaie N
- Alampi D
- Albanese D
- Aldecoa C
- Aldecoa C
- Aldecoa C
- Aldecoa C
- Almekhlafi G
- Alsabbah A
- Ambekar H
- Andersen Fh
- Anglada M
- Anthopoulos G
- Araujo Aguilar P
- Argaud L
- Arias Ortiz J
- Arias J
- Arribas P
- Artigas A
- Artigas A
- Artigas A
- Asfar P
- Astola I
- Baht S
- Bakker J
- Bakker J
- Balik M
- Barrera Groba C
- Basilio C
- Bauer P
- Baumann H
- Beck O
- Belluomo Ac
- Belskiy V
- Benbenishty J
- Bendjelid K
- Benes J
- Benes J
- Bengler C
- Benitez F
- Bestle M
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC.2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response.The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.
- Author
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- Abdeen ZA
- Abu-Rmeileh NM
- Acosta-Cazares B
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- Yngve A
- Yoshihara A
- You QS
- Younger-Coleman NO
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- Zhao D
- Zhao W
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu A
- Zhu D
- Zhussupov B
- Zimmermann E
- Publication venue
- Lancet
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. METHODS: We pooled 2416 population-based studies with measurements of height and weight on 128·9 million participants aged 5 years and older, including 31·5 million aged 5-19 years. We used a Bayesian hierarchical model to estimate trends from 1975 to 2016 in 200 countries for mean BMI and for prevalence of BMI in the following categories for children and adolescents aged 5-19 years: more than 2 SD below the median of the WHO growth reference for children and adolescents (referred to as moderate and severe underweight hereafter), 2 SD to more than 1 SD below the median (mild underweight), 1 SD below the median to 1 SD above the median (healthy weight), more than 1 SD to 2 SD above the median (overweight but not obese), and more than 2 SD above the median (obesity). FINDINGS: Regional change in age-standardised mean BMI in girls from 1975 to 2016 ranged from virtually no change (-0·01 kg/m2 per decade; 95% credible interval -0·42 to 0·39, posterior probability [PP] of the observed decrease being a true decrease=0·5098) in eastern Europe to an increase of 1·00 kg/m2 per decade (0·69-1·35, PP>0·9999) in central Latin America and an increase of 0·95 kg/m2 per decade (0·64-1·25, PP>0·9999) in Polynesia and Micronesia. The range for boys was from a non-significant increase of 0·09 kg/m2 per decade (-0·33 to 0·49, PP=0·6926) in eastern Europe to an increase of 0·77 kg/m2 per decade (0·50-1·06, PP>0·9999) in Polynesia and Micronesia. Trends in mean BMI have recently flattened in northwestern Europe and the high-income English-speaking and Asia-Pacific regions for both sexes, southwestern Europe for boys, and central and Andean Latin America for girls. By contrast, the rise in BMI has accelerated in east and south Asia for both sexes, and southeast Asia for boys. Global age-standardised prevalence of obesity increased from 0·7% (0·4-1·2) in 1975 to 5·6% (4·8-6·5) in 2016 in girls, and from 0·9% (0·5-1·3) in 1975 to 7·8% (6·7-9·1) in 2016 in boys; the prevalence of moderate and severe underweight decreased from 9·2% (6·0-12·9) in 1975 to 8·4% (6·8-10·1) in 2016 in girls and from 14·8% (10·4-19·5) in 1975 to 12·4% (10·3-14·5) in 2016 in boys. Prevalence of moderate and severe underweight was highest in India, at 22·7% (16·7-29·6) among girls and 30·7% (23·5-38·0) among boys. Prevalence of obesity was more than 30% in girls in Nauru, the Cook Islands, and Palau; and boys in the Cook Islands, Nauru, Palau, Niue, and American Samoa in 2016. Prevalence of obesity was about 20% or more in several countries in Polynesia and Micronesia, the Middle East and north Africa, the Caribbean, and the USA. In 2016, 75 (44-117) million girls and 117 (70-178) million boys worldwide were moderately or severely underweight. In the same year, 50 (24-89) million girls and 74 (39-125) million boys worldwide were obese. INTERPRETATION: The rising trends in children's and adolescents' BMI have plateaued in many high-income countries, albeit at high levels, but have accelerated in parts of Asia, with trends no longer correlated with those of adults. FUNDING: Wellcome Trust, AstraZeneca Young Health Programme
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
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- Acheatel R
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- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
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- Aguilar M
- Aguilar M
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- Ahmad I
- Ahmed Sh
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- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
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- Alllison Dc
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- Angiolillo D
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- Wiebusch A
- Wilhoit G
- Wilkins M
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- Willmerdinger M
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- Xu Zj
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- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
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- Zdrenghea D
- Zebrack J
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- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
- Becker M
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr JK
- Belanger-Champagne C
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Beringer J
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- Berlingen J Montejo
- Bernard NR
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- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particle–hole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
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- Aleksandrov IN
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- Yildiz H Duran
- Yorita K
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- Yuen SPY
- Yusuff I
- Zabinski B
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- Zalieckas J
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- Zanzi D
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- Zemaityte G
- Zeng JC
- Zeng Q
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- Zgubic M
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- Zhemchugov A
- Zhou B
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- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Search for the direct production of charginos and neutralinos in final states with tau leptons in √s=13 TeV collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Albergh GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behr JK
- Bell AS
- Bella G
- Bella L Aperio
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
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- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
- Young C
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- Zabinski B
- Zacharis G
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- Zalieckas J
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
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- Zhou N
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- Zibell A
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- Zimine NI
- Zimmermann C
- Zimmermann S
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb−1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ˜χ+1 ˜χ−1 pair production and of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the ˜ τL state is set to be halfway between the masses of the ˜χ±1 and the ˜χ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ˜χ+1 ˜χ−1 for a massless ˜χ01. Common ˜χ±1 and ˜χ02 masses up to 760 GeV are excluded in the case of production of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 assuming a massless ˜χ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the ˜χ±1 and the ˜χ01 are also studied by varying the ˜ τL mass between the masses of the ˜χ±1 and the ˜χ01
Measurement of differential cross sections and W + /W − cross-section ratios for W boson production in association with jets at √s =8 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
This paper presents a measurement of the W boson production cross section and the W + /W − cross-section ratio, both in association with jets, in proton--proton collisions at s √ =8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb −1 . Differential cross sections for events with one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W + /W − the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proto
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