133 research outputs found
Supramolecular control of unidirectional rotary motion in a sterically overcrowded photoswitchable receptor
The control of molecular motion by external stimuli has attracted major interest in recent years. In order to achieve unidirectional rotational motion, intrinsically chiral light-driven molecular motors have been shown to be particularly versatile. We recently introduced a system in which unidirectional rotation is achieved in an achiral photoswitchable receptor upon binding of a chiral guest molecule. In order to gain detailed insight into the rotary steps, we present here a modified design in which the steric crowding is increased such that interconversion between the helical isomers of the (Z)-form of the receptor becomes very slow. DFT calculations support the increase in interconversion barrier. Furthermore, two diastereomeric complexes of the chiral guest bound to the (Z)-receptor are distinguished in the 1H NMR spectrum and the ratio between them slowly changes over time as a result of thermal helix inversion. On the other hand, no enrichment in one of the diastereomeric complexes is observed in the photochemical step. Our studies therefore unequivocally confirm that net rotation, induced by the chiral guest, takes place. This study affords an improved understanding of these dynamic supramolecular systems and expands the possibilities to control chirality transfer and motion at the molecular level, spurring developments of supramolecular recognition and information transfer at the nanoscale.Supramolecular & Biomaterials Chemistr
Fate of the extended states in a vanishing magnetic field: the role of spins in strongly-interacting 2D electron systems
In non-interacting or weakly-interacting 2D electron systems, the energy of
the extended states increases as the perpendicular magnetic field approaches
zero: the extended states "float up" in energy, giving rise to an insulator.
However, in those 2D systems where metallic conductivity has been recently
observed in zero magnetic field, the energy of the extended states remains
constant or even decreases as B -> 0, thus allowing conduction in the limit of
zero temperature. Here we show that aligning the electrons' spins causes the
extended states to once more "float up" in energy in the vanishing
perpendicular magnetic field, as they do for non- or weakly-interacting
electrons. The difference between extended states that float up (an insulator)
or remain finite (a metal) is thus tied to the existence of the spins
Hidden degree of freedom and critical states in a two-dimensional electron gas in the presence of a random magnetic field
We establish the existence of a hidden degree of freedom and the critical
states of a spinless electron system in a spatially-correlated random magnetic
field with vanishing mean. Whereas the critical states are carried by the
zero-field contours of the field landscape, the hidden degree of freedom is
recognized as being associated with the formation of vortices in these special
contours. It is argued that, as opposed to the coherent backscattering
mechanism of weak localization, a new type of scattering processes in the
contours controls the underlying physics of localization in the random magnetic
field system. In addition, we investigate the role of vortices in governing the
metal-insulator transition and propose a renormalization-group diagram for the
system under study.Comment: 17 pages, 16 figures; Figs. 1, 7, 9, and 10 have been reduced in
quality for e-submissio
A Real Space Description of Magnetic Field Induced Melting in the Charge Ordered Manganites: I. The Clean Limit
We study the melting of charge order in the half doped manganites using a
model that incorporates double exchange, antiferromagnetic superexchange, and
Jahn-Teller coupling between electrons and phonons. We primarily use a real
space Monte Carlo technique to study the phase diagram in terms of applied
field and temperature , exploring the melting of charge order with
increasing and its recovery on decreasing . We observe hysteresis in
this response, and discover that the `field melted' high conductance state can
be spatially inhomogeneous even without extrinsic disorder. The hysteretic
response plays out in the background of field driven equilibrium phase
separation. Our results, exploring , , and the electronic parameter
space, are backed up by analysis of simpler limiting cases and a Landau
framework for the field response. This paper focuses on our results in the
`clean' systems, a companion paper studies the effect of cation disorder on the
melting phenomena.Comment: 16 pages, pdflatex, 11 png fig
Spin-Charge Separation in the Model: Magnetic and Transport Anomalies
A real spin-charge separation scheme is found based on a saddle-point state
of the model. In the one-dimensional (1D) case, such a saddle-point
reproduces the correct asymptotic correlations at the strong-coupling
fixed-point of the model. In the two-dimensional (2D) case, the transverse
gauge field confining spinon and holon is shown to be gapped at {\em finite
doping} so that a spin-charge deconfinement is obtained for its first time in
2D. The gap in the gauge fluctuation disappears at half-filling limit, where a
long-range antiferromagnetic order is recovered at zero temperature and spinons
become confined. The most interesting features of spin dynamics and transport
are exhibited at finite doping where exotic {\em residual} couplings between
spin and charge degrees of freedom lead to systematic anomalies with regard to
a Fermi-liquid system. In spin dynamics, a commensurate antiferromagnetic
fluctuation with a small, doping-dependent energy scale is found, which is
characterized in momentum space by a Gaussian peak at (, ) with
a doping-dependent width (, is the doping
concentration). This commensurate magnetic fluctuation contributes a
non-Korringa behavior for the NMR spin-lattice relaxation rate. There also
exits a characteristic temperature scale below which a pseudogap behavior
appears in the spin dynamics. Furthermore, an incommensurate magnetic
fluctuation is also obtained at a {\em finite} energy regime. In transport, a
strong short-range phase interference leads to an effective holon Lagrangian
which can give rise to a series of interesting phenomena including linear-
resistivity and Hall-angle. We discuss the striking similarities of these
theoretical features with those found in the high- cuprates and give aComment: 70 pages, RevTex, hard copies of 7 figures available upon request;
minor revisions in the text and references have been made; To be published in
July 1 issue of Phys. Rev. B52, (1995
\psi(2S) Decays into \J plus Two Photons
Using \gamma \gamma J/\psi, J/\psi \ra e^+ e^- and events
from a sample of \psip decays collected with the BESII
detector, the branching fractions for \psip\ra \pi^0\J, \eta\J, and
\psi(2S)\ar\gamma\chi_{c1},\gamma\chi_{c2}\ar\gamma\gamma\jpsi are measured
to be B(\psip\ra \pi^0\J) = (1.43\pm0.14\pm0.13)\times 10^{-3}, B(\psip\ra
\eta\J) = (2.98\pm0.09\pm0.23)%,
B(\psi(2S)\ar\gamma\chi_{c1}\ar\gamma\gamma\jpsi) = (2.81\pm0.05\pm 0.23)%,
and B(\psi(2S)\ar\gamma\chi_{c2}\ar\gamma\gamma\jpsi) = (1.62\pm0.04\pm
0.12)%.Comment: 7 pages, 6 figures. submitted to Phys. Rev.
Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set
We report a measurement of the bottom-strange meson mixing phase \beta_s
using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays
in which the quark-flavor content of the bottom-strange meson is identified at
production. This measurement uses the full data set of proton-antiproton
collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment
at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity.
We report confidence regions in the two-dimensional space of \beta_s and the
B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2,
-1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in
agreement with the standard model expectation. Assuming the standard model
value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +-
0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +-
0.009 (syst) ps, which are consistent and competitive with determinations by
other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012
Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study
Soluble forms of tau are toxic in Alzheimer's disease
Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau, is a hallmark of Alzheimer Disease. NFT have been considered causative of neuronal death, however, recent evidence challenges this idea. Other species of tau, such as soluble misfolded, hyperphosphorylated, and mislocalized forms, are now being implicated as toxic. Here we review the data supporting soluble tau as toxic to neurons and synapses in the brain and the implications of these data for development of therapeutic strategies for Alzheimer’s disease and other tauopathies
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