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Global economic burden of unmet surgical need for appendicitis

Author: Aahlin E. K.
Aamer A.
Aaniana K.
Ababneh A.
Abaliksta T.
Abantanga F.
Abbas M.
Abbasy J.
Abbo O.
Abbouch M.
Abd-Elmawla M.
Abd-Elrasoul Y.
Abdallah E.
Abdel-Aty A.
Abdel-Hameed N.
Abdel-Kader S. M.
Abdel-Wahab N. Y. E.
Abdelaal A.
Abdelaty M.
Abdelazeam A. R.
Abdelazim G.
Abdelaziz M. A.
Abdelbadeai K.
Abdelfatah A.
AbdelFattah I.
Abdelgelil A.
Abdelghany S.
Abdelhady S.
Abdelhamed R.
Abdelhamid A.
Abdelhaq A.
Abdelkader M.
Abdelkader O.
Abdelkareem A.
Abdelkhalek M.
Abdelmageed E.
Abdelmotaleb I.
Abdelraheim M.
Abdelraouf A. M.
Abdelrouf D. M.
Abdelshafy M.
Abdelshakour M.
Abdrabou A. K.
Abdul-Latif S.
Abdulaziz H.
Abdulbagi O.
Abdulgawad M.
Abdulhakeem E. M.
Abdullah M. A.
Abdullah N.
Abdullah N. A. N.
Abdullahi L.
Abdurrazzaaq A.
Abebe N. S.
Abebe N. S.
Abem O. E.
Abiola O.
Aboarab A.
Aboelella M.
Aboelmagd O.
Aboelsoud M. R.
Aboraya M.
Aboraya M.
Abouelnasr A.
Aboul-Naga M. S.
Abouzahra A.
Abouzaid A.
Abozaid M.
Abozeid K.
Abozyed M. A. F.
Abu-Toyour M.
Abubakr M.
Abudeeb H.
Abuowda Y.
Abuqwaider E.
Abusalem L.
Abuseif M.
Abushamleh S.
Ackom E.
Acquah E.
Adam N.
Adams R.
Adamu A.
Adawi I.
Adawi M.
Adebanjo A.
Adebola O.
Adedeji A.
Adekoya A.
Adel A.
Adel A.
Adel B. E.
Adel I.
Adella F. J.
Adelshone A.
Ademuyiwa A. O.
Adenekan B.
Adeniran J.
Adeniyi A.
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Ziubryte G.
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Zuber M.
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Publication venue: Oxford University Press
Publication date: 01/01/2022
Field of study

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US

92 492 million using approach 1 and

73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was

95 004 million using approach 1 and

75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Archivio istituzionale della ricerca - Università di Ferrara

Archivio della ricerca- Università di Roma La Sapienza

Archivio istituzionale della ricerca - Università di Palermo

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Author: Aahlin EK
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Aaniana K
Ababneh A
Abaliksta T
Abantanga F
Abantanga F
Abbas A
Abbas M
Abbasy J
Abbo O
Abbo O
Abbott T
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Abd El Galeel A
Abd El Hameed OS
Abd El Hamid N
Abd El Salam Y
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Abd El-Salam F
Abd Elrasoul Y
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Abdel-Hameed N
Abdel-Kader SM
Abdel-Wahab NYE
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Abdelazeam AR
Abdelazim G
Abdelaziz MA
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Abdelfatah A
AbdelFattah I
Abdelgelil A
Abdelghany S
Abdelhady S
Abdelhamed R
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Abdelhaq A
Abdelkader M
Abdelkader M
Abdelkader O
Abdelkareem A
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Abdulaziz H
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Abdulbagi O
Abdulgawad M
Abdulhakeem EM
Abdullah AAN
Abdullah MA
Abdullah N
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Abdurrazzaaq A
Abebe NS
Abebe NS
Abem OE
Aber A
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Abiola O
Aboarab A
Aboelella M
Aboelmagd O
Aboelsoud MR
Aboraya M
Aboraya M
Abouelnasr A
Aboul-Naga MS
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Abozeid K
Abozyed MAF
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Cullen F
Curletti G
Currow C
Currow C
D'aguzan N
D'Amours S
D'amours SK
D'cruz R
D'Souza MS
D'Souza R
Da Silva LA
Dabboor M
Dabbour K
Dabessa D
Dablouk M
Dablouk MO
Dagoe E
Dahy A
Dainius E
Dakubo J
Dal Canto M
Dalli J
Dally C
Dambrauskas Z
Dambrauskas Z
Dan I
Danelli P
Daniels I
Daniyan M
Danys D
Dao W
Daqeeq A
Dar M
Dar W
Dardenne S
Darweesh M
Darwish AKZ
Das A
Das K
Das S
Dasari M
Dashnyam E
Dassah V
Datta U
Davenport R
Davies J
Davies R
Davor A
Dawnay G
Dawood K
Dawoud H
Dayie M
De Boni D
De Bono P
De Bono P
De Franciscis S
De Luca E
De Marco P
De Sousa AV
Deal R
Dean R
Deane C
Debrah S
Deckelbaum DL
Decker E
Dedekind B
Dedey F
Deichsel F
Del Basso C
del Pilar Paucar A
Delforge X
Dell A
Dempster E
Denakpo M
Denewar A
Depalma N
Deputy M
Der Y
Dervenis C
Despotidis V
Desta S
Deutschmann P
Devadasar GH
Dharamshi HA
Dhillon D
Di Franco F
Di Martino N
Di Saverio S
Di Saverio S
Diab A
Diaconescu B
Diaconescu I-B
Dias S
Diaz Vico T
Diaz-Jover P
Diaz-Zorrilla C
Dick L
Dickfos M
Dickson L
Dijan E
Dimech T
Din F
Dindyal S
Dindyal S
Dione Parreno-Sacdalan M
Dissanayake T
Djivoh F
Domini E
Domini E
Donnelly P
Donoghue D
Dorani RMNR
Dorisme A
dos Santos DV
Dossou F
Doughan S
Doughty J
Dousset B
Dragatas D
Drake TM
Drake TM
Drake TM
Driscoll A
Drungilas M
Du Plessis D
du Plooy F
Du Toit F
Duane T
Dubois A
Duffy L
Duhoranenayo D
Duinhouwer L
Dulskas A
Dwydar A
Ebdewi H
Ebidy M
Ebidy MM
Ebrahim OS
Eduard P
Edwards J
Edye M
Eid MM
Eisner L
Ekow M
El Ashal G
El Dahab AA
El Deen KN
El Gendy A
El Gendy NH
El Halawany M
El Jamassi A
El Kashash A
El Kholy A
El Magd AA
El Mesery S
El Sayed GS
El Sayed IM
El Shoura Y
El-badawy HA
El-Dien KS
El-Dien KS
El-Din RA
El-Din SA
El-Gizawy E
El-Hamouly AS
El-Kashef H
El-Latif NK
El-Ma'doul AS
El-Rabaa S
El-Sagheer N
El-Sawy A
El-Sehily A
El-Shahat NS
El-Sheemy H
El-Taher E
Elabdin HZ
Elashmawy M
Elashry R
Elazab A
Elazayem AA
Elazoul M
Elbanby E
Elbanby ES
Elbatahgy A
Elbe P
Elbermawy M
Elbisomy KH
Eldafrawy M
Eldamaty L
Eldeeb AZ
Eldeen EA
Eldin MAB
EldosoukyMohammed A
Elebute O
Elebute O
Elena G
Elfarargy A
Elfeki H
Elfeki H
Elfiky M
Elfil M
Elfouly N
Elfouly N
Elfouly Y
Elfouly Y
Elgebaly A
Elgendy AH
Elgendy FI
Elgheriany M
Elhadad A
Elhadary NM
Elhadry S
Elhalawany E
Elhamouly S
Elhelbawy MS
Elhendawy A
Elhendawy AOA
Elhoseny G
Elhusseiny AAE
Elizabeth Lopez C
Elkadsh I
Elkady F
Elkelany A
Elkelany A
Elkelany A
Elkelany A
Elkhadrawi M
Elkhalek EA
Elkholy A
Elkholy SS
Elkolaly SS
Elkorashy AM
Ellison Q
Elmashala A
Elmasry M
Elmelegy R
Elmihy S
Elnagar A
Elnajjar MA
Elnemr AE
Elrazek AA
Elsabbagh N
Elsameea AA
Elsawahly DME
Elsawy A
Elsayed M
Elsayed M
Elsayed N
Elsayed NAR
Elsayed ZM
Elsebaaye AO
Elsehimy M
Elsemelawy R
Elshaar M
Elshaer K
Elshaer M
Elshaer M
Elshafay AE
Elshami M
Elshanwany S
Elsharkawy AA
Elsheikh S
Elsherbiney S
Elsherbiny AS
Elsherif FA
Elshobary M
Elsiddig M
Elsobky S
Elsorogy DEAA
Elwaey A
Elwakil H
Elwan A
Elwan A
Elwy E
Elzahed N
Elzayat I
Elzayat M
Elzayyat I
Elzowawi F
Emadeldin D
Emadeldin H
Emara E
Emile S
Eng C
English W
Esam A
Escalante Salas MDC
Espin-Basany E
Espinoza F
Essam A
Essam AA
Essam M
Essoun S
Esteban E
Estee MM
Estupinian S
Etchill E
Etchill E
Etienne S
Etman M
Etwire V
Evajelista CV
Evans D
Evans E
Eysa A
Eyssartier E
Ezzat E
Ezzat T
Faboya O
Faccincani R
Fadel A
Fahiem A
Fahim M
Fahmy MAB
Fahy C
Fairfield C
Fairfield C
Fairfield C
Fairfield C
Fakher R
Falaschi F
Falco N
Falzon M
Farag A
Farag S
Farah A
Farahat MM
Faraz A
Fares M
Farhad M
Farhan-Alanie MMH
Farhangmehr N
Farinella E
Farmakis K
Farooq T
Farouk SAM
Farquharson A
Farrugia A
Farrugia A
Faruq A
Fathy AM
Fattah AA
Fatuga A
Faturoti O
Faturoti O
Faure A
Fautz T
Favero A
Fawzy A
Feidantsis T
Felipe CO
Fergany A
Fergusson SJ
Fergusson SJ
Fergusson SJ
Fergusson SJ
Fermani C
Fermani CG
Fernandes C
Fernandez C
Fernandez-Bueno F
Fernandez-Vega L
Ferousis C
Ferrero E
Fievet L
Filatau A
Findlay-Cooper K
Firdouse M
Firdouse M
Firdouse M
Firwana A
Fitsum A
Fitzgerald JE
Fitzgerald JE
Florez Farfan ES
Foco M
Fok CYJ
Fontana T
Foo CC
Forlin L
Forno W
Fouad A
Fouad D
Fouad D
Fourcade L
Fowler AJ
Fozard T
Fozard T
Frade F
Fraga GP
Francisco Roxas M
Franco H
Francois P
Francois-Coridon H
Francone E
Freitas AV
Frey D
Frisk B
Fuentes-Rivera L
Fujii F
Furqan MM
Gaafar S
Gaarder T
Gad A
Gad MO
Gadelkarim M
Gadhvi V
Gado A
Gaignard E
Gaignard E
Gaizauskas V
Gala T
Gala T
Galiqi G
Galleano R
Gallo G
Galloway S
Galvez CP
Gamal D
Gamal E
Gamal H
Gamal S
Gamaly E
Gamil D
Gan C
Gan YY
Gani MA
Garaycochea O
Garcia Bernardo C
Garcia Florez LJ
Garcia Septiem J
Garcia Torres CP
Garcia-Florez L
Garland A
Gash K
Gash K
Gash K
Gastaldi P
Gasteratos K
Gaujoux S
Gavagna L
Gbessi DG
Gemeah M
Gemenetzis G
Gemenetzis G
George R
Germanos S
Germanos S
Gerosa A
Gerosa A
Geuoshy A
Ghaben A
Ghandora N
Ghanem A
Ghanem E
Ghanem S
Ghanem S
Ghannam M
Gharib A
Gharib A
Ghazy AA
Gheith A
Ghetia M
Ghetia M
Ghonaim MA
Ghoneem M
Ghoneim O
Giacci L
Giardino FR
Giavarini L
Giglio MC
Gilbert R
Gilbert RW
Giles J
Gillespie M
Gimzewska M
Giraldo RSR
Giuliani S
Giuliani S
Giuriato TF
Gkiokas G
Glasbey J
Glasbey J
Glasbey JC
GlobalSurg Collaborative
Glover TE
Glover-Addy H
Glynn M
Gobin N
Gobin N
Goh CC
Goh CC
Goh W
Gohar ME-SAM
Gokani S
Goldin E
Golding D
Gomaa A
Gomah M
Gonzales Montejo MS
Gonzales Stuva JP
Gonzalez M
Goodstein M
Gosling S
Gosling SG
Gouda A
Gould L
Gouldthorpe C
Gouvas N
Gouws J
Graffeille V
Graffieille V
Gran M
Grandinetti PP
Grant A
Grasset E
Grasset E
Grassi V
Gratton R
Gravante G
Gravante G
Gray D
Grech N
Green N
Grella MG
Gribauskaite J
Griffiths E
Griffiths E
Griffiths M
Grima T
Grisin E
Grizhja B
Grobler DC
Grosos C
Grossart C
Gubeli A
Gudal A
Gudal A
Gudal A
Gudlaugsdottir K
Guevara Torres S
Guevara R
Guglielmo V
Gui D
Gul E
Gulbinas A
Gulcicek OB
Gulielmi A
Gultom PA
Gumar M
Gunaseelan K
Gunawan R
Guner A
Gunnarsson U
Guo W
Gupta A
Gustafsson U
Guzman Duenas C
Gyamfi FE
Gyanchandani N
Gyedu A
Habeeb MA
Habeeb O
Habeebullah A
Hache-Marliere M
Haddad N
Hafez AT
Hafez M
Hafez M
Hafez S
Haffreingue A
Hafiz S
Hagan R
Hagar A
Haines M
Haines S
Hajeh H
Hakim H
Halhouli O
Halhouli O
Halicioglu I
Hall E
Hall N
Hall NJ
Hall TF
Hallam S
Haloho A
Hamad MGM
Hamarshi A
Hamasaki Hamaguchi JL
Hamasaki J
Hamdan A
Hamdan M
Hamed MF
Hamill D
Hammad A
Hammad A
Hammad AM
Hampton M
Hampton MI
Hamsho W
Hanafy M
Hand C
Hanks A
Hanley I
Hanoun S
Hanrahan M
Hanrahan M
Hanrahan M
Hanrahan M
Hantour U
Hantour U
Hany E
Haque M
Har PAL
Haraux E
Harbord P
Haroun A
Harper E
Harrison EM
Harrison EM
Harrison N
Harrison P
Harrison R
Hartford L
Harvey N
Hasan A
Hasan A
Hasan D
Hasanah A
Hasanain D
Hascoet J
Hashad E
Hasheminia A
Hashim A
Hashish A
Hashish M
Haslegrave A
Hassaan A
Hassaan A
Hassan A
Hassan A
Hassan A
Hassan ATA
Hassan I
Hassan M
Hassan OMM
Hassan S
Hassan Z
Hassanain M
Hassanain M
Hassanein AB
Havemann I
Hawkins W
Heard R
Heath J
Heffernan D
Hegazy EM
Hegazy Y
Helene F-C
Helguero-Santin LM
Hemeda D
Hemingway D
Hemmila M
Hemmila M
Henderson L
Henderson L
Heng HE
Henric N
Henry F
Henshall DE
Herebat A
Herikstad R
Herrera Matta JJ
Herrera Puma CM
Herrera N
Herrera-Matta J
Herrod P
Hervieux E
Hervieux E
Hesham O
Hettiarachchi TS
Hewage K
Heywood EG
Highcock S
Hilal K
Hinojosa C
Hjertberg M
Hjertberg M
Hmila S
Ho A
Ho CW
Ho W
Ho WC
Hodonou F
Hogea M
Holte S
Homeida A
Hoogakker E
Horobjowsky A
Hosein S-P
Hosh M
Hossaini S
Hossameldin A
Houlden C
Howells L
Howie EE
Hrora A
Huaman E
Humm G
Hunter K
Hussain M
Hussein A
Hussein S
Husseini M
Husseiny R
Hutch W
Huwait A
Iacono C
Iannone I
Ibraheem AAF
Ibraheem HI
Ibrahem AA
Ibrahem AA
Ibrahim A
Ibrahim A
Ibrahim A
Ibrahim AM
Ibrahim E
Ibrahim EM
Ibrahim I
Ibrahim K
Ibrahim M
Ibrahim MH
Ibrahim Y
Idress T
Idris F
Idris SAI
Iftekhar F
Iftikhar Z
Iftikhar Z
Ignatavicius P
Ihediwa G
Imoro O
Ingabire JCA
Ingabire JCA
Ingabire JCA
Ingabire JDLCA
Ioannidis O
Iordache F-M
Iqbal FM
Iqbal MR
Ireland P
Irtan S
Irtan S
Irwin G
Irwin G
Irwin G
Irwin G
Isabel Villegas M
Ishak N
Iskandar F
Isler V
Ismail A
Ismail L
Ismail L
Ismail L
Ismail L
Ismail L
Ismail M
Ismail M
Ismail MK
Ismail SA
Israelsson L
Ivros N
Iyer D
Iyer D
Iyer D
Jabal MS
Jabbar A
Jaber S
Jackson P
Jacobe M
Jaffry Z
Jaffry Z
Jaich R
Jain P
Jama GM
Jamal L
Janardha KC
Janik M
Jankus T
Jara Quezada JH
Jaradat D
Jarmin M
Jasaitis K
Javaid M
Javed O
Javed O
Jawaid M
Jayathilake AB
Jean-Francois C
Jeffery A
Jeffery A
Jenner E
Jennings L
Jennings V
Jennings V
Jensen E
Jenvey C
Jeo WS
Jeon H
Jeremic L
Jethwani DL
Jeyakumar J
Jeyakumar J
Jha M
Jimenez Carneros V
Jimenez J
Jimenez-Morillas P
Joel LWL
Johanna N
Johnson K
Johnston R
Jokubauskas M
Jokubauskas M
Jokubonis K
Jones C
Jones C
Jones E
Jones TF
Jonnalagadda R
Joosten J
Jordan H
Jose Segura-Sampedro J
Jotautas V
Jotautas V
Jovine E
Jovine E
Jubran AF
Juciute S
Julaihi R
Jurdell E
Kaafarani H
Kabariti R
Kabariti R
Kabba J
Kabongo K
Kache S
Kaci AA
Kadiwar S
Kalakouti E
Kalles V
Kalles V
Kalles V
Kamarajah SK
Kamarulzamil SNA
Kamil R
Kamya S
Kanani A
Kandil AM
Kandil H
Kang MK
Kanta TH
Karabacak U
Karabelias G
Karabulut K
Karahan SR
Karakahya M
Karandikar S
Karandikar S
Kariem N
Karim A
Karim R
Karim S
Karismaningtyas H
Karjiker P
Karkeet M
Karkeet M
Karlo R
Karlo R
Karousos D
Karumnas P
Kaselis N
Kaselis N
Kasem E
Kasem EA
Kasputyte S
Kaul A
Kazanavicius D
Kedar A
Kefalidi E
Keke KR
Kelany M
Kenibar A
Kennedy ED
Kennedy M
Kennedy R
Keogh K
Kerley R
Kershaw S
Kesinger M
Khafagy T
Khairy H
Khairy H
Khajanchi M
Khaled H
Khalifah E
Khalili M
Khalique A
Khallaf S
Khamajeet A
Khan A
Khan K
Khan MA
Khan R
Khan S
Khan T
Khan ZA
Kharsa S
Khatri C
Khatri C
Khattab K
Khedr AE-RH
Khoja A
Khoja A
Khokha D
Khokha V
Khosla S
Khouri Ferreira SA
Khreishi R
Khreishi R
Khulu LB
Khyrallh A
Kiasat A
Kidd T
Kielty P
Kim MY-H
Kim S-H
Kim SB
Kimaro M
Kinandu K
King R
King S
King S
Kinnera SV
Kiran RP
Kirby A
Kirishnan A
Kirupagaran A
Kiudelis M
Kjellin A
Klappenbach R
Knight S
Knight SR
Koay KL
Kobal BB
Koh C
Koh H
Koh PY
Koh S
Koh S
Kojo ATT
Kojo ATT
Kojo ATT
Kolosov A
Komolafe O
Kondrotas P
Kong C
Kong SN
Kong V
Kong V
Konstantina K
Kontos M
Kordorwu HEK
Korkolis D
Kosai NR
Kosai NR
Kose E
Koskenvuo L
Kostov E
Kotb AHE-B
Kotecha D
Koto MZ
Kotobi H
Koumpa F
Kouraklis G
Kourdouli A
Kourdouli A
Kretzmann H
Krishna K
Kruspi S
Kufeji D
Kulasabanathan K
Kuliavas J
Kumar B
Kumar B
Kumar B
Kumar BS
Kumar MN
Kumar S
Kumar S
Kumar S
Kumar S
Kumar T
Kumwenda D
Kushwaha S
Kushwaha S
Kusi K
Kutkevicius J
Kwakyeafriyie P
Kwatiwani C
Kwizera S
Kwok SH-W
Kyereh M
Kyriazanos I
Kyrou G
Kyziridis D
L'Heveder A
La Brocca A
la Medina AR-D
Labib P
Ladukas A
Lafferty K
Lagunavicius K
Lai AC-H
Lakhani SM
Lakshmi HN
Lam FY
Lam JCY
Lam WH
Lamanna GL
Lanau MIV
Lando J
Landolfo G
Landolfo G
Lap G
Lapitan MC
Lapitan MC
Larsen JW
Lasek A
Lasheen A
Lasheen KT
Latif A
Laugzemys E
Laugzemys E
Laurie K
Lauzikas G
Law JH
Lawal A
Lawal AO
Lawal T
Lawal TA
Lawani I
Lawther R
Lazzari G
Lazzari V
Lazzarini Cury AD
Le VTH
Leal A
Leal M
Leanne Almanon C
Lecompte J-F
Lee C
Lee EX
Lee F
Lee K
Lee KC
Lee KY
Lee TSB
Lemaire SB
Leone N
Leong FQH
Leppaniemi A
Leppaniemi A
Leroux J
Leung KW
Leung MF
Leusink A
Lewis J
Li KHG
Li KKK
Li WS
Licari L
Lieske B
Lieske B
Liew I
Liew I
Lilford R
Lilford R
Lim G
Lim H
Lim J
Lim PJ
Lim SJ
Lim SJ
Lim SY
Limache S
Limaye N
Limoges B
Linares Delgado MSDFT
Lintin L
Lipnickas V
Litvin A
Liu Q
Liu Q
Livesey A
Livingston M
Ljuhar D
lo Conte A
loaloa MR
Lockey J
Loizides S
Lokman MAA
Longstaff L
Lopez C
Lopez M
Lopez M
Lopez-Arevalo C
Lorenzon L
Lossius WJ
Loughran D
Low X
Luc AR
Lucia Contreras-Vergara A
Luck J
Luck J
Luck J
Luglio G
Luis Rodicio J
Luiz JS
Lund J
Lund J
Lundgren P-O
Luque L
Luque L
Lytras D
Lytras D
Ma J
Mabitsela ME
Mabrouk M
Macchiavello R
Macchitella Y
Macchitella Y
Macdermid E
Macdonald A
Macdonald E
Macdonald KL
Maceviciute K
Macfarlane A
Machaca M
Machain Vega GM
Machain Vega GM
Maciejec L
Madiba T
Madkor MH
Madrid Barrientos LA
Maffioli A
Maffioli A
Magdy A
Magdy B
Magdy E
Magdy H
Magdy M
Magdy S
Magee C
Maghrabi A
Maghrabi AA
Magri D
Mahanty S
Maharaj G
Mahdi A
Mahdi S
Mahdi S
Maher ME
Mahmoud B
Mahmoud H
Mahmoud M
Mahmoud MA
Mahmoud MI
Mahmoud S
Mahmoud SME
Mahmud K
Maillot B
Maimbo M
Maimbo M
Mairs NG
Maison K
Maistry N
Majauskyte D
Majbar A
Majid AHHA
Majid K
Major CP
Major P
Major P
Mak T
Mak TWC
Makama J
Makinde M
Makupe A
Malaga B
Malavenda M
Malik K
Malik P
Malik TAM
Mamdouh E
Mamdouh R
Manatakis DK
Manchego Bautista AC
Manchego Bautista AC
Manfreda S
Mangan C
Mangan C
Mangiapane M
Manipal CE
Maniscalco A
Mann T
Mannu GS
Mano MJB
Manrique Sila G
Manrique Sila GC
Manriquez-Reyes M
Manrrique Sila G
Mansor EY
Mansour B
Mansour S
Mansuri A
Mao P
Mapasse D
Maple N
Maraie N
Marcelo Delgado J
Marey A
Marey AS
Margaritis M
Maria Garcia-Perez J
Mariani A
Marinkovic B
Marinos C
Marks E
Marples L
Marret J-B
Marroquin Rodriguez DE
Marshall DC
Martian B-V
Martin A
Mas R
Mason C
Mat TNT
Mata LPS
Matheu A
Mathew SW
Matos-Puig R
Mattar O
Matter SM
Mauro L
Mayasari M
Mazelyte R
Mazrimas P
Mazzella A
Mcaleer E
Mcaleer S
Mccarthy K
Mccarthy M
Mccarthy M
McCullagh D
Mcdonald R
McGarvie S
Mcguigan A
McIntosh K
Mcintosh R
Mcintyre CJ
Mcintyre N
Mcintyre R
Mclachlan G
Mclean AL
Mclean K
McMorran D
Mcnish D
Mcphee A
Mealy K
Mehdi A
Mehrez S
Melo Cardozo RA
Melo R
Melo R
Mendel H
Mendez M
Mendez N
Mendoza Arango MC
Mendoza Arango MC
Mendoza Arango MC
Mendoza I
Menegussi J
Mensah E
Menshawy A
Mentula P
Meqbil J
Mercado Rodriguez L-A
Mericliler M
Merlini D
Merlini D
Merlo MS
Mesbah N
Meshref A
Messa Aguilar WL
Messa Aguilar WL
Metwally MM
Migliore M
Mihaljevic AL
Mihaljevic AL
Mihanovic J
Mihanovic J
Mijuskovic B
Mikalauskas S
Mikalauskas S
Mikuckyte D
Mikwar Z
Milligan W
Milligan W
Mingrone P
Minguez Garcia J
Minguez G
Minocha A
Minocha A
Miranda C
Mircea H
Mirghani D
Mironescu A
Mironescu A
Mironescu AS
Mironescu AS
Mirza A
Mirza S
Mistry A
Mitrasinovic S
Mitroudi M
Mitroudis N
Mittal A
Mitul AR
Mitul AR
Miyarde Leon A
Mizzi C
Mizzi S
Mlotshwa M
Moaty M
Mochet S
Modolo MM
Modolo MM
Modolo MM
Moe TT
Mogan YP
Moghazy ME
Mohamed A
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Publication venue
Publication date: 15/10/2018
Field of study

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

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Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Archivio della ricerca - Università degli studi di Napoli Federico II

UCL Discovery

eScholarship - University of California

Archivio della ricerca- Università di Roma La Sapienza

St George's Online Research Archive

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abbas M.
Abdul Rasheed A.
Abdul A.
Abdul-Kadir R.
Abdusamad K.
Abernethy K.
Aboelela H.
Abouzaid M.
Abraham M.
Abraham T.
Abrams J.
Abu H.
Abu-Arafeh A.
Acton C.
Adam F.
Adam M.
Adams C.
Adams C.
Adams D.
Adams L.
Addo A.
Adedeji O.
Adegoke K.
Adewunmi E.
Adeyemo T.
Agbeko R.
Aggarwal S.
Ahmad S.
Ahmed A.
Ahmed I.
Ahmed M.
Ahmed R.
Ahmed R.
Ainsworth M.
Ajmi A.
Akili S.
Al Aaraj A.
Al Balushi A.
Al-Asadi A.
Al-Khalil M.
Al-Ramadhani B.
Al-Saadi Z.
Al-Shahi Salman R.
Al-Sheklly B.
Albert P.
Alegria A.
Alexander A.
Alexander P.
Alhabsha O.
Ali M.
Ali M.
Aliberti E.
Alin J.
Aliyuda F.
Alkhudhayri A.
Allan N.
Allanson A.
Allen E.
Allen L.
Alshaer I.
Altaf S.
Amezaga M.
Amin A.
Amit B.
Anand A.
Anantapatnaikuni S.
Anderson L.
Anderson M.
Anderson M.
Anderson N.
Anderson R.
Andrews A.
Ang A.
Anguvaa L.
Aniruddhan K.
Antonina Z.
Araujo M.
Archer A.
Archer S.
Arimoto R.
Arkley C.
Armah C.
Armistead J.
Armstrong C.
Arnison-Newgass C.
Arora D.
Arya A.
Arya R.
Asghar A.
Ashbrook-Raby C.
Asher G.
Ashley D.
Ashraf S.
Ashton D.
Ashworth R.
Aslam A.
Atomode A.
Attubato E.
Aubrey P.
Aujayeb A.
Aung N.
Avery M.
Avram C.
Aya A.
Ayaz E.
Aziz G.
Babatunde F.
Babington G.
Bachour M.
Badhan G.
Bae J.
Bagley G.
Bagshaw L.
Bailey A.
Baillie J.
Baillie J.K.
Baird D.
Bajandouh A.
Baker D.
Baker K.
Bakere H.
Bakhai A.
Balasingam P.
Balaskas T.
Balasubramaniam M.
Balcombe A.
Baldwin A.
Baldwin-Jones R.
Balfour J.
Balmforth C.
Baluwala A.
Bamford A.
Bancroft H.
Banda J.
Banks H.
Banks P.
Bannister O.
Baptist M.
Barclay C.
Barker D.
Barker J.
Barker-Williams K.
Barnacle J.
Barnard A.
Barnes R.
Barnett-Vanes A.
Barr A.
Barr D.
Barrera M.
Barrett A.
Barrow E.
Bartholomew J.
Bartlett G.
Bartley S.
Barton J.
Barton L.
Baruah R.
Bashir H.
Bashyal A.
Basoglu A.
Bassett J.
Bateman K.
Bates M.
Batra D.
Baxter M.
Bazaz R.
Beacham L.
Beadon K.
Beard K.
Beaumont-Jewell D.
Beazley C.
Beddall H.
Beddows S.
Beer S.
Beety J.
Bega G.
Begg S.
Behrouzi R.
Belcher J.
Belfield K.
Bell J.
Bell N.
Bellamy M.
Bellamy T.
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Benetti N.
Bennett A.
Bennett M.
Benson V.
Bentley A.
Beranova E.
Beresford M.
Bergin C.
Bernatoniene J.
Best K.
Bhadi A.
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Publication venue: Springer Science and Business Media LLC
Publication date: 31/01/2024
Field of study

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

White Rose Research Online

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

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Tedjaatmadja C
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Ter Ez
Tessera G
Teufelberger G
Tew Yy
Tew Yy
Tewari S
Th&apos
Thabet W
Thalgaspitiya Spb
Tham Jc
Thanusan V
Tharmalingam S
Theodosopoulos T
Thollot A
Thomas E
Thompson B
Thomson P
Thorarinsdottir H
Thorarinsdottir H
Thorell A
Thorell A
Thorsen K
Thurairaja R
Ticona Wa
Tierney G
Tilston Tw
Timothy Ok
Ting Jrs
To K
To K
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Toeema Ag
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Tolg C
Tolonen M
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Tori Sa
Torrance Hd
Torrance Hd
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Tou S
Townsend D
Tracy J
Trompetto M
Tselos A
Tshisola Sk
Tugnoli G
Tugnoli G
Tun Ak
Tun M
Tun M
Turati L
Turati L
Turkustani S
Turner M
Tutino R
Tverskis Z
Tyler R
Tyler R
Tze Rge
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Tzikos G
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Ubiali P
Ugalde P
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Upadhyaya V
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Urbonas T
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Utter M
Uzabumwana N
Vaicius A
Valcarcel-Salda&#241
Valioulis I
Van Der Naald N
Van Duren B
Van Niekerk M
Van Straten S
Varcada M
Vargas M
Varkalys K
Vartanoglu T
Vartic M
Vartic M
Vasquez G
Vasquez I
Veen T
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Vega Gmm
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Vella-Baldacchino M
Venclauskas L
Vendramin E
Venskutonis D
Venskutonis D
Venskutonis D
Venskutonis D
Venugopal C
Verbeek A
Vergara Alc
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Vivekanantham S
Vlachogiorgos A
Voulgaris E
Vth Le
Wael N
Wagener M
Wakefield R
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Waleed H
Walker M
Walker N
Walls L
Walsh M
Walsh U
Waqar M
Ward Ae
Ward S
Warda M
Warren O
Warren O
Warwick Am
Waterman A
Watson Nf
Watts A
Weber B
Weber P
Weber P
Weinstein Ms
Werder G
Wheeler J
Whewell H
Whitaker J
White R
White T
Whitehurst K
Wiborg J
Widiastini Ta
Widmer Lw
Wijayarathna Ls
Wild Jrl
Williams E
Williams G
Williams O
Williams O
Williamson A
Wilson A
Wilson L
Wilson M
Wilson M
Wilson Ms
Wilson Msj
Wimalge Pmsn
Winstanley J
Witherspoon P
Wogensen F
Wogensen F
Wogensen F
Woin E
Wold Tb
Wolf B
Wolf B
Wondimu S
Wondoh P
Wondoh P
Wong Cs
Wong Cy
Wong F
Wong Hy
Wood G
Woodward H
Worku M
Worku M
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Wright N
Wright Nj
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Xerri T
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Yakubu M
Yallop L
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Yang J
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Yaseen T
Yaseen Tm
Yau Jd
Yavuz Ma
Ye J
Yeang Lj
Yee J
Yeo Ls
Yeung En
Yeung Mha
Yifieyeh A
Yildirim R
Yip C
Yip Sbs
Ymeri S
Yoganathan P
Yolcu S
Yong Co
Yong Gl
Younis A
Youssef D
Youssef H
Youssef M
Youssif Jh
Yuksek Ma
Yusufali T
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Zadoroznas A
Zahran D
Zakaria E
Zakaria M
Zakaria Y
Zaki A
Zakir M
Zalabia Mf
Zamarin K
Zammit S
Zampitis N
Zani A
Zani A
Zani A
Zanini N
Zanini N
Zapata F
Zarb C
Zardab A
Zegarra S
Zeidan S
Zerihun Ab
Zhang Z
Zheng F
Zidan H
Zidan H
Zidan M
Zielinski M
Ziff O
Zikry M
Zil-E-Ali A
Zilinskas J
Zilinskas J
Zilinskas J
Zilinskas J
Zilinskiene R
Zimmermann Ef
Zohair A
Zorrilla Cd
Zuber M
Zuber M
Zuk G
Zulkifli A
Zumb&#252
Publication venue: 'Wiley'
Publication date: 27/11/2018
Field of study

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

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Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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Abdul Rasheed A.
Abdul A.
Abdul-Kadir R.
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Acton C.
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Publication venue: Nature Publishing Group
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Thigh-length compression stockings and DVT after stroke

Author: Abbas M
Abbasi S
Abbasi S
Abdelaziz A
Abdelfattah M
Abdul B
Abdulmumeen A
Abdulshukkoor N
Abdusamad K
Aboaba A
Abouibrahim M
Abraham M
Abraham T
Abrams J
Abung A
Acharya D
Acharya D
Acheson J
Acosta A
Acosta A
Acton C
Adam M
Adams C
Adams K
Adamus M
Adegoke K
Adenwalla S
Adeyeye E
Adnan A
Agbo C
Aggarwal S
Agwada-Akeru J
Agyapong K Ansu
Ah-Chuen J
Ahmad M
Ahmed I
Ahmed I
Ahmed L
Ahmed L
Ahmed M
Ahmed M Cecilia
Ahmed N
Ahmed N
Ahmed R
Ahmed RA
Ahmed S
Ahmed S Haris
Ail D
Ainsley A
Ainsworth M
Aitken L
Ajibode A
Ajmi A
Ajmi A
Akhtar N
Akili S
Akindolie O
Al Balushi A
Al-Asadi A
Al-Hakim B
Al-Jibury M
Al-Rabahi A
Al-Ramadhani B
Al-Shamkhani W
Al-Sheklly B
Alam S
Aldana A
Aldouri R
Aldridge N
Alegria A
Alexander A
Alexander J
Alexander PDG
Ali F Runa
Ali M
Ali O
Ali S
Ali S
Ali S
Alkhusheh M
Alkhusheh M
Allanson A
Allen L
Allen R
Allen S
Allison K
Allsop L
Alomari L
Alzetani M
Ambler S
Ambrogetti R
Ambrose C
Amezaga M
Amin A
Amosun V
Amosun V
Amsha K
Anand A
Anderson J
Anderson L
Anderson N
Anderson R
Andreou P
Andrews A
Andrews J
Aneke K
Ang A
Angel T
Antill P
Antonina Z
Anu V
Appleby S
Appleyard D
Archer A
Ardley C
Arimoto R
Arkley C
Armah C
Armstrong C
Armstrong S
Armtrong P
Arnison-Newgass C
Arora D
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Arter A
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Ashish A
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Atkinson V
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Aung K Thu
Aung N
Aung Z Myo
Austin E
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Avram C
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Ayaz E
Azam J
Aziz G
Azzopardi G
Babatunde F
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Babi M
Babingto G
Babs-Osibodu A Obaloluwa
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Bacon J
Bacon J
Bagley G
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Baijiu G
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Bailey K
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Publication venue: 'Elsevier BV'
Publication date: 01/07/1994
Field of study

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

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First‐in‐human clinical trial of allogeneic, platelet‐derived extracellular vesicles as a potential therapeutic for delayed wound healing

Author: Alex S. Hall
Anabel Silva
Angus Tester
Anna Cifuentes‐Rius
Chantelle Blyth
Gregor Lichtfuss
Hansi N. Ranasinghe
Ian Dixon
Jancy Johnson
Karmen J. W. Kong
Melanie Schoppet
Melissa B. L. Lim
Mozhgan Shojaee
Mun Joo Chuei
Nenad Sejic
Owen C. Tatford
Patrick F. James
Sadman Bhuiyan
Sam Q. K. Law
Publication venue: Wiley
Publication date: 01/07/2023
Field of study

Abstract The release of growth factors, cytokines and extracellular matrix modifiers by activated platelets is an important step in the process of healthy wound healing. Extracellular vesicles (EVs) released by activated platelets carry this bioactive cargo in an enriched form, and may therefore represent a potential therapeutic for the treatment of delayed wound healing, such as chronic wounds. While EVs show great promise in regenerative medicine, their production at clinical scale remains a critical challenge and their tolerability in humans is still to be fully established. In this work, we demonstrate that Ligand‐based Exosome Affinity Purification (LEAP) chromatography can successfully isolate platelet EVs (pEVs) of clinical grade from activated platelets, which retain the regenerative properties of the parent cell. LEAP‐isolated pEVs display the expected biophysical features of EV populations and transport essential proteins in wound healing processes, including insulin growth factor (IGF) and transforming growth factor beta (TGF‐ß). In vitro studies show that pEVs induce proliferation and migration of dermal fibroblasts and increase dermal endothelial cells' angiogenic potential, demonstrating their wound healing potential. pEV treatment activates the ERK and Akt signalling pathways within recipient cells. In a first‐in‐human, double‐blind, placebo‐controlled, phase I clinical trial of healthy volunteer adults, designed primarily to assess safety in the context of wound healing, we demonstrate that injections of LEAP‐purified pEVs in formulation buffer are safe and well tolerated (Plexoval II study, ACTRN12620000944932). As a secondary objective, biological activity in the context of wound healing rate was assessed. In this cohort of healthy participants, in which the wound bed would not be expected to be deficient in the bioactive cargo that pEVs carry, all wounds healed rapidly and completely and no difference in time to wound closure of the treated and untreated wounds was observed at the single dose tested. The outcomes of this study evidence that pEVs manufactured through the LEAP process can be injected safely in humans as a potential wound healing treatment, and warrant further study in clinical trials designed expressly to assess therapeutic efficacy in patients with delayed or disrupted wound healing

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