369 research outputs found
Bond strength of resin cements to leucite-reinforced ceramics: part 2 – after one-year aging in water
- Author
- Publication venue
- 'Fundacao Educacional da Regiao de Joinville - Univille'
- Publication date
- 04/05/2017
- Field of study
The aim of this study was to compare the shear bond strength (SBS) of two resin cements bonded to four leucite-reinforced ceramics after one week and one year of aging. Material and methods: Forty ceramic blocks (4 mm wide, 14 mm length, and 2 mm thick) were used (1 week) and reused at the back side (1 year). The blocks were abraded with aluminum oxide (90 µm) and randomly divided into eight groups for each time. Two dual resin cements (RelyX ARC and RelyX U200 self-adhesive, 3M ESPE) were bonded to ceramics Creapress (CRE – Creation / Klema), Finesse All-Ceramic (FIN – Dentsply / Ceramco), IPS Empress Esthetic (IEE – Ivoclar Vivadent) and Vita PM9 (PM9-Vita). For each resin, time, and ceramic block, after applications of the 10% hydrofluoric acid (for 1 min) and silane, 3 Tygon cut tubes were positioned over each block and filled in with the resin cements (light-cured for 40 s). The tubing molds were removed to expose the bond specimens as cylinders (area=0.38 mm2) stored in relative humidity at 24±2°C for one week and at 37±2°C for one year. All bonds were tested in an Instron in shear (applied of the base cylinder with a thin wire - 0.25 mm) at speed of 0.5 mm/min, until failure. Results: The results were analyzed by ANOVA (resin cements, ceramic systems, and time) and Tukey test (p<0.05) for rank ordering of SBS. The FIN and IEE ceramics did not show significant SBS decreasing on aging with U200. The mean SBS decreasing for all the ceramics was 36% with ARC and 14% with U200 cement. Conclusion: The SBS of ARC cement were significantly lower for all ceramics with aging than that of U200 cement. The SBS of ARC cement was also weakened by aging. FIN ceramic + U200 cement proved to be the most stable and strongest bond strength, and PM9+ARC cement proved to be the weakest bond strength with low stability.The aim of this study was to compare the shear bond strength (SBS) of two resin cements bonded to four leucite-reinforced ceramics after one week and one year of aging. Material and methods: Forty ceramic blocks (4 mm wide, 14 mm length, and 2 mm thick) were used (1 week) and reused at the back side (1 year). The blocks were abraded with aluminum oxide (90 µm) and randomly divided into eight groups for each time. Two dual resin cements (RelyX ARC and RelyX U200 self-adhesive, 3M ESPE) were bonded to ceramics Creapress (CRE – Creation / Klema), Finesse All-Ceramic (FIN – Dentsply / Ceramco), IPS Empress Esthetic (IEE – Ivoclar Vivadent) and Vita PM9 (PM9-Vita). For each resin, time, and ceramic block, after applications of the 10% hydrofluoric acid (for 1 min) and silane, 3 Tygon cut tubes were positioned over each block and filled in with the resin cements (light-cured for 40 s). The tubing molds were removed to expose the bond specimens as cylinders (area=0.38 mm2) stored in relative humidity at 24±2°C for one week and at 37±2°C for one year. All bonds were tested in an Instron in shear (applied of the base cylinder with a thin wire - 0.25 mm) at speed of 0.5 mm/min, until failure. Results: The results were analyzed by ANOVA (resin cements, ceramic systems, and time) and Tukey test (p<0.05) for rank ordering of SBS. The FIN and IEE ceramics did not show significant SBS decreasing on aging with U200. The mean SBS decreasing for all the ceramics was 36% with ARC and 14% with U200 cement. Conclusion: The SBS of ARC cement were significantly lower for all ceramics with aging than that of U200 cement. The SBS of ARC cement was also weakened by aging. FIN ceramic + U200 cement proved to be the most stable and strongest bond strength, and PM9+ARC cement proved to be the weakest bond strength with low stability
A third source of developmental differences
- Author
- A. Schierwagen
- C. H. Waddington
- Conor V. Dolan
- D. I. Boomsma
- D. I. Boomsma
- D. M. Kurnit
- Dorret I. Boomsma
- E. C. R. Reeve
- F. C. Moon
- G. B. Côté
- G. M. Edelman
- G. Nicolis
- G. Oster
- G.A. Clayton
- H. E. Stanley
- H. Meinhardt
- J. G. Hall
- K. Gaertner
- K. Mather
- K. Mather
- L. J. Eaves
- L. J. Eaves
- P. C. M. Molenaar
- P. C. M. Molenaar
- Peter C. M. Molenaar
- R. H. Benno
- R. L. Burgess
- R. Plomin
- R. Plomin
- R. Plomin
- R. S. Wilson
- S. Scarr
- S. Wright
- T. D. Johnston
- T. T. Soong
- W. B. Province
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Municipal Corporations, Homeowners, and the Benefit View of the Property Tax
- Author
- Albert Hirschman
- Albert O Hirschman
- Alfred Marshall
- Amy E Graham
- Andrew Caplin
- Anthony Downs
- Armen A Alchian
- Brett W King
- Bruce C Daniels
- Bruce W Hamilton
- Bruce W Hamilton
- Bruce W Perlstein
- Caroline Hoxby
- Caroline M Hoxby
- Caroline M Hoxby
- Charles Berger
- Charles M Tiebout
- Charles M Tiebout
- Charles M Tiebout
- Charles M Tiebout
- Charles M Tiebout
- Charles R Adrian
- Charles S Benson
- Choon-Geol Moon
- Christopher Timmins
- Clayton P Gillette
- Colin D Campbell
- Colleen A Dunlavy
- David Card
- David L Coulton
- David L Kirp
- David M Hudson
- Denise Depasquale
- Dennis Epple
- Dennis Epple
- Dennis Epple
- Dennis Epple
- Dick Netzer
- Do
- Dolores T Martin
- Douglas Holtz-Eakin
- Dudley S Hinds
- Ed Danielson
- Edgar O Olsen
- Edward L Glaeser
- Ellwood P Cubberly
- Elwood Hain
- Eric A Hanushek
- Eric H Monkkonen
- Eric H Monkkonen
- Eric J Oliver
- Ernest S Griffith
- Fabio Silva
- Frank H Easterbrook
- Frank H Easterbrook
- Gary J Miller
- Geoffrey K Turnbull
- Gerald Frug
- Hal S Baron
- Harvey Molotch
- Hendrik Hartog
- Henry G Manne
- Henry Pollakowski
- Howard Bowen
- Howard S Bloom
- J Henderson
- J Henderson
- James A Thorson
- James A Thorson
- James C Clingemeyer
- James C Clingermayer
- James M Buchanan
- James M Buchanan
- Jan K Brueckner
- Jan K Brueckner
- Jan K Brueckner
- Jeffrey Chapman
- Jennifer Roback
- Jim Berkovec
- Joan C Williams
- John East
- John G Augenblick
- John J Wallis
- John M Payne
- John P Crecine
- John Yinger
- John Yinger
- Jon C Sonstelie
- Jon C Sonstelie
- Jon C Teaford
- Jon C Teaford
- Jon C Teaford
- Jonathan Banks
- Jorge Martinez-Vazquez
- Joseph Gyourko
- Joseph P Zimmerman
- Joseph T Henke
- Joseph Tracy
- Julie K Underwood
- Karl E Case
- Katharine L Bradbury
- Kee Warner
- Kenneth Baar
- Kenneth N Bickers
- Lawrence Katz
- Lawrence Southwick
- Lionel E Fredman
- Louis A Rose
- Lynne C Burkhardt
- Mark J Roe
- Mark Schneider
- Mark Schneider
- Mary P Ryan
- Michael W Mcconnell
- Mingche M Li
- Molly Mcusic
- Morton Keller
- Neil Littlefield
- O&apos
- Oded Palmon
- Ostrom
- Pamela H Moomau
- Paul A Samuelson
- Paul A Samuelson
- Paul D Carrington
- Paul G Lewis
- Paul Teske
- Pauline Maier
- Peter Mieszkowski
- Peter Schrag
- Peter Teachout
- Randall G Holcombe
- Randall G Holcombe
- Raquel Fernandez
- Raquel Fernandez
- Raymond M Reinhard
- Richard A Musgrave
- Richard A Musgrave
- Richard A Musgrave
- Richard Briffault
- Richard M Cion
- Robert A Caro
- Robert C Ellickson
- Robert C Ellickson
- Robert J Carroll
- Robert L Manwaring
- Robert P Inman
- Roland Benabou
- Sam Peltzman
- Sam Peltzman
- Sam Peltzman
- Sandra E Black
- Sanford J Grossman
- Saul Levmore
- Sheila E Murray
- Sidney Verba
- St
- Stephen Ross
- Tari Renner
- Theodore C Bergstrom
- Theodore C Bergstrom
- Thomas A Husted
- Thomas Borcherding
- Thomas J Nechyba
- Thomas Romer
- Thomas Romer
- Truman F Bewley
- Uriel Reichman
- Victor R Fuchs
- W Grubb
- W Wickwar
- Wallace E Oates
- Wallace E Oates
- Wallace E Oates
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Fischel
- William A Niskanen
- William A. Fischel
- William C Wheaton
- William H Hoyt
- Yoram Barzel
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2000
- Field of study
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
- Author
- Aarøe Jens
- Abbass Hakam
- Abella-Ovalle Luis
- Adam Zul
- Agyemang Michael
- Ahlehof Ole
- Ahlehoff Ole
- Ahmad Yousif
- Al-Lamee Rasha
- Alberdi Lucía
- Aleti Shilpa
- Ali Danish
- Allen Kezia
- Alvares Wilson
- Alzuhairi Karam
- Amed Nadifa
- Anantharam Brijesh
- Andersen Grethe
- Andersen Henning Rud
- Anderson Michelle
- Andiapen Mervyn
- Andrews Michelle
- Ankersen Jens Peter
- Ansell Valerie
- Arango Amalia
- Armstrong Elissa
- Astarci Josenir
- Atkinson Emma
- Austin Rosalynn
- Avanzas Pablo
- Aziz Ahmed
- Azkhalil Mohammed
- Bales Emily
- Banerjee Prithwish
- Barclay Justin
- Barker Deborah
- Barker Joann
- Barmby David
- Bates Rachel
- Baucutt Karen
- Been Martin
- Beirnes Charmaine
- Bell Sheila
- Bennett Amy
- Bennett Lorraine
- Bernardo-Alba Pablo
- Berry Alan
- Berry Colin
- Besana Rissa
- Bhatre Gurbir
- Bhatti Rishma
- Bidle Amanda
- Bijsterveld Petra
- Bose Tuhina
- Boyle Georgina
- Brady Rebecca
- Braybrook Christine
- Breeze Jonathan
- Brennan Oliver
- Brett Sarah
- Brogan Richard
- Brown Janette
- Bucciarelli-Ducci Chiara
- Buchanan Louise
- Buelga-Díaz Covadonga
- Bueno Hector
- Bulluck Heerajnarain
- Burd Amanda
- Burnett Gillian
- Burtonwood Natalie
- Burunsuzoglu Senem
- Butler Robert
- Butler Robert
- Byrne Jean
- Bøtker Hans Erik
- Capel Robert
- Cappelen Helle
- Carruthers Gayle
- Carstensen Steen
- Castro Rafael
- Champney Felicity
- Chant Nicholas
- Charles Thabitha
- Chester Emma
- Chong Jun
- Christensen Erika Frischknecht
- Christiansen Evald Høj
- Christiansen Martin Kirk
- Christmas Natasha
- Chu Rebecca
- Chung Alan
- Cimas Teodorna
- Clapp Brian
- Clare Thomas
- Clarke Millie
- Clayton Tim
- Clifford Piers
- Cockayne Laura
- Colicchia Martina
- Collier Lucy
- Cooper Theresa
- Copas Andrew
- Copestick Jane
- Corps Ellie
- Corrigan Julie
- Cottam Victoria
- Cotton James
- Coward Paul
- Cox Emily
- Crause Jacolene
- Cruden Nick
- Cunliffe Denise
- Cunnington Michael
- Cuxton Josephine
- Dana Ali
- Dana Ali
- Darby Damaris
- Davies John
- Davies Justin
- Davies Nina
- de Cima Sara
- de la Hera Galarza Jesus Maria
- de la Roz Manuel
- De Mance Gianluigi
- De Sousa Phillipa
- Deen Zakhira
- del Valle Raquel
- Delaney Jane
- Denman Joanne
- Dias Priyanthi
- Dillon Angela
- Dimond Kirsty
- Din J.
- Dockerty Francesca
- Dodd Matthew
- Douglas James
- Douthwaite Rebecca
- Drew Martin
- Díaz-González Eloy
- East Clare
- Eaton Michelle
- Ellert Julia
- Elliott Rebecca
- Ellis Howard
- Elshiekh Dr Mohamed
- Elston Ruth
- Emery Lisa
- Engstrom Thomas
- Erntgaard Dennis
- Evans Richard
- Fahrai Gregor
- Farag Mohamed
- Fath-Orboubadi DR Fazin
- Fati Pene
- Fayed Hossam
- Fente Ana I.
- Fernandez Olga
- Fernández Elena
- Fernández-Carral Marcos Fernández-Carral
- Fernández-Gonzalo David
- Fernández-Mallo Francisco J.
- Finch Amanda
- Fleming Catherine
- Fofie Joyce
- Foundun Aboo
- Francis Rohin
- Francis Rohin
- Frank Emma
- Freeman Philip
- Freestone Beth
- Fuentes María D.
- Gale Joanne
- Gale Joanne
- Gallagher Ian
- Galván-Núñez Pablo
- Gamma Reto
- Garcia-Ruiz José Manuel
- García-Alonso María
- García-Castro Alfonso
- Gaughran Lisa
- Germon Rachel
- Gibson Kirsty
- Giebner Matthias
- Gill Abby
- Gill Simrat
- Giuffrida Gaia
- Given Rachel
- Glen James
- Goitia-Martín Javier
- Gomes Sara
- Gorog Diana
- Gorog Diana A
- Gowing Anne
- Gracey Jay
- Grech Ever
- Greenwood John
- Greenwood John P
- Gregory Sally
- Gregson Lisa
- Griffiths Huw
- Grosser Konrad
- Gue Ying
- Guinea Rocío
- Gunn Julian
- Guyatt Samantha
- Hall Charlotte
- Hall Ian
- Hall Lorna
- Hamid Mahmood
- Hansen Henrik Steen
- Hansen Knud Nørregård
- Hansen Poul Anders
- Hansen Troels Martin Hansen
- Harfield Scott
- Harkins Ruth
- Harland Charlotte
- Hartley Amy
- Hausenloy Derek J
- Haworth Peter
- Hayes Michelle
- Hedegaard Kim Witting
- Hedrera Segundo A.
- Helqvist Steffen
- Henderson Rob
- Hendry Cara
- Heppell Richard
- Hermosa Francisco J.
- Hernández Ernesto
- Hetherington Daniel
- Hetherington Simon
- Hildick-Smith David
- Hindle Julia
- Hjort Jakob
- Hoare Amy
- Hobson Alex
- Hodgson Adrian
- Hodierne Jeremy
- Hogrefe Kai
- Holloway Rachael
- Holmvang Lene
- Hoole Stephen
- Hopper Oliver
- Horler Stephanie
- Horner Victoria
- Horwood Carol
- Houghton Richard F
- Housley Kay
- Howe Serena
- Hudson Karen
- Hussein Jodie
- Hyndman Samantha
- Ibanez Borja
- Iglesias-Llaca Fernando
- Ilsley Mary
- Ingoldby Fiona
- Iqbal , Javid
- Iversen Allan
- Jack Pearse
- Jackson-Lawrence Karen
- Jakobsen Lars
- Jamal Zahra
- Jamieson-Leadbitter Caroline
- Jennison Alan
- Jensen Lisette Okkels
- Jensen Svend Eggert
- Johnstone Donna
- Jones Leslie
- Jones Sophie
- Joshi Francis
- Joyce Joan
- Junker Anders
- Jørgensen Erik
- Kaeng Lee
- Kaltoft Anne
- Kanji Rahim
- Kaur Ramandeep
- Kaur-Babooa Priya
- Kaus Henning
- Keate Kirstie
- Kelbæk Henning
- Kelly Julie
- Kelsall Nicci
- Kempel John
- Kennard Sarah
- Khan Arif
- Kharbanda Rajesh
- Kharbanda Rajesh K
- Khawaja Muhammed Zeeshan
- Knight Rosemary
- Knighton Abigail
- Kobson Barbara
- Kodoth Vivek
- Kolakaluri Laurel
- Koothoor Raiji
- Korsgaard Mette Tidemand
- Kotecha Tushar
- Krishnamoorthy Suresh
- Krishnamurthy Arvindra
- Kristensen Steen Dalby
- Laca Sonia I.
- Lakeman Nicki
- Langrish Jeremy
- Lasica Ratko
- Lassen Jens Flensted
- Laurence Julia
- Lazar Nicoleta
- Leathers Chris
- Lee Dr Kaeng
- Lee Kelvin
- Lee Sandra
- Lenzi Valentina
- Leonard Gerry
- Lippert Freddy K
- Llorente-Álvarez Susana
- Lloyd Steph
- Loder Chris
- Longbottom Colin
- Longman Kristel
- Lozano Iñigo
- Lucking Andrew
- Ludman Andrew
- Lønborg Jacob T
- Maart Clint
- Mackenzie Ailie
- Mackie Sarah
- Madsen Morten
- Maeng Michael
- Malik Iqbal
- Marber Michael
- Mark Bettina Løjmand
- Markham-Jones Helene
- Martin Katherine
- Martinez-González Eugenio
- Martins Joe
- Martínez-Bastida Ginés
- Martínez-Fernández César M.
- Martínez-Pérez Polácido J.
- Martínez-Valle Marta
- Massey Ian
- Mathur Anthony
- Matic Dragan
- Mcarthy Rachel
- McCormick Louise
- McFarlane-Henry Eleanor
- McGregor Andrew
- McLeod Jane
- McSkeane Anna
- Meade Tom
- Meadows Deborah
- Medina-Cameán Ana B.
- Mehmedbegovic Zlatko
- Merrick Angela
- Metherell Stella
- Middle Janet
- Milasinovic Dejan
- Milgate Sarah
- Mohiddin Saidi
- Mojela Idah
- Moon Angela
- Moore Donna
- Moore Roger
- More Ranjit
- More Ranjit
- Moreby Berni
- Moreira Silvia
- Morgan Maureen
- Morris Steve
- Morís César
- Mota Paula
- Mudd Alexandra
- Munir Shahzad
- Muriel-Velasco Ana
- Musa Anntoniette
- Musselwhite Janine
- Møller Ulla Kristine
- Nair Sunil
- Naves María C.
- Neal Debbie
- Nelthorpe Faye
- Neubauer Stephen
- Newman Hannah
- Nicholas Jennifer M
- Nicholson Anne
- Nicholson Susan
- Nonide Marta
- Norfolk Derek
- O'Connor John
- O'Donnell Joshua
- O'Kane Peter
- O'Neill James
- Oakes Trevor
- Ocampo Madelaine
- Odedra Toral
- Oliveira Joana
- Oliver Victoria
- Oommen Anu
- Orr Sarah
- Paddy Loveth
- Padrón Remigio
- Panicker Abeesh Sadasiva
- Parsons Georgina
- Pascual Isaac
- Pascual Susana
- Patale Sheetal
- Pavlidis Antonis
- Pedersen Danny Mejsner
- Pedersen Frants
- Pedersen Karin Møller
- Pedersen Knud Erik
- Pedley Lauren
- Pejic Marijana
- Peláez María C.
- Pemberton Chris
- Pengelley Clare
- Penney Lucy
- Pepper Stacey
- Perara Divaka
- Perkins Alexander
- Phillips Hannah
- Phuyal Urmila
- Pine Amy
- Pitcher Louise
- Pitt Mike
- Polokova Karin
- Polwarth Gary
- Pomar-Amillo Ángeles
- Pozo-López Mónica
- Prendergast Bernard
- prentice Scott
- Preston Stephen
- Prodanovic Maja
- Prossora Mary
- Pulikal George
- Quintana Rosa B.
- Radford Elizabeth
- Radosavljevic-Radovanovic Mina
- Radovanovic Nebojsa
- Rai Amrit
- Raju Prashanth
- Rakhit Roby
- Rakhit Roby D
- Ramlall Manish
- Ramos Angelo
- Ratcliffe Amanda
- Raungaard Bent
- Ravkilde Jan
- Redington Andrew
- Redman Emily
- Redwood Simon
- Redwood Simon
- Reed Helen
- Reeve Christy
- Relph Chris
- Richardson James
- Riches Joanne
- Riddervold Ingunn Skogstad
- Riedel Ella
- Roberts Josh
- Robertson Steven
- Rodil-Díaz Juan A.
- Rondán Juan
- Ross David
- Roy Liby
- Roza César L.
- Rozado José
- Ryan Tony
- Ryding Alisdair
- Ryding Alisdair D
- Saclot Louie
- Samaniego Beatriz
- Sanchez-Vidal Ruth
- Sandhu Kully
- Sarti Charlotte
- Saunamäki Kari
- Saunders Heidi
- Savic Lidija
- Schmidt Michael R
- Schumacher Natasha
- Scott Kerry
- Sebastian Deepa
- Sebastian Deepti
- Segovia Eduardo
- Sevillano Annaliza
- Shaw Caroline
- Shelton Rhidian
- Shepherd Lucy
- Sherwood Martin
- Sidgwick Sian
- Simpson Holly
- Skipper Nicola
- Skov Charlotte Schmidt
- Smallwood Andrew
- Smee Joanna
- Smit Angelique
- Smith Bethany
- Smith Clare
- Smith Ian
- Smith Jan
- Smith Megan
- Smith Trevor
- Snow Tom
- Solieri Ashley
- Somers Kathryn
- Spence Sharon
- Spickett Helen
- Spinthakis Nicholas
- Stables Rod
- Staines Jocasta
- Stankovic Goran
- Stimson Leah
- Storey Robert F.
- Strike Philip
- Subotic Ida
- Suttling Anne
- Suárez Alfonso
- Suárez-Coto Raquel
- Suárez-Noriega Raquel
- Sørensen Henrik Toft
- Sørensen Rikke
- Tapp Luke
- Tawiah Cecilia
- Taylor Rebecca
- Terkelsen Christian Juhl
- Thambi Sunil
- Theodorou Nana
- Thim Troels
- Thomas Isobel
- Thompson Rebecca
- Thornborough Lauren
- Thornton Emma
- Thuesen Leif
- Thygesen Kristian
- Tilsted Hans Henrik
- Tipping Aoife
- Tomlinson Lucy
- Tomlinson Sharon
- Topic Dragan
- Tresguerres Jose M.
- Turner Charlotte
- Turner Jenny
- Turney Sharon
- Upton Robert
- Uscumlic Ana
- Van Dyck Laura
- Varma Madhusudhan
- Varma Madhusudhan
- Veerapen Jessry
- Vega-Fernández José L.
- Vegas-Valle Jose M.
- Veien Karsten
- Venugopal Vinod
- Vertue Mark
- Victor Saji
- Villadsen Anton Boel
- Villanueva María J.
- Villar-Fernández Lara
- Vinagrero María S.
- Viribay Fernando M.
- Vlad Ionela
- von Weitzel-Mudersbach Paul
- Vukcevic Vladan
- Vázquez-Suárez María
- Waddington Natalia
- Wain Jill
- Waitrak Paulina
- Waldron Molly
- Wallace Lauren
- Walshe Siobhan
- Walvin Tom
- Warner Karen
- Watkins Richard
- Watkinson Oliver
- Weatherlley Louise
- Webb Ian
- Webb Ian
- Wells Nicki
- Westwood Mark
- Wheeldon Nigel
- Whitehead Helena
- Whiteside Charlene
- Wilkinson Conor
- Wilson Karen
- Wittrock Daniel
- Wolyrum Mathias
- Woods Sarah
- Wragg Christopher
- Yellon Derek M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
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- Byrne J.
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- Byrne-Watts V.
- Cale E.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
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- Chauhan R.
- Chawla V.
- Chen F.
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- Cherrie M.
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- Chilvers A.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
- Collins J.
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- Colton H.
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- Connell E.
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- Connolly G.
- Connor E.
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- Conteh V.
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- Cooke G.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- De Soyza A.
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- Desai A.
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- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Dobbie L.
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- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
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- Elgohary A.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Ferenando G.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Johnstone E.
- Jones A.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Dust and gas absorption in the high mass X-ray binary IGR J16318−4848
- Author
- Aharonian
- Asplund
- Barragán
- Barragán
- Barragán
- Bearden
- Briel
- Chaty
- Chaty
- Clayton
- Corrales
- Daniele Rogantini
- Dauser
- den Herder
- Draine
- Draine
- Draine
- Dwek
- Felix Fürst
- Filliatre
- Fireman
- Foreman-Mackey
- Fortin
- George
- Goodman
- Grevesse
- Han
- Harrison
- Hoffman
- Houck
- Hubbell
- Hubbell
- Ibarra
- Ioanna Psadaraki
- Iyer
- Jansen
- John A. Tomsick
- Jörn Wilms
- Kallman
- Katja Pottschmidt
- Kitaguchi
- Leahy
- Leahy
- Lee
- Lee
- Lia Corrales
- Lodders
- Magdziarz
- Mason
- Mathis
- Matt
- Matt
- Matthias Bissinger né Kühnel
- Maximilian Lorenz
- Moon
- Nagase
- Nandra
- Natalie Hell
- Nozawa
- Odaka
- Peter Kretschmar
- Protassov
- Ralf Ballhausen
- Rogantini
- Scargle
- Smith
- Strüder
- Tarter
- Timothy R. Kallman
- Verner
- Verner
- Victoria Grinberg
- Walter
- Westphal
- Wilms
- Publication venue
- 'EDP Sciences'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Effects of fetal antiepileptic drug exposure Outcomes at age 4.5 years
- Author
- Adab Naghme
- Adeli Khosrow
- Arena Patricia
- Baade Lyle
- Baker G.A
- Baker Gus
- Barkley Gregory
- Barrie Claire
- Bellman Jennifer
- Blalock Temperance
- Booth Alison
- Boyer Katrina
- Bromfield Edward
- Bromley R.L
- Bromley Rebecca
- Browning N
- Browning Nancy
- Casswell Miranda
- Clayton-Smith J
- Clayton-Smith Jill
- Cohen M.J
- Cohen Morris
- Cole Andrew
- Combs Cantrell Deborah T
- Constantino Tawnya
- Crawford Todd
- Denham Megan
- Drane Daniel
- Druzin Maurice
- Dworetzky Barbara
- Echo Joyce
- Epstein Charles
- Ficker David
- Finnell Richard
- Flax Erin
- Gess Jennifer
- Goyal Monisha
- Halperin Lucila
- Harden Cynthia
- Heck Christianne
- Helmers Sandra
- Hendrickson Linda
- Henry Thomas
- Holmes Gregory L
- Jolles Bernadette
- Kalayjian L.A
- Kalayjian Laura
- Kanner A
- Kanner Andres
- Kini Usha
- Kunchai Meghan Kelly
- Labiner David
- Lee Gregory
- Liow Kore
- Liporace J.D
- Liporace Joyce
- Loblein Hayley
- Loring D.W
- Loring David
- Martin Roy
- Mawer George
- Meador K.J
- Meador Kimford J
- Meyer Michelle
- Miller John
- Minter Donna
- Moir Barbara
- Moon Jennifer
- Moore Eugene
- Moore Layne
- Morrell Martha
- Motamedi Gholam
- Murdock Kathryn
- Naylor Cecile
- NEAD Study Grp
- Nelson Lorene
- Nelson Michael N
- Nobles Shelli
- O'Donovan Cormac
- Ogunsola Yinka
- Pack Alison
- Padilla Sonia
- Palmese Christina
- Pennell P.B
- Pennell Page
- Penovich Patricia
- Privitera M
- Privitera Michael
- Ramsay Eugene
- Rosenbaum Gail
- Rosenfeld William
- Russell Steve
- Sam Maria
- Santos Cesar
- Schoenberg Mike R
- Shavel-Jessop Sara
- Sherman Scott
- Silver Cheryl
- Smith Julien
- Tamny-Young Tara
- Veling-Warnke Gisela
- Wells Peter
- Wilcox Kathryn
- Wilensky Alan
- Winestone Jamie
- Wolff Mark
- Yerby Mark
- Zaia Phyllis
- Zajdowicz Thad
- Publication venue
- Lippincott Williams & Wilkins
- Publication date
- 17/04/2012
- Field of study
OBJECTIVE: To examine outcomes at age 4.5 years and compare to earlier ages in children with fetal antiepileptic drug (AED) exposure. METHODS: The NEAD Study is an ongoing prospective observational multicenter study, which enrolled pregnant women with epilepsy on AED monotherapy (1999–2004) to determine if differential long-term neurodevelopmental effects exist across 4 commonly used AEDs (carbamazepine, lamotrigine, phenytoin, or valproate). The primary outcome is IQ at 6 years of age. Planned analyses were conducted using Bayley Scales of Infant Development (BSID at age 2) and Differential Ability Scale (IQ at ages 3 and 4.5). RESULTS: Multivariate intent-to-treat (n = 310) and completer (n = 209) analyses of age 4.5 IQ revealed significant effects for AED group. IQ for children exposed to valproate was lower than each other AED. Adjusted means (95% confidence intervals) were carbamazepine 106 (102–109), lamotrigine 106 (102–109), phenytoin 105 (102–109), valproate 96 (91–100). IQ was negatively associated with valproate dose, but not other AEDs. Maternal IQ correlated with child IQ for children exposed to the other AEDs, but not valproate. Age 4.5 IQ correlated with age 2 BSID and age 3 IQ. Frequency of marked intellectual impairment diminished with age except for valproate (10% with IQ <70 at 4.5 years). Verbal abilities were impaired for all 4 AED groups compared to nonverbal skills. CONCLUSIONS: Adverse cognitive effects of fetal valproate exposure persist to 4.5 years and are related to performances at earlier ages. Verbal abilities may be impaired by commonly used AEDs. Additional research is needed
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
- Author
- A Colao
- A Dejgaard
- A Gualberto
- A Renehan
- A Ward
- AA Jorge
- AA Romano
- AG Renehan
- AG Renehan
- AG Renehan
- AG Renehan
- AG Renehan
- AG Renehan
- AG Renehan
- AJ Deans
- AJ Swerdlow
- AJ Swerdlow
- AM Suikkari
- Andrew G. Renehan
- AV Schally
- AW Roddam
- AW Tolcher
- B Chen
- B Ergun-Longmire
- C Gil-Puig
- C Nava
- C Sell
- C Sell
- CA Sklar
- CE Rogler
- CJ Currie
- D Baris
- D Diehl
- D Feldser
- D Olmos
- D Sachdev
- D Sachdev
- D Wyatt
- D Zhang
- DB Allen
- DE Corpet
- DL Roberts
- DP Rose
- DY Moromisato
- E Denayer
- E Friberg
- E Giovannucci
- E Karna
- E Mira
- E Ron
- E Wilker
- E Wilker
- E Wolf
- E Zelzer
- G Christofori
- G Pandini
- GA Tuffli
- H Brems
- H Wennbo
- H Yu
- H Yu
- HB El-Serag
- HD Moon
- HD Moon
- HD Moon
- HM Colhoun
- I Banerjee
- Indraneel Banerjee
- J Baker
- J Bell
- J Grulich-Henn
- J Ma
- J Mitri
- J Rosenstock
- J Svensson
- J Törnell
- J Törnell
- JC Heuson
- JC Heuson
- JD Wu
- JK Morris
- JM Carboni
- JM Chan
- JM Evans
- JM Jonasson
- JS Kasper
- JS Yuen
- JV Silha
- K Deitel
- K Stochholm
- KK Ho
- KK Kaulsay
- KW Kim
- L Keinan-Boker
- LG Hemkens
- LK Chopin
- LK Midyett
- M Anzo
- M Bentires-Alj
- M Böni-Schnetzler
- M Harvie
- M Pollak
- M Raccurt
- M Slater
- MA Lawlor
- MM Ramsey
- N Koohestani
- N Stahnke
- NA Dallas
- NP Nunez
- O Mehls
- OH Lee
- P Bates
- P Pisani
- PD Home
- Peter E. Clayton
- Philip G. Murray
- PN Nair
- PS Rosenberg
- R Durai
- R Huxley
- R Kaaks
- R Kauppinen-Mäkelin
- R Luft
- R Novosyadlyy
- R Sharon
- RA Jones
- RA Krajcik
- RA Moorehead
- S Khoury-Shakour
- S Lu
- S Mukhina
- S Ressler
- S Rinaldi
- S Schubbert
- S Shigematsu
- S Shukla
- S Watanabe
- S Weijzen
- S Yakar
- S Yakar
- SB Rho
- SC Larsson
- SC Larsson
- SC Larsson
- SC van Buul-Offers
- SD Chernausek
- SE Dunn
- SE Hankinson
- SE Olivo-Marston
- SH Hong
- SJ Howell
- SJ Pocock
- SL Blethen
- SL Bowker
- SM Firth
- SM Orme
- SM Swanson
- T DeAngelis
- T Kimura
- T Lopez
- T Maneatis
- T Sakatani
- T Zhu
- TT Chung
- TT Tran
- U Smith
- WE Tidyman
- WE Tidyman
- X Su
- X Wu
- X Yang
- X Zhang
- XF Yang
- XQ Xu
- Y Nishi
- Y Wu
- Y Wu
- YX Yang
- Z Dai
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
- …