Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii

Expression of a bacterial transporter protein in Toxoplasma gondii results in parasite susceptibility to Formidomycin, a drug targeting isoprenoid precursor synthesis

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease

The recommendations listed in this document are, whenever possible, evidence based. An extensive evidence review was conducted as the document was compiled through December 2008. Repeated literature searches were performed by the guideline development staff and writing committee members as new issues were considered. New clinical trials published in peer-reviewed journals and articles through December 2011 were also reviewed and incorporated when relevant. Furthermore, because of the extended development time period for this guideline, peer review comments indicated that the sections focused on imaging technologies required additional updating, which occurred during 2011. Therefore, the evidence review for the imaging sections includes published literature through December 2011

SHAPE America and physical literacy : an event horizon

In this paper, we reflect on SHAPE America's K-12 National Standards and its connection to physical literacy. We argue physical educators in the United States have primarily engaged with the term physical literacy without engaging with the theoretical and pedagogical depth of the concept. Despite this, SHAPE America does explicitly endorse an adapted version of Whitehead's definition of the physical literacy concept. In drawing on feminist intersectional thought, we make an argument that SHAPE America's adoption of physical literacy has produced an era of 'disorientation' in United States physical education. Within this disorientation, much of the advancements made in theory, pedagogy, sociocultural issues, as well as curriculum have been lost. We conclude by calling for a revamping of the standards that are not bound to a single concept, model or theoretical paradigm

Inter-goal conflict and facilitation as predictors of adherence to dieting goals: an ecological momentary assessment study

Objectives: To examine dieting goals within a system of individual goals, and the patterns by personally-relevant goals mightinterfere or facilitate each other.Design: 94 dieters completed an assessment of goals using Little’spersonal project analysis. Participants identified 7 goals; one ofwhich was pre-defined as adhering to diet. Over the beginning14 days of their diet, participants completed an EcologicalMomentary Assessment study recording their food intake in realtime. Every evening, participants reported their goal engagementand which goals conflicted or facilitated with each other.Main outcome measures/results: Over the study duration,1452 days of food intake and goal conflict/facilitation wererecorded. Participants completed an average of 1.54 (SD= 0.85)snacks, an average of 0.94 (SD= 1.81) goal conflicts, and 4.16(SD = 4.70) goal facilitations per day. Inter-goal conflict was associated with a significant but small improvement on individuals’mood, but was not associated with daily dietary intake or longterm weight-loss. Similarly, inter-goal facilitation was not associated with daily dietary intake or long-term weight-loss. Daily foodintake was a significant predictor of long-term weight-loss.Conclusions: The results of this study suggest the impact ofinter-goal conflict and facilitation on dieting is not via overallsnack or food consumption

Mental health impacts of the COVID-19 pandemic on college students

The COVID-19 pandemic is having profound effects on college students, and those with mental health conditions are more vulnerable to the impact of this stress. Objective: To study the impact of the COVID-19 pandemic on college students’ mental health. Participants: Participants (n=489) were mostly female, undergraduate, and aged 18–25. Methods: Participants completed an online survey assessing symptoms of mental health problems including hopelessness, loneliness, sadness, anxiety, sadness, and anger. Results: Approximately 81.6 % self-reported at least one negative mental health symptom. Students reported increased feelings of hopelessness (+7.8%), loneliness (+6.7%), sadness (+8.8%), depression (+2.6%), anxiety (+5.2%), and anger (+14.6%) during the pandemic than before. LGBTQ students and Black students had significantly more mental health symptoms during the pandemic than straight and White students. Conclusions: Results of this study highlight the negative impact of the pandemic and resultant changes on college students’ mental health