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17 research outputs found

Whole-genome sequencing reveals host factors underlying critical COVID-19

Author: Abd Elghafar M. S.
Abdel-Aziz M.
Abdelrazik M.
Abdollahi H.
Abdullah T.
Abecasis G. R.
Abedalthagafi M.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N. S.
Acquilini D.
Adams C.
Adams E. L.
Adams K.
Adamsara A.
Adanini O.
Adeleye O.
Adra D.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Agasou A.
Agrawal S.
Aguero D.
Ahmad N.
Ahmadi S.
Ahmed A.
Ahmed C.
Akeroyd L.
Akhtar M. N.
Akinkugbe O.
Aksentijevich A.
Al-Afghani H.
Al-Awdah L.
Alaamery M.
Alahmadey Z. Z.
Alaverdian D.
Alavere H.
Albader A.
Albaiceta G. M.
Albakri J. K.
AlBardis H.
Albeladi M.
Albesher N.
Albrich W.
AlDhawi N.
Aldridge J.
Aleagha A. E.
Alexander P.
Alfonso J.
Alghamdi B.
Alghamdi J.
Ali A.
Ali A.
Ali I. A. M.
Ali S.
Aliannejad R.
Aljawini N.
AlJohani S.
Alkwai S.
Allan A.
Allan E.
Allan J.
Alldis Z.
Allen L.
Allen M.
Allen S.
Allibone S.
Allison K. S.
Allos R.
Ally S. M.
AlMalik A.
Almalki F.
Almohammed I.
Almutairi M.
Alotaibi S.
Alowayn A. M.
Alqahtani S.
Alqubaishi F.
Alrashed M.
Alshareef A.
Alsolm E.
Alswailm M.
Altabaibeh A.
Alvaro A.
AlZahrani D.
Amin V.
Amirsavadkouhi A.
Amitrano S.
Anastasescu E.
Anderson F.
Anderson J.
Anderson M.
Anderson P.
Anderson S.
Anderson S.
Anderson T.
Andolfo I.
Andretta F.
Andreucci E.
Andrew A.
Andrew B.
Andrew G.
Andrews E.
Andrews S. J.
Anedda F.
Anemoli V.
Annis A.
Antcliffe D.
Antinori A.
Antoni M. D.
Anumakonda V.
Apetri E.
Aquino M.
Arabi Y. M.
Aravindan L.
Arbane G.
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Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2022
Field of study

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

PubliCatt

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Whole-genome sequencing reveals host factors underlying critical COVID-19

Author: Abd Elghafar M.S.
Abdel-Aziz M.
Abdelrazik M.
Abdollahi H.
Abdullah T.
Abecasis G.R.
Abecasis G.R.
Abedalthagafi M.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N.S.
Acquilini D.
Adams C.
Adams E.L.
Adams K.
Adamsara A.
Adanini O.
Adeleye O.
Adra D.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Agasou A.
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Publication venue: Springer Science and Business Media LLC
Publication date: 07/07/2022
Field of study

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

White Rose Research Online

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abbas M.
Abdul Rasheed A.
Abdul A.
Abdul-Kadir R.
Abdusamad K.
Abernethy K.
Aboelela H.
Abouzaid M.
Abraham M.
Abraham T.
Abrams J.
Abu H.
Abu-Arafeh A.
Acton C.
Adam F.
Adam M.
Adams C.
Adams C.
Adams D.
Adams L.
Addo A.
Adedeji O.
Adegoke K.
Adewunmi E.
Adeyemo T.
Agbeko R.
Aggarwal S.
Ahmad S.
Ahmed A.
Ahmed I.
Ahmed M.
Ahmed R.
Ahmed R.
Ainsworth M.
Ajmi A.
Akili S.
Al Aaraj A.
Al Balushi A.
Al-Asadi A.
Al-Khalil M.
Al-Ramadhani B.
Al-Saadi Z.
Al-Shahi Salman R.
Al-Sheklly B.
Albert P.
Alegria A.
Alexander A.
Alexander P.
Alhabsha O.
Ali M.
Ali M.
Aliberti E.
Alin J.
Aliyuda F.
Alkhudhayri A.
Allan N.
Allanson A.
Allen E.
Allen L.
Alshaer I.
Altaf S.
Amezaga M.
Amin A.
Amit B.
Anand A.
Anantapatnaikuni S.
Anderson L.
Anderson M.
Anderson M.
Anderson N.
Anderson R.
Andrews A.
Ang A.
Anguvaa L.
Aniruddhan K.
Antonina Z.
Araujo M.
Archer A.
Archer S.
Arimoto R.
Arkley C.
Armah C.
Armistead J.
Armstrong C.
Arnison-Newgass C.
Arora D.
Arya A.
Arya R.
Asghar A.
Ashbrook-Raby C.
Asher G.
Ashley D.
Ashraf S.
Ashton D.
Ashworth R.
Aslam A.
Atomode A.
Attubato E.
Aubrey P.
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Baillie J.K.
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Publication venue: Springer Science and Business Media LLC
Publication date: 31/01/2024
Field of study

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

White Rose Research Online

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abbas M.
Abdul Rasheed A.
Abdul A.
Abdul-Kadir R.
Abdusamad K.
Abernethy K.
Aboelela H.
Abouzaid M.
Abraham M.
Abraham T.
Abrams J.
Abu H.
Abu-Arafeh A.
Acton C.
Adam F.
Adam M.
Adams C.
Adams D.
Adams L.
Addo A.
Adedeji O.
Adegoke K.
Adewunmi E.
Adeyemo T.
Agbeko R.
Aggarwal S.
Ahmad S.
Ahmed A.
Ahmed I.
Ahmed M.
Ahmed R.
Ainsworth M.
Ajmi A.
Akili S.
Al Aaraj A.
Al Balushi A.
Al-Asadi A.
Al-Khalil M.
Al-Ramadhani B.
Al-Saadi Z.
Al-Shahi Salman R.
Al-Sheklly B.
Albert P.
Alegria A.
Alexander A.
Alexander P.
Alhabsha O.
Ali M.
Aliberti E.
Alin J.
Aliyuda F.
Alkhudhayri A.
Allan N.
Allanson A.
Allen E.
Allen L.
Alshaer I.
Altaf S.
Amezaga M.
Amin A.
Amit B.
Anand A.
Anantapatnaikuni S.
Anderson L.
Anderson M.
Anderson N.
Anderson R.
Andrews A.
Ang A.
Anguvaa L.
Aniruddhan K.
Antonina Z.
Araujo M.
Archer A.
Archer S.
Arimoto R.
Arkley C.
Armah C.
Armistead J.
Armstrong C.
Arnison-Newgass C.
Arora D.
Arya A.
Arya R.
Asghar A.
Ashbrook-Raby C.
Asher G.
Ashley D.
Ashraf S.
Ashton D.
Ashworth R.
Aslam A.
Atomode A.
Attubato E.
Aubrey P.
Aujayeb A.
Aung N.
Avery M.
Avram C.
Aya A.
Ayaz E.
Aziz G.
Babatunde F.
Babington G.
Bachour M.
Badhan G.
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Bagley G.
Bagshaw L.
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Baillie J.
Baillie J. Kenneth
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Bajandouh A.
Baker D.
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Balasubramaniam M.
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Baldwin A.
Baldwin-Jones R.
Balfour J.
Balmforth C.
Baluwala A.
Bamford A.
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Bannister O.
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Brown J.
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Brraka A.
Bruce J.
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Brudlo W.
Buch Maya H.
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Buck A.
Buck L.
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Bugg G.
Bujazia R.
Bullock E.
Burda D.
Burden T.
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Burman A.
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Butler E.
Butler J.
Butler P.
Butt M.
Button H.
Buttress D.
Byrne J.
Byrne W.
Byrne-Watts V.
Cale E.
Calisti G.
Callens C.
Cameron E.
Cameron S.
Camm C.
Cammack R.
Campbell Hewson Q.
Campbell B.
Campbell D.
Campbell H.
Campbell Mark
Campbell R.
Cann A.
Cannon A.
Cantliff J.
Caplin B.
Capp A.
Carey C.
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Carley S.
Carmody M.
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Carrington Z.
Carroll A.
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Carter J.
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Carty C.
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Casey S.
Cate H.
Caws C.
Central Coordinating Office (for the RECOVERY Collaborative Group)
Century H.
Chadwick J.
Chakkarapani E.
Chakraborty A.
Chamberlain S.
Chambers E.
Chambers L.
Chan E.
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Chaplin J.
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Chappell L.
Charles B.
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Chatar K.
Chatterton D.
Chaudhuri N.
Chauhan R.
Chawla V.
Chen F.
Cheng F.
Cherrie M.
Cheung E.
Cheyne C.
Chilcott S.
Chilvers A.
Chin K.
Chineka R.
Chinonso E.
Chisnall B.
Chiswick C.
Chivima B.
Chmiel C.
Chrisopoulou A.
Christian P.
Christides A.
Christmas D.
Church E.
Cianci N.
Cicconi P.
Clare E.
Clark E.
Clark G.
Clark J.
Clark L.
Clark R.
Clarke A.
Clarke R.
Clarke S.
Clay K.
Clayton-Smith J.
Cleaver C.
Clemente de la Torre C.
Clifford S.
Coakley M.
Cobain K.
Cochrane P.
Cocks S.
Coe A.
Coey D.
Cohen D.
Coker O.
Cole J.
Coleman G.
Coles H.
Collier D.
Collini Paul
Collins J.
Collins V.
Colton H.
Condliffe R.
Connell E.
Connell L.
Connelly K.
Connolly G.
Connor E.
Conroy K.
Conteh V.
Conway R.
Cook E.
Cooke G.
Cooke H.
Cooper D.
Cooper L.
Cooper N.
Cooray S.
Corbett C.
Corbishley A.
Cornwell J.
Corr A.
Corredera M.
Corrigan R.
Cosier T.
Coston C.
Cotterill D.
Coull A.
Courtney E.
Cowen L.
Cowman S.
Cox E.
Coy K.
Cradduck-Bamford A.
Crasta S.
Crause J.
Crawford A.
Crawford E.
Crawshaw S.
Creagh-Brown B.
Cremona J.
Cribb M.
Crichton C.
Crisp L.
Crisp N.
Crosby H.
Cross T.
Crotty S.
Cruickshank C.
Cruise J.
Cryans D.
Cui G.
Cui H.
Cummings-Fosong G.
Curran S.
Currie J.
Currie S.
Curtis K.
Curtis T.
Czylok P.
Daglish J.
Dalgleish H.
Dalton M.
Damm E.
Darbyshire Janet
Darnell S.
Darton T.
Das S.
Dasgin J.
Data Monitoring Committee of the RECOVERY Collaborative Group
Daunt A.
Dave V.
Davey M.
Davidson N.
Davies B.
Davies C.
Davies J.
Davies K.
Davies N.
Davies P.
Davies R.
Davis A.
Davis J.
Davis P.
Dawe C.
Dawson A.
Day Jeremy
de Fonseka D.
de Silva T.
De Soyza A.
de Vos J.
Dean K.
Deane J.
Dear J.
Deelchand V.
Deery J.
DeMets David
Denis E.
Dent M.
Denton E.
Denwood T.
Dermody S.
Desai A.
Deshpande S.
Dey P.
Dhaliwal K.
Dhani S.
Dhasmana Devesh J.
Dhillon R.
Dicks P.
Digby J.
Dimitri P.
Dismore L.
Ditchfield L.
Dixon C.
Dixon K.
Dobbie L.
Dobson C.
Dobson L.
Docherty M.
Dockrell D.
Dodds R.
Dodds S.
Dolan D.
Dolman M.
Donald L.
Donaldson D.
Donaldson K.
Donlon S.
Donohoe A.
Donohoe G.
Dosani M.
Dosanjh D.
Dowden L.
Dowling S.
Downey R.
Downs L.
Dowson S.
Drake C.
Drewett O.
Drogan H.
Drummond G.
Druryk K.
Du Thinh A.
Duckles-Leech H.
Duffield E.
Duffy H.
Duggan A.
Dummer S.
Duncan C.
Duncan F.
Duncan G.
Duncan R.
Dunleavy J.
Dunn A.
Duran B.
Durrans L.
Durrington H.
Duru I.
Dymond H.
D’Costa J.
D’Mello A.
Eades C.
Early J.
Eatough R.
Eddleston M.
Edgerley K.
Edmond N.
Edwards C.
Edwards J.
Ehiorobo L.
Ekoi M.
Elbeshy M.
Elenwa U.
Elgohary A.
Ellis C.
Ellwood A.
Elokl M.
Elsefi T.
Elyoussfi S.
Emberson Jonathan R.
Emms M.
Emond F.
Emonts M.
Essa F.
Evans B.
Evans G.
Evans M.
Evans R.
Everden C.
Everden S.
Evison L.
Ezenduka C.
Fairbairn I.
Fairclough A.
Falconer E.
Faluyi D.
Fancois V.
Farmery T.
Farooq H.
Farrell B.
Farzana S.
Fatemi A.
Fatemi M.
Faust S. N.
Faust Saul N.
Fearby S.
Felton T.
Fenlon K.
Fenn A.
Fenner I.
Fenton C.
Ferenando G.
Ferguson C.
Ferguson S.
Ferguson V.
Fernandez Lopez S.
Ferriman E.
Ferron S.
Fethers N.
Fielding J.
Finch S.
Fineman N.
Finn A.
Fiouni S.
Fisher J.
Fitzgerald F.
Flaherty J.
Fleming L.
Fletcher L.
Fogarty G.
Foot H.
Fordham I.
Forrest A.
Forster E.
Foster E.
Foster R.
Fowler Robert
Fowler S.
Fox A.
Fox C.
Fox S.
Frake R.
Francis S.
Frankland H.
Franklin J.
Franklin S.
Freeman H.
Freeman N.
Frise M.
Froud O.
Fullerton D.
G N.
Gabbitas E.
Gabriel C.
Gabriel Z.
Gale C.
Gale H.
Gallagher B.
Gamble L.
Gan C.
Garden E.
Gardiner P.
Gardiner S.
Garg I.
Garty F.
Gaughan E.
Geele F.
George B.
George S.
George V.
Georgiou D.
Gerdes L.
Gettings S.
Giannopoulou S.
Gibani M.
Gibb C.
Gibbison B.
Gibbons K.
Gibson A.
Gill L.
Gillesen A.
Gillian A.
Gilliland D.
Gillott R.
Gilmour K.
Gipson A.
Glasgow S.
Glover Bengtsson J.
Glynn S.
Gnanalingam C.
Godden E.
Godson E.
Goldacre R.
Goodall J.
Goodenough B.
Goodwin E.
Goodwin J.
Goonasekara M.
Gorsuch T.
Gosai J.
Gotham D.
Gould N.
Gould S.
Gourbault L.
Gowans S.
Gower H.
Graham J.
Grahamslaw J.
Grana G.
Grant A.
Grant D.
Gray A.
Gray G.
Gray J.
Gray K.
Grayson A.
Green A.
Green C.
Green Christopher A.
Green N.
Greene D.
Greenhalgh A.
Gregory K.
Greig J.
Gresty J.
Grey G.
Griffin B.
Griffin M.
Grobovaite E.
Groome R.
Grover H.
Grubb N.
Grundy J.
Guerin J.
Gureviciute A.
Gurung Rai S.
Gurung L.
Hackney P.
Hadfield D.
Hadfield S.
Haider N.
Haigh K.
Haile V.
Hainey S.
Hall A.
Hall C.
Hall E.
Hall J.
Hallas J.
Halls H.
Hamdollah-Zadeh M.
Hameed B.
Hamid I.
Hamilton G.
Hamilton M.
Hamilton S.
Hammans B.
Hammersley S.
Hammond S.
Hamoodi I.
Hampshire K.
Hampson L.
Hanci O.
Handrean S.
Handzewniak N.
Haney S.
Hanison E.
Hannington A.
Hanrath A.
Hanson A.
Hanson H.
Hanson J.
Hanson S.
Harden L.
Harding Z.
Hardman S.
Hargreaves C.
Harin A.
Harman T.
Harper C.
Harper H.
Harris J.
Harris M.
Harrison D.
Harrison M.
Harrison R.
Harrison S.
Harrod E.
Hartrey W.
Harvey A.
Harvey M.
Haslam J.
Hastings B.
Havinden-Williams M.
Hawker L.
Hayat A.
Haynes Richard
Hays C.
Haysom S.
Hazelton T.
Hazenberg P.
Headon E.
Health records (for the RECOVERY Collaborative Group)
Hector G.
Heddon S.
Henry J.
Henshall D.
Hernandez F.
Herrington W.
Heslop P.
Hester S.
Hey S.
Heywood J.
Hicks J.
Hicks S.
Higgins L.
Hill P.
Hilton J.
Hindle A.
Hindmarsh A.
Hine P.
Hird C.
Hobson S.
Hodgen L.
Hodgkinson S.
Hodgson H.
Hodgson S.
Hogg L.
Hoggett L.
Holden C.
Holdhof N.
Holland L.
Hollands M.
Holling N.
Holmes R.
Holt L.
Hope S.
Hopkins B.
Horby Peter W.
Horrobin C.
Horsley A.
Hough M.
Houghton C.
Houghton K.
Houlihan R.
Housely K.
How L.
Howard L.
Howard M.
Howard S.
Howard-Sandy L.
Howell A.
Howie L.
Hrycaiczuk J.
Htwe S.
Hudak A.
Hudson H.
Hughes G.
Hughes H.
Hughes S.
Hulbert R.
Hull D.
Hull R.
Hulme A.
Hulme P.
Hum R.
Hunt L.
Hunter E.
Hunter K.
Hunter N.
Hunter S.
Hurditch E.
Hurley K.
Hussain A.
Hussain S.
Hussain Y.
Hutchinson C.
Hutton P.
Hyslop M.
Ibrahim A.
Ibrahim M.
Ijaz M.
Ilyas F.
Ingham J.
Ingram T.
Ionita A.
Iqbal J.
Iqbal M.
Irons R.
Irving R.
Islam S.
Islim A.
Ismail O.
Iwanikiw S.
Jack C.
Jackman S.
Jackson B.
Jackson S.
Jacob J.
Jacob P.
Jacques N.
Jafar A.
Jagannathan V.
Jaime F.
Jaki Thomas
Jaly Y.
Jama R.
Jamal A.
Jamal S.
James L.
Jameson J.
Janes K.
Japp D.
Jarman C.
Jarvis C.
Jarvis R.
Jastrzebska P.
Jeebun V.
Jeffery Katie
Jeffreys N.
Jeffs B.
Jenkins P.
Jennings F.
Jennings V.
Jerry D.
Jimenez Gil A.
Johal S.
John A.
John M.
Johnson G.
Johnston B.
Johnston S.
Johnstone D.
Johnstone E.
Jones A.
Jones B.
Jones E.
Jones G.
Jones J.
Jones P.
Jones R.
Jones S.
Jones T.
Jordache R.
Jose S.
Joseph G.
Joseph R.
Josiah B.
Ju Wen Kwek A.
Judge P.
Juszczak Edmund
Kailey A.
Kalayi R.
Kamath P.
Kamfose M.
Kanabar D.
Kapoor R.
Karunaratne N.
Kaur J.
Kausar Z.
Kavanagh S.
Kay S.
Kayappurathu J.
Ke M.
Keating L.
Keddie-Gray E.
Kelly E.
Kelly R.
Kelly S.
Kendall E.
Kennedy A.
Kennedy M.
Keogan L.
Khan A.
Khan M.
Khan W.
Khatun T.
Khin H.
Khurana C.
Kibutu F.
Kidd M.
Kidney S.
Kim M.
Kimber A.
King A.
King J.
King S.
King-Oakley E.
Kirk J.
Kirkham E.
Kirkpatrick L.
Kitching T.
Kitto L.
Knight A.
Knight F.
Knight Marian
Knight S.
Knowles C.
Knowles L.
Koch O.
Koe Y.
Koirata A.
Kolakaluri E.
Kononen M.
Koo H.
Kosmidis C.
Kothandaraman E.
Koukou K.
Kountourgioti A.
Krasauskas K.
Krishnamurthy V.
Krizak S.
Krupej S.
Kudsk-Iversen S.
Kudzinskas A.
Kumar R.
Kurani A.
Kurdy M.
Kuriakose K.
Kyere-Diabour T.
Kyi N.
Labao J.
Lacson M.
Ladan Z.
Lagnado A.
Lalloo David
Lalloo F.
Lamb L.
Lamb T.
Landray Martin J.
Lane N.
Lang A.
Lang S.
Langley M.
Langoya C.
Lassa S.
Latham S.
Latham V.
Laurenson M.
Law H.
Lawless L.
Lawrence G.
Lawrence H.
Lawrie R.
Lay M.
Lazo M.
Le V.
Leach L.
Leandro L.
Lee S.
Lees D.
Legge H.
Leitch D.
Lemoine N.
Lennon K.
Levett C.
Levynska A.
Lewis H.
Lewis J.
Lewis K.
Lewis L.
Lewis N.
Liao A.
Lim Wei Shen
Linares C.
Lindergard G.
Lindsay M.
Lipscomb G.
Lipscomb K.
Little J.
Liu P.
Liu S.
Lloyd A.
Lloyd O.
Lo S.
Loader D.
Local Clinical Centre staff (for the RECOVERY Collaborative Group)
Lock S.
Locke T.
Lockett T.
Lodhia K.
Lofthouse M.
Logan M.
Logue C. A.
Lokanathan S.
Lomme K.
Looby L.
Lopez P.
Lord R.
Loro F.
Lovell M.
Low A.
Low S.
Lowe C.
Lowsby R.
Luintel A.
Luke H.
Luke J.
Lunn M.
Luo J.
Lye A.
Lyell B.
Lynch D.
Mabb H.
Macfarlane J.
Macfarlane L.
MacInnes L.
MacIntyre I.
Mackay L.
MacKenzie J.
Mackey A.
Mackintosh C.
Macmahon M.
MacRaild A.
Madden A.
Madeja N.
Mafham Marion
Magnaye L.
Maharajh A.
Mahaveer A.
Mahdi H.
Maheswaran A.
Mahmood W.
Mahmood Z.
Mahony E.
Mahungu T.
Mair L.
Majekdunmi T.
Majumdar Jaydip
Malein Flora
Mancinelli R.
Mandal S.
Manderson L.
Mandeville J.
Mane T.
Manso K.
Mansour M.
Marecka M.
Maren D.
Margabanthu G.
Margaritopoulos G.
Maria del Rocio F.
Mariano V.
Marks B.
Marks P.
Marriott C.
Marriott N.
Marsden P.
Marshall A.
Martin H.
Martin K.
Martin M.
Martinez Garrido J.
Maseda D.
Mashate S.
Masih S.
Masoli M.
Mathen S.
Mather N.
Mathew B.
Mathews J.
Mathioudakis A.
Matila D.
Matisa E.
Matkins E.
Matovu E.
Matthews C.
May P.
Mayanagao I.
Mayer J.
Mayo T.
Mazhani T.
McAlinden P.
McAndrew J.
McBrearty C.
McBride E.
McCafferty G.
McCann C.
McCarthy E.
McCorkindale A.
McCrae J.
McCullagh I.
McCullagh L.
McCullough K.
McCullough S.
McCurrach F.
McDermott J.
McDonald S.
McDonnell N.
McEleavy I.
McEvoy E.
McGhee C.
McGrath B.
McIntyre K.
Mckie H.
Mckie L.
McLachlan H.
McLarty N.
McLeish M.
McLure S.
McMahon G.
McMaster P.
McMillan N.
McMullen H.
McNeill C.
McNeill J.
McNelis U.
McNulty M.
McSorland D.
Mead J.
Meakin O.
Mears K.
Mediana A.
Medine R.
Meghani N.
Megson S.
Mehar A.
Mehra R.
Meiring J.
Melander S.
Mellor F.
Mellor Z.
Melville A.
Melville J.
Membrey H.
Mendonca C.
Mentzer A.
Meredith M.
Merron P.
Metcalfe B.
Metryka A.
Mew L.
Mguni N.
Miah N.
Micallef D.
Michalak N.
Michalec O.
Middle J.
Middleton J.
Middleton M.
Millard J.
Miller J.
Millett L.
Milligan H.
Millington K.
Millington S.
Millward H.
Minton J.
Mishra A.
Mishra B.
Mistry H.
Mital D.
Mitchell B.
Mitchelmore P.
Mitra S.
Moatt E.
Mohamed O.
Mohammed O.
Mok J.
Molina M.
Molloy A.
Monaghan H.
Monsell K.
Montasser M.
Montgomery Alan
Moon A.
Moon J.
Moonan M.
Moore F.
Moores R.
Morales J.
Moran L.
Moray G.
Morgan A.
Morgan L.
Morgan-Smith E.
Morilla J.
Morley W.
Morris L.
Morris P.
Morris S.
Morrison S.
Morrissey M.
Morrow A.
Moss S.
Moth G.
Motherwell N.
Moulton H.
Mounce G.
Mtuwa S.
Muazzam A.
Mudawi D.
Mulcahy M.
Mulligan S.
Mumford Andrew
Munavvar Mohammed
Munt S.
Murphy S.
Murray C.
Murray D.
Murray I.
Murray K.
Murray L.
Murthy M.
Mutch C.
Muzengi N.
Mwaura E.
Nafei M.
Nagarajan T.
Naglik L.
Naguib M.
Naicker K.
Naisbitt J.
Nandani A.
Nandwani T.
Nasa S.
Natarajan N.
Nathvani M.
Navarra H.
Naveed S.
Naz M.
Neal A.
Nelson B.
Nelson S.
Nethercott D.
Newby D.
Newman T.
Newport R.
Ng S.
Ngumo A.
Nicholas N.
Nicholas P.
Nickson I.
Nicol R.
Nightingale T.
Nilsson A.
Ninan P.
Nirmalan M.
Nixon J.
Nizam Ud Din K.
Noe H.
Norton R.
Nourein K.
Nunn K.
Nunn M.
Nunnick J.
Nurgat Z.
Nuttall A.
Nwajiugo P.
Oboh C.
Obukofe R.
Odam M.
Odedra K.
Odell N.
Offord P.
Ohia U.
Okeke T.
OKell E.
Oliver A.
Oliver J.
Oliver Z.
Oomatia A.
Oram R.
Oreilly C.
Osadcow A.
Osanlou R.
Osborne N.
Osborne R.
Osborne W.
Osei-Bobie J.
Oxlade R.
O’Brien R.
O’Callaghan C.
O’Connor G.
O’Donovan C.
O’Farrell S.
O’Riordan D.
O’Sullivan E.
Padden G.
Page I.
Page S.
Pagett K.
Pajak S.
Pakou G.
Palacios A.
Palfrey H.
Pandya T.
Panes A.
Pantin C.
Parambil V.
Parashar S.
Parekh A.
Parekh D.
Parker B.
Parker J.
Parker S.
Parkinson A.
Passby L.
Passey S.
Patachako J.
Patel M.
Patel P.
Patel S.
Patience A.
Patten S.
Patterson C.
Patterson L.
Pauls L.
Paulus S.
Payne B.
Payne E.
Payne R.
Peacock L.
Pearce J.
Pearson K.
Peasley A.
Peggie H.
Pelham C.
Penman C.
Penman J.
Penman R.
Percival R.
Perez E.
Periyasamy L.
Perry A.
Perry M.
Pessoa-Amorim Guilherme
Peters C.
Peterson A.
Peto Leon
Petrova B.
Pezard-Snell M.
Phelan P.
Philbin J.
Phillips N.
PI M.
Pick S.
Pickard J.
Pickering G.
Piercy C.
Pinches H.
Pine K.
Pinjala M.
Pitchford M.
Pleass R.
Plowright M.
Plumptre C.
Pomery F.
Poole L.
Porter D.
Porter L.
Potter A.
Potts J.
Poustie V.
Power N.
Poyner E.
Pradhan V.
Prady H.
Prasath S.
Pratt A.
Pratt S.
Preiss D.
Prest C.
Price A.
Price C.
Price D.
Price K.
Price L.
Price V.
Price-Eland R.
Priest A.
Prince C.
Pringle S.
Pristopan V.
Priyash V.
Prudon Benjamin
Pugh L.
Purdue C.
Purdy R.
Pursell M.
Purvis S.
Putensen D.
Pyart E.
Quek E.
Quigley J.
Quindoyos J.
Quinn T.
Rabinowicz S.
Rafique J.
Rahman M.
Rai S.
Raithatha A.
Rajasri A.
Ramanan A.
Ramasamy M.
Ramchandani A.
Ramirez J.
Rampling T.
Ramsay J.
Ramshaw A.
Rana G.
Rand J.
Rank H.
Rankhelawon R.
Rasheed A.
Ratcliffe S.
Raw J.
Razvi Z.
RECOVERY Collaborative Group
Redknap I.
Redman N.
Rees A.
Rees M.
Rees S.
Rehman Z.
Reilly M.
Reith C.
Renshaw S.
Rey S.
Reynard C.
Reynolds H.
Rhodes J.
Rice E.
Rice M.
Rice N.
Richardson E.
Richardson N.
Rigby L.
Riley M.
Riley P.
Ripley D.
Rishton C.
Riste M.
Ritchings A.
Rivera Ortega P.
Robbins E.
Roberts V.
Robertson C.
Robertson J.
Robertson N.
Robinson J.
Robinson L.
Robinson S.
Robson S.
Roderick M.
Rodger A.
Rodgers A.
Rodgers N.
Rodgers P.
Roehr C.
Rogers J.
Rogers S.
Rogers T.
Rook C.
Rooney L.
Rosby E.
Rose A.
Rose Z.
Ross I.
Rothman A.
Rothwell J.
Roughley L.
Rowan Kathryn
Rowan N.
Rowe A.
Rowe N.
Rowley M.
Rudenko A.
Rule R.
Rushmer J.
Ryan A.
Ryan L.
Ryan P.
Rybka E.
Ryder S.
Salberg A.
Saleh M.
Salih H.
Salman R.
Salmon R.
Sam M.
Sam S.
Saminathan S.
Sammons E.
Sammut D.
Sampson J.
Samuel M.
Samuel Y.
Sanchez Gonzalez A.
Sanchez V.
Sandercock Peter
Sangombe M.
Sanju M.
Santosh R.
Sarfatti A.
Sarkar R.
Sarwar Z.
Sathyanarayanan L.
Saunderson A.
Scaletta D.
Scanlon D.
Scarratt L.
Scattergood S.
Schadenberg A.
Schafers J.
Schneblen W.
Schofield E.
Schumacher N.
Schunke N.
Scobie A.
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Publication venue: Nature Publishing Group
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Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

Author: Aarøe Jens
Abbass Hakam
Abella-Ovalle Luis
Adam Zul
Agyemang Michael
Ahlehof Ole
Ahlehoff Ole
Ahmad Yousif
Al-Lamee Rasha
Alberdi Lucía
Aleti Shilpa
Ali Danish
Allen Kezia
Alvares Wilson
Alzuhairi Karam
Amed Nadifa
Anantharam Brijesh
Andersen Grethe
Andersen Henning Rud
Anderson Michelle
Andiapen Mervyn
Andrews Michelle
Ankersen Jens Peter
Ansell Valerie
Arango Amalia
Armstrong Elissa
Astarci Josenir
Atkinson Emma
Austin Rosalynn
Avanzas Pablo
Aziz Ahmed
Azkhalil Mohammed
Bales Emily
Banerjee Prithwish
Barclay Justin
Barker Deborah
Barker Joann
Barmby David
Bates Rachel
Baucutt Karen
Been Martin
Beirnes Charmaine
Bell Sheila
Bennett Amy
Bennett Lorraine
Bernardo-Alba Pablo
Berry Alan
Berry Colin
Besana Rissa
Bhatre Gurbir
Bhatti Rishma
Bidle Amanda
Bijsterveld Petra
Bose Tuhina
Boyle Georgina
Brady Rebecca
Braybrook Christine
Breeze Jonathan
Brennan Oliver
Brett Sarah
Brogan Richard
Brown Janette
Bucciarelli-Ducci Chiara
Buchanan Louise
Buelga-Díaz Covadonga
Bueno Hector
Bulluck Heerajnarain
Burd Amanda
Burnett Gillian
Burtonwood Natalie
Burunsuzoglu Senem
Butler Robert
Butler Robert
Byrne Jean
Bøtker Hans Erik
Capel Robert
Cappelen Helle
Carruthers Gayle
Carstensen Steen
Castro Rafael
Champney Felicity
Chant Nicholas
Charles Thabitha
Chester Emma
Chong Jun
Christensen Erika Frischknecht
Christiansen Evald Høj
Christiansen Martin Kirk
Christmas Natasha
Chu Rebecca
Chung Alan
Cimas Teodorna
Clapp Brian
Clare Thomas
Clarke Millie
Clayton Tim
Clifford Piers
Cockayne Laura
Colicchia Martina
Collier Lucy
Cooper Theresa
Copas Andrew
Copestick Jane
Corps Ellie
Corrigan Julie
Cottam Victoria
Cotton James
Coward Paul
Cox Emily
Crause Jacolene
Cruden Nick
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Cunnington Michael
Cuxton Josephine
Dana Ali
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Darby Damaris
Davies John
Davies Justin
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de Cima Sara
de la Hera Galarza Jesus Maria
de la Roz Manuel
De Mance Gianluigi
De Sousa Phillipa
Deen Zakhira
del Valle Raquel
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Denman Joanne
Dias Priyanthi
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Thambi Sunil
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Thygesen Kristian
Tilsted Hans Henrik
Tipping Aoife
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Tomlinson Sharon
Topic Dragan
Tresguerres Jose M.
Turner Charlotte
Turner Jenny
Turney Sharon
Upton Robert
Uscumlic Ana
Van Dyck Laura
Varma Madhusudhan
Varma Madhusudhan
Veerapen Jessry
Vega-Fernández José L.
Vegas-Valle Jose M.
Veien Karsten
Venugopal Vinod
Vertue Mark
Victor Saji
Villadsen Anton Boel
Villanueva María J.
Villar-Fernández Lara
Vinagrero María S.
Viribay Fernando M.
Vlad Ionela
von Weitzel-Mudersbach Paul
Vukcevic Vladan
Vázquez-Suárez María
Waddington Natalia
Wain Jill
Waitrak Paulina
Waldron Molly
Wallace Lauren
Walshe Siobhan
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Weatherlley Louise
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Webb Ian
Wells Nicki
Westwood Mark
Wheeldon Nigel
Whitehead Helena
Whiteside Charlene
Wilkinson Conor
Wilson Karen
Wittrock Daniel
Wolyrum Mathias
Woods Sarah
Wragg Christopher
Yellon Derek M
Publication venue: 'Elsevier BV'
Publication date: 01/01/2019
Field of study

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

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Thigh-length compression stockings and DVT after stroke

Author: Abbas M
Abbasi S
Abbasi S
Abdelaziz A
Abdelfattah M
Abdul B
Abdulmumeen A
Abdulshukkoor N
Abdusamad K
Aboaba A
Abouibrahim M
Abraham M
Abraham T
Abrams J
Abung A
Acharya D
Acharya D
Acheson J
Acosta A
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Acton C
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Adamus M
Adegoke K
Adenwalla S
Adeyeye E
Adnan A
Agbo C
Aggarwal S
Agwada-Akeru J
Agyapong K Ansu
Ah-Chuen J
Ahmad M
Ahmed I
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Ahmed L
Ahmed L
Ahmed M
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Ahmed N
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Ahmed R
Ahmed RA
Ahmed S
Ahmed S Haris
Ail D
Ainsley A
Ainsworth M
Aitken L
Ajibode A
Ajmi A
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Akhtar N
Akili S
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Ambler S
Ambrogetti R
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Zulaikha R
Zullo C
Publication venue: 'Elsevier BV'
Publication date: 01/07/1994
Field of study

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

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Mapping the human genetic architecture of COVID-19

Author: Abdelrazik M.
Abdullah T.
Abe R.
Abe S.
Abecasis G. R.
Abel L.
Abernathy C.
Abraheem A.
Abul-Husn N. S.
Acosta-Herrera M.
Acquilini D.
Adachi T.
Adachi Y.
Adams C.
Adams K.
Adanini O.
Adeleye O.
Adeniji K.
Adra D.
Afifi N.
Afilalo J.
Afilalo M.
Afolabi D.
Afrasiabi Z.
Afset J. E.
Agasou A.
Aghemo A.
Agranoff D.
Agrawal S.
Aguirre L. A.
Agwuh K.
Ahmad H. F.
Ahmad N.
Ahmed A.
Ahmed C.
Ahmed K. A.
Ai M.
Ail D.
Akeroyd L.
Akhtar M. N.
Akhtar S.
Akinkugbe O.
Aksentijevich A.
Al Thani A.
Al-Muftah W.
Al-Sarraj Y.
Alarcon C.
Alarcon-Riquelme M. E.
Alasdair F.
Alaverdian D.
Alavere H.
Albertos R.
Albillos A.
Albrecht W.
Albrich W.
Albrich W. C.
Aldera E. L.
Aldridge J.
Alegria A.
Alex B.
Alexander P.
Alfonso J.
Algera A. G.
Ali A.
Ali I. A. M.
Ali S.
Aliberti S.
Allan A.
Allan E.
Allan J.
Alldis Z.
Allen L.
Allen S.
Allibone S.
Allison K. S.
Allos R.
Ally S. M.
Almaden-Boyle C.
Altabaibeh A.
Altmuller J.
Alvaro A.
Amar D.
Amin V.
Amitrano S.
Amiya S.
Ampuero J.
Anan R.
Anania S.
Anastasescu E.
Anderson F.
Anderson J.
Anderson M.
Anderson P.
Anderson S.
Anderson S.
Anderson T.
Ando A.
Andolfo I.
Andrade V.
Andretta F.
Andreucci E.
Andrew A.
Andrew B.
Andrew G.
Andrews E.
Andrews S. J.
Andrikopoulos P.
Anedda F.
Aneli S.
Anemoli V.
Angelini C.
Angus B.
Ann Belli M.
Annis A.
Antcliffe D.
Antinori A.
Antoni M. D.
Anumakonda V.
Anwar M.
Anzai T.
Apetri E.
Arai D.
Arana E.
Arbane G.
Archer K.
Arciero E.
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Zak A.
Zaki A.
Zambon M.
Zamikula J.
Zanella A.
Zanella I.
Zanelli G.
Zara F.
Zarate R.
Zborowski A. C.
Zeberg H.
Zechner M.
Zguro K.
Zhai R.
Zhang M.
Zhao J. H.
Zhen J.
Zheng C.
Zheng T.
Zhou W.
Zhu W.
Zitter L.
Zlatopolsky M.
Zoller H.
Zollner S.
Zongo O.
Zucchi P.
Zyndorf M.
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2021
Field of study

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

Archivio istituzionale della ricerca - Politecnico di Milano

Archivio della ricerca - Università degli studi di Napoli Federico II

Archivio della Ricerca - Università degli Studi di Siena

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Archivio istituzionale della ricerca - Università di Genova

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Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Archivio istituzionale della ricerca - Università di Padova

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Author: Abdelrazik M
Abedalthagafi M
Abel L
Abel L
Abellan J
Abernathy C
Abraheem A
Acklery A
Acosta-Isaac R
Adam R
Adams C
Adams K
Adams N
Adanini O
Afolabi D
Agasou A
Agravante K
Agravante K
Agrawal S
Aguado JM
Aguilar C
Aguilar PM
Aguilera-Albesa S
Ahmad N
Ahmadhaider N
Ahmed A
Ahmed C
Aitkin E
Akeroyd L
Akhtar MN
Akinkugbe O
Al-Moasseb H
Alasdair F
Alba J
Albu S
Alcalá-Gallardo KAM
Alcoba-Florez J
Aldridge J
Alex B
Alexander P
Alfonso J
Algarin-Lara HR
Ali A
Ali HH
Ali IAM
Ali S
Allan A
Allan E
Allan J
Alldis Z
Allen L
Allen M
Allen S
Allibone S
Allison KS
Ally SM
Almadana V
Almaden-Boyle C
Almeida J
Almoguera B
Alonso MR
Altabaibeh A
Alvarez N
Alvaro A
Alves MDM
Amamio M
Amamio M
Amin V
Anastasescu E
Anderson J
Anderson M
Anderson P
Anderson S
Anderson S
Anderson T
Andreou P
Andreu-Bernabeu Á
Andrew A
Andrew B
Andrew G
Andrews J
Andrikopoulos P
Antcliffe D
Antoine P
Antonijoan MR
Antony S
Anumakonda V
Anwer M
Apetri E
Aquino M
Arana-Arri E
Aranda C
Arango C
Araque C
Araujo IMT
Araujo NK
Aravindan L
Arbane G
Arcanjo AC
Archer K
Arden T
Arias SS
Arif S
Armistead J
Armstrong D
Armstrong L
Armstrong R
Arnaiz A
Arnott A
Arora M
Arranz MJ
Artiga M-J
Ashby K
Ashok SR
Ashraf S
Ashton L
Aslibekyan S
Astin-Chamberlain R
Atayeva N
Attwood B
Atwal I
Auld F
Austin K
Austin P
Auton A
Avello-Malaver Y
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Ayuso C
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Badal B
Baddeley A
Bafitis V
Baikady RR
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Baillie JK
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Bamford A
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Conejo IP
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Álvarez-Navia F
Íñiguez M
Publication venue: Springer Nature
Publication date: 17/05/2023
Field of study

Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability: Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)

Brunel University Research Archive

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abbas M
Abbasi S
Abbasi S
Abdelaziz A
Abdelfattah M
Abdul B
Abdulmumeen A
Abdulshukkoor N
Abdusamad K
Aboaba A
Abouibrahim M
Abraham M
Abraham T
Abrams J
Abung A
Acharya D
Acharya D
Acheson J
Acosta A
Acosta A
Acton C
Adam M
Adams C
Adams K
Adamus M
Adegoke K
Adenwalla S
Adeyeye E
Adnan A
Agbo C
Aggarwal S
Agwada-Akeru J
Agyapong K Ansu
Ah-Chuen J
Ahmad M
Ahmed I
Ahmed I
Ahmed L
Ahmed L
Ahmed M
Ahmed M Cecilia
Ahmed N
Ahmed N
Ahmed R
Ahmed RA
Ahmed S
Ahmed S Haris
Ail D
Ainsley A
Ainsworth M
Aitken L
Ajibode A
Ajmi A
Ajmi A
Akhtar N
Akili S
Akindolie O
Al Balushi A
Al-Asadi A
Al-Hakim B
Al-Jibury M
Al-Rabahi A
Al-Ramadhani B
Al-Shamkhani W
Al-Sheklly B
Alam S
Aldana A
Aldouri R
Aldridge N
Alegria A
Alexander A
Alexander J
Alexander PDG
Ali F Runa
Ali M
Ali O
Ali S
Ali S
Ali S
Alkhusheh M
Alkhusheh M
Allanson A
Allen L
Allen R
Allen S
Allison K
Allsop L
Alomari L
Alzetani M
Ambler S
Ambrogetti R
Ambrose C
Amezaga M
Amin A
Amosun V
Amosun V
Amsha K
Anand A
Anderson J
Anderson L
Anderson N
Anderson R
Andreou P
Andrews A
Andrews J
Aneke K
Ang A
Angel T
Antill P
Antonina Z
Anu V
Appleby S
Appleyard D
Archer A
Ardley C
Arimoto R
Arkley C
Armah C
Armstrong C
Armstrong S
Armtrong P
Arnison-Newgass C
Arora D
Arter A
Arter A
Asghar A
Ashbrook-Raby C
Ashish A
Ashish A
Ashraf S
Ashton D
Asrar A
Assaf O
Astin-Chamberlain R
Athorne D
Atkinson J
Atkinson V
Aubrey P
Aung K Thu
Aung N
Aung Z Myo
Austin E
Avery M
Avram C
Awadzi G
Aya A
Ayaz E
Azam J
Aziz G
Azzopardi G
Babatunde F
Babi M
Babi M
Babingto G
Babs-Osibodu A Obaloluwa
Bacon G
Bacon J
Bacon J
Bagley G
Bahadori K
Baijiu G
Bailey K
Bailey K
Bailey L
Baillie H
Baillie JK
Baillie JK
Baillie K
Baird D
Bajandouh A
Baker E
Baker-Moffatt M
Bakoulas P
Balachandran N
Balachandran N
Balan A
Balaskas T
Balasubramaniam M
Balcombe A
Baldwin A
Baldwin D
Baldwin L
Balfour J
Ball C
Bamfo S Danso
Bamford A
Bamford A
Bamford P
Bamgboye A
Bancroft H
Banda J
Bandi S
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Bandla N
Bandyopadhyam S
Bandyopadhyam S
Banerjee R
Banerjee S
Banks H
Banks L
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Bannister O
Baptist M
Baqai T
Barclay A
Bari S
Barker D
Barker J
Barker L
Barker-Williams K
Barla J
Barla J
Barlow G
Barnard A
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Barr D
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Bartlett C
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Barton J
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Baryschpolec S
Bashyal A
Basker B
Basoglu A
Bassoy B
Basumatary A
Bataineh A
Bateman K
Bates M
Batha R
Batham S
Batla A
Batra D
Batty H
Batty T
Batty T
Bax S
Bax S
Baxter M
Bazaz R
Bazli A
Beacham L
Beale A
Beaver T
Beavis S
Beckett V
Beddall H
Beddows S
Beeby D
Beer S
Beety J
Beghini S
Begum S
Behrouzi R
Belcher J
Belfield K
Belgaumkar A
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Bellamy M
Bendall L
Benesh N
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Benison-Horner G
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Bennett A
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Bentley A
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Beresford M
Bergin C
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Best K
Beuvink Y
Bexhell H
Bhadi A
Bhakta S
Bhalla R
Bhalme M
Bhandal K
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Bhatia N
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Bhojwani D
Bhuiyan S
Bhushan A Kala
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Biggs S
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Bird S
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Blazeby J
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Bloom B
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Bobruk K
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Boehmer G
Bokhari S
Bokhari S
Bokhari S Owais
Boles A
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Borra C
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Boult Z
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Boyapati G
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Brandl-Salutz E
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Brewer C
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Bruce D
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Bruce M
Bruce M Schuster
Brudlo W
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Butterworth-Cowin N
Buttery R
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Buttress D
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Byrne W
Byrne-Watts V
Cade R
Cadwgan A
Calderwood C
Callaghan J
Callens C
Calver C
Cameron F
Cameron S
Camm C
Cammack RFD
Campbell A
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Cann J
Cannan R
Cannon E
Cannon M
Cantliff J
Capp A
Capstick T
Carmody M
Caroline C
Carrington Z
Carter J
Carter P
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Carty C
Cassimon B
Caswell M
Catana A Maria
Cate H
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Chandler KJ
Chandrasekaran B
Chaplin J
Chapman G
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Chappell L
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Charalambou A
Charles B
Charlton D
Chatar K
Chaudhary M Yafaa Naveed
Chaudhry I
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Chauhan A
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Chauhan R Singh
Chavasse N
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Chen F
Chen H Min
Chen T
Cheng L Yin
Cheng Z
Chengappa A
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Cheung C Kay
Cheyne C
Chhabra S
Chicano R
Chimbo P
Chin K
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Colton HE
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Contingency DHSC Med Supply
Convery R
Conway G
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Coombs C
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Craig V
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Crichton C
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Cross T
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Croysdill R
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Cunliffe V
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D Gilliland
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Davey M
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de Fonseka D
de la Torre C Clemente
de Silva T
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del Rocio F Mendoza Maria
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Depala D
Dermody S
Desai A
Desai P
Dey P
Dhaliwal K
Dhani S
Dhanoa A
Dhar M
Dhillon E
Dhillon R
Dhillon R
DHSC Dept Hlth Social Care
Diaz A Sobrino
Diaz-Pratt K
Dicks P
Dickson M
Dimitri P
Din K Nizam Ud
Dirmantaite L
Diver S
Divikar N
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Dixon C
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Donald L
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Donnelly C
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dos Reis I Ponte Bettencourt
Dosanjh D
Dowden L
Dowling S
Downe H
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Dragan C
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Dube H
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Duff N
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Dufour L
Duggan A
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Dugh P
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Duncan B
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Dunn A
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Dunphy A
Duraiswamy V
Duran B
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Durrington H
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Foo A
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Zinyemba V
Zipitis C
Zmierczak A
Zuhra N
Zulaikha R
Zullo C
Publication venue: 'Elsevier BV'
Publication date: 01/02/2021
Field of study

Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research

University of Liverpool Repository

Spiral - Imperial College Digital Repository

Presentation, care and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.

Author: Abdekader R
Abdelhameed M
Abdelhamid M
Abdelmottaleb W
Abdin A
Abdrabou M
Abid L
Abraham J A
Abraheem A
Abras M
Adam C
Adamyan M
Adel M
Adlam D
Aerts S
Affleck D-C
Afsar A
Ageev F
Aguiar C Tavares
Ahangari F
Ahmad W A Wan
Ahmad Wan Azman Wan
Ahmed A
Ahmed A
Ahmed F
Ahmed I M
Ahmed S
Ahmed S Waqar
Ailoaei S
Akgun A
Akhmatova F
Akhtar N
Al Mahmeed W A R
Al-Kinani T
Al-Mashari S
Al-Obaidi F
Al-Riyami A
Al-Riyami H
Al-Zaidi M
Alegre O
Alemzadeh-Ansari M J
Aleti S
Algamal H Mahrous
Alhussein F
Ali A
Ali H Hameed
Ali M
Ali M
Ali T
Ali Y
Alla M Dafa
Almeida A Rocha
Almeida I
Almeida S
Almubarak E
Almyahi M Hashim
Alrahimi J
Alsina M
Altaher S
Altinier A
Alvarado K
Alyavi A
Alyavi B
Alyavi Baxrom
Amadi C
Amber K
Ambroziak M
Amen S
Amirov B
Andrade L A Fajardo
Andrei C-L
Aneel A
Anguita M J Fernandez
Anselmi M
Antonijevic J
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Marcinkeviciene J
Marin F
Marin L A Martinez
Marinkovic M
Marino M
Marinoski T
Marinskiene J
Marjeh Y Bani
Markovski R
Marsden K
Martin K
Martin M D
Martin R
Martinez L
Martinez-Basterra J
Martinovic S Salinger
Martins V
Maruri R
Maruthanayagam R
Masoumi G
Massey I
Massoz M
Masumoto A
Mateo V Martinez
Matias F
Matic D
Matskeplishvili S
Matsukawa R
Matthews I G
Mavuri M
Maxian R
Maximov D
Mayedah R
Mayne D
Mbakwem A
Mccarrick A
Mcdonald J
Mcdonald S
Mcgee C
Mcgill Y
Mcleod A
Meder B
Mellows K
Meloni L
Mendes D Espregueira
Mendes M
Mendonca C
Meray I
Mercea S
Merella P
Merlo M
Mgazeel F
Micklewright L
Middle J
Mielniczuk M
Mihajlovic M
Mijatovic Z
Mila L
Milasinovic Dejan
Milasinovic Dejan
Milkas A
Mills H
Milosevic A
Mimoso J
Miranda H
Mirrakhimov E
Mirrakhimov Erkin
Mitchell M
Mitic V
Mitre A
Miyoshi Y
Mizia-Stec K
Mkhitaryan S
Mocilnik M
Mohamed A
Mohamed Awad
Moisi M
Mojsovska V
Mondo C
Mongiardo A
Monteil B
Monteiro C
Monteiro P
Monteiro S
Monteiro Silvia
Montisci R
Moreno G
Morgan M
Moris C
Morisco C
Mornos C
Moscalu V
Mostafa A
Mostafa A Magdy
Mosteoru S
Mota P
Mota T
Motherwell N
Mougenot E
Moura A R
Mouret J-P
Mpatsouli A
Mshengu E
Muderrisoglu H
Mujaric E
Mujovic N
Mujtaba M Shaikh
Mulla A Al
Munoz C Gallego
Munt S
Murataliev T
Murray V
Musija E
Mussida M
Nadar S K
Nadar Sunil K
Nadarajah Ramesh
Naessens S
Nageh T
Nagy K V
Nagy K V
Nagy K V
Nair R
Nakad G
Navickaite A
Nawrotek B
Neale T
Nedoshivin A
Nedoshivin A
Negahban A Q
Neglia D
Neiva J
Nejjari M
Nembhard S
Neykova A
Nicholson A
Nickenig G
Nicolas-Franco S
Nikitin I
Nikojajevic I
Nilsson A
Nishino S
Nizam S U
Noori F
Noorzadeh M
Novas V
Novitskii N
Novo G
Nowotta F
Ntoliou P
Nédio M
Obaid D
Obradovic I
Oginetz N
Ojeda F Bosa
Oksul M
Oliveira I
Oliveira M
Omar Z
Omelanczuk-Wiech E
Oney S
Oommen A
Opolski G
Opris D
Oprita O C
Oronsaye E
Ortega J
Orvin K
Orvin Katia
Osmanagic A
Paczynska M
Padron A Lara
Pais G
Pais J
Pamias R Freixa
Panoulas V
Pantic T
Papadaki S T
Papadopoulos C
Papaioannou S
Pape A Le
Papoutsaki E
Parati G
Paravati V
Parker E
Parkinson V
Parzakonis N
Pascalau L
Pascual I
Pasquet A A
Paterson P
Patialiatos T
Pavan D
Peachey T
Pejkov H
Peluso A
Pendlebury C
Peovska I Mitevska
Pereda D Cordero
Perez L E
Perez-Lopez C M Bianchi
Perkan A
Perret T
Pesl L
Peters G
Petit F
Petrescu L
Petridou M
Petronio A-P
Petronio A-S
Petrovic M
Philippart R
Philippe F
Philippe François
Phillips H
Phillips S
Picarra B
Pierard S
Pietila M
Pilalidou A
Pilkiene A
Pinchuk T
Pinto P
Pipertzi A
Pippard L
Piquart A
Pisaryuk A
Pitt-Kerby T
Pleskovic A
Pllaha E
Plugaru A
Poghosyan H
Poghosyan K
Poh K-K
Pojskic B
Pojskic L
Polimeni A
Ponomareva E
Pop D
Pop-Moldovan A L
Popescu B A
Popescu M Ioachim
Popescu R A
Poposka L
Popovic B
Popovici I
Popovici M
Popovici Mihail
Porter J
Potapov P
Potepa M
Potpara T
Pourbaix S
Poznic N Glavnik
Prendergast C
Prescott E
Preston S
Price A
Price C
Prieur F
Prior P
Prokopczuk J
Prota C
Pruszczyk P
Przybylo P
Pupic L
Pustjens T
Pylarinou V
Qamar N
Qamar Nadeem
Quaino G
Queiroz P
Queirós C
Quesada D
Quesada Daniel
Quinn J
Quintana R Bangueses
Rabacal C
Radano I
Radovanovic M
Radovanovic Mina
Radzhapova Z
Raj R
Rajeeb A
Ramanauskaite D
Ramani F
Ranc S
Rand J
Rasool B
Razmoski D
Read P
Rebic D
Rechcinski T
Reddington S
Redfearn H
Redkina M
Redzepovic A
Reed F
Regan S
Reis J
Reis L
Renders F
Resic N
Ressencourt O
Revenco V
Rezek M
Reznik E V
Reznik Elena Vladimirovna
Rezun M
Richards S
Riegler L
Rinaldi M
Rincon L M
Rio S
Ripley D P
Ristovski V
Rivera-Caravaca J M
Rivers V
Roberts K
Roberts S
Rocha A R
Rocsoreanu A
Rodriguez O Alcalde
Rodriguez S O Rosillo
Rodríguez-López J
Roger M-P
Rogers P
Rogozhina A
Roik M
Roleder T
Roman C
Romero J
Roohafza H
Roos-Hesselink J W
Roos-Hesselink J W
Rosa S Aguiar Oliveira
Rossello F J
Rossetto L
Rowe K
Roy N
Roy R Sagar
Rudzik R
Ruiz A Bardají
Ruiz A Carol
Runnett C
Rus M
Ruschitzka F
Russell M
Ruzicic D
Ruzsa Z
Ryabov V
Ryczek R
S R
Saad A
Sabanoglu C
Sacha J
Sachpekidis V
Sadeghi M
Sadeghipour P
Sadeghipour Parham
Saghir T
Sagirashvili E
Sakalidis A
Sakalyte G
Sakellaropoulou A
Salarifar M
Salikov A
Salkauskaite A
Sallam S
Sambola A
Samborski S
Samir A
Samir A
Samir A B
Samoila N
Sanmartin M
Santos A P
Santos A R
Santos H
Santos M
Sanz-Girgas E
Saraiva F
Sarrafzadegan N
Satendra M
Sauguet A
Savic L
Savvidis M
Saw K
Scaletta D
Scardino C
Schaubroek H
Schelfaut D
Schuh-Eiring T
Schumacher N
Sedaghat A
Sekerci S Sert
Selas M
Selimovic H
Semenka J
Semu T
Sen TANER
Senesael I
Seoane-Garcia T
Sepkhanyan M S
Serdarevic N
Serpytis R
Shafeie M
Shaheen S M
Shaimaa A Al
Shaker A Foad
Sharma S
Shebzukhova M
Sheikh U
Sherwood M
Shetty R
Shevchenko I
Shitaya K
Shokry K
Shokry Khaled
Sia C-H
Silinskiene D
Silva G
Silva L
Silvestrova G
Simbelyte T
Simon C
Sinagra G
Sinan U Y
Sinanis T
Sinanis Theodoros
Sindelarova S
Sinescu C-J
Singh R
Sinha A
Sinha Ajay
Sinnaeve F
Sionis A
Siswanto B B
Sitar J
Skantzis P
Skuladottir F Bjork
Smith J
Smith J
Smith S
Snepvangers M
Sobkowicz B
Sobolewska J
Sola N Basterra
Somers V
Somkereki C
Sonego E
Sorici G
Sorrentino S
Sosnowska-Pasiarska B
Sotelo L Rodriguez
Sousa C
Spaccarotella C
Spagnolo C
Spica G
Spychaj J-C
Srinivasan M
Ssemanda S
Stables R
Stachura J
Staigyte J
Stamatiadis N
Stankovic M
Stanojevic D
Staroverov I
Steblovnik K
Stimjanin E
Stirrup J
Stolbova S
Storey R F
Strisciuglio T
Strong C
Styliadis I
Subo A
Subotic I
Sugi K
Sukhinina T
Summerhayes A
Summers-Wall J
Surmeli A O
Sus I
Sustersic M
Sut M
Sutton J
Szastok H
Szygula J
Szyszkowska A
Tadevosyan M
Taha H Salah Eldin
Taleska B Zafirovska
Taneja A
Tapia V
Tasar O
Tasnic M
Tavares J
Taylor B
Taylor T
Tchetche D
Teimouri-Jervekani Z
Tello-Montoliu A
Temple N
Ten Berg J
Teterina M
Theobald T
Thomas C
Thomas H E
Tibaut M
Tierney C
Timiras E
Timóteo A T
Tomoaia R
Tomulic V
Tonks L
Toohie J
Torbica A
Torres S
Torromeo C
Torun A
Totladze L
Toulgaridis F
Tousek F
Trajkovic M
Tralhão A
Trim F
Tripathy N
Tsinopoulos G
Tsognemekh B
Tuncay B
Tupare S
Turnbull A
Turner A
Turner V
Turney S
Tutic M
Twiss S
Tycinska A
Tyrovolas K
Tzanis G
Tzifos V
Tzvetkov B
Upegui M P Tobon
Uscumlic A
Usmiani T
Utku O
Uttley A
Uuetoa T
Uulu E Sultan
Uzokov J
Vahanian A
Vailati L
Van Caenegem O
Van de Werf F
Van Den Buijs D
Van'T Hof A
Vardanyan A
Vargas C Mendez
Varlot J
Vavlukis M
Vecherko V I
Vendrametto F
Vervaet P
Ververeli C-L
Vesic O
Vidal P
Vinod M
Virbickiene A
Viswanathan G
Vizel R
Volcescu A
Volkova A L
Vorobeva D
Vucic R
Wain J
Wajid I
Walker R
Wallentin L
Wanda I
Ward T
Warda H M
Watkin R
Weferling M
Weidinger F
Weidinger F
Wells K
Wells T
Wester A
Weston C
Whyte A
Widdows P
Wiklo K
Wilkinson A
Wilkinson V
Williams F
Williams M
Wilmshurst N
Wilson A
Wolter J-S
Wouters S
Wray G
Wren L
Wright J
Wybraniec M
Xuereb R G
Xuereb Robert George
Xuereb S
Yadangi S
Yagmur B
Yanes G
Yaseen I F
Yashoman M
Yildirim C
Yildiz Ö
Yin D Chan Pin
Yonis A
Young E
Zachoval C
Zagnoni S
Zahran A
Zaliunas R
Zamorano J L
Zapata P Sanchez
Zaputovic L
Zateyshchikov D
Zeren G
Zeymer U
Zeymer U
Zhanyshbekova N
Zhukova N
Zibounoumi N
Zimbakov Z
Ziubryte G
Ziyrek M
Zlatic N
Zubova E
Zventsova V
Zvizdic F
Publication venue: 'Oxford University Press (OUP)'
Publication date: 03/02/2023
Field of study

Kütahya Health Sciences University Research Information System