76 research outputs found
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
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- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
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- Bayliss Pauline
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- Bell Jo
- Bell Murdina
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- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
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- Blank Catrin
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- Board Sarah
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- Buckle Steve
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- Chandrakumar Aberami
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- Chapman Nicola
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- Chopra Neha
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- Cunningham Mishell
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- Dennis Martin
- Dennis Martin S
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- Doherty Mandy
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- Doyle Donna
- Drever Jonathan
- du Plessis Johann C
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
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- Durairaj Ramesh
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- Edwards Mandy
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- Epstein Daniel
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- Esisi Bernard
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- Esson Derek
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- Evans Sue
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- Finlay Sarah
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- Fitzsimmons Paul
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- Fletcher Jo
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- Foote Leanne
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- Fotherby Ken
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- Fraser Ruth
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- Gleave Laura
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- Halse Omid
- Handley Dominic
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- Haque Mohammad
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- Harrison Thomas
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- Hedstrom Amanda
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- Howcroft Deborah
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- Huang Xuya
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- Hughes Tom
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- Humphries Fiona
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- Hunt Nicholas
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- Hunter Neil
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- Hurley Jennifer
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- Hutchison Aidan
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- Hyatt Lisa
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- Iqbal Arshi
- Iqbal Mohammad Shazad
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- Ivatts Simone
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- Jackson Linda
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- Jagpal Baljit
- James Ali
- James Claire
- James Martin
- Jarapa Rowilson
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- Jelley Benjamin
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- Jennings-Preece Karla
- Jeyaraj Naomi
- Jha Ratneshwari
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- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
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- Kalathil Latheef
- Kalladka Dheeraj
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- Krishnamoorthy Shrivakumar
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- Kumar Balakrishna
- Kumar Pradeep
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- Langhorne Peter
- Lasserson Daniel
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- Law Zhe
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- Lerpiniere Christine
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- Lowe Gordon
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- Maanoosi Mehran
- Maatouk Ahmad
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- MacInnes Brian
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- MacLeod Mary
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- MacRaild Allan
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- Maguire Holly
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- Majmudar Nikhil
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- Manning Lisa
- Manoj Aravind
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- Marigold James Richard
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- Marsden Tracy
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- Mashate Sheila
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- Mate Abhijit
- Mathieson Philip
- Matias Oliver
- Matthews Christopher
- Maund Bev
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- McArdle Damian
- Mcauley Sean
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- McCarron Mark
- McClelland Beverley
- McCormick Katrina
- McCormick Katrina
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- McDonald Susan
- Mcgee Joanne
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- McGill Connor
- McGrath Aileen
- McIlmoyle James
- McKee Jacqueline
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- McVerry Ferghal
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- Mead Gillian
- Meir Julie
- Menon Nisha
- Mercer Lily
- Metcalf Kneale
- Miller Keniesha
- Miller Richard
- Milligan Josette
- Minks David
- Minks David P.
- Miriam Skelton
- Mistri Amit
- Mitchell Jennifer
- Mitra Dipayan
- Mitra Dipayan
- Mohammed Niaz
- Mohd Nor Azlisham
- Mokoena Betty
- Moores Andrew
- Moqsith Mohammed
- Morell Jordi
- Moreton Fiona
- Morgan Debbie
- Moroney Helen
- Morse Bethan
- Moseley Sally
- Motherwell Nichola
- Moynihan Barry
- Mpelembue Mushiya
- Mudd Paul
- Muddegowda Girish
- Muir Keith
- Mukherjee Indranil
- Murali Elodie
- Murphy Peter
- Murray Gordon D
- Musarrat Kashif
- Myint Min
- Naeem Muhammad
- Naing Zin
- Nair Anand
- Nallasivan Arumugam
- Nasar Mohammad
- Nasim Ashraf
- Naylor Charde
- Needle Ann
- Nelson Sandra
- Newby David E
- Newton Sophie
- Ng Kheng Xiong
- Ngo David
- Nguyen Vinh
- Ngwako Mmua
- Ni Hlaing
- Nicholas Paul
- Nicolson Anne
- Niranchanan Rangah
- Nisar Nabeela
- Njoku Kelechi
- Nott Claire
- Nott Claire
- Nozedar Tarn
- Nyabadza Sheila
- O'Brien Eoin
- O'Brien Richard
- O'Brien Richard
- O'Connell Susan
- O'Loughlin Victoria
- O'Reilly Joanna
- O'Toole Sarah
- OConnell Janice
- Oji Nnebuife
- Orath Prabakaran Rajalakshmi
- Orefo Chukwuka
- Orugun Enoch
- Osborn Mairead
- Osborne Emily
- Oshodi Anne
- Osman Ahmed
- Ovington Catherine
- Owings Paula
- Owoyele Emmanuelle
- Owusu-Agyei Peter
- Pai Yogish
- Palmer Jeb
- Papavasileiou Vasileios
- Parakramawansha Ruwan
- Parker Richard
- Parry Anthea
- Parry-Jones Adrian
- Pasco Kath
- Patel Bhavini
- Patel Champa
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- Patel Krishna
- Patterson Chris
- Paulton Ruth
- Pawley Corinne
- Peixoto Cassilda
- Penge Justin
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- Perry Jack
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- Rashmi Sindhu
- Ravenhill Garth
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- Reckless Ian
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- Reddan Julie
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- Redjep Ozlem
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- Richards Emma
- Rinkel Gabriel
- Roberts Josh
- Robinson Matthew
- Robinson Naomi
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- Rodrigues Mark A
- Rodriguez Aryelly
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- Roffe Jack
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- Rogers Emily
- Rogers Gill
- Rojas Javier
- Ross Sarah
- Roughan Caroline
- Rudd Tony
- Rudenko Hannah
- Saada Janak
- Saastamoinen Kari
- Sajid Mahmud
- Sakka Eleni
- Salehin Maqsud
- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
- Sarah Procter
- Sarah Procter
- Sattar Naweed
- Sattar Saira
- Saulat Afaq
- Saulat Afaq
- Schofield Christine
- Schulz Ursula
- Schumacher Natasha
- Schwarz Stefan
- Seagrave Samantha
- Sekaran Lakshmanan
- Sesay Juliana
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- Shahmehri Shahrzad
- Sharma Nikhil
- Sharpe Simon
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- Shekhar Raj
- Shelton Faye
- Shinh Naval
- Shread Ian
- Shukla Avani
- Siddegowda Prasad
- Siddiq Muhammad
- Siddiqui Amber
- Siddiqui Anwer
- Sigsworth Andrew
- Simon Rohan
- Sims Don
- Singh Arun
- Sinha Devesh
- Skinner Helen
- Slade Peter
- Smart Amanda
- Smith Andrew
- Smith Fiona
- Smith Gemma Marie
- Smith Simon
- Smith Wilma
- Smyth Nigel
- Spencer Jayne
- Sprigg Nikola
- Sprigg Nikola
- Srinivasan Meena
- Stafford Samantha
- Stafford Samantha
- Stanners Andrew
- Steele Amy
- Stephen Jacqueline
- Stephens Claire
- Stevens Angela
- Stevens Stephanie
- Stevenson Sarah
- Stewart Kelvin
- Stocks Kathy
- Stone Andrew
- Storton Sharon
- Strain David
- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
- Sukdeo Varthi
- Sullivan Frank
- Sultan Sulaiman
- Suttling Anne
- Sutton Claire
- Sutton Patrick
- Sutton Victoria
- Sword Jane
- Sykes Lucy
- Symonds Stuart
- Szabo Susan
- Tallantyre Emma
- Tanate Alfonso
- Tandy Jane
- Tate Margaret
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- Tayler Michelle
- Taylor Pat
- Taylor Vicky
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- Thant Hlaing
- Thavanesan Kamy
- Thomas Isobel
- Thomas Kelly
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- Thompson Susan
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- Thomson Audrey
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- Thorpe Kevin
- Tilley Victoria
- Tiwari Divya
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- Triscott Claire
- Tryambake Dinesh
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- Tucker Susan
- Turfrey Jennifer
- Tysoe Sharon
- Ullah Khalil
- Valentine Stacey
- van Someren Chloe
- Varquez Resti
- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
- Veraque Emelda
- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
A Phase II Trial of Sorafenib in Metastatic Melanoma with Tissue Correlates
- Author
- A Gorden
- A Hauschild
- A Sharma
- A Viros
- Anna C. Pavlick
- Anne Hamilton
- AP Albino
- AY Bedikian
- B Escudier
- Christina Min
- CJ Sherr
- D Handolias
- David Polsky
- DF McDermott
- E Sala
- EL Korn
- F Carlomagno
- FA Karreth
- FS Hodi
- G Hatzivassiliou
- H Davies
- Herman Yee
- Iman Osman
- J Bukur
- J Dong
- J Lutzky
- J Tsai
- JA Curtin
- JA Curtin
- JM Llovet
- Joanne Yoon
- John J. Wright
- KP Hoeflich
- KS Smalley
- KT Flaherty
- L Jilaveanu
- Lauren Goldberg
- Leonard Liebes
- M Karasarides
- M Yancovitz
- Michael Buckley
- MR Middleton
- P Therasse
- Patrick A. Ott
- Paul J. Christos
- PB Chapman
- PI Poulikakos
- R Kumar
- Roger Chammas
- Sara Safarzadeh-Amiri
- SM Wilhelm
- SR Hingorani
- T Eisen
- Publication venue
- Public Library of Science
- Publication date
- 29/12/2010
- Field of study
Sorafenib monotherapy in patients with metastatic melanoma was explored in this multi-institutional phase II study. In correlative studies the impact of sorafenib on cyclin D1 and Ki67 was assessed. mutational status and clinical activity. No significant changes in expression of cyclin D1 or Ki67 with sorafenib treatment were demonstrable in the 15 patients with pre-and post-treatment tumor samples. mutational status of the tumor was not associated with clinical activity and no significant effect of sorafenib on cyclin D1 or Ki67 was seen, suggesting that sorafenib is not an effective BRAF inhibitor or that additional signaling pathways are equally important in the patients who benefit from sorafenib
A randomized controlled trial of an intervention for infants’ behavioral sleep problems
- Author
- A Monitoring
- A Sadeh
- A Sadeh
- A Sadeh
- A Sadeh
- Ambulatory Monitoring
- American Academy of Sleep Medicine
- AMH Price
- Amiram Gafni
- BL Belza
- DJ Buysse
- E Touchette
- E Touchette
- E Touchette
- Eileen Hutton
- GJ Reid
- H Hiscock
- H Hiscock
- H Hiscock
- H Hiscock
- I Boutron
- J Martin
- J Quach
- JA Mindell
- Jean Paul Collet
- JMB Morrell
- JMT Henderson
- Joanne Wooldridge
- K So
- K Spruyt
- Kathy Gregg
- Kathy Triolet
- KG France
- L Tikotzky
- L Tse
- Lillian Tse
- LJ Meltzer
- LS Radloff
- M Bélanger
- M Thunström
- MB Ramamurthy
- OF Buxton
- Osman Ipsiroglu
- P Palmstierna
- R Gruber
- R Lucas-Thompson
- Radhika Bhagat
- RK Dagher
- Rollin F. Brant
- Roy Saunders
- SD Stojanovski
- SL Sitnick
- T Golik
- WA Hall
- WA Hall
- WA Hall
- Wendy A. Hall
- Y Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial
- Author
- A Escobar
- A Osman
- A Ruyssen-Witrand
- AF Subar
- B Schmidt
- BC de Vos
- BC de Vos
- Betsy Hackney
- BW Penninx
- C Cooper
- CA Brand
- D Coggon
- D Moher
- D Riebe
- D Watson
- Daniel P. Beavers
- David J. Hunter
- DW Baker
- E Diener
- E Lewis-Faning
- E McAuley
- EJ Nightingale
- Elena Losina
- EM Roos
- EM Roos
- ER Pamuk
- F Tubach
- FE Thompson
- Gary D. Miller
- GD Miller
- GD Sanders
- investigators TA
- J Aaboe
- J Bauer
- JC Fortney
- JE Siegel
- JE Ware Jr
- Jeffrey N. Katz
- JM Guralnik
- Joanne M. Jordan
- Jovita Newman
- K Esposito
- K Gooch
- Kate Queen
- KD Brownell
- KE Thorpe
- L Fernandes
- L Murphy
- LC Li
- Leigh F. Callahan
- M Basedow
- M Harrington
- MA Burnam
- Mary F. Lyles
- MC Reilly
- MC Weinstein
- MJ Karvonen
- MJ Sullivan
- MM Clark
- N Bellamy
- N Bellamy
- O Sangha
- OE Owen
- Paul DeVita
- PJ Neumann
- R Altman
- RA Washburn
- RC Lawrence
- RE Leach
- Richard F. Loeser
- S Cohen
- Sara A. Quandt
- Shannon L. Mihalko
- SL Mihalko
- SP Messier
- SP Messier
- SP Messier
- SP Messier
- SP Messier
- Stephen P. Messier
- T Vos
- W Zhang
- WH Ettinger Jr
- WJ Chodzko-Zajko
- ZS Nasreddine
- ZS Nasreddine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown. Thus, the policy relevant and clinically important question is: Can we adapt this successful solution to a pervasive public health problem in real-world clinical and community settings? This study aims to develop a systematic, practical, cost-effective diet-induced weight loss and exercise intervention implemented in community settings and to determine its effectiveness in reducing pain and improving other clinical outcomes in persons with knee OA.
Methods/Design: This is a Phase III, pragmatic, assessor-blinded, randomized controlled trial. Participants will include 820 ambulatory, community-dwelling, overweight and obese (BMI ≥ 27 kg/m2) men and women aged ≥ 50 years who meet the American College of Rheumatology clinical criteria for knee OA. The primary aim is to determine whether a community-based 18-month diet-induced weight loss and exercise intervention based on social cognitive theory and implemented in three North Carolina counties with diverse residential (from urban to rural) and socioeconomic composition significantly decreases knee pain in overweight and obese adults with knee OA relative to a nutrition and health attention control group. Secondary aims will determine whether this intervention improves self-reported function, health-related quality of life, mobility, and is cost-effective.
Discussion: Many physicians who treat people with knee OA have no practical means to implement weight loss and exercise treatments as recommended by numerous OA treatment guidelines. This study will establish the effectiveness of a community program that will serve as a blueprint and exemplar for clinicians and public health officials in urban and rural communities to implement a diet-induced weight loss and exercise program designed to reduce knee pain and improve other clinical outcomes in overweight and obese adults with knee OA
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
- Author
- Anson James
- Applebee Jackie
- Arnold Natasha
- Awsare Ninaad
- Bambra Clare
- Banks Ian
- Bareford David
- Basarab Adriana
- Beadsworth Mike
- Beer Naomi
- Bell David
- Bell David
- Bennett-Richards Phillip
- Bhatti Osman
- Boomla Kambiz
- Bossano David
- Bostock David
- Boswell John P
- Bratty Catherine
- Brearey Steve
- Brown Kirsten
- Brown Raymond
- Buhrs Ernst
- Burgess-Allen Jilla
- Bury Bob
- Buttivant Helen
- Caan Woody
- Cabot Kate
- Camilleri-Ferrante Corinne
- Carter Lucy
- Chamberlain MA
- Chandy Rajiv
- Cheeroth Sheila
- Clark Leon
- Clarke Aileen
- Clarke Edward
- Coates Jonathan
- Cole Jim
- Coleman Michel
- Colvin Deborah
- Cook Derek
- Cripwell Michael
- Crome Peter
- Cullinan Paul
- Currie Jonny
- Daley Helen
- Danby Jude
- Darling Jonathan
- Davies David
- Davies Gerry
- Davis Jacky
- Deveson Pete
- Dickinson Jane
- Dickson Harriet
- Domizio Paola
- Duncan John AT
- Edwards Mark
- Edwards Martin
- Ehrhardt Peter
- Eisner Maggie
- Erskine Jonathan
- Etherington Robert
- Evans David
- Evans-Jones John
- Farrelly George
- Feder Gene
- Feehally John
- Fell Henry
- Fellows Griffith
- Fielding Richard
- Finer Nick
- Finer Sarah
- Fisher Brian
- Fitchett Mike
- Fitzgerald Richard
- Fleming Peter
- Fleming Peter
- Fluxman Jonathan
- Folb Jonathan
- Folb Jonathan
- Ford Amy
- Ford Steven
- Franks Andrea
- Freud Kathy McAdam
- Gawler Jeff
- Gibbs John
- Gill Alison
- Godfrey Peter
- Goodger V
- Gore Jonathan
- Gould Derek A
- Greenhalgh Trisha
- Griffiths Alun
- Grunewald Richard
- Gurling Hugh
- Hall Alyson
- Hall Peter
- Hamlyn Adrian N
- Hawkins David
- Highton Clare
- Hirst Julie
- Hobson Esther
- Holland Walter
- Holt Kim
- Holt Victoria J
- Hopkinson Nicholas
- Hotchkiss Julie
- Hughes Richard
- Ingrams Grant
- Ireland Maggie
- Irvine Louise
- Irving William L
- Jacobson Bobbie
- Jeffreys Anne
- Jenner David
- Jenner David
- Johnson Guy
- Johnston Sally
- Johnstone Chris
- Jones Anna
- Jones Coral
- Jones Phil
- Kendall Bryony
- Kinmonth Ann-Louise
- Kirwin Simon
- Klonin Hilary
- Knight David
- Koperski M
- Kraemer Sebastian
- Landers Aileen
- Lau Alice
- Lawrence David
- Lee Alan
- Lefevre Dianne
- Leigh Martha
- Lewis David
- Lewis David
- Lewis Geoffrey
- Livingstone Anna
- Lockwood Kate
- Logan Jane
- Logan Mary
- Logan Stuart
- Lowes Simon
- Lyttelton Laura
- Ma Richard
- Macfarlane Alison
- Macgibbon Robert
- Macklon AF
- Maclennan Iain
- Macpherson Jamie
- Main John
- Mann Nick
- Marlowe Gary
- Marmot Saul
- Martin P
- Maryon-Davis Alan
- Mason Rebecca
- McCartney Margaret
- McCoy David
- McEewen J
- McElderry Elisabeth
- McKee Martin
- McPherson Klim
- Michael Benedict
- Middleton John
- Miller Jo
- Mindell Jennifer
- Mitchel Sarah
- Mitchison Sally
- Moore Robert
- Morrison Richard
- Mullen Paul
- Munday Pat
- Murphy E
- Newell Jo
- Nixon Jonathan
- Noor R
- Nsutebu Emmanuel
- Ormerod Julian
- Ormerod Oliver
- Paintin David
- Patel Anita
- Paul Ashish
- Peedell Clive
- Pollock Alyson
- Pride Neil
- Puntis John
- Rainbow Daniel
- Rawaf Salman
- Reeve Joanne
- Reissman Gerard
- Ross Wendy
- Rossiter Brian
- Salim Asad
- Savage Wendy
- Sayer Mel
- Schweiger Martin
- Scott Brian
- Scott-Samuel Alex
- Sharma Ajay
- Sharp Deborah J
- Sharvill John
- Sikorski Jim
- Silverman Ruth
- Singer Ron
- Singh G
- Singh Surinder
- Smailes Alison
- Smyth Alan
- Souza Richard de
- Stevenson Nicola
- Stobbart Kate
- Suckling Ruth
- Tallis Ray
- Tebboth Louise
- Timmis Alison
- Timms Philip
- Tomlinson Jonathon
- Tomlinson Laurie
- Tomson D
- Tomson Mike
- Torabi Payam
- Tulloch Alex
- Turner Gill
- Venning Helen
- Walker Jonathan
- Waterston Tony
- Wesby Barbara
- West Andrew
- West Robert
- West Robert
- Whincup Peter
- Wolfe Ingrid
- Wortley Pam
- Wrigley David
- Young Gail
- Young Jane
- Yudkin John S
- Zinkin Pam
- Publication venue
- 'BMJ'
- Publication date
- 20/03/2013
- Field of study
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
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- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abbas Dehghan
- Abdonas Tamosiunas
- Abdullatif S Husseini
- Abhijit Sen
- Abla M Sibai
- Adela Chirita-Emandi
- Adolfo Rubinstein
- Afshin Ostovar
- Ahmad Ali Noorbala
- Ahmad Ali Zainuddin
- Ahmad Faudzi Yusoff
- Aicha Soumare
- Aida Pilav
- Akihiro Yoshihara
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Albert Hofman
- Albertino Damasceno
- Alberto Barceló
- Alejandro Diaz
- Aleksandar Džakula
- Aleksander Giwercman Wu
- Aleksandra Piwonska
- Alet H Wijga
- Aletta E Schutte
- Alexandre C Pereira
- Alicia Matijasevich
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline Wagner
- Alireza Ahmadvand
- Alisha N Wade
- Alison J Hayes
- Allan Linneberg
- Altan Onat
- Aluisio J D Barros
- Alun Evans
- Ambady Ramachandran
- Amina Barkat
- Amir Kasaeian
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Henriques
- Ana Jelaković
- Ana Maria B Menezes
- Ana Paula C Cândido
- Anders Grøntved
- Andre L Guimaraes
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- Aneta Grajda
- Angela Chetrit
- Angela Döring
- Angelique W Chan
- Ann-Sofie Forslund
- Anna Bugge
- Anna G Iannone
- Annamari Lundqvist
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette Peters
- Annika Rosengren
- Anoosheh Ghasemian
- Anselmo J Mc Donald Posso
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- Krishna K Aryal
- Krista Fischer
- Kumiko Ohara
- Kurt Widhalm
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- Lariane M Ono
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- Lizzy M Brewster
- Lorenza Pilotto
- Louise A Baur
- Louise Eriksen
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- Maciej Banach
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- Mahboubeh Parsaeian
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- Malgorzata Mossakowska
- Mangesh S Pednekar
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- Maria Wany Strufaldi
- Mariachiara Di Cesare
- Marianna Noale
- Mariano Bonet Gorbea
- Marieke B Snijder
- Marika Ferrari
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- Marius B Bjertness
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- Martijn Huisman
- Martin Bobak
- Martin C Gulliford
- Martin Neovius
- Martina Müller-Nurasyid
- Mary Simon
- Maryam Kavousi
- María del Cristo Rodriguez-Perez
- María José Tormo
- María-Dolores Chirlaque
- Masanori Iwasaki
- Massimo Salvetti
- Mathilde Kersting
- Mathur Prashant
- Maties Torrent
- Matthias Nauck
- Mattias Johansson
- Maung Maung Than Htike
- Mauro V Barros
- Melanie J Cowan
- Michael Bursztyn
- Michael Hobbs
- Michael Knoflach
- Michael Sjöström
- Michel Joffres
- Mieczyslaw Litwin
- Mikhail Benet
- Ming-Dong Wang
- Miquel Porta
- Mohamed Bamoshmoosh
- Mohamed M Ali
- Mohammad Esmaeel Motlagh
- Mohammad Khateeb
- Mohammed Rasoul Tarawneh
- Mohan Deepa
- Mohannad Al Nsour
- Mohd Azahadi Omar
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- Nahla Hwalla
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- Nazgul Akhtaeva
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- Osman Ali
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- Ozren Polašek
- Paibul Suriyawongpaisal
- Panayiotis K Yiallouros
- Paolo Vineis
- Pascal Bovet
- Patrick Kolsteren
- Paul Elliott
- Paul Ferdinand M Reganit
- Paul Korrovits
- Paula Duarte de Oliveira
- Paula Margozzini
- Paulo A Lotufo
- Pawel Kurjata
- Pedro Marques-Vidal
- Pedro Ordunez
- Pedro Plans-Rubió
- Per Lytsy
- Per Tynelius
- Peter Bjerregaard
- Peter H Whincup
- Peter Lund Kristensen
- Peter Stehle
- Peter Ueda
- Peter Vollenweider
- Peter Willeit
- Petra H Peeters
- Philippe Amouyel
- Pierre Traissac
- Pietro A Modesti
- Piotr Bandosz
- Prabhdeep Kaur
- Pradeep Joshi
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- Reza Malekzadeh
- Ricardas Radisauskas
- Rildo S Wanderley
- Robert Beaglehole
- Robert Eggertsen
- Robert J Adams
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- Sine Skovbjerg
- Sirkka Keinänen-Kiukaanniemi
- Slawomir Koziel
- Snehalatha Chamukuttan
- Sofia Malyutina
- Sok King Ong
- Son Thai Pham
- Songhomitra Panda-Jonas
- Soon-Woo Park
- Sophie Visvikis-Siest
- Sounnia Mediene-Benchekor
- Stefaan De Henauw
- Stefan Kiechl
- Stefan Söderberg
- Stefania Maggi
- Steinar Krokstad
- Stela McLachlan
- Stephen T McGarvey
- Sudha Ramachandra Rao
- Sudhir Kowlessur
- Suhad Bahijri
- Suka Machi
- Sumit Bharadwaj
- Susana Sans
- Susi Kriemler
- Suzanne C Ho
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- Tandi E Matsha
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- Tazeen Jafar
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- Teresa Norat
- Terho Lehtimäki
- Thein Thein Htay
- Thet Thet Mu
- Thomas M Dantoft
- Thor Aspelund
- Thorkild I A Sørensen
- Tien Yin Wong
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Vlasoff
- Timothy Key
- Tobias F Rinke de Wit
- Tom Wilsgaard
- Tomas Vega
- Tomasz Grodzicki
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Torben Jørgensen
- Toshiharu Ninomiya
- Tran Quoc Bao
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- Tuyen D Le
- Ty T Dickerson
- Ulf Ekelund
- Ulrich Keil
- Urho M Kujala
- Ursula Kiechl-Kohlendorfer
- Valérie Deschamps
- Vanina Bongard
- Vanja Ivkovic
- Veikko Salomaa
- Ver Bilano
- Vera Grujic
- Vera Lanska
- Vera Musil
- Vesna Jureša
- Vilma E Irazola
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Virginija Dulskiene
- Viswanathan Mohan
- Viviane C Cardoso
- W M Monique Verschuren
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wan Zhu Zhang
- Wei Zheng
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenhua Zhao
- Wichai Aekplakorn
- William A Neal
- Winsome R Parnell
- Wojciech Drygas
- Wolfgang Ahrens
- Xenophon Theodoridis
- Xiaoguang Yang
- Xingwang Ye
- Xu Lin
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yannis Manios
- Yanping Li
- Yeon-Yong Kim
- Yi Song
- Yi Zeng
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Youchan Shin
- Young-Ho Khang
- Young-Ho Khang
- Yousef Saleh Khader
- Yufang Bi
- Yuki Fujita
- Yumi Cho
- Yuna He
- Yvonne T van der Schouw
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zhengming Chen
- Zhengming Chen
- Ziad A Abdeen
- Publication venue
- ZU Scholars
- Publication date
- 01/01/2018
- Field of study
© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Agdeppa Imelda A.
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Naser
- Ahmadvand Alireza
- Ahrens Wolfgang
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M.
- Al-Othman Amani Rashed
- Al-Raddadi Rajaa
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M.
- Ali Osman
- Alkerwi Ala'a
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amouyel Philippe
- Amuzu Antoinette
- Anderssen Sigmund A.
- Angquist Lars H.
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anselmo Olinto Maria Teresa
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assuncao Maria Cecilia F.
- Aung May Soe
- Auvinen Juha
- Avdicova Maria
- Azevedo Ana
- Azizi Fereidoun
- Azmin Mehrdad
- Babu Bontha V.
- Baharudin Azli
- Bahijri Suhad
- Baker Jennifer L.
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas Jose R.
- Barbagallo Carlo M.
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- Barkat Amina
- Barros Aluisio J. D.
- Barros Mauro V. G.
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- Batista Rosangela L.
- Battakova Zhamilya
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- Bebakar Wan Mohamad Wan
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- Benedics Judith
- Benet Mikhail
- Bennett James E.
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- Berkinbayev Salim
- Bernabe-Ortiz Antonio
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- Danaei Goodarz
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- Dasgupta Parasmani
- Dastgiri Saeed
- Dauchet Luc
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- De Backer Guy
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- Dias-da-Costa Juvenal Soares
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- Eddie Ricky
- Egbagbe Eruke E.
- Eggertsen Robert
- Eiben Gabriele
- Ekelund Ulf
- El Ati Jalila
- Eldemire-Shearer Denise
- Eliasen Marie
- Elliott Paul
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- Erasmus Rajiv T.
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- Ferguson Trevor S.
- Fernandes Romulo A.
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrari Marika
- Ferreccio Catterina
- Ferrer Eldridge
- Ferrieres Jean
- Fijalkowska Anna
- Fink Gunther
- Fischer Krista
- Flores Eric Monterubio
- Foeger Bernhard
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- Forslund Ann-Sofie
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- Franco Maria do Carmo
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- Furusawa Takuro
- Gaciong Zbigniew
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- Galeone Daniela
- Galvano Fabio
- Gao Jingli
- Garba Jamila Abubakar
- Garcia-de-la-Hera Manoli
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- Garnett Sarah P.
- Gaspoz Jean-Michel
- Gasull Magda
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- Geiger Harald
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- Grajda Aneta
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- Gregor Ronald D.
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- Haghshenas Rosa
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- Heidinger-Felso Regina
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- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta Jose Maria
- Huhtaniemi Ilpo Tapani
- Huisman Martijn
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- Huybrechts Inge
- Hwalla Nahla
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- Jamrozik Konrad
- Janszky Imre
- Janus Edward
- Jarani Juel
- Jarvelin Marjo-Riitta
- Jasienska Grazyna
- Jelakovic Ana
- Jelakovic Bojan
- Jennings Garry
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- Jerome Charles Sossa
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- Jorgensen Torben
- Joshi Pradeep
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- Jozwiak Jacek
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Kaaks Rudolf
- Kafatos Anthony
- Kajantie Eero O.
- Kalter-Leibovici Ofra
- Kamaruddin Nor Azmi
- Kameli Yves
- Kapantais Efthymios
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- Kasaeian Amir
- Katibeh Marzieh
- Katz Joanne
- Katzmarzyk Peter T.
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli
- Keil Ulrich
- Keinan-Boker Lital
- Keinanen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kelleher Cecily
- Kemper Han C. G.
- Kengne Andre P.
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khanh Le Nguyen Bao Khanh Le Nguyen Bao
- Khateeb Mohammad
- Khaw Kay-Tee
- Kheiri Bahareh
- Khosravi Alireza
- Khouw Ilse M. S. L.
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Jeongseon
- Kim Yeon-Yong
- Klimont Jeannette
- Klumbiene Jurate
- Knoflach Michael
- Koenig Jurgen
- Koirala Bhawesh
- Kolle Elin
- Kolsteren Patrick
- Korpelainen Raija
- Korrovits Paul
- Korzycka Magdalena
- Koskinen Seppo
- Kouda Katsuyasu
- Kovacs Viktoria A.
- Kowlessur Sudhir
- Koziel Slawomir
- Kratzer Wolfgang
- Kriemler Susi
- Kristensen Peter Lund
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kuciene Renata
- Kuh Diana
- Kujala Urho M.
- Kujundzic Enisa
- Kulaga Zbigniew
- Kumar R. Krishna
- Kumar Rachakulla Hari
- Kunesova Marie
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Latt Tint Swe
- Laugsand Lars E.
- Lauria Laura
- Laxmaiah Avula
- Lazo-Porras Maria
- Le Port Agnes
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lee Paul H.
- Lehtimaki Terho
- Lele Elysee Claude Bika
- Lemogoum Daniel
- Levitt Naomi S.
- Li Yanping
- Lilly Christa L.
- Lim Wei-Yen
- Lima-Costa M. Fernanda
- Lin Hsien-Ho
- Lin Xu
- Lind Lars
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Loit Helle-Mai
- Lopes Luis
- Lopez Tania
- Lopez-Garcia Esther
- Lorbeer Roberto
- Lotufo Paulo A.
- Lozano Jose Eugenio
- Luksiene Dalia
- Lundqvist Annamari
- Lundqvist Robert
- Lunet Nuno
- Lytsy Per
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L. L.
- Machado-Rodrigues Aristides M.
- Machi Suka
- Maggi Stefania
- Magliano Dianna J.
- Magriplis Emmanuella
- Maire Bernard
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Fatemeh
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia
- Maniego Lynell V.
- Manios Yannis
- Mann Jim I.
- Manzato Enzo
- Margozzini Paula
- Markaki Anastasia
- Markey Oonagh
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martin Rosemarie
- Martin-Prevel Yves
- Martorell Reynaldo
- Martos Eva
- Marventano Stefano
- Masoodi Shariq R.
- Mathiesen Ellisiv B.
- Mathur Prashant
- Matijasevich Alicia
- Matsha Tandi E.
- Mazur Artur
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- McGarvey Stephen T.
- Mckee Martin
- McLachlan Stela
- McLean Rachael M.
- McLean Scott B.
- McNulty Breige A.
- Mediene-Benchekor Sounnia
- Medzioniene Jurate
- Mehdipour Parinaz
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- Meisfjord Jorgen
- Meisinger Christa
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- Mensink Gert B. M.
- Mereke Alibek
- Meshram Indrapal I.
- Metspalu Andres
- Meyer Haakon E.
- Mi Jie
- Michaelsen Kim F.
- Michels Nathalie
- Mikkel Kairit
- Milanovic Sanja Music
- Miller Jody C.
- Minderico Claudia S.
- Minh Hoang Van
- Miranda J. Jaime
- Mirkopoulou Daphne
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
- Mistretta Antonio
- Mocanu Veronica
- Modesti Pietro A.
- Moghaddam Sahar Saeeidi
- Mohajer Bahram
- Mohamed Mostafa K.
- Mohammad Kazem
- Mohammadifard Noushin
- Mohamud Wan Nazaimoon Wan
- Mohan Viswanathan
- Mohanna Salim
- Mohebi Farnam
- Moitry Marie
- Molbo Drude
- Mollehave Line T.
- Moller Niels C.
- Molnar Denes
- Momenan Amirabbas
- Mondo Charles K.
- Monterrubio Eric A.
- Monyeki Kotsedi Daniel K.
- Moon Jin Soo
- Moreira Leila B.
- Morejon Alain
- Moreno Luis A.
- Morgan Karen
- Morin Suzanne
- Morovic Maja Lang
- Mortensen Erik Lykke
- Moschonis George
- Mossakowska Malgorzata
- Mostafa Aya
- Mota Jorge
- Mota-Pinto Anabela
- Motlagh Mohammad Esmaeel
- Motta Jorge
- Msyamboza Kelias P.
- Mu Thet Thet
- Muc Magdalena
- Mueller-Nurasyid Martina
- Mugosa Boban
- Muiesan Maria Lorenza
- Mukhtorova Parvina
- Murphy Neil
- Mursu Jaakko
- Murtagh Elaine M.
- Musil Vera
- Nabipour Iraj
- Naderimagham Shohreh
- Nagel Gabriele
- Naidu Balkish M.
- Nakamura Harunobu
- Namesna Jana
- Nang Ei Ei K.
- Nangia Vinay B.
- Nankap Martin
- Narake Sameer
- Nardone Paola
- Nauck Matthias
- Navarrete-Munoz Eva Maria
- Neal William A.
- Nelis Keiu
- Nelis Liis
- Nenko Ilona
- Neovius Martin
- Nervi Flavio
- Nguyen Chung T.
- Nguyen Nguyen D.
- Nieto-Martinez Ramfis E.
- Ning Guang
- Ninomiya Toshiharu
- Nishtar Sania
- Noale Marianna
- Noboa Oscar A.
- Norat Teresa
- Norie Sawada
- Noto Davide
- Nurk Eha
- Nyirenda Moffat
- O'Neill Terence W.
- O'Reilly Dermot
- Obreja Galina
- Ochoa-Aviles Angelica M.
- Oda Eiji
- Oh Kyungwon
- Ohara Kumiko
- Ohtsuka Ryutaro
- Olafsson Orn
- Oliveira Isabel O.
- Oltarzewski Maciej
- Omar Mohd Azahadi
- Onat Altan
- Ong Sok King
- Ono Lariane M.
- Ordunez Pedro
- Ornelas Rui
- Ortiz Ana P.
- Ortiz Pedro J.
- Osler Merete
- Osmond Clive
- Ostojic Sergej M.
- Ostovar Afshin
- Otero Johanna A.
- Overvad Kim
- Owusu-Dabo Ellis
- Paccaud Fred Michel
- Paciorek Christopher J.
- Padez Cristina
- Pagkalos Ioannis
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palloni Alberto
- Palmieri Luigi
- Pan Wen-Harn
- Panda-Jonas Songhomitra
- Pandey Arvind
- Panza Francesco
- Papandreou Dimitrios
- Park Soon-Woo
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pascanu Ionela M.
- Patel Nikhil D.
- Pecin Ivan
- Pednekar Mangesh S.
- Peer Nasheeta
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C.
- Perez Cynthia M.
- Perez-Farinos Napoleon
- Peters Annette
- Petersmann Astrid
- Petkeviciene Janina
- Petrauskiene Ausra
- Petrescu Constanta Huidumac
- Peykari Niloofar
- Pierannunzio Daniela
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pistelli Francesco
- Pitakaka Freda
- Piwonska Aleksandra
- Plans-Rubio Pedro
- Poh Bee Koon
- Pohlabeln Hermann
- Pop Raluca M.
- Popovic Stevo R.
- Porta Miquel
- Portegies Marileen L. P.
- Posch Georg
- Poulimeneas Dimitrios
- Pouraram Hamed
- Pourshams Akram
- Poustchi Hossein
- Pradeepa Rajendra
- Price Alison J.
- Price Jacqueline F.
- Puder Jardena J.
- Pudule Iveta
- Puhakka Soile E.
- Puiu Maria
- Punab Margus
- Qasrawi Radwan F.
- Qorbani Mostafa
- Quang Ngoc La Quang Ngoc La
- Quang Ngoc Nguyen Quang Ngoc Nguyen
- Radhika Madhari S.
- Radic Ivana
- Radisauskas Ricardas
- Rahim Norsyamlina Che Abdul
- Rahman Mahfuzar
- Rahman Mahmudur
- Raitakari Olli
- Raj Manu
- Rajkumar Hemalatha
- Rakhmatulloev Sherali
- Ramachandran Ambady
- Ramke Jacqueline
- Ramos Elisabete
- Ramos Rafel
- Rampal Lekhraj
- Rampal Sanjay
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rascon-Pacheco Ramon A.
- Rasmussen Mette
- Redon Josep
- Reganit Paul Ferdinand M.
- Regecova Valeria
- Revilla Luis
- Ribas-Barba Lourdes
- Ribeiro Robespierre
- Riboli Elio
- Rigo Fernando
- Riley Leanne M.
- Rinaldo Natascia
- Rito Ana
- Ritti-Dias Raphael M.
- Rivera Juan A.
- Robitaille Cynthia
- Rodrigues Daniela
- Rodriguez-Artalejo Fernando
- Rodriguez-Martinez Andrea
- Rodriguez-Villamizar Laura A.
- Rojas-Martinez Rosalba
- Rojroongwasinkul Nipa
- Romaguera Dora
- Rosario Angelika Schaffrath
- Rosengren Annika
- Rouse Ian
- Roy Joel G. R.
- Rubinstein Adolfo
- Ruhli Frank J.
- Ruidavets Jean-Bernard
- Ruiz Moreno Emma
- Russo Paola
- Rust Petra
- Rutkowski Marcin
- Sabanayagam Charumathi
- Sachdev Harshpal S.
- Safiri Saeid
- Saidi Olfa
- Salanave Benoit
- Salazar-Martinez Eduardo
- Salmeron Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Sanchez-Abanto Jose
- Sandjaja Sandjaja
- Sandra Ruiz-Betancourt Blanca
- Sans Susana
- Sant'Angelo Victoria Farrugia
- Santa-Marina Loreto
- Santos Sanz Sara
- Santos Silva Diego Augusto
- Santos Diana A.
- Santos Ina S.
- Santos Osvaldo
- Santos Rute
- Saramies Jouko L.
- Sardinha Luis B.
- Sarrafzadegan Nizal
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Scazufca Marcia
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O.
- Schmidt Ida Maria
- Schoettker Ben
- Schultsz Constance
- Schutte Aletta E.
- Sebert Sylvain
- Sein Aye Aye
- Selamat Rusidah
- Sember Vedrana
- Sen Abhijit
- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Sequera Victor
- Serra-Majem Luis
- Servais Jennifer
- Shalnova Svetlana A.
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shengelia Lela
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shin Dong Wook
- Shin Youchan
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
- Sibai Abla M.
- Silva Antonio M.
- Simon Mary
- Simons Judith
- Simons Leon A.
- Sjoberg Agneta
- Sjostrom Michael
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- Snijder Marieke B.
- So Hung-Kwan
- Sobngwi Eugene
- Soderberg Stefan
- Soekatri Moesijanti Y. E.
- Soemantri Agustinus
- Solfrizzi Vincenzo
- Solomon Bethlehem D.
- Son Thai Pham Son Thai Pham
- Sonestedt Emily
- Song Yi
- Sophiea Marisa K.
- Sorensen Thorkild I. A.
- Soric Maroje
- Soumare Aicha
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A.
- Stamm Hanspeter
- Starc Gregor
- Stathopoulou Maria G.
- Staub Kaspar
- Stavreski Bill
- Steene-Johannessen Jostein
- Stehle Peter
- Stein Aryeh D.
- Stergiou George S.
- Stessman Jochanan
- Stevens Gretchen A.
- Stocks Tanja
- Stoeckl Doris
- Stokwiszewski Jakub
- Stratton Gareth
- Stronks Karien
- Strufaldi Maria Wany
- Sturua Lela
- Suarez-Medina Ramon
- Sun Chien-An
- Sundstrom Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Swinburn Boyd A.
- Sy Rody G.
- Sylva Rene Charles
- Szponar Lucjan
- Taddei Cristina
- Tai Hing Lam Tai Hing Lam
- Tai E. Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Tchibindat Felicite
- Tebar William R.
- Tell Grethe
- Tello Tania
- Theobald Holger
- Theodoridis Xenophon
- Thijs Lutgarde
- Thuesen Betina H.
- Ticha Lubica
- Timmermans Erik J.
- Tjonneland Anne
- Tolonen Hanna K.
- Tolstrup Janne S.
- Topbas Murat
- Topor-Madry Roman
- Tormo Maria Jose
- Tornaritis Michael J.
- Torrent Maties
- Toselli Stefania
- Traissac Pierre
- Tran Quoc Bao Tran Quoc Bao
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tsao Yu-Hsiang
- Tshepo Lechaba
- Tsigga Maria
- Tsugane Shoichiro
- Tulloch-Reid Marshall K.
- Tullu Fikru
- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
- Turley Maria L.
- Tynelius Per
- Tzotzas Themistoklis
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice E.
- Ukoli Flora A. M.
- Ulmer Hanno
- Unal Belgin
- Uusitalo Hannu M. T.
- Vaitkeviciute Justina
- Valdivia Gonzalo
- Vale Susana
- Valvi Damaskini
- van der Schouw Yvonne T.
- Van Herck Koen
- van Rossem Lenie
- Van Schoor Natasja M.
- van Valkengoed Irene G. M.
- Vanderschueren Dirk
- Vanuzzo Diego
- Varela-Moreiras Gregorio
- Varona-Perez Patricia
- Vatten Lars
- Vega Tomas
- Veidebaum Toomas
- Velasquez-Melendez Gustavo
- Velika Biruta
- Veronesi Giovanni
- Verschuren W. M. Monique
- Victora Cesar G.
- Viegi Giovanni
- Viet Lucie
- Vineis Paolo
- Vioque Jesus
- Virtanen Jyrki K.
- Visser Marjolein
- Visvikis-Siest Sophie
- Viswanathan Bharathi
- Vlasoff Tiina
- Vollenweider Peter
- Volzke Henry
- Voutilainen Ari
- Voutilainen Sari
- Vrijheid Martine
- Vrijkotte Tanja G. M.
- Vrkic Tajana Zeljkovic
- Wade Alisha N.
- Wagner Aline
- Waldhoer Thomas
- Walton Janette
- Wanderley Rildo S., Jr.
- Wang Ming-Dong
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S. Goya
- Wareham Nicholas
- Weber Adelheid
- Weerasekera Deepa
- Weghuber Daniel
- Wei Wenbin
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Wiecek Andrzej
- Wijga Alet H.
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Frederick C.
- Wu Jianfeng
- Wu Shouling
- Xu Haiquan
- Xu Liang
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilova Hana
- Zapata Maria Elisa
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zeng Yi
- Zhao Dong
- Zhao Wenhua
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zhussupov Baurzhan
- Zimmermann Esther
- Zuniga Cisneros Julio
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
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- Abdellah Zahra
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- Kershaw Joanna
- Kettleborough Ross
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kube Michael
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- Lamerdin Jane E.
- Lander Eric S.
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
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- MacLean Christine
- Madabhushi Ramki
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- Sutton Angelica E.
- Svatek Amanda F.
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- Tatum Owatha I.
- Taudien Stefan
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- Tian Chaoguang
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- Tong Jingli
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- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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