Adaptive Probabilistic Flooding for Multipath Routing

In this work, we develop a distributed source routing algorithm for topology discovery suitable for ISP transport networks, that is however inspired by opportunistic algorithms used in ad hoc wireless networks. We propose a plug-and-play control plane, able to find multiple paths toward the same destination, and introduce a novel algorithm, called adaptive probabilistic flooding, to achieve this goal. By keeping a small amount of state in routers taking part in the discovery process, our technique significantly limits the amount of control messages exchanged with flooding -- and, at the same time, it only minimally affects the quality of the discovered multiple path with respect to the optimal solution. Simple analytical bounds, confirmed by results gathered with extensive simulation on four realistic topologies, show our approach to be of high practical interest.Comment: 6 pages, 6 figure

Cache Side-Channel Attacks Through Electromagnetic Emanations of DRAM Accesses

Remote side-channel attacks on processors exploit hardware and micro-architectural effects observable from software measurements. So far, the analysis of micro-architectural leakages over physical side-channels (power consumption, electromagnetic field) received little treatment. In this paper, we argue that those attacks are a serious threat, especially against systems such as smartphones and Internet-of-Things (IoT) devices which are physically exposed to the end-user. Namely, we show that the observation of Dynamic Random Access Memory (DRAM) accesses with an electromagnetic (EM) probe constitutes a reliable alternative to time measurements in cache side-channel attacks. We describe the EVICT+EM attack, that allows recovering a full AES key on a T-Tables implementation with similar number of encryptions than state-of-the-art EVICT+RELOAD attacks on the studied ARM platforms. This new attack paradigm removes the need for shared memory and exploits EM radiations instead of high precision timers. Then, we introduce PRIME+EM, which goal is to reverse-engineer cache usage patterns. This attack allows to recover the layout of lookup tables within the cache. Finally, we present COLLISION+EM, a collision-based attack on a System-on-chip (SoC) that does not require malicious code execution, and show its practical efficiency in recovering key material on an ARM TrustZone application. Those results show that physical observation of the micro-architecture can lead to improved attacks

Association between volume of lung damage and endoplasmic reticulum stress expression among severe COVID-19 ICU patients

IntroductionLinks have been established between SARS-CoV-2 and endoplasmic reticulum stress (ERS). However, the relationships between inflammation, ERS, and the volume of organ damage are not well known in humans. The aim of this study was to explore whether ERS explains lung damage volume (LDV) among COVID-19 patients admitted to the intensive care unit (ICU).Materials and methodsWe conducted a single-center retrospective study (ancillary analysis of a prospective cohort) including severe COVID-19 ICU patients who had a chest computed tomography (CT) scan 24 h before/after admission to assess LDV. We performed two multivariate linear regression models to identify factors associated with plasma levels of 78 kDa-Glucose-Regulated Protein (GRP78; ERS marker) and Interleukin-6 (IL-6; inflammation marker) at admission.ResultsAmong 63 patients analyzed, GRP78 plasma level was associated with LDV in both multivariate models (β = 22.23 [4.08;40.38]; p = 0.0179, β = 20.47 [0.74;40.20]; p = 0.0423) but not with organ failure (Sequential Organ Failure Assessment (SOFA) score) at admission (r = 0.03 [−0.22;0.28]; p = 0.2559). GRP78 plasma level was lower among ICU survivors (1539.4 [1139.2;1941.1] vs. 1714.2 [1555.2;2579.1] pg./mL. respectively; p = 0.0297). IL-6 plasma level was associated with SOFA score at admission in both multivariate models (β = 136.60 [65.50;207.70]; p = 0.0003, β = 193.70 [116.60;270.90]; p < 0.0001) but not with LDV (r = 0.13 [−0.14;0.39]; p = 0.3219). IL-6 plasma level was not different between ICU survivors and non-survivors (12.2 [6.0;43.7] vs. 30.4 [12.9;69.7] pg./mL. respectively; p = 0.1857). There was no correlation between GRP78 and IL-6 plasma levels (r = 0.13 [−0.13;0.37]; p = 0.3106).ConclusionAmong severe COVID-19 patients, ERS was associated with LDV but not with systemic inflammation, while systemic inflammation was associated with organ failure but not with LDV

Metathesis of Fatty Acid Ester Derivatives in 1,1-Dialkyl and 1,2,3-Trialkyl Imidazolium Type Ionic Liquids

The self-metathesis of methyl oleate and methyl ricinoleate was carried out in the presence of ruthenium alkylidene catalysts 1–4 in [bmim] and [bdmim][X] type ionic liquids (RTILs) (X = PF6−, BF4− and NTf2−) using the gas chromatographic technique. Best catalytic performance was obtained in [bdmim][X] type ionic liquids when compared with [bmim][X] type ionic liquids. Catalyst recycling studies were also carried out in the room temperature ionic liquids (RTILs) with catalysts 1–4 in order to explore their possible industrial application

IoT protocols, architectures, and applications

The proliferation of embedded systems, wireless technologies, and Internet protocols have made it possible for the Internet-of-things (IoT) to bridge the gap between the physical and the virtual world and thereby enabling monitoring and control of the physical environment by data processing systems. IoT refers to the inter-networking of everyday objects that are equipped with sensing, computing, and communication capabilities. These networks can collaborate to autonomously solve a variety of tasks. Due to the very diverse set of applications and application requirements, there is no single communication technology that is able to provide cost-effective and close to optimal performance in all scenarios. In this chapter, we report on research carried out on a selected number of IoT topics: low-power wide-area networks, in particular, LoRa and narrow-band IoT (NB-IoT); IP version 6 over IEEE 802.15.4 time-slotted channel hopping (6TiSCH); vehicular antenna design, integration, and processing; security aspects for vehicular networks; energy efficiency and harvesting for IoT systems; and software-defined networking/network functions virtualization for (SDN/NFV) IoT

Brain metastasis and renal cell carcinoma : prognostic scores assessment in the era of targeted therapies

Aim: This study aimed at exploring several brain metastatic prognostic scores in patients with renal cell carcinoma. Patients and Methods: We retrospectively analyzed data of 93 metastatic renal cell carcinoma patients who were diagnosed with brain metastases between October 2005 and July 2016 who received targeted therapy. Potential prognostic factors (RTOG RPA, BS-BM, and a newly developed score CERENAL) were analyzed. Results: A total of 75 patients received targeted therapy. All scores showed prognostic value in progression-free survival after first-line treatment with CERENAL being the sole independent prognostic factor associated with improved duration of first-line treatment. Both RTOG RPA and CERENAL were potential prognosticators for overall survival, whereas only the CERENAL score was associated with prolonged disease-specific survival. Conclusion: Several prognostic scores can be useful to predict survival of patients with brain metastases from renal cancer, especially the newly developed CERENAL score

Synthesis of an (NHC)2Pd(SiMe3)2 (NHC = N-Heterocyclic Carbene) Complex. Catalytic, cis-Bis-Silylations of Internal Alkynes with Unactivated Disilanes

The novel complex cis-[(ITMe)2Pd(SiMe3)2 (ITMe =1,3,4,5-tetramethylimidazol-2-ylidene) has been synthesised by mild oxidative cleavage of Me3SiSiMe3 using (ITMe)2Pd(0). The use of this complex as precatalyst for the cis-bis-silylation of internal alkynes using unactivated disilanes is reported

Everlasting sensor networks

Poster for " L'énergie demain. Transition énergétique : recherches et ingénierie " symposium. May 30-31, 2013, MINES ParisTechWithin the team CSAM (Circuits, Systèmes et Applications des Microondes) of IEMN (Institut d'Électronique, de Microélectronique et de Nanotechnologie) and within IRCICA (Institut de Recherche sur les Composants logiciels et matériels pour l'Information et la Communication Avancée - USR CNRS 3080) we develop a research on ultra low power sensor networks. Our goal is to minimize the energy consumption so that the life duration of the network could be infinitely long. We develop studies including nanotechnologies (energy harvesting, storage devices), RF front-ends design, energy management but also radio channel and interference modeling and MAC layer optimization

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.