4 research outputs found
Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
- Author
- A Berge
- A Grupe
- A Meier
- A Nicholls
- A Poltorak
- Aimee K. Zaas
- AY Jong
- B Ho-Tin-Noe
- Clarice Weinberg
- D Collen
- D Fox
- DA Case TAD
- David A. Schwartz
- David Shore
- E Lee
- E Suenson
- FE Wall
- G Liao
- G Overland
- G Tronchin
- Gary Peltz
- Guochun Liao
- H Sun
- I Weide
- J Ge
- J Wang
- JaPG Wang
- Jason W. Chien
- JC Bowman
- JD Crowe
- JL Coleman
- John R. Perfect
- Jonathan Flint
- Jonathan Usuka
- JP Bouchara
- JW Mitchell
- K Bower
- K Lahteenmaki
- KA Marr
- Kieren A. Marr
- KW Seo
- Lalith Perera
- Lauranell H. Burch
- M Dubourdeau
- M Levi
- M Sanderson-Smith
- MD Boyle
- MG Netea
- OA Sodeinde
- R Bianchini
- R Herbrecht
- R Prentice
- RF Hector
- RG Hinners
- S Ascioglu
- S Bellocchio
- S Bellocchio
- S Greenland
- S Kesh
- Steven S. Giles
- T Syrovets
- TJ Walsh
- VA Ploplis
- WD Cornell
- WJ Steinbach
- Y Gong
- Y Guo
- Y Guo
- Publication venue
- Public Library of Science
- Publication date
- 01/06/2008
- Field of study
Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been identified. However, genetic factors that affect risk for developing IA have not been clearly identified. We report that host genetic differences influence outcome following establishment of pulmonary aspergillosis in an exogenously immune suppressed mouse model. Computational haplotype-based genetic analysis indicated that genetic variation within the biologically plausible positional candidate gene plasminogen (Plg; Gene ID 18855) correlated with murine outcome. There was a single nonsynonymous coding change (Gly110Ser) where the minor allele was found in all of the susceptible strains, but not in the resistant strains. A nonsynonymous single nucleotide polymorphism (Asp472Asn) was also identified in the human homolog (PLG; Gene ID 5340). An association study within a cohort of 236 allogeneic hematopoietic stem cell transplant (HSCT) recipients revealed that alleles at this SNP significantly affected the risk of developing IA after HSCT. Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection
Amino acid substitutions in Erg11p of azole-resistant Candida glabrata: Possible effective substitutions and homology modelling
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
- Author
- André Capron
- Auriault C
- Balloul JM
- Balloul JM
- Balloul JM
- Bouchara HO
- Boulanger D
- Boulanger D
- Bout D
- Camille Locht
- Colditz GA
- De Bont J
- Dupré L
- Fallon PG
- Franck Remoué
- Fynan EF
- Gilles Riveau
- Grezel D
- Grzych JM
- Huygen K
- Ismail MM
- Ivanoff N
- Khan CMA
- Kremer L
- Ladel CH
- Lai WC
- Locht C
- Loïc Dupré
- McNair A
- Mielcarek N
- Mielcarek N
- Mitchell GF
- Mountford AP
- Nathalie Mielcarek
- Odile Poulain-Godefroy
- Pancré V
- Phillips NC
- Porchet E
- Renauld-Mongenie G
- Riveau GJ
- Stover CK
- Taylor JB
- Trottein F
- Trottein FM
- Ulmer JB
- Wang B
- Xu C-B
- Xu CB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/1998
- Field of study
One stop mycology
- Author
- Abate
- Abbas
- Abdalla
- Abdel Mallek
- Abdel Sater
- Abdennader
- Aboujawdah
- Abraham
- Abraham
- Abubakar
- Achar
- Adamikova
- Adler
- Adolph
- Aebi
- Aggelis
- Aggelis
- Ahlich
- Ahmad
- Airaudi
- Aji
- Akimov
- Alb
- Alcorn
- Alderman
- Alderman
- Aleksiev
- Alex
- Alexander
- Ali
- Alias
- Alkubisi
- Allagui
- Allen
- Allen
- Alstrup
- Alvarez-Villafane
- Amador
- Amaral
- Amicucci
- Amitani
- Anaya
- Andaluz
- Andersen
- Andersen
- Anderson
- Andersson
- Ando
- Ando
- Antuch
- Aoki
- Aramayo
- Arambarri
- Argiriou
- Armstrong
- Arnold
- Arora
- Arora
- Arrese
- Arroyo
- Asante-Owusu
- Ashford
- Asiegbu
- Asiegbu
- Asiegbu
- Asiegbu
- Athar
- Audit
- Avila
- Ayer
- Azcon
- Ba
- Badran
- Bagagli
- Bagirova
- Bago
- Bagyaraj
- Bai
- Bai
- Baird
- Baird
- Baird
- Baka
- Balaguer
- Balali
- Balardin
- Balayan
- Balestrini
- Balota
- Bandala
- Banerjee
- Banerjee
- Banfield
- Barasubiye
- Bardgett
- Barr
- Barr
- Barrie
- Bartling
- Basabe
- Bates
- Bathgate
- Baumlein
- Bayman
- Becker
- Becker
- Beckerman
- Belisario
- Bell
- Belov
- Ben Yagoub
- Benchetrit
- Bendich
- Bennett
- Bennett
- Bentivenga
- Berg
- Berkower
- Bermingham
- Bermudez
- Bernai
- Berndt
- Berrocal
- Bever
- Bezalel
- Bhalla
- Bi
- Biagini
- Bianciotto
- Bibel
- Biere
- Bigelow
- Bignell
- Bilbrey
- Bills
- Black
- Blackwell
- Blanchard
- Blinder
- Blok
- Bock
- Bogan
- Boisselier-Dubayle
- Bolan
- Bono
- Bonzi
- Bossier
- Bouchara
- Boumans
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- Bouwman
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- Brandrud
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- Breierova
- Breuil
- Britton
- Broadhurst
- Broda
- Brooks
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- Brundrett
- Bruno
- Buchta
- Buga
- Bugbee
- Buhr
- Bulajic
- Bulavko
- Bullis
- Bullock
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- Bunn
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- Burda
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- Chang
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- Charpentier
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- Cheah
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- Chen
- Chen
- Chen
- Chen
- Chen
- Chen
- Chew
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- Chi
- Chlebicki
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- Chungu
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- Cimon
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- Longtine
- Loomis
- Lopez-Ribot
- Lopez-Ribot
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- Lorillou
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- Loubradou
- Lovering
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- Wahleithner
- Wainwright
- Walker
- Warbrick
- Warfield
- Warren
- Warwar
- Wasser
- Watanabe
- Weaver
- Weber
- Weber
- Webster
- Welihinda
- Welty
- Welty
- Wenzelides
- Werres
- Wetzel
- Whalley
- White
- White
- Whittaker
- Wickes
- Williams
- Williamson
- Wilson
- Wilson
- Wilson
- Winderickx
- Winkelhausen
- Winkler
- Wolf
- Wolff
- Wong
- Wrather
- Wright
- Wu
- Wu
- Wu
- Wu
- Xoconost-Lecazares
- Xu
- Xu
- Yadwad
- Yamaguchi-Iwai
- Yamamoto
- Yamaoka
- Yan
- Yanar
- Yang
- Yang
- Yaninek
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yao
- Yarden
- Ye
- Ying
- Ylimattila
- Yompakdee
- Yoshida
- Yoshida
- You
- Young
- Yuasa
- Yurlova
- Zacharias
- Zacheus
- Zadrazil
- Zadzinski
- Zak
- Zakeljmavric
- Zarb
- Zelada
- Zelicof
- Zervakis
- Zeze
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhou
- Zhu
- Zhu
- Zhurbenko
- Zhwang
- Ziegelhoffer
- Zurek
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study