From Surfaces to Interfaces: Ambient Pressure XPS and Beyond

The rapidly increasing field of surfaces under ambient conditions of temperature, and pressure in gas and liquid environments, reflects the importance of understanding surface properties in conditions closer to practical situations. This has been enabled by the emergence in the last two decades of a number of new techniques, both spectroscopy and microscopy, that can deliver atomic scale information with the required surface/interface sensitivity. Here we present a short review of recent advances to illustrate the novel understanding derived from the use of new techniques focusing on the gas–solid interface, where two barriers have been bridged: the pressure gap, and the temperature gap. The later gap is very important when dealing with weakly bound molecules, where only by the presence of gas at a suitable pressure can a measurable coverage of adsorbed molecules be achieved. The temperature gap manifests also in the removal of kinetic barriers. Future developments to continue extending the range of pressures are also mentioned. Finally, new challenges that appear, both from X-ray and electron-induced damage to the sample, and from contamination under high pressure of desired gases, while maintaining very low pressures of undesirable ones

The Effects of Large-Scale Magnetic Fields on Disk Formation and Evolution

This is a draft chapter for a book, entitled Physical Processes in Circumstellar Disks around Young Stars, which is scheduled for publication by the University of Chicago Press as one of its Theoretical Astrophysics Series volumes. Sect. 1 presents the motivation for considering the effects of a large-scale, ordered magnetic field on the formation and evolution of protostellar disks. Sect. 2 outlines the physical principles that underlie the magnetohydrodynamics of disks that are threaded by such a field. Sect. 3 discusses the formation and early evolution of disks that result from the collapse of a rotating molecular cloud core that is coupled to the insterstellar magnetic field. Sect. 4 reviews the observational evidence for the disk--wind connection and describes the structure of magnetically accelerated disk outflows, focusing on centrifugally driven winds; it then goes on to discuss the equilibrium and stability properties of weakly ionized protostellar accretion disks in which the transport of angular momentum is dominated by a wind of this type. Sect. 5 considers the coupling between the central protostar and the surrounding disk through the protostellar magnetic field, covering, in turn, the phenomenology, basic concepts, and results of numerical simulations. The chapter is summarized in Sect. 6, which also contains a discussion of future research directions.Comment: 68 pages, 8 figures, to appear in Physical Processes in Circumstellar Disks around Young Stars, ed. P. J. V. Garcia (Chicago: University of Chicago Press), uses svmult.cl

Predicting Surface Clustering at Ambient Conditions from Thermodynamic Data

Scanning tunneling microscopy (STM) has proved to be a prime tool to characterize the atomic structure of crystal surfaces under UHV conditions. With the development of high-pressure scanning tunneling microscopy (HP-STM), the scope of this technique has been largely extended, as new structures were found to occur under gas phase chemical potentials achieved under ambient conditions. Particularly interesting is the substantial restructuring of initially flat and stable surfaces into new orientations by formation of nanoclusters. Here we discuss the possible generality of this phenomenon by analyzing cases where atomically flat surfaces of certain transition metals undergo such changes in the presence of CO at room temperature (RT) while some remain unchanged. From our analysis we argue that such changes can be predicted from thermodynamic data published in the literature, particularly from the difference in adsorption energy on low-and high-coordination sites, like terrace and step sites, which can be obtained from thermal desorption spectroscopy (TDS) measurements, and possibly also from theoretical calculations. For the vicinal surfaces with high Miller indices, changes in the repulsive elastic interactions between the ordered steps due to adsorbates may also play an important role

Synergistic growth factor microenvironments

Growth factors (GF) are remarkably powerful signalling molecules that orchestrate developmental biology. GFs are currently used in medjcal applications with limited success but it is clear that if their potential can be harnessed for biomedicine then they could underpin the discipline of regenerative medicine. However, while we understand that biology uses cell-secreted growth factors tethered to the ECM, biologists typically employ GFs in soluble format at high concentrations. When used in vivo, this causes off-target, unwanted effects, which severely limits their use. There is a vast amount of literature dealing with material systems that control the delivery of GFs. However, it was soon observed that GFs could be more effectively presented bound to surfaces from a solid-phase state rather than in soluble form, recapitulating the way the extracellular matrix (ECM) binds GFs. In parallel, evidence was found that within the ECM, GFs can actually work in cooperation with integrins and that this produced ehnaced GF signalling due to the crosstalk between both receptors. Recently this knowledge was used to engineer microenvironments that target simultaneous integrin and GF receptor engagement seeking to maximise GF effects in vitro (e.g. in terms of stem cell differentiation) but also tissue repair in vivo (e.g. bone regeneration and wound healing). This feature article introduces the concept of synergistic GF/integrin signalling and then introduces GF delivery systems that were key in the development of more advanced synergistic growth factor microenvironments

Wind-driving protostellar accretion discs. II. Numerical method and illustrative solutions

(abridged) We continue our study of weakly ionized protostellar discs that are threaded by a large-scale magnetic field and power a centrifugally driven wind. It has been argued that in several protostellar systems such a wind transports a significant fraction of the angular momentum from at least some part of the disc. We model this case by considering a radially localized disc model in which the matter is well coupled to the field and the wind is the main repository of excess angular momentum. We consider stationary solutions in which magnetic diffusion counters the shearing and advection of the field lines. In Wardle & K\"onigl we analysed the disc structure in the hydrostatic approximation and presented disc/wind solutions for the ambipolar diffusivity regime. In K\"onigl, Salmeron & Wardle (Paper I) we generalized the hydrostatic analysis to the Hall and Ohm diffusivity domains and identified the parameter sub-regimes in which viable solutions occur. In this paper we test these results by deriving numerical solutions (integrated through the sonic critical surface) of the disc equations in the Hall domain. We confirm the predictions of the hydrostatic analysis and demonstrate its usefulness for clarifying the behaviour of the derived solutions. We show that the solutions can be extended to larger scales (so that they also cross the Alfv\'en critical surface) by matching the localized disc solutions to global wind solutions of the type introduced by Blandford & Payne. To facilitate this matching, we construct a library of wind solutions, which is made available to the community. The results presented in Wardle & K\"onigl, Paper I and this work form a comprehensive framework for the study of wind-driving accretion discs in protostellar and other astrophysical environments. This tool could be useful for interpreting observations and for guiding numerical simulations of such systems.Comment: 20 pages, 13 figures, 3 tables; submitted for publication in MNRA

Angular momentum transport in protostellar discs

Angular momentum transport in protostellar discs can take place either radially, through turbulence induced by the magnetorotational instability (MRI), or vertically, through the torque exerted by a large-scale magnetic field that threads the disc. Using semi-analytic and numerical results, we construct a model of steady-state discs that includes vertical transport by a centrifugally driven wind as well as MRI-induced turbulence. We present approximate criteria for the occurrence of either one of these mechanisms in an ambipolar diffusion-dominated disc. We derive ``strong field'' solutions in which the angular momentum transport is purely vertical and ``weak field'' solutions that are the stratified-disc analogues of the previously studied MRI channel modes; the latter are transformed into accretion solutions with predominantly radial angular-momentum transport when we implement a turbulent-stress prescription based on published results of numerical simulations. We also analyze ``intermediate field strength'' solutions in which both modes of transport operate at the same radial location; we conclude, however, that significant spatial overlap of these two mechanisms is unlikely to occur in practice. To further advance this study, we have developed a general scheme that incorporates also the Hall and Ohm conductivity regimes in discs with a realistic ionization structure.Comment: 8 pages, 4 figures, 1 table; accepted for publication in MNRA

Designing stem cell niches for differentiation and self-renewal

Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries

Liberación de iones flúor en materiales dentales

Tesis de Doctorado que contiene el análisis y la cuantificación del flúor liberado en algunos materiales dentales como lo son Cementos de Ionómero de vidrio, Selladores de fosas y fisuras, pastas dentales y barnices.INTRODUCCIÓN: El flúor es reconocido como un agente anticariogénico, y ha sido incorporado a diferentes productos dentales, aplicar estos materiales liberadores de flúor a los diferentes proyectos de salud pública ha generado el interés de los investigadores. OBJETIVO: Determinar cuál de los materiales y productos para la higiene oral utilizados en odontología presenta una mayor y más constante liberación de flúor. MATERIAL Y MÉTODO: Se utilizaron 4 selladores, 3 ionómeros de vidrio, 4 dentífricos y 5 barnices disponibles comercialmente. En el caso de los ionómeros y selladores se fabricaron bloques con una matriz de teflón y se almacenaron en frascos de plástico con agua deionizada. Los barnices fueron aplicados en bloques de dientes extraídos por razones ortodóncicas y almacenados de la misma manera. La evaluación de los dentífricos se llevó a cabo pesando 5 gramos extraídos del envase o tubo de cada casa comercial, los cuales fueron diluidos en agua deionizada. Las lecturas para determinar la concentración de flúor se llevaron a cabo utilizando un electrodo selectivo para ión flúor y solución TISAB II. Los datos fueron analizados mediante la prueba ANOVA y la prueba t de student para muestras relacionadas, utilizando el programa estadístico SPSS. RESULTADOS: Se observó que la mayoría de los barnices evaluados presentaron una liberación similar durante las primeras 24 horas. En cuanto a los selladores, el que presentó una mayor y más constante liberación con diferencias estadísticamente significativas con respecto al resto fue el Giomer. Los dentífricos no presentaron diferencias estadísticamente significativas aunque es importante destacar que todos presentaron valores menores a los representados en sus respectivas etiquetas. Con respecto a los ionómeros se observó que estos materiales son los que liberaron una mayor cantidad de iones flúor y esta liberación fue más constante y prolongada que en el resto de los materiales evaluados en este estudio. CONCLUSIONES: El ionómero de vidrio es el material que presentó una mayor y más constante liberación de flúor en comparación con el resto de los materiales utilizados en esta investigación lo que lo convierte en una útil herramienta a considerar por los programas de salud.