A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies

Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies

A Transdiagnostic Examination of Cognitive Heterogeneity in Children and Adolescents with Neurodevelopmental Disorders

Children and adolescents with neurodevelopmental disorders (NDDs) demonstrate extensive cognitive heterogeneity that is not adequately captured by traditional diagnostic systems. Using a transdiagnostic approach, a retrospective cohort study of cognitive functioning was conducted with a large heterogenous sample (n = 1529) of children and adolescents 7 to 18 years of age with NDDs. Measures of short-term memory, verbal ability, and reasoning were administered to participants with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), comorbid ADHD/ASD, and typically developing (TD) participants using a 12-item web-based neurocognitive testing battery. Unsupervised machine learning techniques were implemented to create a self-organizing map (SOM), an artificial neural network, in conjunction with k-means clustering algorithms to identify data-driven subgroups. Six clusters representing different cognitive profiles were identified, including participants with varying degrees of cognitive impairment. Diagnostic status did not correspond with cluster-membership, providing evidence for the application of transdiagnostic approaches to understanding cognitive heterogeneity in children and adolescents with NDDs. Additionally, the findings suggest that many TD participants may have undiagnosed learning difficulties, emphasizing the need for accessible cognitive assessment tools in school-based settings

Why do people (not) engage in social distancing? Proximate and ultimate analyses of Norm-Following during the COVID-19 pandemic

COVID-19 has had a profound negative effect on many aspects of human life. While pharmacological solutions are being developed and implemented, the onus of mitigating the impact of the virus falls, in part, on individual citizens and their adherence to public health guidelines. However, promoting adherence to these guidelines has proven challenging. There is a pressing need to understand the factors that influence people’s adherence to these guidelines in order to improve public compliance. To this end, the current study investigated whether people’s perceptions of others’ adherence predict their own adherence. We also investigated whether any influence of perceived social norms was mediated by perceptions of the moral wrongness of non-adherence, anticipated shame for non-adherence, or perceptions of disease severity. One hundred fifty-two Australians participated in our study between June 6, 2020 and August 21, 2020. Findings from this preliminary investigation suggest that (1) people match their behavior to perceived social norms, and (2) this is driven, at least in part, by people using others’ behavior as a cue to the severity of disease threat. Such findings provide insight into the proximate and ultimate bases of norm-following behavior, and shed preliminary light on public health-related behavior in the context of a pandemic. Although further research is needed, the results of this study—which suggest that people use others’ behavior as a cue to how serious the pandemic is and as a guide for their own behavior—could have important implications for public health organizations, social movements, and political leaders and the role they play in the fight against epidemics and pandemics

GenX uptake by wheat and rice in flooded and non-flooded soils : A greenhouse experiment

Funding Amnah Al Zbedy: financial support of her scholarship from the Cultural Bureau of Saudi Arabia, London. Viktoria Müller: financial support of her scholarship from the Macaulay Development Trust, UK.Peer reviewe

Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites

Peer reviewedPublisher PD

Photometric and spectroscopic observations of three rapidly rotating late-type stars: EY Dra, V374 Peg and GSC 02038-00293

Here, BV(RI)c broad band photometry and intermediate resolution spectroscopy in Halpha region are presented for two rapidly rotating late-type stars: EY Dra and V374 Peg. For a third rapid rotator, GSC 02038-00293, intermediate resolution Halpha spectroscopy and low resolution spectroscopy are used for spectral classification and stellar parameter investigation of this poorly known object. The low resolution spectrum of GSC 02038-00293 clearly indicates that it is a K-type star. Its intermediate resolution spectrum can be best fitted with a model with Teff=4750K and vsini=90km/s, indicating a very rapidly rotating mid-K star. The Halpha line strength is variable, indicating changing chromospheric emission on GSC 02038-00293. In the case of EY Dra and V374 Peg, the stellar activity in the photosphere is investigated from the photometric observations, and in the chromosphere from the Halpha line. The enhanced chromospheric emission in EY Dra correlates well with the location of the photospheric active regions, indicating that these features are spatially collocated. Hints of this behaviour are also seen in V374 Peg, but it cannot be confirmed from the current data. The photospheric activity patterns in EY Dra are stable during one observing run lasting several nights, whereas in V374 Peg large night-to-night variations are seen. Two large flares, one in the Halpha observations and one from the broadband photometry, and twelve smaller ones were detected in V374 Peg during the observations spanning nine nights. The energy of the photometrically detected largest flare is estimated to be 4.25x10^31 - 4.3x10^32 ergs, depending on the waveband. Comparing the activity patterns in these two stars, which are just below and above the mass limit of full convection, is crucial for understanding dynamo operation in stars with different internal structures.Comment: Accepted for publication in Astronomische Nachrichten (Astronomical Notes

Regime mapping and the role of the intermediate region in wall-coated microreactors

Operation of a wall-coated microreactor can occur in several mass transfer-reaction regimes. We define these regimes analytically in several planes of a multi-parametric map, taking into account the different degrees of concentration profile development, as well as the influence of non-unity orders of reaction and reactant inhibition in the kinetic law. It was found that the regions where conversion can be calculated from simplified mass transfer models are not discriminated by common results for entrance-length. We also illustrate the trade-offs that exist across this operating map concerning the catalyst design (costs associated with loading and volume) and overall system performance (evaluated in terms of reactant conversion, flow efficiency and microreactor effectiveness). It is shown that under certain conditions, the existence of moderate mass transfer resistance can be advantageous (even if internal limitations cannot be avoided), clarifying the role of the intermediate transport-reaction region

Experimental investigation of thermo-physical properties of soil using solarisation technology

Soil Thermo-Physical Properties (TPP) depend on heat transfer in the soil. This paper presents a study on different soil solarisation technologies influenced by soil TPP. This study evaluates three factors: The tillage depth for soil at three levels (15, 25 and 45 cm), the number of plastic film at three levels (single, double and without plastic film) and three cases of fertilizers (chemical fertilizer, organic fertilizer and without fertilizer). The parameters explored in this study include soil bulk density (Mg/cm3), soil porosity (%), soil volumetric moisture content (cm3/cm3) and soil thermal diffusivity (m2/sec). Data management and analysis were performed using SAS 9.1 statistical software and the spilt-plot under Randomized Complete Block Design (RCBD). The results show that soil Tillage Depth (TD) strongly influences TPP, as well as a significant effect on soil bulk density (ρb), porosity (Φ), volumetric moisture content (θ) and thermal diffusivity (D). The results also reveal that a tillage depth of 15 cm produces lower values of ρb, θ and D (1.25 Mg/cm3, 0.131 cm3/cm3 and 1.24×10-6 m2/sec, respectively) and a higher value of Φ (52.78%). In addition, the finding indicates that ρb is increased by increasing TD. There was a significant positive correlation between the number of plastic film and parameters studied. The soil double plastic film produced lower values of ρb and D for soil (1.253 Mg/cm3, 7.76×10-7m2/sec). However, it recorded higher values for Φ and θ for soil (52.70% and 0.231 cm3/cm3, respectively). Furthermore, the current study shows significant differences between the types of fertilizers on ρb. Organic Fertilizer (OF) obtained a lower value of ρb (1.2 Mg/m3), compared with chemical fertilizer and without fertilizer (1.28 and 1.31 Mg/m3, respectively). In contrast, contrary to expectations, this study did not find significant differences between the types of fertilizer on D and θ for soil. A positive correlation was found in the interaction between the studied factors in the parameters. Furthermore, D increased with increasing soil bulk density (pb) and tillage depth

Securitizing the Muslim Brotherhood: state violence and authoritarianism in Egypt after the Arab Spring

Unprecedented levels of state violence against the Muslim Brotherhood, and the widespread acceptance of this violence by Egyptians following the July 2013 military coup, have been under-examined by scholars of both critical security studies and Middle East politics, reflecting implicit assumptions that state violence is unexceptional beyond Europe. This article explores how the deployment of such levels of violence was enabled by a securitization process in which the Egyptian military successfully appropriated popular opposition to Muslim Brotherhood rule, constructing the group as an existential threat to Egypt and justifying special measures against it. The article builds on existing critiques of the Eurocentrism of securitization theory, alongside the writings of Antonio Gramsci, to further refine its application to non-democratic contexts. In addition to revealing the exceptionalism of state violence against the Muslim Brotherhood and highlighting the important role of nominally non-state actors in constructing the Muslim Brotherhood as a threat to Egypt, the article also signals the role of securitization in re-establishing authoritarian rule in the wake of the 2011 uprising. Thus, we argue that securitization not only constitutes a break from ‘normal politics’ but may also be integral to the reconstitution of ‘normal politics’ following a period of transition