Proper Motions of the Jets in the Region of HH 30 and HL/XZ Tau. Evidence for a Binary Exciting Source of the HH 30 Jet

We present [SII] images of the HH 30 and HL/XZ Tau region obtained at two epochs, as well as long-slit optical spectroscopy of the HH 30 jet. We measured proper motions of about 100-300 km/s for the HH 30 jet and counterjet, and of about 120 km/s for the HL Tau jet. Inclination angles with respect to the plane of the sky are 0-40 deg for the HH 30 jet and 60 deg for the HL Tau jet. Comparison with previous observations suggests that most of the jet knots consist of persisting structures. Also, we corroborate that the HH 30-N knots correspond to the head of the HH 30 jet. The overall HH 30 jet structure can be well described by a wiggling ballistic jet, arising either by the orbital motion of the jet source around a primary or by precession of the jet axis because of the tidal effects of a companion. In the first scenario, the orbital period would be 53 yr and the total mass 0.25-2 solar masses. In the precession scenario, the mass of the jet source would be 0.1-1 solar masses, the orbital period <1 yr, and the mass of the companion less than a few times 0.01 solar masses, thus being a substellar object or a giant exoplanet. In both scenarios a binary system with a separation <18 AU (<0.13 arcsec) is required. Since the radius of the flared disk observed with the HST is about 250 AU, we conclude that this disk appears to be circumbinary rather than circumstellar, suggesting that the search for the collimating agent of the HH 30 jet should be carried out at much smaller scales.Comment: 42 pages, 7 figures, 5 tables. To Appear in The Astronomical Journal, Vol. 133 No. 6 (June 2007

A Latency-Aware Real-Time Video Surveillance Demo: Network Slicing for Improving Public Safety

© 2021 IEEE.  Personal use of this material is permitted.  Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other worksWe report the automated deployment of 5G services across a latency-aware, semidisaggregated, and virtualized metro network. We summarize the key findings in a detailed analysis of end-to-end latency, service setup time, and soft-failure detection timeThe research leading to these results has received funding from the EC and BMBF through the METRO-HAUL project (G.A. No. 761727) and OTB-5G+ project (reference No. 16KIS0979K

Estudio piloto sobre discalculia usando el “Dyscalculia Screener” de Butterworth

Having screening tools to identify students at risk of learning difficulties in mathematics is an essential resource to address future interventions that reduce failure and poor performance in mathematics.We present a pilot study with 49 students (average age of 9 years, 5 months) of 4th year of primary education to which we have evaluated with the computerized test of Butterworth (2003), Dyscalculia Screener. This tool consists of 4 subtests: 1. Simple Reaction Time, which evaluates the reaction time of the student before the presentation of a stimulus; 2. Point enumeration, which evaluates the ability to estimate the small numbers that is fundamental to learn to count, since it allows to check the result of the enumeration (Fuson, 1988). It is believed that this ability is innate, and a deficit could contribute to dyscalculia. 3. Comparison of numbers (also called as numerical effect of Stroop), is a test of ability to order numbers by their size. Homework also requires a fluid understanding of numbers. Students with deficits in the ability to recognize and understand numbers may have stopped forming efficient connections between numbers and their meanings so that a deficit could contribute to dyscalculia; 4. Test of Arithmetic Performance (addition and multiplication), the student has to answer quickly if an operation is correct or not.The results of this pilot study show a percentage of the risk population of 6.1%, which is in a range similar to that of other studies on the prevalence of dyscalculia (Devine et al., 2013, Dirks et al., 2008) .In the future, the expansion of the sample and its classification will provide an initial device to address a more complete assessment of students with learning difficulties in mathematics. Likewise, this screening allows the development of more specific intervention actions.Disponer de herramientas de cribado (screening) para identificar a estudiantes en riesgo de dificultades de aprendizaje en matemáticas es un  recurso imprescindible para abordar futuras intervenciones que disminuyan el fracaso y el bajo rendimiento en matemáticas.Presentamos un estudio piloto con 49 alumnos (media de edad de 9 años, 5 meses ) de 4º de educación Primaria a los que hemos evaluado con el test informatizado de Butterworth (2003), Dyscalculia Screener. Esta herramienta consta de 4 subtests: 1. Tiempo de Reacción Simple, que evalúa el tiempo de reacción del alumno ante la presentación de un estímulo; 2. Enumeración de puntos, que evalúa la capacidad para estimar los números pequeños que es fundamental para aprender a contar, ya que permite comprobar el resultado de la enumeración (Fuson, 1988). Se cree que esta capacidad es innata, y un déficit podría contribuir a la discalculia. 3. Comparación de números (también denominada como efecto numérico de Stroop), es una prueba de capacidad para ordenar numerosidades por su tamaño. La tarea también requiere una comprensión fluida de los números. Los alumnos con déficits en la capacidad de reconocer y comprender numerosidades pueden haber dejado de formar conexiones eficientes entre los números y sus significados por lo que un déficit podría contribuir a la discalculia; 4. Test de Rendimiento Aritmético (suma y multiplicación), el alumno tiene que contestar rápidamente si una operación es o no correcta.Los resultados de este estudio piloto muestran un porcentaje de población de riesgo del 6,1%, que se encuentra en un rango similar al de otros estudios sobre prevalencia de la discalculia (Devine et al., 2013; Dirks et al., 2008).En el futuro la ampliación de la muestra y su tipificación permitirá disponer de un dispositivo inicial para abordar una evaluación más completa de estudiantes con dificultades de aprendizaje de las matemáticas. Asimismo, este cribado permite desarrollar acciones más específicas de intervención.

The kinematics of the large western knot in the halo of the young planetary nebula NGC 6543

A detailed analysis is presented of the dominant ionised knot in the halo of the planetary nebula NGC 6543. Observations were made at high spectral and spatial resolution of the [OIII] 5007 line using the Manchester echelle spectrometer combined with the 2.1-m San Pedro Martir Telescope. A 20-element multislit was stepped across the field to give almost complete spatial coverage of the knot and surrounding halo. The spectra reveal, for the first time, gas flows around the kinematically inert knot. The gas flows are found to have velocities comparable to the sound speed as gas is photo-evaporated off an ionised surface. No evidence is found of fast wind interaction with the knot and we find it likely that the fast wind is still contained in a pressure-driven bubble in the core of the nebula. This rules out the possibility of the knot having its origin in instabilities at the interface of the fast and AGB winds. We suggest that the knot is embedded in the slowly expanding Red Giant wind and that its surfaces are being continually photoionised by the central star.Comment: 13 pages, 11 figures (all eps format). To be published in MNRAS, accepted on 6/7/0

Empty Urbanism: the bursting of the Spanish housing bubble

The depth of the Spanish housing crisis manifests itself in the collapse of construction activity and in the amount of housing and land stocks. The geography of the crisis shows its widespread nature, and the intensity of the previous bubble explains spatial differences. Resulting from this collapse are some problematic areas of 'empty urbanism'. An enormous land bubble, emerging from the peculiar Spanish urban development model, was a key factor in the impacts - caused by the crisis - on the territory and land-use plans. The crisis has demonstrated the unsustainability of this and the urgency of change in the existing land-use plans

Encapsulation of Lactobacillus plantarum in casein-chitosan microparticles facilitates the arrival to the colon and develops an immunomodulatory effect

The current work describes the capability of casein-chitosan microparticles to encapsulate Lactobacillus plantarum (CECT 220 and WCFS1 strains) and evaluates their ability to target the distal areas of the gut and to stimulate the immune system. Microparticles were prepared by complex coacervation, between sodium caseinate and chitosan in an aqueous suspension of the bacteria, and dried by spray-drying. In order to increase the survival rate of the loaded bacteria, microparticles were cross-linked with one of the following cross-linkers: tripolyphosphate, calcium salts or vanillin. Overall, microparticles displayed a mean size of about 7.5 μm with a bacteria loading of about 11 Log CFU/g, when cross-linked with vanillin (MP-LP-V). For conventional microparticles, the payload was 10.12 Log CFU/g. The storage stability study at 25 ◦C/60% RH, MP-LP-V offered the highest degree of protection without signif- icant modification of the payload in 260 days. Compared with control (aqueous suspension of bacteria), MP-LP-V also displayed a significantly higher degree of protection against probiotic inactivation in simulated gastric and intestinal fluids. In vivo results evidenced that microparticles, orally administered to rats, were able to reach the distal ileum and colon in about 4 h post-administration. Additionally, the effect of the daily administration of 107 CFU/mouse of MP-LP-V, for 3 weeks, induced an immunomodulatory effect characterized by an important enhancement of Th1 and Th17 responses. In conclusion, these microparticles seem to be a promising strategy for increasing survival and efficacy of probiotics, allowing the formulation of cost-effective and more stable and effective probiotic-based nutraceuticals

Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions.

Journal Article; Research Support, Non-U.S. Gov't; Review;Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide and are responsible for several types of drug hypersensitivity reactions (DHRs) in all age groups. The 2 major groups of DHRs to NSAIDs are those induced by immunological mechanisms (selective reactions) and those where inflammatory mediators are released through activation of the prostaglandin-leukotriene pathway without specific immunological recognition (cross-intolerance). In the present review, we focus on cross-intolerance reactions, which are the most frequent DHRs and are becoming a topic of major interest in children and adolescents. Paracetamol and ibuprofen are the drugs that most frequently cause DHRs in children; other NSAIDs are responsible for reactions in adolescents. In vivo and in vitro tests are of limited diagnostic value, with some exceptions for the less common selective reactions. In cross-intolerance, the clinical history and controlled administration are in many instances the only way to establish a diagnosis and look for alternatives. The clinical history is diagnostic when consistent symptoms occur repeatedly after exposure to NSAIDs with different chemical structures. Cutaneous and respiratory symptoms often co-occur in young children. The natural history of these reactions in children is unknown, and some patients can develop tolerance over time. Atopy remains a major risk factor for cross-intolerant reactions. The increasing interest in hypersensitivity to NSAIDs with improvements in patient phenotyping and the information provided by pharmacogenetics will improve our understanding and management of these reactions in the near future.The present study was supported by grants from the Carlos III National Health Institute RD12/0013 (RIRAAF Network), FIS PI12/02247, and FIS PI13/02598. It was also supported by Marie Curie (IAPP 7th Framework Program Mr. SymBioMath, no. 324554) and the Andalusian Public Health Service (PI-0279-2012 and PI-0463-2013).YesLos antiinflamatorios no esteroideos (AINEs) son ampliamente utilizados en todo el mundo y en todos los tramos de edad. Son responsables de un número importante de reacciones de hipersensibilidad a fármacos (RHFs), que no sólo afectan a adultos sino también a niños y adolescentes. Existen dos grandes grupos: reacciones selectivas, inducidas por mecanismos inmunológicos específicos, y de intolerancia cruzada (IC), donde se liberan mediadores inflamatorios en ausencia de reconocimiento inmunológico específico. En esta revisión nos ocuparemos de la IC, que es la causa más frecuente de RHFs y resulta de gran interés en niños y adolescentes. El paracetamol y el ibuprofeno son los medicamentos más frecuentemente implicados en las RHFs en niños. El uso diagnóstico de los tests in vivo e in vitro es muy limitado, con algunas excepciones en las reacciones selectivas. En las de IC, la historia clínica y la administración controlada son en ocasiones la única vía para confirmar el diagnóstico y determinar las alternativas terapéuticas más adecuadas. La historia clínica tiene valor diagnóstico cuando se reproducen síntomas consistentes repetidamente tras la exposición a AINEs no relacionados estructuralmente. En niños de corta edad es especialmente frecuente la combinación de síntomas cutáneos y respiratorios. Aunque se desconoce la historia natural de la IC en niños, es probable que se desarrolle tolerancia a lo largo de la vida. El fenotipado detallado junto con la información proporcionada por la fármaco-genética no sólo proporcionarán un conocimiento más preciso de la IC sino que también facilitará el manejo clínico de estos pacientes

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care

<p>Abstract</p> <p>Background</p> <p>Vaginitis is a common complaint in primary care. In uncomplicated candidal vaginitis, there are no differences in effectiveness between oral or vaginal treatment. Some studies describe that the preferred treatment is the oral one, but a Cochrane's review points out inconsistencies associated with the report of the preferred way that limit the use of such data. Risk factors associated with recurrent vulvovaginal candidiasis still remain controversial.</p> <p>Methods/Design</p> <p>This work describes a protocol of a multicentric prospective observational study with one year follow up, to describe the women's reasons and preferences to choose the way of administration (oral vs topical) in the treatment of not complicated candidal vaginitis. The number of women required is 765, they are chosen by consecutive sampling. All of whom are aged 16 and over with vaginal discharge and/or vaginal pruritus, diagnosed with not complicated vulvovaginitis in Primary Care in Madrid.</p> <p>The main outcome variable is the preferences of the patients in treatment choice; secondary outcome variables are time to symptoms relief and adverse reactions and the frequency of recurrent vulvovaginitis and the risk factors. In the statistical analysis, for the main objective will be descriptive for each of the variables, bivariant analysis and multivariate analysis (logistic regression).. The dependent variable being the type of treatment chosen (oral or topical) and the independent, the variables that after bivariant analysis, have been associated to the treatment preference.</p> <p>Discussion</p> <p>Clinical decisions, recommendations, and practice guidelines must not only attend to the best available evidence, but also to the values and preferences of the informed patient.</p