An Economic Analysis of An Innovative Floating Offshore Wind Platform Built with Concrete: The SATH® Platform

[Abstract] The goal of this work is to carry out an economic analysis of a novel floating offshore wind structure, of which the main material is concrete: the SATH® platform. It takes a step forward in floating marine wind energy research, in which traditional platforms are mainly composed of steel. The technique to calculate the costs of the platform and the economic parameters to decide if the farm is economically feasible are explained in the paper. This case study analyzes a possible farm of 500 MW located in Portugal and several scenarios considering different electric tariffs and capital costs (Scenario 1: electric tariff of 50 €/MWh and 6% of capital cost; Scenario 2: electric tariff of 50 €/MWh and 8% of capital cost; Scenario 3: electric tariff of 150 €/MWh and 6% of capital cost; Scenario 4: electric tariff of 150 €/MWh and 8% of capital cost). Results show the economic feasibility of a farm with the characteristics of Scenarios 3 and 4. This work is significant in order to provide a new approach to analyzing traditional floating offshore wind structures, which can represent a path towards the future of floating offshore renewable energy technologies.European Commission; EAPA_344/2016This research was funded by EAPA_344/2016 ARCWIND project, co-financed by the European Regional Development Fund though the Interreg Atlantic Area Programme

La evaluación del docente de matemática y su incidencia en los procesos de enseñanza aprendizaje.

La educación es un derecho que tienen todas personas a nivel de todas las naciones del mundo y por ende a nivel latinoamericano, la cual busca el desarrollo y mejoramiento del nivel de vida, de esta manera dejar de ser países subdesarrollados y dependientes. Por tal motivo la educación impartida por docentes en conjunto con autoridades y administrativos de los planteles educativos debe ser de calidad y nos debería conducir a una constante evaluación de los procesos de enseñanza aprendizaje, enfatizando en el proceso docente y administrativo, el Colegio Nacional Mixto Santo Domingo de los Colorados, es un establecimiento de educación media que funciona en la ciudad del mismo nombre. la formación académica se está innovando constantemente, la investigación aplicada es de Campo, con un método descriptivo, tomando en cuenta el contacto directo con el objeto, se aplicó un muestra y entrevista a  22 docentes, 22 estudiantes y74 padres de familia, con esta  evaluación que en su esencia busca el análisis permanente e integral del estudiante no para que de manera consciente asuma sus aciertos y errores; se ha convertido en la medición de la repetición de lo enseñado por el profesor transformándose en una evaluación netamente cuantitativa que busca la promoción del estudiante a nivel científico, producto de la visión que los maestros tienen al respecto

Correlación de la t(9;22), t(12;21) e hiperdiploidía de ADN con el inmunofenotipo y la tasa de proliferación de células B neoplásicas en niños con leucemia linfoblástica aguda de precursores B

Introduction. 60-80% of patients with acute B lymphoblastic leukemia show genetic abnormalities that influence the prognosis of the disease and the biology of the tumor. Objective. To analyze different genetic abnormalities in acute B lymphoblastic leukemia in children, its relationship to immunophenotype and proliferative rate compared to normal B cell precursors. Materials and methods. A total of 44 samples were studied by flow cytometry for immunophenotype, DNA content and proliferative rate and RT-PCR for translocations t(9;22), t(12;21), t(4;11) and t(1;19). Using a hierarchical cluster analysis some immunophenotypic patterns were identified and associated to genetic abnormalities when compared to normal B cell precursors. Results. DNA quantification showed that 21% of the cases were hyperdiploid high index and 47.47% hyperdiploid low index. The presence of hyperdiploidy was associated with increased tumor proliferation and aberrant immunophenotypes including abnormal expression of CD10, TdT, CD38 and CD45 and increased size of the lymphoblasts. The presence of t(9;22) and t(12;21) discriminates normal cells of the tumor cells with aberrant immunophenotype in the expression of CD19, CD22, CD13, CD33, CD38, CD34 and CD45. Conclusions. The aberrant immunophenotype profile detected in neoplastic cells in conjunction with abnormalities in proliferative rate was significantly associated with DNA hyperdiploidy and clearly distinguished blasts with t(9;22) and t(12;21) of normal B cell precursors. The identification of these parameters is useful as a tool for classification and monitoring of these patients. doi: http://dx.doi.org/10.7705/biomedica.v33i3.1441Introducción. Del 60 al 80 % de los pacientes con leucemia linfoblástica aguda de precursores B presentan alteraciones genéticas que influyen en el pronóstico de la enfermedad y en la biología del tumor.Objetivo. Analizar distintas alteraciones genéticas en leucemia linfoblástica aguda de precursores B en niños, y su relación con el inmunofenotipo y con la tasa de proliferación, en comparación con precursores B normales.Materiales y métodos. En 44 pacientes se evaluó, por citometría de flujo, el inmunofenotipo, el contenido de ADN y la proliferación, y por RT-PCR, las traslocaciones t(9;22), t(12;21), t(4;11) y t(1;19). Mediante un análisis jerarquizado de conglomerados se identificaron los patrones inmunofenotípicosde expresión asociados a las traslocaciones, tomando como referencia precursores B normales.Resultados. La cuantificación del ADN mostró que el 21 % de los casos de leucemia linfoblástica aguda de precursores B eran hiperdiploides de índice alto y, el 47,7 %, hiperdiploides de índice bajo. La presencia de hiperdiploidía se asoció con mayor proliferación tumoral y con inmunofenotipos aberrantes, que incluyeron expresión anormal de CD10, TdT, CD38 y CD45 y un mayor tamaño de los linfoblastos. La presencia de t(9;22) y t(12;21) discrimina células normales de células tumorales con aberraciones en la expresión de CD19, CD20, CD13, CD33, CD38, CD34 y CD45.Conclusiones. El perfil de aberraciones fenotípicas detectado en conjunto con anormalidades en la proliferación tumoral, se asocia de forma significativa con hiperdiploidiía de ADN y discrimina deforma clara linfoblastos con t(9;22) y t(12;21) de los precursores B normales. La identificación de estos parámetros será de gran utilidad como herramienta para la clasificación y seguimiento de lospacientes. doi: http://dx.doi.org/10.7705/biomedica.v33i3.1441

Aproximaciones en Psicología educacional : diversidades ante la contingencia actual

Educación, sociedad y cultura : claves para proyectar el siglo XXI / Gallegos, Miguel; Bonantini, Carlos; Quiroga, Víctor; Berra, Martina -- Antecedentes históricos de la psicología educacional en Chile / Salas, Gonzalo; Inzunza, Jorge -- El desarrollo cognitivo desde el modelo de Reuven Feuerstein / Morales, Patricia -- Talento académico. Una aproximación al estado del arte / Cornejo, Claudia; Benavides, Emilia -- Evaluación del funcionamiento cognitivo de niños y adolescentes con discapacidad intelectual / Muñoz, María Teresa; Lucero, Boris -- Adolescencia y prácticas sociales en la educación : aproximaciones a un proceso transicional en un contexto de incertidumbre / Contreras, Roberto -- Rol del psicólogo educacional en contextos educativos no formales e informales / Rodríguez, Luis Alberto -- Resiliencia y educación : nuevas miradas / González Arratia, Norma Ivonne; Valdez, José Luis -- Resiliencia familiar y mundo rural / Saavedra, Eugenio; Castro, Ana -- Rendimiento académico y representación mental del apego con adolescentes hombres y mujeres que muestran alto y bajo nivel de resiliencia / Espinosa, Nancy; Saavedra, Eugenio -- El fracaso escolar : una experiencia española / Artuch, Raquel -- La Psicología Educacional en perspectiva / Catalán, Jorg

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

O império dos mil anos e a arte do "tempo barroco": a águia bicéfala como emblema da Cristandade

The article reveals that between the mid-17th century and the mid-18th century, in the ecclesiastical world of the religious orders (Jesuits, franciscans, Carmelites, Cistercians, Augustinian, etc.) and the episcopate, there was the progressive adoption of the imperial symbol, the double-headed eagle, attribute of the Christian Empire, the germanic Holy Roman Empire emblem. However, in the religious field, this imperial eagle of the baroque time appears without the political insignia (sword, scepter and the imperial orb), adorning altars, monstrances, trumphal archs, facades of temples, doors, walls, domes, pulpits, sacred washbasins, sculptures and paintings of the Virgin and Child, liturgical robes, etc.; therefore related to the cult and the dogmas of the Catholic faith - in artistic works, the association between the double eagle and the flesh-spirit or human-divine unity, axial principle of the Catholic faith, represented by Virgin-Mother and Christ, is often indicated directly. The research has located and identified numerous remnants of the double eagle emblem in religious field in Portugal and Spain and in their conquests and dominions in America, Asia and Africa, and also in Italy, and the historiography on painful birth of the modern era in the West has never realized this phenomenon. Symbolizing absolute power, universal power, these works with sacred significance, as the ecclesiastical discourse of the time, demonstrate movement occurred in religious plane. With the aim to assert not only spiritual but also temporal power of Christ and his mystical body, the Church was impelled by the idea of restoring the "Republica Christiana" or Christendon - disrupted by conflicts of power and faith - and of introducing a Universal Apostolic Monarchy extended to all mankind: the Empire of the Last Days, the Empire of Christ in the world, the fifth Empire

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Análisis de cumplimiento de las obligaciones tributarias de la asociación de pequeños comerciantes “Primero de Mayo”, cantón la Concordia.Análisis de cumplimiento de las obligaciones tributarias de la asociación de pequeños comerciantes “Primero de Mayo”,

Los ejecutivos hacen fuertes exigencia para mejorar el control de dicha institución que dirigen. Los controles internos se implantan para mantener la campaña en la dirección de sus objetivos de rentabilidad y en la consecución de su misión, así como para minimizarlas sorpresas en el camino. Ellos hacen posible a la administración negociar en ambiente económico y competitivo, ajustándose a las demandas y prioridades de los que conforman dicha institución y restaurándose para el crecimiento futuro. Los controles internos promueven la eficiencia y reduce el riesgo de pérdida de activos y ayudan asegurar la confiabilidad de los estados financiero y el cumplimiento de las leyes y regulaciones .Se aplicó  una investigación de campo, con un método analítico, descriptiva, exploratorio, con el fin de dar solución a la problemática determinada y especifica  que se presenta en dicha institución, la muestra con la que se  trabajó  es de 49 personas distribuidas de la siguiente manera: directivos, docentes, administrativos 17, padres de familia 21, estudiantes 11, Producto de la evaluación realizada a la Unidad Educativa Nacional  Simón Plata Torres para el año 2017 se llegó a determinar que dicha entidad presenta un alto grado de confianza, pese aquello tiene deficiencias en el manejo de su control interno y no se está poniendo en práctica mi cumplimiento con ciertas normas emitidas en la Ley Orgánica de la Contraloría General del Estado material de control

Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species

Flavonoids have attracted great interest due to their possible anticancer activities. Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 μM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. These effects on viability were accompanied by the concentration- and time-dependent appearance of apoptosis as evidenced by DNA fragmentation, formation of apoptotic bodies and a sub-G1 ratio increase. Comparative studies with the best-studied bioflavonoid quercetin indicate that gardenin B is a more cytotoxic and more apoptotic inducer than quercetin. Cell death induced by gardenin B was associated with: (i) a significant induction of caspase-2, -3, -8 and -9 activities; (ii) cleavage of the initiator caspases (caspase-2, -8 and -9), of the executioner caspase-3, and of poly(ADP-ribose) polymerase; and (iii) a concentration-dependent reactive oxygen species generation. In conclusion, apoptosis induced by gardenin B is associated with activation of both the extrinsic and the intrinsic apoptotic pathways of cell death and occurs through a mechanism that is independent of the generation of reactive oxygen species.Fil: Cabrera, Javier. Universidad de Las Palmas de Gran Canaria; EspañaFil: Saavedra, Ester. Universidad de Las Palmas de Gran Canaria; EspañaFil: del Rosario, Henoc. Universidad de Las Palmas de Gran Canaria; EspañaFil: Perdomo, Juan. Universidad de Las Palmas de Gran Canaria; EspañaFil: Loro, Juan F.. Universidad de Las Palmas de Gran Canaria; EspañaFil: Cifuente, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: García, Celina. Universidad de La Laguna; EspañaFil: Quintana, José. Universidad de Las Palmas de Gran Canaria; EspañaFil: Estévez, Francisco. Universidad de Las Palmas de Gran Canaria; Españ