219 research outputs found
Toroidal Orientifolds in IIA with General NS-NS Fluxes
Type IIA toroidal orientifolds offer a promising toolkit for model builders,
especially when one includes not only the usual fluxes from NS-NS and R-R field
strengths, but also fluxes that are T-dual to the NS-NS three-form flux. These
new ingredients are known as metric fluxes and non-geometric fluxes, and can
help stabilize moduli or can lead to other new features. In this paper we study
two approaches to these constructions, by effective field theory or by toroidal
fibers twisted over a toroidal base. Each approach leads us to important
observations, in particular the presence of D-terms in the four-dimensional
effective potential in some cases, and a more subtle treatment of the
quantization of the general NS-NS fluxes. Though our methods are general, we
illustrate each approach on the example of an orientifold of T^6/Z_4.Comment: 59 pages, references adde
T-duality, Generalized Geometry and Non-Geometric Backgrounds
We discuss the action of O(d,d), and in particular T-duality, in the context
of generalized geometry, focusing on the description of so-called non-geometric
backgrounds. We derive local expressions for the pure spinors descibing the
generalized geometry dual to an SU(3) structure background, and show that the
equations for N=1 vacua are invariant under T-duality. We also propose a local
generalized geometrical definition of the charges f, H, Q and R appearing in
effective four-dimensional theories, using the Courant bracket. We then address
certain global aspects, in particular whether the local non-geometric charges
can be gauged away in, for instance, backgrounds admitting a torus action, as
well as the structure of generalized parallelizable backgrounds.Comment: 33 page
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. To better define the pathways controlling the most abundant neuronal cells in the mammalian cerebellum, cerebellar granule cell progenitors (GCPs), we performed RNA-sequencing of GCPs exiting the cell cycle. Time-series modeling of GCP cell cycle exit identified downregulation of activity of the epigenetic reader protein Brd4. Brd4 binding to the Gli1 locus is controlled by Casein Kinase 1δ (CK1 δ)-dependent phosphorylation during GCP proliferation, and decreases during GCP cell cycle exit. Importantly, conditional deletion of Brd4 in vivo in the developing cerebellum induces cerebellar morphological deficits and ataxia. These studies define an essential role for Brd4 in cerebellar granule cell neurogenesis and are critical for designing clinical trials utilizing Brd4 inhibitors in neurological indications
Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set
We report a measurement of the bottom-strange meson mixing phase \beta_s
using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays
in which the quark-flavor content of the bottom-strange meson is identified at
production. This measurement uses the full data set of proton-antiproton
collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment
at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity.
We report confidence regions in the two-dimensional space of \beta_s and the
B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2,
-1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in
agreement with the standard model expectation. Assuming the standard model
value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +-
0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +-
0.009 (syst) ps, which are consistent and competitive with determinations by
other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012
The geology and geophysics of Kuiper Belt object (486958) Arrokoth
The Cold Classical Kuiper Belt, a class of small bodies in undisturbed orbits beyond Neptune, are primitive objects preserving information about Solar System formation. The New Horizons spacecraft flew past one of these objects, the 36 km long contact binary (486958) Arrokoth (2014 MU69), in January 2019. Images from the flyby show that Arrokoth has no detectable rings, and no satellites (larger than 180 meters diameter) within a radius of 8000 km, and has a lightly-cratered smooth surface with complex geological features, unlike those on previously visited Solar System bodies. The density of impact craters indicates the surface dates from the formation of the Solar System. The two lobes of the contact binary have closely aligned poles and equators, constraining their accretion mechanism
Effects of sleep deprivation on neural functioning: an integrative review
Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research
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