20 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Thigh-length compression stockings and DVT after stroke
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- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Evaluation and Management of Graves' Orbitopathy
- Author
- Al-Mefty
- Antoszyk
- Bahn
- Bahn
- Bartalena
- Bartalena
- Bartley
- Boyle
- Brennan
- Brix
- Capo
- Cartlidge
- Char
- Cheng
- Clague
- Dallow
- DeGroot
- Fatourechi
- Feldon
- Friedman
- Goldsmith
- Gorman
- Gouch
- H.B. Harold Lee
- Hurbli
- I. Rand Rodgers
- John J. Woog
- Kadrmas
- Kazim
- Kumar
- Leone
- McCord
- Migliori
- Mouritis
- Nunery
- Nunery
- Olivari
- Parsons
- Prabhakar
- Pritchard
- Prummel
- Prummel
- Rotella
- Shorr
- Tarrus-Montaner
- Valyasevi
- Wakelkamp
- Wall
- Weetman
- Werner
- Werner
- Wiersinga
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textUnusual Peroxide-Dependent, Heme-Transforming Reaction Catalyzed by HemQ
- Author
- Arianna I. Celis
- Bali S.
- Bennett R. Streit
- Berry E. A.
- Celis A. I.
- Cheung L. D.
- Choudhury K.
- Dailey H.
- Dailey H. A.
- Dailey H. A.
- Dailey T. A.
- Erman J. E.
- Garrett C. Moraski
- Goblirsch B. R.
- Gudrun S. Lukat-Rodgers
- Hiner A. N.
- Hu S.
- Jennifer L. DuBois
- Kenton R. Rodgers
- Kuhner M.
- Lash T. D.
- Lash T. D.
- Lash T. D.
- Layer G.
- Lee W. C.
- Lobo S. A. L.
- Luo J.
- Mak P.
- Matsui T.
- Mayfield J. A.
- Panek H.
- Podstawka E.
- Poulos T. L.
- Rand K.
- Ravi Kant
- Rwere F.
- Rwere F.
- Rwere F.
- Skaar E. P.
- Smulevich G.
- Stephenson J. R.
- Timothy D. Lash
- Uchida K.
- Wilks A.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
No full textElimination of copper-zinc intermetallic interferences in anodic stripping voltammetry
- Author
- Christian G. D.
- Copeland R.
- Copeland T. R.
- Flato J. B.
- Gerlach W.
- Janz G. J.
- Kemula W.
- Marion A.
- Parren G. M.
- Parry E. P.
- R. A. Osteryoung
- R. K. Skogerboe
- Rand Kenan The William
- Rodgers R. S.
- Scribner B. F.
- Siegerman H.
- Staunton J. J.
- Stepanova O. S.
- Stepanova O. S.
- T. R. Copeland
- te) Environmental Protection Agency
- Trúmpler G.
- Vesely J.
- Vesely J.
- Zakharov M. S.
- Zakharov M. S.
- Zebreva A. I.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
No full textBariatric Surgery in Pediatrics - Is it Time?
- Author
- Abu-Abeid S
- Allen SR
- Anderson AE
- Angrisani L
- Apovian CM
- Barlow SE
- Barlow SE
- Bitsori M
- Braghetto I
- Capella JF
- Dietz WH
- Dietz WH
- Dolan K
- Dousei T
- Drazen DL
- Ebbeling CB
- Epstein LH
- Epstein LH
- Flodmark CE
- Fobi M
- Garcia VF
- Garcia VF
- Greenstein RJ
- Inge TH
- Inge TH
- Kirk S
- Kremen AJ
- Langer FB
- Mason EE
- Milone L
- Mognol P
- Must A
- Papavramidis ST
- Rand CS
- Regan JP
- Rodgers BM
- Rosenbaum
- Santoro S
- Santoro S
- Silberhumer GR
- Soper RT
- Stanford A
- Strauss RS
- Suter M
- Towbin A
- Troiano RP
- Yitzhak A
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- Field of study
No full textLaboratory Techniques Used to Diagnose Constitutional Platelet Dysfunction
- Author
- A A Abaeva
- A A Barg
- A A Ignatova
- A Albanyan
- A Awidi
- A Billio
- A C Kirkpatrick
- A E Knight
- A Grassetto
- A Greinacher
- A J Quick
- A Kerényi
- A Lecchi
- A M Dyszkiewicz-Korpanty
- A R Muir
- A Sharda
- A T Nurden
- A T Nurden
- A Tosetto
- B B Dawood
- B EJ Spurgeon
- B Hechler
- B Linnemann
- B Savage
- B Shenkman
- C Gachet
- C I Prodan
- C I Prodan
- C M Korse
- C P Hayward
- C PM Hayward
- C PM Hayward
- D C Cardinal
- D Mezzano
- D Whiting
- E Berrou
- E Berrou
- E C Reddy
- E J Favaloro
- E J Favaloro
- E Maurer-Spurej
- E O Agbani
- G A FitzGerald
- G A Fritsma
- G Colucci
- G F Mao
- G L Dale
- H Cai
- H P Lorez
- H Patscheke
- H Takahashi
- I van Asten
- I van Asten
- J Campbell
- J D Sweeney
- J D Sweeney
- J E Wall
- J G Brunet
- J G White
- J N George
- K Freson
- K Freson
- K Sandrock-Lang
- K Saxena
- L K Jennings
- L Pasalic
- L Stefanini
- M B Brooks
- M B Callan
- M Bellio
- M Canault
- M Canault
- M Cattaneo
- M Cattaneo
- M Cattaneo
- M Cattaneo
- M Cattaneo
- M Cortese
- M Diamandis
- M Diamandis
- M Gunay-Aygun
- M Handa
- M L Rand
- M L Wei
- M L Zighetti
- M Othman
- M Pai
- M S Badin
- M Shiraga
- M-C Alessi
- N Hézard
- O Andres
- P Gresele
- P Gresele
- P H Mangin
- P Harrison
- P J Sims
- P Robert
- P Saultier
- R K Andrews
- R P Rodgers
- R Paniccia
- S J Israels
- S MN Mulliez
- S Murugappa
- S Nomura
- T Gremmel
- T Gremmel
- T M Quinton
- T M Quinton
- T Quiroga
- W H Kahr
- W Introne
- Y M Patel
- Y Zhou
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 22/10/2020
- Field of study
No full textInternational audiencePlatelets play a major role in primary hemostasis, where activated platelets form plugs to stop hemorrhaging in response to vessel injuries. Defects in any step of the platelet activation process can cause a variety of platelet dysfunction conditions associated with bleeding. To make an accurate diagnosis, constitutional platelet dysfunction (CPDF) should be considered once von Willebrand disease and drug intake are ruled out. CPDF may be associated with thrombocytopenia or a genetic syndrome. CPDF diagnosis is complex, as no single test enables the analysis of all aspects of platelet function. Furthermore, the available tests lack standardization, and repeat tests must be performed in specialized laboratories especially for mild and moderate forms of the disease. In this review, we provide an overview of the laboratory tests used to diagnose CPDF, with a focus on light transmission platelet aggregation (LTA), flow cytometry (FC), and granules assessment. Global tests, mainly represented by LTA, are often initially performed to investigate the consequences of platelet activation on platelet aggregation in a single step. Global test results should be confirmed by additional analytical tests. FC represents an accurate, simple, and reliable test to analyze abnormalities in platelet receptors, and granule content and release. This technique may also be used to investigate platelet function by comparing resting- and activated-state platelet populations. Assessment of granule content and release also requires additional specialized analytical tests. High-throughput sequencing has become increasingly useful to diagnose CPDF. Advanced tests or external research laboratory techniques may also be beneficial in some cases
Postoperative Analgesia in Morbid Obesity
- Author
- A Hindle
- A Levin
- A Rodgers
- A Wadhwa
- Adrian Alvarez
- AG Doufas
- Ashish C. Sinha
- B Al-Nasser
- B Tufanogullari
- BD Sites
- BS Ungern-Sternberg von
- C Remy
- CD Franco
- CSW Rand
- D Michaloudis
- DA Sherwinter
- DR Cottam
- DR Farley
- EH Ellinas
- F Aubrun
- FP Buckley
- FW Abdallah
- G Blaudszun
- G Niraj
- GS Oliveira De
- GW Smetana
- H Hayashi
- H Kehlet
- HT Liu
- I Wong
- J Hernández-Palazón
- J Zakine
- J-H Ryu
- J-P Laulin
- JB Brodsky
- JB Brodsky
- JB Gross
- JM Feld
- JS Sprigge
- JT Cotter
- K Hirota
- KC Sasse
- KE Davies
- LED Baerdemaeker
- M Kaur
- M Yildiz
- MC Cabrera Schulmeyer
- MR Yeomans
- MR Yeomans
- N Kumar
- N Rawal
- NT Nguyen
- P Thaisetthawatkul
- PM Singh
- PP Lopez
- Preet Mohinder Singh
- R Govindarajan
- R Schumann
- R Schumann
- RH Savel
- RJ Moraca
- RL Schmid
- S Gelman
- S Kralingen Van
- S Taylor
- SA Lang
- XZ Khawaja
- Y Ding
- YK Choi
- ZM Naja
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
